NTDB

Overview

Name	comE/blpR	Type	Regulator
Locus tag	JZI57_RS08900	Genome accession	NZ_CP071142
Coordinates	1837733..1838470 (-)	Length	245 a.a.
NCBI ID	WP_012679508.1	Uniprot ID	C0M9Q1
Organism	Streptococcus equi subsp. equi strain 489_004
Function	activate transcription of early competence genes; regulation of comX expression (predicted from homology) Competence regulation

Genomic Context

Location: 1832733..1843470

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
JZI57_RS08875 (JZI57_08875)	-	1833448..1833783 (-)	336	WP_251004697.1	hypothetical protein	-
JZI57_RS08880 (JZI57_08880)	-	1833823..1835165 (+)	1343	WP_173292424.1	IS3 family transposase	-
JZI57_RS08885 (JZI57_08885)	-	1835190..1836233 (-)	1044	WP_230197352.1	ABC transporter permease subunit	-
JZI57_RS08890 (JZI57_08890)	-	1836239..1837093 (-)	855	WP_012679510.1	ABC transporter ATP-binding protein	-
JZI57_RS08895 (JZI57_08895)	-	1837160..1837360 (-)	201	WP_012679509.1	ComC/BlpC family leader-containing pheromone/bacteriocin	-
JZI57_RS08900 (JZI57_08900)	comE/blpR	1837733..1838470 (-)	738	WP_012679508.1	response regulator transcription factor	Regulator
JZI57_RS08905 (JZI57_08905)	-	1839221..1839526 (-)	306	WP_012679507.1	hypothetical protein	-
JZI57_RS08910 (JZI57_08910)	-	1839528..1839866 (-)	339	WP_012679506.1	cupin domain-containing protein	-
JZI57_RS08915 (JZI57_08915)	-	1839894..1840649 (-)	756	WP_042356922.1	class I SAM-dependent methyltransferase	-
JZI57_RS08920 (JZI57_08920)	-	1840910..1841365 (+)	456	WP_012515587.1	DUF1836 domain-containing protein	-
JZI57_RS08925 (JZI57_08925)	-	1841349..1841999 (+)	651	WP_012515586.1	hemolysin III family protein	-
JZI57_RS08930 (JZI57_08930)	-	1842109..1843013 (+)	905	Protein_1720	diacylglycerol kinase family protein	-

Sequence

Protein

Download Length: 245 a.a. Molecular weight: 28892.31 Da Isoelectric Point: 7.8796

                                >NTDB_id=543072 JZI57_RS08900 WP_012679508.1 1837733..1838470(-) (comE/blpR) [Streptococcus equi subsp. equi strain 489_004]

MNIFILEDDLGQQFRLEMKIQEILDKHHWTCDRFEVYGKPYQLLANVTERGRHQLFFLDIQIRNDEKKGLAVAREIRKRD

PYALIVFVTTHSELMPVSFRYQVSALDFIDKELSMKHFSDRIERAIIYAYEEQENVTSEGLFIFATAKAQVQVPFSSLLF

IETSSTPHKLILHSQNERIEFYGFLSEVLKQDSRLVQCHRSYVINPYNVSFLDRDKRLLYFKNGQSCMVSRLKMKALEAS

IKALH

Nucleotide

Download Length: 738 bp

                                >NTDB_id=543072 JZI57_RS08900 WP_012679508.1 1837733..1838470(-) (comE/blpR) [Streptococcus equi subsp. equi strain 489_004]

ATGAATATTTTTATTCTCGAAGATGATCTAGGCCAACAGTTTAGGCTTGAGATGAAGATTCAAGAGATATTGGATAAGCA

TCACTGGACTTGTGATCGTTTTGAAGTTTATGGAAAGCCCTACCAGCTTCTGGCAAATGTTACAGAGAGAGGCAGGCATC

AGCTTTTCTTTCTCGATATTCAAATTCGAAATGATGAGAAAAAGGGCTTAGCTGTTGCTCGTGAGATCAGAAAGCGTGAC

CCTTATGCCCTCATTGTTTTTGTCACCACACATTCTGAGCTTATGCCAGTTTCTTTTCGTTATCAGGTGTCTGCTCTAGA

TTTTATCGATAAGGAATTGTCAATGAAACATTTCTCAGATAGGATTGAAAGAGCCATTATATATGCTTATGAAGAGCAAG

AAAATGTAACCTCAGAGGGCTTATTTATTTTTGCAACGGCTAAGGCTCAGGTGCAGGTTCCTTTTTCAAGCCTATTGTTC

ATTGAGACCTCTAGTACTCCTCACAAGTTGATTTTGCATTCTCAAAACGAGCGAATAGAATTTTATGGCTTTCTTTCAGA

GGTTCTTAAGCAAGATTCCAGACTAGTCCAATGTCATCGTTCTTATGTTATCAATCCTTACAATGTTTCGTTTCTTGATC

GTGATAAGCGTTTACTCTATTTCAAGAATGGGCAGTCTTGCATGGTTTCAAGACTAAAAATGAAAGCACTTGAGGCGTCT

ATTAAGGCTTTGCATTGA

Domains

Predicted by InterproScan.

LytTr DNA-binding domain (LytTR)

(151-240)

Response regulator receiver domain (Response_reg)

(18-122)

Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.

3D structure

Source	ID	Structure
AlphaFold DB	C0M9Q1

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.

Visualization of predicted probability:

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	H_a-value
comE/blpR	Streptococcus mutans UA159	54.132	98.776	0.535
comE/comE1	Streptococcus equinus JB1	45.455	98.776	0.449
comE/comE2	Streptococcus equinus JB1	37.295	99.592	0.371

Detailed information NTG0543072