NTDB

Overview

Name	comEA/celA/cilE	Type	Machinery gene
Locus tag	J4Q31_RS06165	Genome accession	NZ_CP071918
Coordinates	1195154..1195804 (-)	Length	216 a.a.
NCBI ID	WP_000387328.1	Uniprot ID	A0A4N9N7Z7
Organism	Streptococcus pneumoniae strain 19A-19343
Function	dsDNA binding to the cell surface (predicted from homology) DNA binding and uptake

Genomic Context

Location: 1190154..1200804

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
J4Q31_RS06145 (J4Q31_06150)	-	1190759..1191940 (-)	1182	WP_000655951.1	membrane protein	-
J4Q31_RS06150 (J4Q31_06155)	-	1191944..1192531 (-)	588	WP_000939884.1	ATP-binding cassette domain-containing protein	-
J4Q31_RS06155 (J4Q31_06160)	-	1192564..1192788 (-)	225	WP_000583432.1	hypothetical protein	-
J4Q31_RS06160 (J4Q31_06165)	comEC/celB	1192930..1195170 (-)	2241	WP_000942392.1	DNA internalization-related competence protein ComEC/Rec2	Machinery gene
J4Q31_RS06165 (J4Q31_06170)	comEA/celA/cilE	1195154..1195804 (-)	651	WP_000387328.1	ComEA family DNA-binding protein	Machinery gene
J4Q31_RS06170 (J4Q31_06175)	-	1195872..1196441 (-)	570	WP_000443775.1	GNAT family N-acetyltransferase	-
J4Q31_RS06175	-	1196618..1197547 (+)	930	Protein_1238	alanine dehydrogenase	-
J4Q31_RS06180 (J4Q31_06195)	-	1197848..1198174 (-)	327	Protein_1239	TfoX/Sxy family protein	-
J4Q31_RS06185 (J4Q31_06200)	-	1198177..1198677 (-)	501	WP_000566986.1	GNAT family N-acetyltransferase	-
J4Q31_RS06190 (J4Q31_06210)	-	1198870..1199838 (-)	969	WP_000658198.1	PhoH family protein	-
J4Q31_RS06195 (J4Q31_06215)	-	1199924..1200139 (-)	216	WP_001232081.1	YozE family protein	-

Sequence

Protein

Download Length: 216 a.a. Molecular weight: 23230.59 Da Isoelectric Point: 5.0667

                                >NTDB_id=549101 J4Q31_RS06165 WP_000387328.1 1195154..1195804(-) (comEA/celA/cilE) [Streptococcus pneumoniae strain 19A-19343]

MEAIIEKIKEYKIIVICTGLGLLVGGFFLLKPAPQTPVKETNLQAEVAAVSKDLVSEEEVNKEEKEEPLEQDLITVDVKG

AVKSPGIYDLPVGSRVNDAVQKAGGLTEQADSKSLNLAQKVSDEALVYVPTKGEEAVSQQTGLGTASSISKEKKVNLNKA

SLEELKQVKGLGGKRAQDIIDHREANGKFKSVDELKKVSGIGGKTIEKLKDYVTVD

Nucleotide

Download Length: 651 bp

                                >NTDB_id=549101 J4Q31_RS06165 WP_000387328.1 1195154..1195804(-) (comEA/celA/cilE) [Streptococcus pneumoniae strain 19A-19343]

ATGGAAGCAATTATCGAGAAAATCAAAGAGTATAAAATCATCGTCATCTGTACTGGTCTGGGCTTGCTTGTAGGAGGATT

TTTCCTGCTAAAACCAGCTCCACAAACACCTGTCAAAGAGACGAATTTGCAGGCTGAAGTCGCAGCTGTTTCCAAGGATT

TGGTATCCGAAGAGGAAGTGAACAAGGAAGAAAAGGAAGAACCCCTTGAACAAGATCTAATCACAGTAGATGTCAAAGGT

GCTGTCAAATCGCCAGGGATTTATGACTTGCCTGTAGGTAGTCGAGTCAATGATGCTGTTCAGAAGGCTGGTGGCTTGAC

AGAGCAAGCAGACAGCAAGTCGCTCAATCTAGCTCAGAAAGTTAGTGATGAGGCTCTGGTTTACGTTCCTACTAAGGGAG

AAGAAGCAGTTAGCCAACAGACTGGTTTGGGGACAGCTTCTTCAATAAGCAAGGAAAAGAAGGTCAATCTCAACAAGGCC

AGTCTGGAAGAACTCAAGCAGGTCAAGGGACTGGGAGGAAAACGAGCTCAGGACATTATCGACCATCGTGAGGCAAATGG

CAAGTTCAAGTCAGTAGACGAGCTCAAGAAGGTCTCTGGCATTGGTGGCAAAACAATAGAAAAGCTTAAAGACTATGTTA

CAGTGGATTAA

Domains

Predicted by InterproScan.

SLBB domain (SLBB)

(76-126)

Helix-hairpin-helix motif (HHH_3)

(151-214)

Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.

3D structure

Source	ID	Structure
AlphaFold DB	A0A4N9N7Z7

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.

Visualization of predicted probability:

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	H_a-value
comEA/celA/cilE	Streptococcus pneumoniae Rx1	99.537	100	0.995
comEA/celA/cilE	Streptococcus pneumoniae D39	99.537	100	0.995
comEA/celA/cilE	Streptococcus pneumoniae R6	99.537	100	0.995
comEA/celA/cilE	Streptococcus pneumoniae TIGR4	96.759	100	0.968
comEA/celA/cilE	Streptococcus mitis NCTC 12261	95.833	100	0.958
comEA/celA/cilE	Streptococcus mitis SK321	89.815	100	0.898
comEA	Lactococcus lactis subsp. cremoris KW2	43.172	100	0.454
comEA	Bacillus subtilis subsp. subtilis str. 168	41.579	87.963	0.366

Detailed information NTG0549101