Detailed information NTG0053968

Bioinformatically predicted

Overview

• Name: clpE
• Type: Regulator
• Locus tag: GGS_RS07205
• Genome accession: NC_018712
• Coordinates: 1468275..1470566 (+)
• Length: 763 a.a.
• NCBI ID: WP_003060519.1
• Uniprot ID: A0AB38Y0Z5
• Organism: Streptococcus dysgalactiae subsp. equisimilis RE378
• Function: repress competence development (at the early growth phase) (predicted from homology) Competence regulation

Genomic Context

Location: 1463275..1475566

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
GGS_RS07180 (GGS_1360)	feoB	1463365..1465524 (-)	2160	WP_015017220.1	ferrous iron transport protein B	-
GGS_RS07185 (GGS_1361)	-	1465521..1466000 (-)	480	WP_003056958.1	ferrous iron transport protein A	-
GGS_RS07190 (GGS_1362)	-	1466199..1466933 (-)	735	WP_015017221.1	amino acid ABC transporter ATP-binding protein	-
GGS_RS07195 (GGS_1363)	-	1466933..1467619 (-)	687	WP_015017222.1	amino acid ABC transporter permease	-
GGS_RS07200	-	1467747..1467977 (-)	231	WP_003051836.1	DUF1797 family protein	-
GGS_RS07205 (GGS_1365)	clpE	1468275..1470566 (+)	2292	WP_003060519.1	ATP-dependent Clp protease ATP-binding subunit	Regulator
GGS_RS07210 (GGS_1366)	-	1470684..1471139 (+)	456	WP_042357958.1	NUDIX hydrolase	-
GGS_RS07215 (GGS_1367)	-	1471189..1471491 (+)	303	WP_003051842.1	DUF1827 family protein	-
GGS_RS07220 (GGS_1368)	ileS	1471894..1474695 (-)	2802	WP_003062434.1	isoleucine--tRNA ligase	-

Sequence

Protein

• Length: 763 a.a.
• Molecular weight: 84971.26 Da
• Isoelectric Point: 5.3453

>NTDB_id=53968 GGS_RS07205 WP_003060519.1 1468275..1470566(+) (clpE) [Streptococcus dysgalactiae subsp. equisimilis RE378]
MLCQNCNLNESTIHLYTNVNGKQKQVDLCQNCYQIMKTDPTNPILGGLNGGQRAQERSSNPFFDDFFGDLNNFRAFGNLP
NTPPTQAGQNGNGGGRHGGHFNGQRPTQPQTPNQQAKGLLEEFGINVTDIARHGDIDPVIGRDDEITRVIEILNRRTKNN
PVLIGEPGVGKTAVVEGLAQKIVDGTVPHKLQGKQVIRLDVVSLVQGTGIRGQFEERMQKLMEEIRQRKDVILFIDEIHE
IVGAGSAGDGNMDAGNILKPALARGELQLVGATTLNEYRIIEKDAALERRMQPVKVDEPSVEETITILKGIQPKYEDYHH
VKYSPAAIEAAAHLSNRYIQDRFLPDKAIDLLDEAGSKMNLTLNFVDPKEIDKRLIEAENLKAQATRDEDYERAAYFRDQ
IAKYKEMQAQKVDEQDIPIITEKTIEAIIEQKTNIPVGDLKEKEQSQLVNLANDLKAHVIGQDDAVDKIAKAIRRNRVGL
GTPNRPIGSFLFVGPTGVGKTELSKQLAIELFGSADNMIRFDMSEYMEKHAVAKLVGAPPGYVGYEEAGQLTEQVRRNPY
SLILLDEVEKAHPDVMHMFLQVLDDGRLTDGQGRTVSFKDTIIIMTSNAGTGKSEASVGFGAAREGRTSSVLGELSNFFS
PEFMNRFDGIIEFKALSKDNLLHIVDLMLEDVNKRLSYNGIHLDVTQKVKEKLVDLGYDPKMGARPLRRTIQDYIEDAIT
DYYLEHPTEKDLRAIMTSNSNIMIKAAKKDETVTAKQDKTDEN

Nucleotide

• Length: 2292 bp

>NTDB_id=53968 GGS_RS07205 WP_003060519.1 1468275..1470566(+) (clpE) [Streptococcus dysgalactiae subsp. equisimilis RE378]
ATGCTTTGTCAAAATTGTAATTTAAACGAATCAACCATTCACCTCTACACGAATGTTAATGGAAAACAAAAACAAGTTGA
CCTTTGTCAAAACTGTTATCAAATCATGAAGACTGACCCTACTAATCCTATTTTAGGTGGTCTAAATGGAGGTCAAAGAG
CCCAAGAACGCTCATCCAACCCCTTCTTTGATGACTTTTTTGGGGACTTAAATAATTTTAGAGCCTTTGGCAACCTTCCA
AATACCCCACCTACTCAGGCAGGGCAAAATGGAAATGGTGGGGGACGCCATGGTGGTCATTTCAATGGACAACGTCCCAC
TCAGCCACAAACACCAAATCAGCAAGCAAAAGGCTTGCTAGAAGAATTTGGCATTAATGTGACCGATATTGCAAGACATG
GTGATATTGACCCTGTCATCGGTCGAGATGACGAGATTACACGTGTCATCGAAATCCTTAACCGTCGGACTAAAAATAAC
CCTGTGCTTATTGGGGAACCAGGAGTTGGTAAAACAGCTGTTGTAGAAGGTCTAGCCCAAAAAATTGTAGATGGCACAGT
ACCTCACAAATTGCAAGGTAAGCAAGTGATCCGTCTAGATGTGGTTAGTCTTGTTCAAGGCACAGGTATCCGTGGTCAAT
TCGAAGAACGCATGCAAAAATTAATGGAAGAAATTCGTCAACGCAAAGATGTGATTCTCTTTATTGATGAAATTCATGAA
ATTGTAGGTGCTGGTTCTGCTGGAGATGGCAATATGGATGCTGGCAATATTTTAAAACCAGCCTTGGCCCGTGGTGAGTT
GCAACTCGTTGGTGCTACTACCTTAAATGAATACCGTATTATTGAAAAAGATGCTGCCTTGGAGCGGCGGATGCAGCCGG
TGAAAGTTGACGAACCTTCTGTAGAAGAAACCATTACCATCTTAAAAGGTATCCAACCCAAATATGAAGACTATCATCAT
GTCAAATATAGCCCAGCAGCTATCGAGGCTGCTGCACACTTATCCAATCGCTACATCCAAGACCGATTCCTCCCTGATAA
GGCCATTGACCTTCTGGACGAAGCTGGTTCAAAAATGAATTTAACTCTTAATTTTGTTGACCCTAAAGAGATTGACAAAC
GTCTGATTGAAGCAGAAAACCTCAAAGCTCAAGCAACTCGTGACGAAGATTACGAACGAGCAGCCTATTTCCGTGATCAA
ATTGCGAAATACAAGGAAATGCAAGCTCAAAAAGTCGACGAACAGGATATTCCTATCATTACTGAAAAAACCATTGAAGC
CATCATTGAACAAAAAACCAATATTCCAGTTGGCGACTTGAAAGAAAAAGAACAATCTCAACTCGTTAATTTGGCTAATG
ATTTGAAAGCTCACGTGATTGGCCAAGATGATGCCGTTGACAAAATTGCCAAGGCCATTCGCCGGAACCGTGTGGGATTG
GGAACTCCAAATCGTCCTATTGGTTCTTTCCTATTCGTTGGGCCAACAGGTGTTGGTAAAACAGAGTTGTCTAAGCAACT
AGCTATTGAACTCTTTGGCTCTGCTGACAATATGATTCGCTTTGATATGTCCGAATACATGGAAAAACATGCCGTTGCTA
AATTAGTCGGGGCTCCTCCTGGTTATGTGGGCTATGAAGAAGCTGGCCAGTTAACGGAACAAGTTCGCCGCAACCCATAT
TCACTTATTCTCTTAGATGAGGTGGAAAAGGCTCATCCTGACGTCATGCACATGTTTTTACAAGTTCTTGATGATGGCCG
TTTAACAGATGGTCAAGGACGGACAGTCAGCTTCAAGGATACTATTATTATCATGACCTCTAATGCCGGAACAGGTAAAA
GCGAAGCTTCTGTTGGATTTGGTGCAGCTAGAGAAGGACGAACAAGCTCTGTCCTTGGTGAATTAAGTAACTTCTTCAGC
CCAGAGTTCATGAACCGTTTCGATGGTATTATTGAATTTAAGGCCTTGAGCAAAGATAACCTCTTGCATATCGTTGATTT
AATGCTGGAAGATGTTAATAAGCGCTTAAGCTATAATGGGATTCACCTTGATGTGACACAAAAAGTCAAAGAAAAATTAG
TAGATTTAGGCTATGATCCTAAAATGGGTGCTCGACCACTCCGTCGTACCATCCAAGATTATATCGAAGATGCGATTACG
GACTACTATTTGGAACACCCCACTGAAAAGGACTTGCGTGCCATAATGACAAGTAACAGTAATATCATGATTAAAGCTGC
CAAAAAAGATGAAACGGTAACAGCTAAACAAGATAAGACCGACGAGAACTAA

Domains

Predicted by InterproScan.

• AAA domain (Cdc48 subfamily) (AAA_2) (485-648)

• ATPase family associated with various cellular activities (AAA) (AAA) (162-281)

• C-terminal, D2-small domain, of ClpB protein (ClpB_D2-small) (656-730)

• AAA lid domain (AAA_lid_9) (300-397)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
clpE	Streptococcus mutans UA159	85.582	99.083	0.848
clpE	Streptococcus pneumoniae Rx1	84.19	99.476	0.837
clpE	Streptococcus pneumoniae D39	84.19	99.476	0.837
clpE	Streptococcus pneumoniae R6	84.19	99.476	0.837
clpE	Streptococcus pneumoniae TIGR4	84.058	99.476	0.836
clpC	Lactococcus lactis subsp. cremoris KW2	76.495	96.461	0.738
clpC	Bacillus subtilis subsp. subtilis str. 168	51.138	86.37	0.442
clpC	Lactococcus lactis subsp. lactis strain DGCC12653	46.462	85.19	0.396
clpC	Streptococcus pneumoniae TIGR4	48	81.913	0.393
clpC	Streptococcus pneumoniae Rx1	48	81.913	0.393
clpC	Streptococcus pneumoniae D39	48	81.913	0.393
clpC	Streptococcus mutans UA159	47.573	80.996	0.385
clpC	Streptococcus thermophilus LMD-9	46.635	81.782	0.381
clpC	Streptococcus thermophilus LMG 18311	46.314	81.782	0.379