Detailed information NTG0544510

Bioinformatically predicted

Overview

• Name: clpC
• Type: Regulator
• Locus tag: LO741_RS20515
• Genome accession: NZ_CP087290
• Coordinates: 4185752..4188028 (+)
• Length: 758 a.a.
• NCBI ID: WP_000934041.1
• Uniprot ID: P0ABI0
• Organism: Escherichia coli strain APEC 102026
• Function: degradation of ComK; degradation of DegU (predicted from homology) Competence regulation

Genomic Context

Location: 4180752..4193028

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
LO741_RS20490 (LO741_20440)	macA	4181723..4182838 (+)	1116	WP_000746441.1	macrolide transporter subunit MacA	-
LO741_RS20495 (LO741_20445)	macB	4182835..4184781 (+)	1947	WP_000188133.1	macrolide ABC transporter ATP-binding protein/permease MacB	-
LO741_RS20500 (LO741_20450)	cspD	4184854..4185078 (-)	225	WP_000410785.1	cold shock-like protein CspD	-
LO741_RS20505 (LO741_20455)	yljB	4185228..4185302 (+)	75	WP_001406719.1	protein YljB	-
LO741_RS20510 (LO741_20460)	clpS	4185401..4185721 (+)	321	WP_000520781.1	ATP-dependent Clp protease adapter ClpS	-
LO741_RS20515 (LO741_20465)	clpC	4185752..4188028 (+)	2277	WP_000934041.1	ATP-dependent Clp protease ATP-binding subunit ClpA	Regulator
LO741_RS20525 (LO741_20475)	infA	4188713..4188931 (-)	219	WP_001040187.1	translation initiation factor IF-1	-
LO741_RS20530 (LO741_20480)	aat	4189216..4189920 (-)	705	WP_001241678.1	leucyl/phenylalanyl-tRNA--protein transferase	-
LO741_RS20535 (LO741_20485)	cydC	4189962..4191683 (-)	1722	WP_001202181.1	cysteine/glutathione ABC transporter ATP-binding protein/permease CydC	-

Sequence

Protein

• Length: 758 a.a.
• Molecular weight: 84206.93 Da
• Isoelectric Point: 6.2512

>NTDB_id=544510 LO741_RS20515 WP_000934041.1 4185752..4188028(+) (clpC) [Escherichia coli strain APEC 102026]
MLNQELELSLNMAFARAREHRHEFMTVEHLLLALLSNPSAREALEACSVDLVALRQELEAFIEQTTPVLPASEEERDTQP
TLSFQRVLQRAVFHVQSSGRNEVTGANVLVAIFSEQESQAAYLLRKHEVSRLDVVNFISHGTRKDEPTQSSDPGSQPNSE
EQAGGEERMENFTTNLNQLARVGGIDPLIGREKELERAIQVLCRRRKNNPLLVGESGVGKTAIAEGLAWRIVQGDVPEVM
ADCTIYSLDIGSLLAGTKYRGDFEKRFKALLKQLEQDTNSILFIDEIHTIIGAGAASGGQVDAANLIKPLLSSGKIRVIG
STTYQEFSNIFEKDRALARRFQKIDITEPSIEETVQIINGLKPKYEAHHDVRYTAKAVRAAVELAVKYINDRHLPDKAID
VIDEAGARARLMPVSKRKKTVNVADIESVVARIARIPEKSVSQSDRDTLKNLGDRLKMLVFGQDKAIEALTEAIKMARAG
LGHEHKPVGSFLFAGPTGVGKTEVTVQLSKALGIELLRFDMSEYMERHTVSRLIGAPPGYVGFDQGGLLTDAVIKHPHAV
LLLDEIEKAHPDVFNILLQVMDNGTLTDNNGRKADFRNVVLVMTTNAGVRETERKSIGLIHQDNSTDAMEEIKKIFTPEF
RNRLDNIIWFDHLSTDVIHQVVDKFIVELQVQLDQKGVSLEVSQEARNWLAEKGYDRAMGARPMARVIQDNLKKPLANEL
LFGSLVDGGQVTVALDKEKNELTYGFQSAQKHKAEAAH

Nucleotide

• Length: 2277 bp

>NTDB_id=544510 LO741_RS20515 WP_000934041.1 4185752..4188028(+) (clpC) [Escherichia coli strain APEC 102026]
ATGCTCAATCAAGAACTGGAACTCAGTTTAAATATGGCTTTCGCCAGAGCGCGCGAGCACCGTCATGAGTTTATGACCGT
CGAGCACTTGTTACTGGCGCTGCTCAGTAACCCATCTGCCCGGGAGGCGCTGGAAGCGTGCTCTGTGGATTTGGTTGCGC
TCCGTCAGGAACTGGAAGCCTTTATTGAACAAACCACACCCGTTCTGCCTGCCAGTGAAGAGGAGCGCGACACACAGCCG
ACGCTGAGTTTTCAGCGTGTACTGCAACGTGCGGTCTTCCATGTCCAGTCCTCCGGTCGCAATGAGGTTACCGGTGCAAA
CGTTCTGGTCGCTATCTTTAGCGAACAGGAGTCGCAGGCGGCATATCTGTTGCGCAAACATGAAGTCAGCCGTCTCGATG
TGGTGAACTTTATCTCTCATGGCACGCGTAAAGACGAGCCGACACAGTCTTCTGATCCTGGCAGCCAGCCAAACAGCGAA
GAACAAGCTGGTGGGGAGGAACGTATGGAGAATTTCACGACGAACCTGAATCAGCTTGCACGTGTGGGCGGAATCGACCC
ACTGATTGGTCGTGAGAAGGAGCTGGAGCGTGCTATTCAGGTTCTCTGCCGTCGCCGTAAAAACAACCCGCTGCTGGTGG
GGGAGTCTGGTGTCGGTAAAACCGCGATTGCGGAGGGGCTTGCATGGCGAATTGTTCAGGGCGATGTGCCGGAAGTGATG
GCTGACTGTACGATTTACTCTCTCGATATCGGTTCTCTGTTAGCGGGCACAAAATATCGCGGCGACTTTGAAAAACGTTT
TAAAGCGTTGCTCAAGCAGCTGGAGCAGGACACTAACAGCATCCTGTTTATTGATGAGATCCACACCATTATCGGTGCGG
GTGCAGCGTCTGGTGGCCAGGTCGATGCGGCTAACCTGATTAAACCGTTGCTCTCCAGCGGTAAAATTCGCGTAATTGGT
TCGACAACCTATCAGGAGTTCAGCAACATTTTCGAGAAAGACCGTGCTCTGGCGCGTCGCTTCCAGAAAATTGATATTAC
TGAACCGTCGATAGAAGAAACCGTACAGATCATCAATGGCCTGAAACCGAAGTATGAAGCGCACCACGACGTGCGTTATA
CCGCAAAAGCGGTGCGTGCAGCGGTAGAGCTGGCGGTGAAATACATTAACGATCGTCATCTGCCGGATAAAGCCATTGAC
GTTATCGACGAAGCGGGCGCTCGCGCACGCCTGATGCCGGTAAGCAAACGCAAGAAAACCGTTAATGTGGCGGATATTGA
GTCCGTGGTGGCCCGTATTGCGCGCATTCCAGAGAAGAGTGTTTCGCAGAGTGACCGCGATACCCTGAAAAACCTCGGCG
ATCGCCTGAAAATGCTGGTCTTCGGTCAGGATAAAGCCATTGAGGCGCTGACTGAAGCCATTAAGATGGCGCGTGCAGGT
TTAGGTCACGAACATAAACCGGTCGGTTCGTTCCTGTTTGCCGGTCCTACCGGGGTCGGGAAAACAGAGGTGACGGTACA
GCTTTCGAAAGCGTTGGGCATTGAGCTTCTGCGCTTTGATATGTCCGAGTATATGGAACGCCATACCGTCAGCCGTCTGA
TTGGTGCGCCTCCGGGATACGTTGGTTTTGATCAGGGCGGTTTGCTGACTGATGCGGTCATCAAGCATCCACATGCGGTG
CTGCTGCTGGACGAAATCGAGAAAGCGCACCCGGACGTGTTCAATATTCTGTTGCAGGTGATGGACAACGGTACGCTGAC
CGATAACAACGGACGCAAAGCGGACTTCCGTAACGTGGTATTGGTGATGACCACCAACGCTGGGGTACGAGAAACTGAGC
GTAAATCGATTGGTCTTATCCACCAGGACAACAGTACCGATGCGATGGAAGAGATCAAGAAGATCTTTACGCCGGAGTTT
CGTAACCGTCTCGACAACATTATCTGGTTCGATCATCTCTCCACCGACGTGATCCATCAGGTAGTGGATAAATTCATCGT
CGAGTTGCAGGTTCAGCTGGATCAGAAAGGTGTTTCTCTGGAAGTGAGCCAGGAAGCGCGTAACTGGCTGGCCGAGAAAG
GTTACGACCGGGCAATGGGCGCACGTCCGATGGCGCGTGTCATCCAGGACAACCTGAAAAAACCGCTCGCCAACGAACTG
TTGTTTGGTTCGCTGGTGGACGGCGGTCAGGTGACGGTTGCGCTGGATAAAGAGAAAAATGAGCTGACTTATGGATTCCA
GAGTGCACAAAAGCACAAGGCGGAAGCAGCGCATTAA

Domains

Predicted by InterProScan.

• AAA domain (Cdc48 subfamily) (AAA_2) (486-647)

• ATPase family associated with various cellular activities (AAA) (AAA) (211-342)

• AAA lid domain (AAA_lid_9) (350-452)

• Clp amino terminal domain, pathogenicity island component (Clp_N) (13-62)

• C-terminal, D2-small domain, of ClpB protein (ClpB_D2-small) (653-733)

3D structure

• AlphaFold DB: P0ABI0

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
clpC	Bacillus subtilis subsp. subtilis str. 168	38.868	100	0.408
clpA	Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819	41.346	96.042	0.397
clpC	Lactococcus lactis subsp. lactis strain DGCC12653	35.46	100	0.381
clpC	Streptococcus thermophilus LMD-9	42.37	89.05	0.377
clpC	Streptococcus thermophilus LMG 18311	42.222	89.05	0.376
clpC	Streptococcus mutans UA159	39.407	93.404	0.368