Detailed information NTG0054325

Bioinformatically predicted

Overview

• Name: clpC
• Type: Regulator
• Locus tag: SDSE_RS20580
• Genome accession: NC_019042
• Coordinates: 2046324..2048768 (-)
• Length: 814 a.a.
• NCBI ID: WP_015058108.1
• Uniprot ID: A0AB33R7Z5
• Organism: Streptococcus dysgalactiae subsp. equisimilis AC-2713
• Function: degradation of ComX (predicted from homology) Competence regulation

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type	MGE coordinates	Gene coordinates	Relative position	Distance (bp)
Prophage	2044195..2055110	2046324..2048768	within	0

Gene organization within MGE regions

Location: 2044195..2055110

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
SDSE_RS20570 (S_dysgal_equisimilis_AC2713_2103)	groL	2044195..2045820 (-)	1626	WP_012767614.1	chaperonin GroEL	-
SDSE_RS20575 (S_dysgal_equisimilis_AC2713_2104)	groES	2045856..2046146 (-)	291	WP_003054738.1	co-chaperone GroES	-
SDSE_RS20580 (S_dysgal_equisimilis_AC2713_2105)	clpC	2046324..2048768 (-)	2445	WP_015058108.1	ATP-dependent Clp protease ATP-binding subunit	Regulator
SDSE_RS20585 (S_dysgal_equisimilis_AC2713_2106)	-	2048768..2049229 (-)	462	WP_003054759.1	CtsR family transcriptional regulator	-
SDSE_RS20590 (S_dysgal_equisimilis_AC2713_2107)	-	2049425..2049628 (-)	204	WP_003053018.1	cold-shock protein	-
SDSE_RS20595 (S_dysgal_equisimilis_AC2713_2108)	-	2050129..2051013 (+)	885	WP_256096233.1	amidohydrolase family protein	-
SDSE_RS20600 (S_dysgal_equisimilis_AC2713_2109)	-	2051058..2052543 (-)	1486	Protein_1934	IS1182 family transposase	-
SDSE_RS20605 (S_dysgal_equisimilis_AC2713_2111)	-	2052567..2052827 (-)	261	Protein_1935	DUF4355 domain-containing protein	-
SDSE_RS20610 (S_dysgal_equisimilis_AC2713_2112)	-	2052965..2053189 (-)	225	WP_015058113.1	hypothetical protein	-
SDSE_RS20615 (S_dysgal_equisimilis_AC2713_2113)	-	2053242..2053661 (-)	420	WP_015058114.1	HD domain-containing protein	-
SDSE_RS20620 (S_dysgal_equisimilis_AC2713_2114)	-	2053658..2053864 (-)	207	WP_015058115.1	hypothetical protein	-
SDSE_RS20625 (S_dysgal_equisimilis_AC2713_2115)	-	2053866..2055110 (-)	1245	WP_015058116.1	phage head morphogenesis protein	-

Sequence

Protein

• Length: 814 a.a.
• Molecular weight: 90337.03 Da
• Isoelectric Point: 6.8331

>NTDB_id=54325 SDSE_RS20580 WP_015058108.1 2046324..2048768(-) (clpC) [Streptococcus dysgalactiae subsp. equisimilis AC-2713]
MIMYSLKMQEIFRQAQFQAARFDSQYLETWHILLAMARVDHSLAGLVLSEFDAKVAVEEYEAAAILAMGKSPKYQVSHID
FRPQSKTLTNLLQFAQAISQVTKDQEVGSEHVLFAILLNPDIMATRLLEMAGYTIKDKGNGEPRLADLRKAIEIHAGYSK
EIIKAIHELRKPKKTKNQGSFSDMMKPPSTAGDLADFTRDLTEMASQGLLEPVIGRDAEVSRMIQVLSRKTKNNPVLVGD
AGVGKTALAYGLAQRIANGAIPYELQDMRVLELDMMSVVAGTRFRGDFEERMNQIIDDIESDGKIILFVDELHTIMGSGS
GIDSTLDAANILKPALSRGTLHMVGATTQEEYQKHIEKDAALSRRFAKILIEEPNVEDAYQILLGLKGSYETYHNVTIAN
QAVRTAVKMAHRYLTSKNLPDSAIDLLDEASATVQGMVKKSRPEIITPLDQALIDGDMKKASRLLAKDVKGQHRKPTAVT
EEDILTTLSKLSGIPLEKLSQADSKKYLNLEKELHKRVIGQEDAVSAISRAIRRNQSGIRTGKRPIGSFMFLGPTGVGKT
ELAKALAEVLFDAASALIRFDMSEYMEKFAASRLNGAPPGYVGYDEGGELTEKVRNKPYSVLLFDEVEKAHPDIFNVLLQ
VLDDGMLTDSRGRKVDFSNTIIIMTSNLGATALRDDKTVGFGAKGISHDHQAMEKRILEELKKAYRPEFINRIDEKVVFH
SLTQDNMREVVKIMVQPLMATLAEKGITLKFQPMALKYLSEEGYDVEMGARPLRRTLQTQVEDKLSELILAGELASGHTL
KIGLSHGKLSFNLE

Nucleotide

• Length: 2445 bp

>NTDB_id=54325 SDSE_RS20580 WP_015058108.1 2046324..2048768(-) (clpC) [Streptococcus dysgalactiae subsp. equisimilis AC-2713]
ATGATCATGTATTCATTGAAGATGCAAGAAATTTTCAGGCAGGCGCAGTTTCAAGCAGCCCGCTTTGATAGCCAATACCT
AGAAACTTGGCATATATTGCTAGCTATGGCGAGGGTTGACCACTCCCTAGCGGGTTTGGTGCTAAGCGAATTTGATGCTA
AGGTTGCAGTGGAAGAATATGAGGCTGCAGCTATTTTAGCGATGGGCAAAAGTCCTAAATACCAAGTGTCTCACATTGAC
TTTAGGCCTCAGTCAAAAACCTTAACGAACCTTTTGCAATTTGCCCAAGCTATCAGTCAAGTCACCAAAGACCAAGAGGT
AGGTTCAGAGCATGTTCTCTTTGCCATTTTGCTTAATCCAGATATTATGGCTACTCGCTTATTAGAGATGGCGGGTTATA
CTATCAAGGATAAAGGAAACGGGGAGCCTCGCTTAGCTGATTTACGAAAAGCTATCGAGATTCATGCAGGCTATAGCAAG
GAAATAATTAAGGCTATCCACGAGTTGCGTAAGCCAAAGAAAACCAAAAATCAAGGTTCTTTTTCAGACATGATGAAGCC
ACCAAGCACGGCTGGGGACTTGGCGGACTTTACACGTGATTTGACCGAGATGGCAAGCCAAGGTCTCTTAGAGCCAGTTA
TTGGCCGTGATGCTGAAGTGTCACGGATGATTCAAGTACTGAGTCGTAAAACAAAGAATAACCCTGTTCTTGTGGGTGAT
GCAGGTGTGGGTAAAACGGCCCTTGCCTACGGCCTAGCCCAACGTATTGCTAATGGTGCTATTCCTTATGAGCTGCAAGA
CATGCGTGTTCTAGAATTAGACATGATGAGTGTTGTTGCGGGGACCCGTTTTCGTGGGGATTTTGAAGAGCGCATGAATC
AAATCATTGACGATATTGAGTCAGATGGCAAAATTATTCTCTTCGTAGATGAATTGCACACCATTATGGGATCAGGAAGT
GGTATTGATAGCACGCTTGATGCTGCCAATATTTTAAAACCAGCCTTATCTCGTGGAACCCTCCATATGGTGGGTGCAAC
AACGCAGGAAGAATACCAAAAACACATTGAAAAAGATGCCGCTCTTTCGCGCCGCTTTGCTAAGATTTTAATTGAAGAAC
CTAATGTAGAAGATGCTTATCAGATTCTGCTAGGACTAAAAGGCTCTTACGAGACTTACCATAATGTGACCATTGCTAAT
CAGGCTGTTAGAACCGCTGTGAAAATGGCACATCGCTATCTGACCAGCAAAAACCTTCCGGATTCTGCCATTGATTTGTT
GGATGAAGCCAGTGCTACAGTGCAAGGTATGGTTAAAAAATCTAGGCCAGAAATCATCACGCCATTAGATCAAGCTTTGA
TTGATGGCGATATGAAGAAGGCCTCTCGTTTGTTGGCAAAAGACGTTAAAGGGCAACATCGCAAGCCAACAGCTGTGACA
GAAGAGGACATCCTGACGACCTTGAGCAAGCTATCAGGTATTCCACTGGAAAAACTCAGCCAAGCTGATAGCAAAAAATA
CCTTAATTTGGAAAAAGAACTGCATAAGCGCGTGATTGGGCAAGAAGATGCTGTCTCAGCTATTTCTAGAGCCATTCGCC
GTAATCAGTCAGGCATTCGTACAGGTAAACGTCCAATCGGTTCTTTCATGTTCCTTGGTCCAACAGGGGTTGGTAAGACC
GAGTTGGCAAAAGCCTTGGCAGAAGTTCTCTTTGATGCCGCGTCCGCCCTTATCCGCTTTGATATGTCAGAGTATATGGA
GAAATTTGCGGCTTCTCGCCTTAATGGCGCACCTCCAGGCTATGTTGGTTACGATGAAGGTGGTGAATTAACAGAGAAGG
TCAGAAACAAGCCTTATTCTGTGCTCCTCTTTGACGAGGTGGAAAAAGCTCACCCTGATATTTTCAACGTCCTCTTACAA
GTGCTTGATGATGGCATGTTGACAGATAGCCGTGGGCGTAAAGTGGACTTCTCAAATACCATTATTATCATGACAAGTAA
TCTAGGGGCAACAGCTCTGCGTGATGATAAAACAGTTGGCTTTGGGGCAAAAGGCATTAGCCATGACCACCAAGCCATGG
AAAAACGGATTTTGGAAGAGTTGAAAAAAGCTTACCGACCAGAATTTATCAACCGAATTGATGAAAAGGTTGTCTTCCAC
AGCCTCACTCAGGACAATATGAGAGAAGTAGTCAAGATTATGGTGCAGCCGTTGATGGCTACTTTGGCAGAAAAAGGCAT
TACCCTCAAATTCCAGCCAATGGCCCTCAAGTATTTATCAGAAGAAGGGTATGATGTGGAAATGGGTGCTCGTCCATTAC
GCCGCACTTTGCAAACTCAGGTGGAAGATAAATTGTCTGAATTGATTCTTGCTGGTGAATTGGCAAGTGGTCATACCCTG
AAAATTGGCCTTTCTCATGGAAAACTCAGCTTTAACCTTGAGTGA

Domains

Predicted by InterproScan.

• C-terminal, D2-small domain, of ClpB protein (ClpB_D2-small) (722-801)

• AAA domain (Cdc48 subfamily) (AAA_2) (544-715)

• ATPase family associated with various cellular activities (AAA) (AAA) (236-368)

• Clp amino terminal domain, pathogenicity island component (Clp_N) (15-53)

• Clp amino terminal domain, pathogenicity island component (Clp_N) (95-137)

• AAA lid domain (AAA_lid_9) (376-462)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
clpC	Streptococcus mutans UA159	76.384	99.877	0.763
clpC	Streptococcus thermophilus LMG 18311	72.672	100	0.729
clpC	Streptococcus thermophilus LMD-9	72.672	100	0.729
clpC	Streptococcus pneumoniae TIGR4	67.036	99.877	0.67
clpC	Streptococcus pneumoniae Rx1	67.036	99.877	0.67
clpC	Streptococcus pneumoniae D39	67.036	99.877	0.67
clpC	Lactococcus lactis subsp. lactis strain DGCC12653	48.681	100	0.499
clpC	Bacillus subtilis subsp. subtilis str. 168	42.72	100	0.436