Detailed information NTG0542833

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: JYA70_RS00460
• Genome accession: NZ_CP071102
• Coordinates: 82466..83509 (+)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus strain CI/BAC/25/13/W
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 77466..88509

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
JYA70_RS00430 (JYA70_000086)	-	77951..78061 (+)	111	WP_001790257.1	hypothetical protein	-
JYA70_RS00435 (JYA70_000087)	-	78090..78503 (+)	414	WP_001566709.1	hypothetical protein	-
JYA70_RS00440 (JYA70_000088)	-	78934..79920 (-)	987	WP_000999713.1	aromatic acid exporter family protein	-
JYA70_RS00445 (JYA70_000089)	map	80392..81150 (+)	759	WP_000636138.1	type I methionyl aminopeptidase	-
JYA70_RS00450 (JYA70_000090)	-	81367..81753 (+)	387	WP_001110179.1	hypothetical protein	-
JYA70_RS00455 (JYA70_000091)	liaF	81768..82469 (+)	702	WP_000149064.1	cell wall-active antibiotics response protein LiaF	-
JYA70_RS00460 (JYA70_000092)	vraS	82466..83509 (+)	1044	WP_001017131.1	sensor histidine kinase	Regulator
JYA70_RS00465 (JYA70_000093)	vraR	83499..84128 (+)	630	WP_000153536.1	two-component system response regulator VraR	Regulator
JYA70_RS00470 (JYA70_000094)	-	84240..85457 (-)	1218	WP_000037079.1	YihY/virulence factor BrkB family protein	-
JYA70_RS00475 (JYA70_000095)	-	85735..86010 (-)	276	WP_000428171.1	hypothetical protein	-
JYA70_RS00480 (JYA70_000096)	-	86017..86481 (-)	465	WP_000228666.1	low molecular weight protein-tyrosine-phosphatase	-
JYA70_RS00485 (JYA70_000097)	-	86628..86828 (+)	201	WP_000180460.1	DUF1128 family protein	-
JYA70_RS00490 (JYA70_000098)	-	86831..88087 (+)	1257	WP_001789555.1	aminopeptidase	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=542833 JYA70_RS00460 WP_001017131.1 82466..83509(+) (vraS) [Staphylococcus aureus strain CI/BAC/25/13/W]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=542833 JYA70_RS00460 WP_001017131.1 82466..83509(+) (vraS) [Staphylococcus aureus strain CI/BAC/25/13/W]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTATTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTCTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTACTCGCATACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACACTCGTACCTTTAAATCAAGAATTGCATAAGTTGCGACTTAAAACTCAAAATTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTGGCTCGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGTTATCTGCTATCAAAGAAACGAAGTTAGAACCACCATTAGACCAACAAATTCC
GATTTTAGAGAAAATGGTTCAAGATTCGCAGTTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCGATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGACAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1