Detailed information
Bioinformatically predicted
Overview
| Name | sepM | Type | Regulator |
| Locus tag | J7U00_RS02060 | Genome accession | NZ_CP072431 |
| Coordinates | 380196..381272 (+) | Length | 358 a.a. |
| NCBI ID | WP_011681549.1 | Uniprot ID | - |
| Organism | Streptococcus thermophilus strain S24745 | ||
| Function | processing of CSP (predicted from homology) Competence regulation |
||
Related MGE
Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.
Gene-MGE association summary
| MGE type | MGE coordinates | Gene coordinates | Relative position | Distance (bp) |
|---|---|---|---|---|
| ICE | 317085..386587 | 380196..381272 | within | 0 |
Gene organization within MGE regions
Location: 317085..386587
| Locus tag | Gene name | Coordinates (strand) | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| J7U00_RS01765 (J7U00_01765) | addA | 317990..321643 (+) | 3654 | WP_014608679.1 | helicase-exonuclease AddAB subunit AddA | - |
| J7U00_RS01770 (J7U00_01770) | - | 321995..322726 (-) | 732 | WP_014608678.1 | DUF554 domain-containing protein | - |
| J7U00_RS01775 (J7U00_01775) | - | 323001..323732 (+) | 732 | WP_002891761.1 | ABC transporter ATP-binding protein | - |
| J7U00_RS01780 (J7U00_01780) | - | 323735..325324 (+) | 1590 | WP_014608677.1 | ABC transporter permease | - |
| J7U00_RS01785 (J7U00_01785) | proB | 325445..326248 (+) | 804 | WP_014608676.1 | glutamate 5-kinase | - |
| J7U00_RS01790 (J7U00_01790) | - | 326250..327500 (+) | 1251 | WP_207559893.1 | glutamate-5-semialdehyde dehydrogenase | - |
| J7U00_RS01795 (J7U00_01795) | - | 327833..328000 (+) | 168 | WP_153300736.1 | hypothetical protein | - |
| J7U00_RS01800 (J7U00_01800) | - | 328349..328705 (+) | 357 | WP_023909925.1 | DUF805 domain-containing protein | - |
| J7U00_RS01805 (J7U00_01805) | - | 329011..329274 (-) | 264 | WP_162877224.1 | hypothetical protein | - |
| J7U00_RS01810 (J7U00_01815) | - | 329600..330334 (+) | 735 | WP_224103476.1 | hypothetical protein | - |
| J7U00_RS01815 (J7U00_01820) | rsmH | 330501..331451 (+) | 951 | WP_002888254.1 | 16S rRNA (cytosine(1402)-N(4))-methyltransferase RsmH | - |
| J7U00_RS01820 (J7U00_01825) | ftsL | 331454..331774 (+) | 321 | WP_014608671.1 | cell division protein FtsL | - |
| J7U00_RS01825 (J7U00_01830) | pbp2X | 331778..334045 (+) | 2268 | WP_011226508.1 | penicillin-binding protein PBP2X | - |
| J7U00_RS01830 (J7U00_01835) | mraY | 334047..335069 (+) | 1023 | WP_011227524.1 | phospho-N-acetylmuramoyl-pentapeptide- transferase | - |
| J7U00_RS01835 (J7U00_01840) | - | 335144..336487 (+) | 1344 | WP_014608670.1 | DEAD/DEAH box helicase | - |
| J7U00_RS01840 (J7U00_01850) | - | 337335..338690 (+) | 1356 | WP_002948886.1 | bifunctional UDP-sugar hydrolase/5'-nucleotidase | - |
| J7U00_RS01845 (J7U00_01855) | - | 338745..339467 (+) | 723 | WP_011226505.1 | YutD family protein | - |
| J7U00_RS01850 (J7U00_01860) | rlmN | 339471..340640 (+) | 1170 | WP_011226504.1 | 23S rRNA (adenine(2503)-C(2))-methyltransferase RlmN | - |
| J7U00_RS01855 (J7U00_01865) | - | 340642..341169 (+) | 528 | WP_011226503.1 | VanZ family protein | - |
| J7U00_RS01860 | - | 341374..341580 (+) | 207 | WP_002948879.1 | hypothetical protein | - |
| J7U00_RS01865 (J7U00_01875) | - | 341768..343525 (+) | 1758 | WP_014608668.1 | ABC transporter ATP-binding protein | - |
| J7U00_RS01870 (J7U00_01880) | - | 343518..345263 (+) | 1746 | WP_024703994.1 | ABC transporter ATP-binding protein | - |
| J7U00_RS01875 (J7U00_01890) | - | 346277..348429 (+) | 2153 | Protein_361 | peptide cleavage/export ABC transporter | - |
| J7U00_RS01880 (J7U00_01895) | - | 348445..349812 (+) | 1368 | WP_011681574.1 | bacteriocin secretion accessory protein | - |
| J7U00_RS01885 (J7U00_01900) | - | 349827..349988 (+) | 162 | WP_011681573.1 | ComC/BlpC family leader-containing pheromone/bacteriocin | - |
| J7U00_RS01890 | - | 350006..350809 (-) | 804 | WP_223899638.1 | ATP-binding protein | - |
| J7U00_RS01895 (J7U00_01910) | - | 351340..352077 (-) | 738 | WP_011681571.1 | LytTR family DNA-binding domain-containing protein | - |
| J7U00_RS01900 (J7U00_01915) | - | 352328..352504 (+) | 177 | WP_011681570.1 | Blp family class II bacteriocin | - |
| J7U00_RS01905 (J7U00_01920) | - | 352523..352723 (+) | 201 | WP_011681569.1 | hypothetical protein | - |
| J7U00_RS01910 (J7U00_01925) | - | 353079..353309 (+) | 231 | WP_014608662.1 | bacteriocin class II family protein | - |
| J7U00_RS01915 | - | 354314..354715 (+) | 402 | WP_024703992.1 | hypothetical protein | - |
| J7U00_RS01920 (J7U00_01930) | - | 354966..355220 (+) | 255 | WP_014608660.1 | Blp family class II bacteriocin | - |
| J7U00_RS01925 (J7U00_01935) | - | 355366..356940 (-) | 1575 | Protein_371 | IS3-like element ISSth1b family transposase | - |
| J7U00_RS01930 (J7U00_01940) | - | 357134..357823 (+) | 690 | WP_011681563.1 | thioredoxin family protein | - |
| J7U00_RS01935 (J7U00_01945) | - | 357854..358060 (+) | 207 | WP_011681562.1 | hypothetical protein | - |
| J7U00_RS01940 (J7U00_01950) | - | 358225..358521 (+) | 297 | WP_004197070.1 | bacteriocin immunity protein | - |
| J7U00_RS01945 (J7U00_01955) | - | 358843..359106 (+) | 264 | WP_002945924.1 | hypothetical protein | - |
| J7U00_RS01950 (J7U00_01960) | - | 359231..359611 (+) | 381 | WP_002951783.1 | hypothetical protein | - |
| J7U00_RS01955 (J7U00_01965) | - | 359691..361958 (-) | 2268 | WP_011681561.1 | Xaa-Pro dipeptidyl-peptidase | - |
| J7U00_RS01960 (J7U00_01970) | gla | 362079..362942 (+) | 864 | WP_002951781.1 | aquaglyceroporin Gla | - |
| J7U00_RS01965 (J7U00_01975) | - | 363029..363391 (-) | 363 | WP_014608659.1 | CPBP family intramembrane glutamic endopeptidase | - |
| J7U00_RS01970 (J7U00_01980) | - | 363673..364428 (+) | 756 | WP_011681560.1 | CppA family protein | - |
| J7U00_RS01975 (J7U00_01985) | - | 364428..365384 (+) | 957 | WP_002951776.1 | serine hydrolase domain-containing protein | - |
| J7U00_RS01980 (J7U00_01990) | - | 365587..366237 (+) | 651 | WP_011681559.1 | ATP-binding cassette domain-containing protein | - |
| J7U00_RS01985 (J7U00_01995) | fetB | 366234..366989 (+) | 756 | WP_011681558.1 | iron export ABC transporter permease subunit FetB | - |
| J7U00_RS01990 (J7U00_02000) | mobV | 367434..367942 (+) | 509 | Protein_384 | MobV family relaxase | - |
| J7U00_RS01995 (J7U00_02005) | - | 367967..368272 (+) | 306 | WP_014621914.1 | restriction endonuclease subunit S | - |
| J7U00_RS02000 (J7U00_02010) | - | 368623..369075 (-) | 453 | WP_014608655.1 | GNAT family N-acetyltransferase | - |
| J7U00_RS02005 (J7U00_02015) | - | 369126..369908 (-) | 783 | WP_011681555.1 | carbonic anhydrase | - |
| J7U00_RS02010 (J7U00_02020) | pflB | 370175..372484 (-) | 2310 | WP_011226473.1 | formate C-acetyltransferase | - |
| J7U00_RS02015 (J7U00_02025) | dinB | 372763..373866 (+) | 1104 | WP_014608654.1 | DNA polymerase IV | - |
| J7U00_RS02020 (J7U00_02030) | - | 374164..374397 (+) | 234 | WP_002947030.1 | hypothetical protein | - |
| J7U00_RS02025 (J7U00_02035) | - | 374857..375687 (+) | 831 | WP_014608653.1 | transporter substrate-binding domain-containing protein | - |
| J7U00_RS02030 (J7U00_02040) | - | 376083..376829 (+) | 747 | WP_095559509.1 | amino acid ABC transporter permease | - |
| J7U00_RS02035 (J7U00_02045) | - | 376829..377572 (+) | 744 | WP_011681551.1 | amino acid ABC transporter ATP-binding protein | - |
| J7U00_RS02040 (J7U00_02050) | - | 377787..378011 (+) | 225 | WP_082309114.1 | DUF4059 family protein | - |
| J7U00_RS02045 (J7U00_02055) | trxB | 378044..378997 (+) | 954 | WP_259699870.1 | thioredoxin-disulfide reductase | - |
| J7U00_RS02050 (J7U00_02060) | rsmD | 379088..379687 (+) | 600 | Protein_396 | 16S rRNA (guanine(966)-N(2))-methyltransferase RsmD | - |
| J7U00_RS02055 (J7U00_02065) | coaD | 379721..380218 (+) | 498 | WP_011681550.1 | pantetheine-phosphate adenylyltransferase | - |
| J7U00_RS02060 (J7U00_02070) | sepM | 380196..381272 (+) | 1077 | WP_011681549.1 | SepM family pheromone-processing serine protease | Regulator |
| J7U00_RS02065 (J7U00_02075) | - | 381357..382301 (+) | 945 | WP_138496612.1 | TIGR01212 family radical SAM protein | - |
| J7U00_RS02070 (J7U00_02080) | - | 382298..382846 (+) | 549 | WP_011226462.1 | class I SAM-dependent methyltransferase | - |
| J7U00_RS02075 (J7U00_02085) | - | 382843..383085 (+) | 243 | WP_084830769.1 | hypothetical protein | - |
| J7U00_RS02080 (J7U00_02090) | - | 383094..385160 (+) | 2067 | WP_138496610.1 | sodium:proton antiporter | - |
| J7U00_RS02085 (J7U00_02100) | - | 385779..386561 (-) | 783 | WP_024703988.1 | ABC transporter ATP-binding protein | - |
Sequence
Protein
Download Length: 358 a.a. Molecular weight: 39172.02 Da Isoelectric Point: 9.3888
>NTDB_id=552737 J7U00_RS02060 WP_011681549.1 380196..381272(+) (sepM) [Streptococcus thermophilus strain S24745]
MANKTKSKALLEKMWRIKWWLLSIFTVLFLLFALFFPLNNYYVELPGGAFDTKEVLTVNKKADDSKGSYNFVAVAQTKAT
LALMLYAQFNDFAKLQTAEEATGNYSDEDFMRINQFYMETSQNQAVYQGLTLAGKEVSLEYMGVYVLQVADDSSFKGVLN
IADTVTAVNGNTFDNSTDMIKYVQGLKLGSKVKVTYMRDGKEKTATGKIIKIANGKNGIGIGLTDHTEIKSPENVKFKLD
GVGGPSAGLMFTLAIYDQVSGQDLKAGRKIAGTGTIEKDGAVGDIGGAYLKVKSAADSGADIFFVPNNLVTKEMKKADPD
AKTNYQEAKEAAEKLGTKMKIVPVKTAQEAIDYLKKTK
MANKTKSKALLEKMWRIKWWLLSIFTVLFLLFALFFPLNNYYVELPGGAFDTKEVLTVNKKADDSKGSYNFVAVAQTKAT
LALMLYAQFNDFAKLQTAEEATGNYSDEDFMRINQFYMETSQNQAVYQGLTLAGKEVSLEYMGVYVLQVADDSSFKGVLN
IADTVTAVNGNTFDNSTDMIKYVQGLKLGSKVKVTYMRDGKEKTATGKIIKIANGKNGIGIGLTDHTEIKSPENVKFKLD
GVGGPSAGLMFTLAIYDQVSGQDLKAGRKIAGTGTIEKDGAVGDIGGAYLKVKSAADSGADIFFVPNNLVTKEMKKADPD
AKTNYQEAKEAAEKLGTKMKIVPVKTAQEAIDYLKKTK
Nucleotide
Download Length: 1077 bp
>NTDB_id=552737 J7U00_RS02060 WP_011681549.1 380196..381272(+) (sepM) [Streptococcus thermophilus strain S24745]
GTGGCAAACAAGACAAAATCTAAAGCGCTATTAGAGAAAATGTGGCGTATTAAGTGGTGGTTATTAAGTATTTTTACGGT
ACTTTTCCTCCTTTTTGCCCTCTTTTTCCCGCTCAATAATTACTATGTGGAGCTTCCGGGTGGTGCTTTTGATACCAAGG
AAGTCTTGACAGTGAATAAGAAAGCTGATGATTCTAAGGGCTCCTATAATTTTGTGGCGGTGGCTCAAACCAAGGCGACT
TTGGCCTTGATGCTCTATGCTCAGTTTAATGATTTTGCAAAGCTTCAAACGGCTGAAGAGGCAACTGGAAATTACTCTGA
TGAAGATTTCATGCGCATCAACCAATTTTACATGGAGACTTCTCAAAACCAAGCGGTTTATCAGGGCTTGACTCTGGCTG
GTAAGGAGGTTAGTTTGGAGTATATGGGTGTCTATGTGCTTCAGGTTGCTGATGATTCTAGCTTCAAGGGTGTCCTCAAT
ATTGCTGATACGGTGACGGCTGTTAATGGTAATACCTTTGATAATTCTACTGACATGATTAAATACGTTCAAGGACTTAA
GCTGGGTTCAAAGGTCAAGGTCACTTATATGAGAGATGGCAAAGAAAAGACTGCTACTGGTAAGATTATTAAGATTGCCA
ATGGCAAAAATGGTATTGGTATCGGCCTAACGGACCATACTGAGATCAAGAGTCCTGAGAATGTTAAGTTTAAACTGGAT
GGTGTCGGTGGGCCAAGTGCTGGTCTTATGTTTACCTTGGCTATTTACGATCAGGTGTCTGGTCAAGACCTCAAGGCTGG
CCGCAAGATTGCTGGTACAGGAACTATTGAAAAAGATGGGGCTGTCGGTGATATCGGTGGGGCCTATCTCAAGGTGAAAT
CTGCGGCTGATAGTGGCGCAGACATTTTCTTCGTGCCAAATAATCTAGTAACTAAGGAAATGAAAAAGGCTGATCCGGAT
GCCAAGACTAATTATCAAGAGGCCAAGGAAGCTGCCGAGAAACTGGGGACCAAGATGAAAATCGTCCCTGTTAAAACAGC
TCAAGAAGCCATTGATTATTTGAAAAAGACTAAATGA
GTGGCAAACAAGACAAAATCTAAAGCGCTATTAGAGAAAATGTGGCGTATTAAGTGGTGGTTATTAAGTATTTTTACGGT
ACTTTTCCTCCTTTTTGCCCTCTTTTTCCCGCTCAATAATTACTATGTGGAGCTTCCGGGTGGTGCTTTTGATACCAAGG
AAGTCTTGACAGTGAATAAGAAAGCTGATGATTCTAAGGGCTCCTATAATTTTGTGGCGGTGGCTCAAACCAAGGCGACT
TTGGCCTTGATGCTCTATGCTCAGTTTAATGATTTTGCAAAGCTTCAAACGGCTGAAGAGGCAACTGGAAATTACTCTGA
TGAAGATTTCATGCGCATCAACCAATTTTACATGGAGACTTCTCAAAACCAAGCGGTTTATCAGGGCTTGACTCTGGCTG
GTAAGGAGGTTAGTTTGGAGTATATGGGTGTCTATGTGCTTCAGGTTGCTGATGATTCTAGCTTCAAGGGTGTCCTCAAT
ATTGCTGATACGGTGACGGCTGTTAATGGTAATACCTTTGATAATTCTACTGACATGATTAAATACGTTCAAGGACTTAA
GCTGGGTTCAAAGGTCAAGGTCACTTATATGAGAGATGGCAAAGAAAAGACTGCTACTGGTAAGATTATTAAGATTGCCA
ATGGCAAAAATGGTATTGGTATCGGCCTAACGGACCATACTGAGATCAAGAGTCCTGAGAATGTTAAGTTTAAACTGGAT
GGTGTCGGTGGGCCAAGTGCTGGTCTTATGTTTACCTTGGCTATTTACGATCAGGTGTCTGGTCAAGACCTCAAGGCTGG
CCGCAAGATTGCTGGTACAGGAACTATTGAAAAAGATGGGGCTGTCGGTGATATCGGTGGGGCCTATCTCAAGGTGAAAT
CTGCGGCTGATAGTGGCGCAGACATTTTCTTCGTGCCAAATAATCTAGTAACTAAGGAAATGAAAAAGGCTGATCCGGAT
GCCAAGACTAATTATCAAGAGGCCAAGGAAGCTGCCGAGAAACTGGGGACCAAGATGAAAATCGTCCCTGTTAAAACAGC
TCAAGAAGCCATTGATTATTTGAAAAAGACTAAATGA
3D structure
| Source | ID | Structure |
|---|
Similar proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|---|---|---|---|
| sepM | Streptococcus mutans UA159 |
62.757 |
95.251 |
0.598 |