Detailed information
Bioinformatically predicted
Overview
| Name | sepM | Type | Regulator |
| Locus tag | J7U22_RS01195 | Genome accession | NZ_CP072428 |
| Coordinates | 229590..230666 (+) | Length | 358 a.a. |
| NCBI ID | WP_011681549.1 | Uniprot ID | - |
| Organism | Streptococcus thermophilus strain S24749 | ||
| Function | processing of CSP (predicted from homology) Competence regulation |
||
Related MGE
Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.
Gene-MGE association summary
| MGE type | MGE coordinates | Gene coordinates | Relative position | Distance (bp) |
|---|---|---|---|---|
| ICE | 165048..235981 | 229590..230666 | within | 0 |
Gene organization within MGE regions
Location: 165048..235981
| Locus tag | Gene name | Coordinates (strand) | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| J7U22_RS00895 (J7U22_00885) | addA | 165953..169606 (+) | 3654 | WP_260222891.1 | helicase-exonuclease AddAB subunit AddA | - |
| J7U22_RS00900 (J7U22_00890) | - | 170000..170731 (-) | 732 | WP_260222892.1 | DUF554 domain-containing protein | - |
| J7U22_RS00905 (J7U22_00895) | - | 171006..171737 (+) | 732 | WP_002891761.1 | ABC transporter ATP-binding protein | - |
| J7U22_RS00910 (J7U22_00900) | - | 171740..173329 (+) | 1590 | WP_014608677.1 | ABC transporter permease | - |
| J7U22_RS00915 (J7U22_00905) | proB | 173450..174253 (+) | 804 | WP_014608676.1 | glutamate 5-kinase | - |
| J7U22_RS00920 (J7U22_00910) | - | 174255..175505 (+) | 1251 | WP_014608675.1 | glutamate-5-semialdehyde dehydrogenase | - |
| J7U22_RS00925 (J7U22_00915) | - | 175838..176005 (+) | 168 | WP_153300736.1 | hypothetical protein | - |
| J7U22_RS00930 (J7U22_00920) | - | 176354..176695 (+) | 342 | Protein_158 | DUF805 domain-containing protein | - |
| J7U22_RS00935 (J7U22_00925) | - | 177015..177278 (-) | 264 | WP_162877224.1 | hypothetical protein | - |
| J7U22_RS00940 (J7U22_00935) | - | 177607..178338 (+) | 732 | WP_224103288.1 | hypothetical protein | - |
| J7U22_RS00945 (J7U22_00940) | rsmH | 178505..179455 (+) | 951 | WP_002888254.1 | 16S rRNA (cytosine(1402)-N(4))-methyltransferase RsmH | - |
| J7U22_RS00950 (J7U22_00945) | ftsL | 179458..179778 (+) | 321 | WP_014608671.1 | cell division protein FtsL | - |
| J7U22_RS00955 (J7U22_00950) | pbp2X | 179782..182049 (+) | 2268 | WP_011226508.1 | penicillin-binding protein PBP2X | - |
| J7U22_RS00960 (J7U22_00955) | mraY | 182051..183073 (+) | 1023 | WP_372588838.1 | phospho-N-acetylmuramoyl-pentapeptide- transferase | - |
| J7U22_RS00965 (J7U22_00960) | - | 183148..184491 (+) | 1344 | WP_014608670.1 | DEAD/DEAH box helicase | - |
| J7U22_RS00970 (J7U22_00970) | - | 185339..186694 (+) | 1356 | WP_002948886.1 | bifunctional UDP-sugar hydrolase/5'-nucleotidase | - |
| J7U22_RS00975 (J7U22_00975) | - | 186749..187471 (+) | 723 | WP_011226505.1 | YutD family protein | - |
| J7U22_RS00980 (J7U22_00980) | rlmN | 187475..188644 (+) | 1170 | WP_011226504.1 | 23S rRNA (adenine(2503)-C(2))-methyltransferase RlmN | - |
| J7U22_RS00985 (J7U22_00985) | - | 188646..189173 (+) | 528 | WP_011226503.1 | VanZ family protein | - |
| J7U22_RS00990 | - | 189378..189584 (+) | 207 | WP_002948879.1 | hypothetical protein | - |
| J7U22_RS00995 (J7U22_00995) | - | 189772..191531 (+) | 1760 | Protein_171 | ABC transporter ATP-binding protein | - |
| J7U22_RS01000 (J7U22_01000) | - | 191524..193269 (+) | 1746 | WP_263604486.1 | ABC transporter ATP-binding protein | - |
| J7U22_RS01005 (J7U22_01010) | - | 194283..196435 (+) | 2153 | Protein_173 | peptide cleavage/export ABC transporter | - |
| J7U22_RS01010 (J7U22_01015) | - | 196451..197818 (+) | 1368 | WP_011681574.1 | bacteriocin secretion accessory protein | - |
| J7U22_RS01015 (J7U22_01020) | - | 197833..197994 (+) | 162 | WP_011681573.1 | ComC/BlpC family leader-containing pheromone/bacteriocin | - |
| J7U22_RS01020 | - | 198012..198815 (-) | 804 | WP_223899638.1 | ATP-binding protein | - |
| J7U22_RS01025 (J7U22_01030) | - | 199346..200083 (-) | 738 | WP_011681571.1 | LytTR family DNA-binding domain-containing protein | - |
| J7U22_RS01030 (J7U22_01035) | - | 200334..200510 (+) | 177 | WP_011681570.1 | Blp family class II bacteriocin | - |
| J7U22_RS01035 (J7U22_01040) | - | 200529..200729 (+) | 201 | WP_011681569.1 | hypothetical protein | - |
| J7U22_RS01040 (J7U22_01045) | - | 201085..201315 (+) | 231 | WP_260223024.1 | bacteriocin class II family protein | - |
| J7U22_RS01045 | - | 202302..202703 (+) | 402 | WP_024703992.1 | hypothetical protein | - |
| J7U22_RS01050 (J7U22_01050) | - | 202954..203208 (+) | 255 | WP_014608660.1 | Blp family class II bacteriocin | - |
| J7U22_RS01060 (J7U22_01060) | - | 205115..205807 (+) | 693 | WP_224103184.1 | thioredoxin family protein | - |
| J7U22_RS01065 (J7U22_01065) | - | 205838..206044 (+) | 207 | WP_011681562.1 | hypothetical protein | - |
| J7U22_RS01070 (J7U22_01070) | - | 206209..206505 (+) | 297 | WP_004197070.1 | bacteriocin immunity protein | - |
| J7U22_RS01075 (J7U22_01075) | - | 206827..207090 (+) | 264 | WP_002945924.1 | hypothetical protein | - |
| J7U22_RS01080 (J7U22_01080) | - | 207215..207595 (+) | 381 | WP_002951783.1 | hypothetical protein | - |
| J7U22_RS01085 (J7U22_01085) | - | 207754..209002 (+) | 1249 | Protein_189 | ISL3 family transposase | - |
| J7U22_RS01090 (J7U22_01090) | - | 209093..211360 (-) | 2268 | WP_372588840.1 | Xaa-Pro dipeptidyl-peptidase | - |
| J7U22_RS01095 (J7U22_01095) | gla | 211481..212344 (+) | 864 | WP_002951781.1 | aquaglyceroporin Gla | - |
| J7U22_RS01100 (J7U22_01100) | - | 212431..212793 (-) | 363 | WP_014608659.1 | CPBP family intramembrane glutamic endopeptidase | - |
| J7U22_RS01105 (J7U22_01105) | - | 213075..213830 (+) | 756 | WP_372588841.1 | CppA family protein | - |
| J7U22_RS01110 (J7U22_01110) | - | 213830..214786 (+) | 957 | WP_002951776.1 | serine hydrolase domain-containing protein | - |
| J7U22_RS01115 (J7U22_01115) | - | 214989..215639 (+) | 651 | WP_011681559.1 | ATP-binding cassette domain-containing protein | - |
| J7U22_RS01120 (J7U22_01120) | fetB | 215636..216391 (+) | 756 | WP_011681558.1 | iron export ABC transporter permease subunit FetB | - |
| J7U22_RS01125 (J7U22_01125) | mobV | 216836..217344 (+) | 509 | Protein_197 | MobV family relaxase | - |
| J7U22_RS01130 (J7U22_01130) | - | 217369..217674 (+) | 306 | WP_372429342.1 | restriction endonuclease subunit S | - |
| J7U22_RS01135 (J7U22_01135) | - | 218025..218477 (-) | 453 | WP_014608655.1 | GNAT family N-acetyltransferase | - |
| J7U22_RS01140 (J7U22_01140) | - | 218528..219310 (-) | 783 | WP_372588842.1 | carbonic anhydrase | - |
| J7U22_RS01145 (J7U22_01145) | pflB | 219577..221886 (-) | 2310 | WP_011226473.1 | formate C-acetyltransferase | - |
| J7U22_RS01150 (J7U22_01150) | dinB | 222165..223268 (+) | 1104 | WP_014608654.1 | DNA polymerase IV | - |
| J7U22_RS01155 (J7U22_01155) | - | 223566..223799 (+) | 234 | WP_002947030.1 | hypothetical protein | - |
| J7U22_RS01160 (J7U22_01160) | - | 224259..225089 (+) | 831 | WP_014608653.1 | transporter substrate-binding domain-containing protein | - |
| J7U22_RS01165 (J7U22_01165) | - | 225477..226223 (+) | 747 | WP_100284797.1 | amino acid ABC transporter permease | - |
| J7U22_RS01170 (J7U22_01170) | - | 226223..226966 (+) | 744 | WP_014608652.1 | amino acid ABC transporter ATP-binding protein | - |
| J7U22_RS01175 (J7U22_01175) | - | 227181..227405 (+) | 225 | WP_014621911.1 | DUF4059 family protein | - |
| J7U22_RS01180 (J7U22_01180) | trxB | 227438..228391 (+) | 954 | WP_255136104.1 | thioredoxin-disulfide reductase | - |
| J7U22_RS01185 (J7U22_01185) | rsmD | 228482..229081 (+) | 600 | Protein_209 | 16S rRNA (guanine(966)-N(2))-methyltransferase RsmD | - |
| J7U22_RS01190 (J7U22_01190) | coaD | 229115..229612 (+) | 498 | WP_011681550.1 | pantetheine-phosphate adenylyltransferase | - |
| J7U22_RS01195 (J7U22_01195) | sepM | 229590..230666 (+) | 1077 | WP_011681549.1 | SepM family pheromone-processing serine protease | Regulator |
| J7U22_RS01200 (J7U22_01200) | - | 230751..231695 (+) | 945 | WP_011226463.1 | TIGR01212 family radical SAM protein | - |
| J7U22_RS01205 (J7U22_01205) | - | 231692..232240 (+) | 549 | WP_011226462.1 | class I SAM-dependent methyltransferase | - |
| J7U22_RS01210 (J7U22_01210) | - | 232237..232479 (+) | 243 | WP_084830769.1 | hypothetical protein | - |
| J7U22_RS01215 (J7U22_01215) | - | 232488..234554 (+) | 2067 | WP_372588843.1 | cation:proton antiporter | - |
| J7U22_RS01220 (J7U22_01220) | - | 235173..235955 (-) | 783 | WP_024703988.1 | ABC transporter ATP-binding protein | - |
Sequence
Protein
Download Length: 358 a.a. Molecular weight: 39172.02 Da Isoelectric Point: 9.3888
>NTDB_id=552556 J7U22_RS01195 WP_011681549.1 229590..230666(+) (sepM) [Streptococcus thermophilus strain S24749]
MANKTKSKALLEKMWRIKWWLLSIFTVLFLLFALFFPLNNYYVELPGGAFDTKEVLTVNKKADDSKGSYNFVAVAQTKAT
LALMLYAQFNDFAKLQTAEEATGNYSDEDFMRINQFYMETSQNQAVYQGLTLAGKEVSLEYMGVYVLQVADDSSFKGVLN
IADTVTAVNGNTFDNSTDMIKYVQGLKLGSKVKVTYMRDGKEKTATGKIIKIANGKNGIGIGLTDHTEIKSPENVKFKLD
GVGGPSAGLMFTLAIYDQVSGQDLKAGRKIAGTGTIEKDGAVGDIGGAYLKVKSAADSGADIFFVPNNLVTKEMKKADPD
AKTNYQEAKEAAEKLGTKMKIVPVKTAQEAIDYLKKTK
MANKTKSKALLEKMWRIKWWLLSIFTVLFLLFALFFPLNNYYVELPGGAFDTKEVLTVNKKADDSKGSYNFVAVAQTKAT
LALMLYAQFNDFAKLQTAEEATGNYSDEDFMRINQFYMETSQNQAVYQGLTLAGKEVSLEYMGVYVLQVADDSSFKGVLN
IADTVTAVNGNTFDNSTDMIKYVQGLKLGSKVKVTYMRDGKEKTATGKIIKIANGKNGIGIGLTDHTEIKSPENVKFKLD
GVGGPSAGLMFTLAIYDQVSGQDLKAGRKIAGTGTIEKDGAVGDIGGAYLKVKSAADSGADIFFVPNNLVTKEMKKADPD
AKTNYQEAKEAAEKLGTKMKIVPVKTAQEAIDYLKKTK
Nucleotide
Download Length: 1077 bp
>NTDB_id=552556 J7U22_RS01195 WP_011681549.1 229590..230666(+) (sepM) [Streptococcus thermophilus strain S24749]
GTGGCAAACAAGACAAAATCTAAAGCGCTATTAGAGAAAATGTGGCGTATTAAGTGGTGGTTATTAAGTATTTTTACGGT
ACTTTTCCTCCTTTTTGCCCTCTTTTTCCCGCTCAATAATTACTATGTGGAGCTTCCGGGTGGTGCTTTTGATACCAAGG
AAGTCTTGACAGTGAATAAGAAAGCTGATGATTCTAAGGGCTCCTATAATTTTGTGGCGGTGGCTCAAACCAAGGCGACT
TTGGCCTTGATGCTCTATGCTCAGTTTAATGATTTTGCAAAGCTTCAAACGGCTGAAGAGGCAACTGGAAATTACTCTGA
TGAAGATTTCATGCGCATCAACCAATTTTACATGGAGACTTCTCAAAACCAAGCGGTTTATCAGGGCTTGACTCTGGCTG
GTAAGGAGGTTAGTTTGGAGTATATGGGTGTCTATGTGCTTCAGGTTGCTGATGATTCTAGCTTCAAGGGTGTCCTCAAT
ATTGCTGATACGGTGACGGCTGTTAATGGTAATACCTTTGATAATTCTACTGACATGATTAAATACGTTCAAGGACTTAA
GCTGGGTTCAAAGGTCAAGGTCACTTATATGAGAGATGGCAAAGAAAAGACTGCTACTGGTAAGATTATTAAGATTGCCA
ATGGCAAAAATGGTATTGGTATCGGCCTAACGGACCATACTGAGATCAAGAGTCCTGAGAATGTTAAGTTTAAACTGGAT
GGTGTCGGTGGGCCAAGTGCTGGTCTTATGTTTACCTTGGCTATTTACGATCAGGTGTCTGGTCAAGACCTCAAGGCTGG
CCGCAAGATTGCTGGTACAGGAACTATTGAAAAAGATGGGGCTGTCGGTGATATCGGTGGGGCCTATCTCAAGGTGAAAT
CTGCGGCTGATAGTGGCGCAGACATTTTCTTCGTGCCAAATAATCTAGTAACTAAGGAAATGAAAAAGGCTGATCCGGAT
GCCAAGACTAATTATCAAGAGGCCAAGGAAGCTGCCGAGAAACTGGGGACCAAGATGAAAATCGTCCCTGTTAAAACAGC
TCAAGAAGCCATTGATTATTTGAAAAAGACTAAATGA
GTGGCAAACAAGACAAAATCTAAAGCGCTATTAGAGAAAATGTGGCGTATTAAGTGGTGGTTATTAAGTATTTTTACGGT
ACTTTTCCTCCTTTTTGCCCTCTTTTTCCCGCTCAATAATTACTATGTGGAGCTTCCGGGTGGTGCTTTTGATACCAAGG
AAGTCTTGACAGTGAATAAGAAAGCTGATGATTCTAAGGGCTCCTATAATTTTGTGGCGGTGGCTCAAACCAAGGCGACT
TTGGCCTTGATGCTCTATGCTCAGTTTAATGATTTTGCAAAGCTTCAAACGGCTGAAGAGGCAACTGGAAATTACTCTGA
TGAAGATTTCATGCGCATCAACCAATTTTACATGGAGACTTCTCAAAACCAAGCGGTTTATCAGGGCTTGACTCTGGCTG
GTAAGGAGGTTAGTTTGGAGTATATGGGTGTCTATGTGCTTCAGGTTGCTGATGATTCTAGCTTCAAGGGTGTCCTCAAT
ATTGCTGATACGGTGACGGCTGTTAATGGTAATACCTTTGATAATTCTACTGACATGATTAAATACGTTCAAGGACTTAA
GCTGGGTTCAAAGGTCAAGGTCACTTATATGAGAGATGGCAAAGAAAAGACTGCTACTGGTAAGATTATTAAGATTGCCA
ATGGCAAAAATGGTATTGGTATCGGCCTAACGGACCATACTGAGATCAAGAGTCCTGAGAATGTTAAGTTTAAACTGGAT
GGTGTCGGTGGGCCAAGTGCTGGTCTTATGTTTACCTTGGCTATTTACGATCAGGTGTCTGGTCAAGACCTCAAGGCTGG
CCGCAAGATTGCTGGTACAGGAACTATTGAAAAAGATGGGGCTGTCGGTGATATCGGTGGGGCCTATCTCAAGGTGAAAT
CTGCGGCTGATAGTGGCGCAGACATTTTCTTCGTGCCAAATAATCTAGTAACTAAGGAAATGAAAAAGGCTGATCCGGAT
GCCAAGACTAATTATCAAGAGGCCAAGGAAGCTGCCGAGAAACTGGGGACCAAGATGAAAATCGTCCCTGTTAAAACAGC
TCAAGAAGCCATTGATTATTTGAAAAAGACTAAATGA
3D structure
| Source | ID | Structure |
|---|
Similar proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|---|---|---|---|
| sepM | Streptococcus mutans UA159 |
62.757 |
95.251 |
0.598 |