Detailed information
Bioinformatically predicted
Overview
| Name | ccrA | Type | Machinery gene |
| Locus tag | J6L63_RS10250 | Genome accession | NZ_CP072116 |
| Coordinates | 2043543..2044892 (+) | Length | 449 a.a. |
| NCBI ID | WP_000815646.1 | Uniprot ID | Q9XB96 |
| Organism | Staphylococcus aureus strain TCH32929 | ||
| Function | promote SCCmec transfer (predicted from homology) Homologous recombination |
||
Related MGE
Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.
Gene-MGE association summary
| MGE type | MGE coordinates | Gene coordinates | Relative position | Distance (bp) |
|---|---|---|---|---|
| SCCmec | 2043543..2083045 | 2043543..2044892 | within | 0 |
Gene organization within MGE regions
Location: 2043543..2083045
| Locus tag | Gene name | Coordinates (strand) | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| J6L63_RS10250 (J6L63_10190) | ccrA | 2043543..2044892 (+) | 1350 | WP_000815646.1 | cassette chromosome recombinase CcrA | Machinery gene |
| J6L63_RS10255 (J6L63_10195) | ccrB | 2044914..2046542 (+) | 1629 | WP_001186602.1 | cassette chromosome recombinase CcrB | Machinery gene |
| J6L63_RS10260 (J6L63_10200) | - | 2047060..2047410 (+) | 351 | WP_000859155.1 | SAUGI family uracil-DNA glycosylase inhibitor | - |
| J6L63_RS10265 (J6L63_10205) | - | 2047497..2047808 (+) | 312 | WP_000700853.1 | DUF960 family protein | - |
| J6L63_RS10270 (J6L63_10210) | - | 2047826..2048332 (+) | 507 | WP_001092169.1 | DUF1643 domain-containing protein | - |
| J6L63_RS10275 (J6L63_10215) | - | 2048353..2048670 (+) | 318 | WP_000659050.1 | JAB domain-containing protein | - |
| J6L63_RS10280 (J6L63_10220) | - | 2048789..2049874 (+) | 1086 | WP_000868132.1 | tyrosine-type recombinase/integrase | - |
| J6L63_RS10285 (J6L63_10225) | - | 2049871..2051763 (+) | 1893 | WP_001557544.1 | site-specific integrase | - |
| J6L63_RS10290 (J6L63_10230) | - | 2051770..2052147 (+) | 378 | WP_000361059.1 | DUF6262 family protein | - |
| J6L63_RS10295 (J6L63_10235) | - | 2052298..2053080 (+) | 783 | WP_000067268.1 | aminoglycoside nucleotidyltransferase ANT(9)-Ia | - |
| J6L63_RS10300 (J6L63_10240) | erm(A) | 2053206..2053937 (-) | 732 | WP_001072201.1 | 23S rRNA (adenine(2058)-N(6))-methyltransferase Erm(A) | - |
| J6L63_RS14485 (J6L63_10245) | - | 2053985..2054041 (-) | 57 | WP_176746567.1 | erythromycin resistance leader peptide | - |
| J6L63_RS10305 (J6L63_10250) | - | 2054433..2055095 (+) | 663 | WP_001092058.1 | class I SAM-dependent methyltransferase | - |
| J6L63_RS10310 (J6L63_10260) | - | 2055440..2056078 (-) | 639 | Protein_1994 | sulfite exporter TauE/SafE family protein | - |
| J6L63_RS10315 (J6L63_10265) | cstR | 2056078..2056338 (-) | 261 | WP_000220507.1 | persulfide-sensing transcriptional repressor CstR | - |
| J6L63_RS10320 (J6L63_10270) | - | 2056474..2057538 (+) | 1065 | WP_000438836.1 | DsrE/DsrF/DrsH-like family protein | - |
| J6L63_RS10325 (J6L63_10275) | cstB | 2057571..2058905 (+) | 1335 | Protein_1997 | persulfide dioxygenase-sulfurtransferase CstB | - |
| J6L63_RS10330 (J6L63_10280) | - | 2059019..2060128 (-) | 1110 | WP_000943131.1 | ROK family transcriptional regulator | - |
| J6L63_RS10335 (J6L63_10285) | psm-mec | 2060483..2060551 (+) | 69 | WP_014532405.1 | phenol-soluble modulin PSM-mec | - |
| J6L63_RS10340 (J6L63_10290) | mecI | 2060636..2061007 (-) | 372 | WP_000369214.1 | mecA-type methicillin resistance repressor MecI | - |
| J6L63_RS10345 (J6L63_10295) | mecR1 | 2061007..2062764 (-) | 1758 | WP_000952923.1 | beta-lactam sensor/signal transducer MecR1 | - |
| J6L63_RS10350 (J6L63_10300) | mecA | 2062861..2064870 (+) | 2010 | WP_001801873.1 | PBP2a family beta-lactam-resistant peptidoglycan transpeptidase MecA | - |
| J6L63_RS10355 (J6L63_10305) | - | 2064916..2065344 (-) | 429 | WP_000872606.1 | MaoC family dehydratase | - |
| J6L63_RS10360 (J6L63_10310) | - | 2065441..2066184 (-) | 744 | WP_000958858.1 | glycerophosphoryl diester phosphodiesterase | - |
| J6L63_RS10365 (J6L63_10315) | - | 2066449..2067123 (+) | 675 | WP_001106057.1 | IS6-like element IS257 family transposase | - |
| J6L63_RS10370 (J6L63_10320) | aadD1 | 2067316..2068086 (+) | 771 | WP_001795128.1 | aminoglycoside O-nucleotidyltransferase ANT(4')-Ia | - |
| J6L63_RS10375 (J6L63_10325) | bleO | 2068303..2068707 (+) | 405 | WP_001242578.1 | bleomycin binding protein | - |
| J6L63_RS10380 (J6L63_10330) | mobV | 2069214..2070476 (+) | 1263 | WP_000119405.1 | MobV family relaxase | - |
| J6L63_RS10385 (J6L63_10335) | - | 2070721..2071704 (+) | 984 | Protein_2009 | protein rep | - |
| J6L63_RS10390 (J6L63_10345) | - | 2071795..2072469 (+) | 675 | WP_001106057.1 | IS6-like element IS257 family transposase | - |
| J6L63_RS10395 (J6L63_10350) | - | 2072501..2072740 (-) | 240 | WP_001282728.1 | hypothetical protein | - |
| J6L63_RS10400 (J6L63_10355) | - | 2073155..2074411 (-) | 1257 | WP_000566670.1 | MrcB family domain-containing protein | - |
| J6L63_RS10405 (J6L63_10360) | - | 2075637..2077562 (-) | 1926 | WP_031783917.1 | heavy metal translocating P-type ATPase | - |
| J6L63_RS10410 (J6L63_10365) | - | 2077892..2078218 (-) | 327 | WP_000391495.1 | metalloregulator ArsR/SmtB family transcription factor | - |
| J6L63_RS10415 (J6L63_10370) | - | 2078425..2078784 (+) | 360 | WP_001631039.1 | hypothetical protein | - |
| J6L63_RS10420 (J6L63_10375) | - | 2078896..2079234 (-) | 339 | Protein_2016 | recombinase family protein | - |
| J6L63_RS10425 (J6L63_10380) | - | 2079243..2079872 (+) | 630 | Protein_2017 | hypothetical protein | - |
| J6L63_RS10430 (J6L63_10385) | ccrA | 2080059..2081420 (+) | 1362 | WP_001631036.1 | cassette chromosome recombinase CcrA | Machinery gene |
| J6L63_RS10435 (J6L63_10390) | ccrB | 2081417..2083045 (+) | 1629 | WP_001631035.1 | cassette chromosome recombinase CcrB | Machinery gene |
Sequence
Protein
Download Length: 449 a.a. Molecular weight: 52607.20 Da Isoelectric Point: 9.9585
>NTDB_id=550596 J6L63_RS10250 WP_000815646.1 2043543..2044892(+) (ccrA) [Staphylococcus aureus strain TCH32929]
MKQVIGYLRQSTMKQQSLAAQKQAIEAIAEKHHIQHINFYSDKQSGRKDNRSGYRQMTQLIQQGQCDILCCYRLNRLHRN
LKNALKLIKLCQTYHVHILSVHDGYFDMDQAFDRFKLNIFISLAELESDNIGEQVRNGLQEKAKQGRLITTHAPFGYEYH
NGAFIINQNESPTVKAVFNYYIKGHGYKKIAQLLEEDNTYINRQPYQVRNIIINPNYCGRVNNQYGQFDNMFPSIVSTSI
YEQAQRLRSQKQIKQTSSDNQLKQKIKCPCCNTTLTNMTVRKKNHTLRYYVCPKNMNASRFVCDFKGINAQTLEDKVLEV
CKDFYQNQRIYTKIKGAIDKRIKRQRNIEKHHTLTQEQLIEKLAQGIIDAETFREQTQSLRQQPQRTTSINGHQIQHTIQ
NIIQKRFTLNILYPYIETIHITKDKNLIGIYFKNEPLNIVNQTMQSSIA
MKQVIGYLRQSTMKQQSLAAQKQAIEAIAEKHHIQHINFYSDKQSGRKDNRSGYRQMTQLIQQGQCDILCCYRLNRLHRN
LKNALKLIKLCQTYHVHILSVHDGYFDMDQAFDRFKLNIFISLAELESDNIGEQVRNGLQEKAKQGRLITTHAPFGYEYH
NGAFIINQNESPTVKAVFNYYIKGHGYKKIAQLLEEDNTYINRQPYQVRNIIINPNYCGRVNNQYGQFDNMFPSIVSTSI
YEQAQRLRSQKQIKQTSSDNQLKQKIKCPCCNTTLTNMTVRKKNHTLRYYVCPKNMNASRFVCDFKGINAQTLEDKVLEV
CKDFYQNQRIYTKIKGAIDKRIKRQRNIEKHHTLTQEQLIEKLAQGIIDAETFREQTQSLRQQPQRTTSINGHQIQHTIQ
NIIQKRFTLNILYPYIETIHITKDKNLIGIYFKNEPLNIVNQTMQSSIA
Nucleotide
Download Length: 1350 bp
>NTDB_id=550596 J6L63_RS10250 WP_000815646.1 2043543..2044892(+) (ccrA) [Staphylococcus aureus strain TCH32929]
ATGAAACAAGTCATAGGCTATTTACGTCAAAGTACGATGAAACAACAATCTCTTGCAGCACAGAAACAGGCTATCGAAGC
AATAGCCGAAAAACATCATATTCAACATATCAACTTTTATAGCGACAAACAATCAGGACGCAAAGATAATCGTAGTGGGT
ATCGACAAATGACGCAATTAATTCAACAAGGGCAATGTGACATATTATGTTGTTATCGTCTTAATAGATTACATCGTAAT
CTGAAAAATGCATTAAAACTCATCAAATTATGTCAAACATACCATGTTCATATCTTAAGCGTACACGATGGTTACTTTGA
TATGGATCAAGCTTTCGACCGATTCAAGCTTAATATTTTTATCAGCTTGGCCGAACTTGAATCAGATAACATTGGAGAAC
AAGTCAGAAATGGGCTTCAAGAAAAAGCAAAGCAAGGTCGATTGATTACAACCCATGCGCCCTTTGGTTACGAATATCAC
AACGGAGCATTCATCATCAATCAAAATGAGTCACCAACGGTAAAGGCTGTATTCAATTATTACATTAAAGGTCATGGTTA
TAAGAAAATTGCACAGTTATTAGAAGAAGATAACACGTATATCAATCGACAACCCTATCAAGTTCGTAACATTATCATCA
ATCCTAATTATTGTGGTCGTGTCAACAATCAATATGGCCAATTCGACAATATGTTTCCTTCTATTGTTTCCACAAGTATA
TATGAGCAAGCGCAGAGACTTCGATCGCAAAAACAAATCAAACAGACATCTTCGGATAACCAACTAAAACAAAAAATCAA
ATGCCCATGTTGTAATACAACACTTACGAATATGACCGTTAGAAAAAAGAATCATACATTACGTTACTACGTCTGTCCTA
AAAACATGAATGCTTCTCGCTTTGTCTGTGATTTTAAAGGCATCAATGCACAAACACTTGAAGATAAAGTATTAGAAGTG
TGCAAAGACTTTTATCAAAATCAACGCATCTACACAAAAATTAAAGGTGCGATTGACAAACGCATCAAAAGACAAAGAAA
CATAGAAAAACATCACACATTGACTCAAGAACAACTGATAGAAAAGTTGGCACAAGGCATCATCGATGCAGAAACGTTCA
GAGAACAAACGCAATCATTACGTCAACAACCGCAACGCACTACATCTATCAATGGACATCAAATACAACACACCATTCAA
AATATTATTCAAAAACGTTTCACGTTAAACATATTGTACCCCTATATTGAAACCATTCACATTACGAAAGATAAAAATCT
TATAGGAATCTATTTCAAAAATGAACCACTCAATATCGTCAATCAAACCATGCAATCATCGATTGCATAA
ATGAAACAAGTCATAGGCTATTTACGTCAAAGTACGATGAAACAACAATCTCTTGCAGCACAGAAACAGGCTATCGAAGC
AATAGCCGAAAAACATCATATTCAACATATCAACTTTTATAGCGACAAACAATCAGGACGCAAAGATAATCGTAGTGGGT
ATCGACAAATGACGCAATTAATTCAACAAGGGCAATGTGACATATTATGTTGTTATCGTCTTAATAGATTACATCGTAAT
CTGAAAAATGCATTAAAACTCATCAAATTATGTCAAACATACCATGTTCATATCTTAAGCGTACACGATGGTTACTTTGA
TATGGATCAAGCTTTCGACCGATTCAAGCTTAATATTTTTATCAGCTTGGCCGAACTTGAATCAGATAACATTGGAGAAC
AAGTCAGAAATGGGCTTCAAGAAAAAGCAAAGCAAGGTCGATTGATTACAACCCATGCGCCCTTTGGTTACGAATATCAC
AACGGAGCATTCATCATCAATCAAAATGAGTCACCAACGGTAAAGGCTGTATTCAATTATTACATTAAAGGTCATGGTTA
TAAGAAAATTGCACAGTTATTAGAAGAAGATAACACGTATATCAATCGACAACCCTATCAAGTTCGTAACATTATCATCA
ATCCTAATTATTGTGGTCGTGTCAACAATCAATATGGCCAATTCGACAATATGTTTCCTTCTATTGTTTCCACAAGTATA
TATGAGCAAGCGCAGAGACTTCGATCGCAAAAACAAATCAAACAGACATCTTCGGATAACCAACTAAAACAAAAAATCAA
ATGCCCATGTTGTAATACAACACTTACGAATATGACCGTTAGAAAAAAGAATCATACATTACGTTACTACGTCTGTCCTA
AAAACATGAATGCTTCTCGCTTTGTCTGTGATTTTAAAGGCATCAATGCACAAACACTTGAAGATAAAGTATTAGAAGTG
TGCAAAGACTTTTATCAAAATCAACGCATCTACACAAAAATTAAAGGTGCGATTGACAAACGCATCAAAAGACAAAGAAA
CATAGAAAAACATCACACATTGACTCAAGAACAACTGATAGAAAAGTTGGCACAAGGCATCATCGATGCAGAAACGTTCA
GAGAACAAACGCAATCATTACGTCAACAACCGCAACGCACTACATCTATCAATGGACATCAAATACAACACACCATTCAA
AATATTATTCAAAAACGTTTCACGTTAAACATATTGTACCCCTATATTGAAACCATTCACATTACGAAAGATAAAAATCT
TATAGGAATCTATTTCAAAAATGAACCACTCAATATCGTCAATCAAACCATGCAATCATCGATTGCATAA
Similar proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|---|---|---|---|
| ccrA | Staphylococcus aureus N315 |
100 |
100 |
1 |
| ccrA | Staphylococcus aureus COL |
74.833 |
100 |
0.748 |