Detailed information NTG0054488

Bioinformatically predicted

Overview

• Name: sepM
• Type: Regulator
• Locus tag: UC509_RS10735
• Genome accession: NC_019435
• Coordinates: 2121784..2122815 (-)
• Length: 343 a.a.
• NCBI ID: WP_011677213.1
• Uniprot ID: A0A166ZHD8
• Organism: Lactococcus cremoris subsp. cremoris UC509.9
• Function: processing of CSP (predicted from homology) Competence regulation

Genomic Context

Location: 2116784..2127815

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
UC509_RS10710 (uc509_2133)	-	2117987..2118484 (-)	498	WP_011677211.1	nitroreductase family protein	-
UC509_RS10715 (uc509_2134)	-	2118471..2118680 (-)	210	WP_011677212.1	hypothetical protein	-
UC509_RS10720	-	2118677..2118901 (-)	225	WP_021211256.1	hypothetical protein	-
UC509_RS10725 (uc509_2135)	-	2118968..2119858 (+)	891	WP_015082946.1	IS982 family transposase	-
UC509_RS10730 (uc509_2136)	kwcM	2119965..2121284 (-)	1320	WP_015082947.1	KxxxW cyclic peptide radical SAM maturase	-
UC509_RS12700 (uc509_2137)	-	2121352..2121465 (-)	114	WP_011836076.1	KxxxW-cyclized peptide pheromone	-
UC509_RS10735 (uc509_2138)	sepM	2121784..2122815 (-)	1032	WP_011677213.1	SepM family pheromone-processing serine protease	Regulator
UC509_RS10740 (uc509_2139)	coaD	2122799..2123299 (-)	501	WP_011677214.1	pantetheine-phosphate adenylyltransferase	-
UC509_RS10745 (uc509_2140)	rsmD	2123347..2123886 (-)	540	WP_031286167.1	16S rRNA (guanine(966)-N(2))-methyltransferase RsmD	-
UC509_RS10750 (uc509_2141)	-	2124056..2125276 (-)	1221	WP_011677216.1	MFS transporter	-
UC509_RS10755 (uc509_2142)	lmrP	2125356..2126582 (-)	1227	Protein_2091	multidrug efflux MFS transporter LmrP	-
UC509_RS10760 (uc509_2143)	-	2126770..2127264 (+)	495	WP_015082948.1	RNA polymerase sigma factor	-

Sequence

Protein

• Length: 343 a.a.
• Molecular weight: 37398.03 Da
• Isoelectric Point: 9.8499

>NTDB_id=54488 UC509_RS10735 WP_011677213.1 2121784..2122815(-) (sepM) [Lactococcus cremoris subsp. cremoris UC509.9]
MKKKNKKISPKLKWGISIGLIIVALLVLVYPTNYYVEMPGTTEPLGKMVKVEGKKDEHKGDFFLTTVQIARANLATMIYS
HFNSFTSIYSEQEMTGGLNDAQFNRVNQFYMETAQNTAVYQAFKLANKPYELKYEGVYVLDIAKNSTFKNKLELSDTITA
VNGEEFKSSADMIAYVSKQKVGDSVTIEYTRIDGSKHKSTGKYIKIANGKTGIGIGLVDHTEVVTDPKVTVNAGSIGGPS
AGIMFTLEIYSQLTGKDLRGGREIAGTGTIEHDGSIGQIGGVDKKVATASKEGAKVFLVPDSGTKKESSNNYLGAKAAAK
KLKTKMKIVPVKTIQDALDYLEK

Nucleotide

• Length: 1032 bp

>NTDB_id=54488 UC509_RS10735 WP_011677213.1 2121784..2122815(-) (sepM) [Lactococcus cremoris subsp. cremoris UC509.9]
ATGAAGAAAAAAAATAAAAAAATCAGTCCCAAATTAAAATGGGGCATCTCTATTGGTCTGATTATTGTCGCTCTCCTTGT
TTTAGTGTATCCAACAAATTACTATGTGGAAATGCCTGGAACAACCGAGCCATTAGGAAAAATGGTCAAAGTCGAAGGAA
AAAAAGATGAGCACAAAGGTGACTTTTTCCTTACTACCGTTCAAATTGCGCGCGCTAATCTTGCCACAATGATTTACAGT
CATTTTAATAGTTTTACAAGCATTTACAGTGAACAAGAAATGACCGGTGGCCTTAATGATGCGCAGTTCAATCGTGTCAA
CCAGTTTTACATGGAAACGGCACAAAATACAGCCGTTTATCAGGCCTTCAAGTTGGCAAATAAACCCTATGAACTGAAAT
ATGAAGGGGTTTATGTCCTTGATATCGCTAAAAATTCGACTTTTAAAAATAAATTGGAACTTTCGGACACGATTACAGCA
GTCAATGGGGAAGAATTTAAATCAAGTGCAGATATGATTGCTTACGTTTCGAAGCAAAAAGTCGGCGATTCAGTTACCAT
TGAATATACACGGATTGATGGAAGTAAACACAAGTCTACTGGAAAATATATCAAAATCGCTAATGGAAAAACTGGAATCG
GAATTGGACTAGTTGACCATACTGAAGTAGTCACAGACCCAAAAGTTACAGTCAATGCAGGTTCAATCGGTGGACCATCT
GCCGGAATAATGTTTACACTAGAGATTTACAGTCAGTTGACAGGTAAAGATTTACGTGGTGGTCGCGAAATAGCAGGAAC
TGGAACGATTGAACATGATGGAAGCATTGGCCAAATCGGTGGGGTTGATAAAAAAGTAGCTACTGCTAGCAAAGAAGGCG
CAAAAGTTTTCTTAGTTCCTGACTCAGGCACCAAAAAAGAAAGCAGCAATAACTATCTTGGAGCCAAAGCAGCCGCTAAA
AAATTAAAAACGAAGATGAAAATTGTTCCCGTCAAGACTATTCAGGACGCTTTAGATTATTTAGAAAAATAA

Domains

Predicted by InterproScan.

• Lon protease (S16) C-terminal proteolytic domain (Lon_C) (229-339)

• PDZ domain (PDZ_2) (135-193)

3D structure

• AlphaFold DB: A0A166ZHD8

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
sepM	Streptococcus mutans UA159	48.696	100	0.49