Detailed information NTG0549775

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: J4Z26_RS04440
• Genome accession: NZ_CP071988
• Coordinates: 949830..950876 (+)
• Length: 348 a.a.
• NCBI ID: WP_001830374.1
• Uniprot ID: A0A0N1EGU4
• Organism: Staphylococcus epidermidis strain CBPA-ST-10002 isolate HPB10235
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 944830..955876

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
J4Z26_RS04415 (J4Z26_000880)	isaB	945971..946507 (+)	537	WP_001830372.1	immunodominant staphylococcal antigen IsaB family protein	-
J4Z26_RS04420 (J4Z26_000881)	-	946658..947644 (-)	987	WP_002457091.1	FUSC family protein	-
J4Z26_RS04425 (J4Z26_000882)	map	947818..948573 (+)	756	WP_001830397.1	type I methionyl aminopeptidase	-
J4Z26_RS04430 (J4Z26_000883)	-	948731..949117 (+)	387	WP_001830382.1	hypothetical protein	-
J4Z26_RS04435 (J4Z26_000884)	liaF	949132..949833 (+)	702	WP_002457093.1	cell wall-active antibiotics response protein LiaF	-
J4Z26_RS04440 (J4Z26_000885)	vraS	949830..950876 (+)	1047	WP_001830374.1	sensor histidine kinase	Regulator
J4Z26_RS04445 (J4Z26_000886)	vraR	950866..951495 (+)	630	WP_001830439.1	two-component system response regulator VraR	Regulator
J4Z26_RS04450 (J4Z26_000887)	-	951552..952730 (-)	1179	WP_001830411.1	YihY/virulence factor BrkB family protein	-
J4Z26_RS04455 (J4Z26_000888)	-	953137..953421 (-)	285	WP_001830401.1	YtxH domain-containing protein	-
J4Z26_RS04460 (J4Z26_000889)	-	953429..953893 (-)	465	WP_001830437.1	low molecular weight protein-tyrosine-phosphatase	-
J4Z26_RS04465 (J4Z26_000890)	-	954034..954249 (+)	216	WP_001830421.1	DUF1128 domain-containing protein	-
J4Z26_RS04470 (J4Z26_000891)	-	954251..955492 (+)	1242	WP_001832467.1	aminopeptidase	-

Sequence

Protein

• Length: 348 a.a.
• Molecular weight: 40066.49 Da
• Isoelectric Point: 5.8512

>NTDB_id=549775 J4Z26_RS04440 WP_001830374.1 949830..950876(+) (vraS) [Staphylococcus epidermidis strain CBPA-ST-10002 isolate HPB10235]
MNHYIRAIGSMLILVYSMLIAFLFIDKVFVNIIFFQGMFYTQIFGIPVFLFLNLLIVLLCIIVGSVLAYKINQQNDWIIS
QIERSIEGQTVGINDQNIELYTETIDIYHTLVPLNQELHRLRMKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKESKLEPPLNQQIPILEKMVQDSQLEMRALLLHLRPIGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFEVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNQEDYLLLRIQDNGKGFNVDEKFEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEENSSGD

Nucleotide

• Length: 1047 bp

>NTDB_id=549775 J4Z26_RS04440 WP_001830374.1 949830..950876(+) (vraS) [Staphylococcus epidermidis strain CBPA-ST-10002 isolate HPB10235]
ATGAATCACTACATAAGAGCTATAGGCTCAATGCTTATATTAGTATATAGTATGCTTATTGCTTTTTTATTTATTGATAA
AGTGTTTGTAAATATTATCTTTTTTCAGGGGATGTTTTATACACAAATATTTGGAATACCTGTTTTTCTATTTTTAAATT
TATTAATTGTTCTTTTATGTATTATAGTTGGATCTGTTTTAGCTTATAAAATTAATCAACAAAATGATTGGATTATTTCA
CAAATAGAAAGATCAATAGAAGGACAAACAGTAGGTATCAATGATCAAAATATCGAATTATATACAGAAACGATAGATAT
TTATCATACACTAGTTCCATTAAATCAAGAATTACATCGACTTAGAATGAAGACTCAAAATTTAACTAATGAAAACTACA
ATATTAATGATGTAAAAGTCAAAAAGATTATCGAAGATGAGCGACAACGACTTGCCAGGGAATTACATGATTCTGTTAGT
CAACAATTATTTGCTGCGAGCATGATGCTATCGGCGATAAAAGAGTCGAAATTAGAACCACCTTTAAATCAACAGATACC
AATTCTTGAAAAAATGGTTCAAGACTCACAACTTGAAATGAGAGCTTTGTTATTACATTTAAGACCGATAGGTTTAAAAG
ATAAGTCTTTAGGTGAAGGAATTAAAGATTTAGTCATCGATTTACAAAAGAAAGTACCAATGAAAGTTGTGCATGAAATT
CAAGATTTTGAAGTGCCAAAAGGCATTGAAGATCACTTGTTCAGAATTACACAAGAAGCTATTTCAAATACATTGAGACA
TTCAAATGGTACAAAAGTAACTGTGGAATTATTTAATCAAGAGGATTATCTTTTACTAAGAATTCAAGATAATGGAAAAG
GGTTTAATGTAGATGAAAAATTTGAACAAAGTTATGGTTTGAAAAATATGCGAGAACGAGCGTTAGAAATTGGTGCGACG
TTTCATATTGTATCTTTACCTGATTCAGGTACACGAATTGAAGTTAAGGCACCATTGAATAAGGAGGAGAATTCAAGTGG
CGATTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0N1EGU4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	93.023	98.851	0.92