Detailed information NTG0537528

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: I6K93_RS07190
• Genome accession: NZ_CP069951
• Coordinates: 1478151..1479197 (-)
• Length: 348 a.a.
• NCBI ID: WP_001830374.1
• Uniprot ID: A0A0N1EGU4
• Organism: Staphylococcus epidermidis strain FDAARGOS_1363
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 1473151..1484197

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
I6K93_RS07160 (I6K93_07165)	-	1473535..1474776 (-)	1242	WP_001832467.1	aminopeptidase	-
I6K93_RS07165 (I6K93_07170)	-	1474778..1474993 (-)	216	WP_010959205.1	DUF1128 domain-containing protein	-
I6K93_RS07170 (I6K93_07175)	-	1475134..1475598 (+)	465	WP_001830437.1	low molecular weight protein-tyrosine-phosphatase	-
I6K93_RS07175 (I6K93_07180)	-	1475606..1475890 (+)	285	WP_001830401.1	YtxH domain-containing protein	-
I6K93_RS07180 (I6K93_07185)	-	1476297..1477475 (+)	1179	WP_021298785.1	YihY/virulence factor BrkB family protein	-
I6K93_RS07185 (I6K93_07190)	vraR	1477532..1478161 (-)	630	WP_001830439.1	two-component system response regulator VraR	Regulator
I6K93_RS07190 (I6K93_07195)	vraS	1478151..1479197 (-)	1047	WP_001830374.1	sensor histidine kinase	Regulator
I6K93_RS07195 (I6K93_07200)	liaF	1479194..1479895 (-)	702	WP_002457093.1	cell wall-active antibiotics response protein LiaF	-
I6K93_RS07200 (I6K93_07205)	-	1479910..1480296 (-)	387	WP_001830382.1	hypothetical protein	-
I6K93_RS07205 (I6K93_07210)	map	1480454..1481209 (-)	756	WP_001830397.1	type I methionyl aminopeptidase	-
I6K93_RS07210 (I6K93_07215)	-	1481383..1482369 (+)	987	WP_002457091.1	aromatic acid exporter family protein	-
I6K93_RS07215 (I6K93_07220)	-	1482520..1483056 (-)	537	WP_001830372.1	hypothetical protein	-

Sequence

Protein

• Length: 348 a.a.
• Molecular weight: 40066.49 Da
• Isoelectric Point: 5.8512

>NTDB_id=537528 I6K93_RS07190 WP_001830374.1 1478151..1479197(-) (vraS) [Staphylococcus epidermidis strain FDAARGOS_1363]
MNHYIRAIGSMLILVYSMLIAFLFIDKVFVNIIFFQGMFYTQIFGIPVFLFLNLLIVLLCIIVGSVLAYKINQQNDWIIS
QIERSIEGQTVGINDQNIELYTETIDIYHTLVPLNQELHRLRMKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKESKLEPPLNQQIPILEKMVQDSQLEMRALLLHLRPIGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFEVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNQEDYLLLRIQDNGKGFNVDEKFEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEENSSGD

Nucleotide

• Length: 1047 bp

>NTDB_id=537528 I6K93_RS07190 WP_001830374.1 1478151..1479197(-) (vraS) [Staphylococcus epidermidis strain FDAARGOS_1363]
ATGAATCACTACATAAGAGCTATAGGCTCAATGCTTATATTAGTATATAGTATGCTTATTGCTTTTTTATTTATTGATAA
AGTGTTTGTAAATATTATCTTTTTTCAGGGGATGTTTTATACACAAATATTTGGAATACCTGTTTTTCTATTTTTAAATT
TATTAATTGTTCTTTTATGTATTATAGTTGGATCTGTTTTAGCTTATAAAATTAATCAACAAAATGATTGGATTATTTCA
CAAATAGAAAGATCAATAGAAGGACAAACAGTAGGTATCAATGATCAAAATATCGAATTATATACAGAAACGATAGATAT
TTATCATACACTAGTTCCATTAAATCAAGAATTACATCGACTTAGAATGAAGACTCAAAATTTAACTAATGAAAACTACA
ATATTAATGATGTAAAAGTCAAAAAGATTATCGAAGATGAGCGACAACGACTTGCCAGGGAATTACATGATTCTGTTAGT
CAACAATTATTTGCTGCGAGCATGATGCTATCGGCGATAAAAGAGTCGAAATTAGAACCACCTTTAAATCAACAGATACC
AATTCTTGAAAAAATGGTTCAAGACTCACAACTTGAAATGAGAGCTTTGTTATTACATTTAAGACCGATAGGTTTAAAAG
ATAAGTCTTTAGGTGAAGGAATTAAAGATTTAGTCATCGATTTACAAAAGAAAGTACCAATGAAAGTTGTGCATGAAATT
CAAGATTTTGAAGTGCCAAAAGGCATTGAAGATCACTTGTTCAGAATTACACAAGAAGCTATTTCAAATACATTGAGACA
TTCAAATGGTACAAAAGTAACTGTGGAATTATTTAATCAAGAGGATTATCTTTTACTAAGAATTCAAGATAATGGAAAAG
GGTTTAATGTAGATGAAAAATTTGAACAAAGTTATGGTTTGAAAAATATGCGAGAACGAGCGTTAGAAATTGGTGCGACG
TTTCATATTGTATCTTTACCTGATTCAGGTACACGAATTGAAGTTAAGGCACCATTGAATAAGGAGGAGAATTCAAGTGG
CGATTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0N1EGU4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	93.023	98.851	0.92