Detailed information NTG0557338

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: KAJ74_RS11750
• Genome accession: NZ_CP073012
• Coordinates: 2421183..2422226 (+)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus strain SA14+
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 2416183..2427226

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
KAJ74_RS11720 (KAJ74_11720)	-	2416728..2416838 (+)	111	WP_031775032.1	hypothetical protein	-
KAJ74_RS11725 (KAJ74_11725)	-	2416867..2417280 (+)	414	WP_001670387.1	hypothetical protein	-
KAJ74_RS11730 (KAJ74_11730)	-	2417711..2418697 (-)	987	WP_000999713.1	aromatic acid exporter family protein	-
KAJ74_RS11735 (KAJ74_11735)	map	2419109..2419867 (+)	759	WP_000636142.1	type I methionyl aminopeptidase	-
KAJ74_RS11740 (KAJ74_11740)	-	2420084..2420470 (+)	387	WP_001110179.1	hypothetical protein	-
KAJ74_RS11745 (KAJ74_11745)	liaF	2420485..2421186 (+)	702	WP_000149064.1	cell wall-active antibiotics response protein LiaF	-
KAJ74_RS11750 (KAJ74_11750)	vraS	2421183..2422226 (+)	1044	WP_001017131.1	sensor histidine kinase	Regulator
KAJ74_RS11755 (KAJ74_11755)	vraR	2422216..2422845 (+)	630	WP_000153535.1	two-component system response regulator VraR	Regulator
KAJ74_RS11760 (KAJ74_11760)	-	2422957..2424174 (-)	1218	WP_000037078.1	YihY/virulence factor BrkB family protein	-
KAJ74_RS11765 (KAJ74_11765)	-	2424452..2424727 (-)	276	WP_000428172.1	YtxH domain-containing protein	-
KAJ74_RS11770 (KAJ74_11770)	-	2424734..2425198 (-)	465	WP_000228666.1	low molecular weight protein-tyrosine-phosphatase	-
KAJ74_RS11775 (KAJ74_11775)	-	2425345..2425545 (+)	201	WP_000180460.1	DUF1128 family protein	-
KAJ74_RS11780 (KAJ74_11780)	-	2425548..2426804 (+)	1257	WP_001789555.1	aminopeptidase	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=557338 KAJ74_RS11750 WP_001017131.1 2421183..2422226(+) (vraS) [Staphylococcus aureus strain SA14+]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=557338 KAJ74_RS11750 WP_001017131.1 2421183..2422226(+) (vraS) [Staphylococcus aureus strain SA14+]
ATGAACCACTATATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTATTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTCTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTACTCGCATACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACACTCGTACCTTTAAATCAAGAATTGCATAAGTTGCGACTTAAAACTCAAAATTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTGGCTCGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGTTATCTGCTATCAAAGAAACGAAGTTAGAACCACCATTAGACCAACAAATTCC
GATTTTAGAGAAAATGGTTCAAGATTCGCAGTTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCAATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGACAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1