Detailed information    

insolico Bioinformatically predicted

Overview

Name   covS   Type   Regulator
Locus tag   J7U24_RS01630 Genome accession   NZ_CP072440
Coordinates   304308..305825 (+) Length   505 a.a.
NCBI ID   WP_014607970.1    Uniprot ID   A0A2H4K9K6
Organism   Streptococcus thermophilus strain S24730     
Function   repress comR expression (predicted from homology)   
Competence regulation

Genomic Context

Location: 299308..310825
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  J7U24_RS01600 - 299588..299758 (+) 171 Protein_275 ascorbate 6-phosphate lactonase -
  J7U24_RS01605 (J7U24_01600) - 299775..300446 (-) 672 WP_002946492.1 TrkA family potassium uptake protein -
  J7U24_RS01610 (J7U24_01605) - 300486..301850 (-) 1365 WP_138496717.1 TrkH family potassium uptake protein -
  J7U24_RS01615 (J7U24_01610) rsmG 301920..302633 (-) 714 WP_138496718.1 16S rRNA (guanine(527)-N(7))-methyltransferase RsmG -
  J7U24_RS01620 (J7U24_01615) - 302930..303466 (+) 537 WP_002946488.1 DUF177 domain-containing protein -
  J7U24_RS01625 (J7U24_01620) covR 303622..304311 (+) 690 WP_002949638.1 response regulator transcription factor Regulator
  J7U24_RS01630 (J7U24_01625) covS 304308..305825 (+) 1518 WP_014607970.1 HAMP domain-containing histidine kinase Regulator
  J7U24_RS01635 (J7U24_01630) nrdR 305947..306426 (+) 480 WP_011680738.1 transcriptional regulator NrdR -
  J7U24_RS01640 (J7U24_01635) - 306423..307598 (+) 1176 WP_011680739.1 DnaD domain protein -
  J7U24_RS01645 (J7U24_01640) dnaI 307602..308504 (+) 903 WP_014607971.1 primosomal protein DnaI -
  J7U24_RS01650 (J7U24_01645) der 308610..309920 (+) 1311 WP_014607972.1 ribosome biogenesis GTPase Der -
  J7U24_RS01655 (J7U24_01650) - 309984..310643 (+) 660 Protein_286 HI_0552 family protein -

Sequence

Protein


Download         Length: 505 a.a.        Molecular weight: 57550.96 Da        Isoelectric Point: 5.2689

>NTDB_id=553205 J7U24_RS01630 WP_014607970.1 304308..305825(+) (covS) [Streptococcus thermophilus strain S24730]
MSKLFGKVTIRKKLTMTTAVVFFLVLSMFTLVVVFSANTLLLQRERQNVNNTISKVVTYIEKDWDSDEELSPEPLLAALY
SPKNIYPSIINGVLSEKRSLDGQVAVSNRLYSNQSIYVYDKKGTFIFTSEEDTDSPPGMSEVNKLKLVSYKGKRGFLLQV
PIYGKDKKTIVGYAQVFHDLEFYYALKERLIFLLIFLEVGMTVLVIAVTVVVLTSILRPMRQLHETMGIIIDSPSDLELR
SKIESHDEIGALALNFNCMMDKIQENNQMQMRFLSDVSHELRTPIAVIKGHMDLLQRWGKNDPEILEESLEAASHEANRM
TIMINDMLDSIRVKGSFDNHRNDTCDLNSSIRTVIGNFRVLHDDYQFYLNDSEGSDRPAQIYSQHFEQVITILIDNAVKY
SPVNKKIQITIKALEDEMLVQVQDNGEGISKEDIEHIFERFYRSDKARNRTTTQSGVGIGLSILYQIVEAYRCHIDVSSE
LGVGTRFDLYIPFAESETTTPQIEG

Nucleotide


Download         Length: 1518 bp        

>NTDB_id=553205 J7U24_RS01630 WP_014607970.1 304308..305825(+) (covS) [Streptococcus thermophilus strain S24730]
ATGAGTAAATTATTTGGTAAAGTAACCATTAGAAAAAAGTTGACCATGACAACTGCTGTGGTCTTCTTTCTTGTATTGTC
GATGTTCACTCTGGTTGTTGTATTTTCAGCCAATACGCTTCTTTTGCAACGTGAACGTCAAAATGTAAATAATACAATCT
CAAAAGTTGTTACTTATATCGAAAAGGACTGGGACTCTGATGAAGAGTTGAGTCCAGAGCCGCTTTTAGCGGCCCTTTAT
TCACCGAAAAATATCTATCCATCAATCATTAATGGAGTGCTTTCTGAAAAGCGTTCCTTAGATGGTCAAGTTGCGGTTTC
TAATAGATTATATTCCAACCAGTCTATCTATGTTTATGACAAAAAGGGAACTTTTATCTTTACTTCTGAGGAGGATACAG
ACTCACCTCCAGGCATGTCTGAGGTCAATAAACTGAAGTTGGTTTCCTATAAAGGTAAACGTGGTTTCTTACTACAAGTT
CCAATCTATGGCAAGGATAAGAAGACCATTGTTGGGTATGCTCAAGTTTTCCATGATTTGGAATTCTACTATGCGTTAAA
AGAGCGTTTAATTTTCCTATTGATATTCCTTGAAGTAGGAATGACGGTCTTAGTTATTGCAGTAACTGTAGTTGTCTTGA
CATCTATTCTTCGTCCGATGAGGCAGTTACACGAAACGATGGGTATTATTATCGATTCGCCAAGTGATTTGGAGCTTCGA
TCTAAGATTGAGAGTCATGATGAGATTGGTGCTTTGGCACTTAACTTTAACTGTATGATGGATAAAATTCAAGAAAATAA
TCAGATGCAGATGCGTTTCTTGAGTGACGTCAGTCACGAATTACGTACTCCCATTGCAGTTATTAAAGGACATATGGACC
TCTTGCAACGTTGGGGTAAAAATGATCCTGAAATCCTTGAAGAAAGTCTTGAAGCTGCAAGTCACGAAGCCAACCGTATG
ACGATTATGATTAACGATATGTTGGATTCTATTCGTGTTAAAGGGTCATTTGACAATCATAGAAATGATACATGTGATTT
GAATTCTTCAATCCGTACGGTTATTGGGAATTTTCGTGTCCTACATGACGACTACCAATTCTACCTCAATGATTCTGAGG
GTTCAGATCGTCCAGCACAGATTTACAGCCAGCACTTTGAACAGGTTATTACTATTTTGATTGATAATGCGGTCAAGTAT
TCGCCTGTTAATAAGAAAATCCAGATTACTATCAAGGCTCTGGAAGATGAGATGCTGGTACAGGTACAGGATAATGGTGA
GGGTATCTCTAAAGAAGATATTGAACATATATTTGAACGCTTCTATCGTTCAGATAAGGCGCGTAATCGTACGACAACCC
AATCTGGTGTGGGTATTGGTTTATCAATCCTCTATCAAATTGTGGAAGCTTATCGATGCCATATCGATGTCAGTTCAGAA
CTTGGTGTGGGTACACGTTTTGACCTCTACATTCCTTTTGCAGAGTCAGAAACTACGACACCTCAAATTGAAGGTTAA

Domains

Predicted by InterproScan.

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c)

(384-494)

ArlS sensor domain (ArlS_N)

(39-187)

His Kinase A (phospho-acceptor) domain (HisKA)

(270-329)

HAMP domain (HAMP)

(213-265)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A2H4K9K6

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  covS Streptococcus salivarius strain HSISS4

94.422

99.406

0.939