Detailed information NTG0535602

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: I6J75_RS07220
• Genome accession: NZ_CP069565
• Coordinates: 1449238..1450281 (+)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus strain FDAARGOS_1245
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 1444238..1455281

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
I6J75_RS07190 (I6J75_07190)	-	1444608..1444718 (+)	111	WP_001790257.1	hypothetical protein	-
I6J75_RS07195 (I6J75_07195)	-	1444747..1445160 (+)	414	WP_001549145.1	hypothetical protein	-
I6J75_RS07200 (I6J75_07200)	-	1445650..1446636 (-)	987	WP_000999713.1	aromatic acid exporter family protein	-
I6J75_RS07205 (I6J75_07205)	map	1447164..1447922 (+)	759	WP_000636142.1	type I methionyl aminopeptidase	-
I6J75_RS07210 (I6J75_07210)	-	1448139..1448525 (+)	387	WP_001110179.1	hypothetical protein	-
I6J75_RS07215 (I6J75_07215)	liaF	1448540..1449241 (+)	702	WP_000149064.1	cell wall-active antibiotics response protein LiaF	-
I6J75_RS07220 (I6J75_07220)	vraS	1449238..1450281 (+)	1044	WP_001017131.1	sensor histidine kinase	Regulator
I6J75_RS07225 (I6J75_07225)	vraR	1450271..1450900 (+)	630	WP_000153530.1	two-component system response regulator VraR	Regulator
I6J75_RS07230 (I6J75_07230)	-	1451016..1452233 (-)	1218	WP_000037075.1	YihY/virulence factor BrkB family protein	-
I6J75_RS07235 (I6J75_07235)	-	1452511..1452786 (-)	276	WP_000428172.1	YtxH domain-containing protein	-
I6J75_RS07240 (I6J75_07240)	-	1452793..1453257 (-)	465	WP_000228666.1	low molecular weight protein-tyrosine-phosphatase	-
I6J75_RS07245 (I6J75_07245)	-	1453404..1453604 (+)	201	WP_000180461.1	DUF1128 family protein	-
I6J75_RS07250 (I6J75_07250)	-	1453607..1454863 (+)	1257	WP_001795438.1	aminopeptidase	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=535602 I6J75_RS07220 WP_001017131.1 1449238..1450281(+) (vraS) [Staphylococcus aureus strain FDAARGOS_1245]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=535602 I6J75_RS07220 WP_001017131.1 1449238..1450281(+) (vraS) [Staphylococcus aureus strain FDAARGOS_1245]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTGTTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTTTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTACTCGCTTACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACACTCGTACCTTTAAATCAAGAATTGCATAAGTTGCGACTTAAAACTCAAAACTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTAGCACGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTATCTGCTATCAAAGAAACGAAGTTAGAACCACCATTAGACCAACAAATTCC
TATTTTAGAGAAAATGGTTCAAGATTCGCAGTTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCAATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGATAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1