Detailed information NTG0534891

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: I6J76_RS04485
• Genome accession: NZ_CP069470
• Coordinates: 869917..870960 (+)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus strain FDAARGOS_1246
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 864917..875960

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
I6J76_RS04455 (I6J76_04455)	-	865287..865397 (+)	111	WP_001790257.1	hypothetical protein	-
I6J76_RS04460 (I6J76_04460)	-	865426..865839 (+)	414	WP_001549145.1	hypothetical protein	-
I6J76_RS04465 (I6J76_04465)	-	866329..867315 (-)	987	WP_000999713.1	aromatic acid exporter family protein	-
I6J76_RS04470 (I6J76_04470)	map	867843..868601 (+)	759	WP_000636142.1	type I methionyl aminopeptidase	-
I6J76_RS04475 (I6J76_04475)	-	868818..869204 (+)	387	WP_001110179.1	hypothetical protein	-
I6J76_RS04480 (I6J76_04480)	liaF	869219..869920 (+)	702	WP_000149064.1	cell wall-active antibiotics response protein LiaF	-
I6J76_RS04485 (I6J76_04485)	vraS	869917..870960 (+)	1044	WP_001017131.1	sensor histidine kinase	Regulator
I6J76_RS04490 (I6J76_04490)	vraR	870950..871579 (+)	630	WP_000153530.1	two-component system response regulator VraR	Regulator
I6J76_RS04495 (I6J76_04495)	-	871695..872912 (-)	1218	WP_000037075.1	YihY/virulence factor BrkB family protein	-
I6J76_RS04500 (I6J76_04500)	-	873190..873465 (-)	276	WP_000428172.1	YtxH domain-containing protein	-
I6J76_RS04505 (I6J76_04505)	-	873472..873936 (-)	465	WP_000228666.1	low molecular weight protein-tyrosine-phosphatase	-
I6J76_RS04510 (I6J76_04510)	-	874083..874283 (+)	201	WP_000180461.1	DUF1128 family protein	-
I6J76_RS04515 (I6J76_04515)	-	874286..875542 (+)	1257	WP_001795438.1	aminopeptidase	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=534891 I6J76_RS04485 WP_001017131.1 869917..870960(+) (vraS) [Staphylococcus aureus strain FDAARGOS_1246]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=534891 I6J76_RS04485 WP_001017131.1 869917..870960(+) (vraS) [Staphylococcus aureus strain FDAARGOS_1246]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTGTTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTTTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTACTCGCTTACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACACTCGTACCTTTAAATCAAGAATTGCATAAGTTGCGACTTAAAACTCAAAACTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTAGCACGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTATCTGCTATCAAAGAAACGAAGTTAGAACCACCATTAGACCAACAAATTCC
TATTTTAGAGAAAATGGTTCAAGATTCGCAGTTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCAATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGATAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1