Detailed information NTG0053387

Bioinformatically predicted

Overview

• Name: comFC/cflB
• Type: Machinery gene
• Locus tag: HMPREF1038_RS10890
• Genome accession: NC_018630
• Coordinates: 2031664..2032326 (-)
• Length: 220 a.a.
• NCBI ID: WP_000649974.1
• Uniprot ID: A0A0F7YBW3
• Organism: Streptococcus pneumoniae gamPNI0373
• Function: ssDNA transport into the cell (predicted from homology) DNA binding and uptake

Genomic Context

Location: 2026664..2037326

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
HMPREF1038_RS10865 (HMPREF1038_02210)	-	2026814..2027080 (-)	267	WP_001278167.1	Veg family protein	-
HMPREF1038_RS10870 (HMPREF1038_02211)	dnaB	2027082..2028434 (-)	1353	WP_000852486.1	replicative DNA helicase	-
HMPREF1038_RS10875 (HMPREF1038_02212)	rplI	2028478..2028930 (-)	453	WP_000864220.1	50S ribosomal protein L9	-
HMPREF1038_RS10880 (HMPREF1038_02213)	-	2028927..2030900 (-)	1974	WP_000715109.1	DHH family phosphoesterase	-
HMPREF1038_RS10885 (HMPREF1038_02214)	hpf	2031036..2031584 (-)	549	WP_000599104.1	ribosome hibernation-promoting factor, HPF/YfiA family	-
HMPREF1038_RS10890 (HMPREF1038_02215)	comFC/cflB	2031664..2032326 (-)	663	WP_000649974.1	ComF family protein	Machinery gene
HMPREF1038_RS10895 (HMPREF1038_02216)	comFA/cflA	2032323..2033621 (-)	1299	WP_000867601.1	DEAD/DEAH box helicase	Machinery gene
HMPREF1038_RS10900 (HMPREF1038_02217)	-	2033677..2034312 (+)	636	WP_000395739.1	YigZ family protein	-
HMPREF1038_RS10905 (HMPREF1038_02218)	cysK	2034597..2035517 (+)	921	WP_000029860.1	cysteine synthase A	-
HMPREF1038_RS10910 (HMPREF1038_02219)	-	2035756..2036106 (-)	351	Protein_2046	IS66 family transposase	-
HMPREF1038_RS12595	-	2036106..2036377 (+)	272	Protein_2047	transposase	-
HMPREF1038_RS10920 (HMPREF1038_02221)	tnpB	2036568..2036855 (-)	288	WP_000973412.1	IS66 family insertion sequence element accessory protein TnpB	-

Sequence

Protein

• Length: 220 a.a.
• Molecular weight: 25169.03 Da
• Isoelectric Point: 7.7116

>NTDB_id=53387 HMPREF1038_RS10890 WP_000649974.1 2031664..2032326(-) (comFC/cflB) [Streptococcus pneumoniae gamPNI0373]
MKCLLCGQTMKTVLTFSSLLLLRNDDSCLCSDCDSTFERIGEENCPNCMKTELSTKCQDCQLWCKEGVGVSHRAIFTYNQ
AMKDFFSRYKFDGDFLLRKVFASFLSEELKKYKEYQFVVIPLSPDRYANRGFNQVEGLVEAAGFEYLDLLEKREERASSS
KNRSERLGTELPFFIKSGVTIPKKILLIDDIYTTGATINRVKKLLEEAGAKDVKTFSLVR

Nucleotide

• Length: 663 bp

>NTDB_id=53387 HMPREF1038_RS10890 WP_000649974.1 2031664..2032326(-) (comFC/cflB) [Streptococcus pneumoniae gamPNI0373]
ATGAAGTGCTTGTTATGTGGGCAGACTATGAAGACTGTTTTAACTTTTAGTAGTCTCTTACTTCTGAGGAATGATGACTC
TTGTCTTTGTTCAGACTGTGATTCTACTTTTGAAAGAATTGGGGAAGAGAACTGTCCAAATTGTATGAAAACAGAGTTGT
CAACAAAGTGTCAAGATTGTCAACTTTGGTGTAAAGAAGGAGTTGGAGTCAGTCATAGAGCGATTTTTACTTACAATCAA
GCTATGAAGGATTTTTTCAGTCGGTATAAGTTTGATGGAGACTTCCTGTTAAGAAAAGTTTTCGCTTCATTTTTAAGTGA
GGAGTTGAAAAAGTACAAAGAGTATCAATTTGTTGTAATTCCCCTAAGTCCTGATAGATATGCTAATAGAGGATTTAATC
AGGTTGAGGGCTTGGTAGAGGCAGCAGGCTTTGAGTATCTAGATTTATTAGAGAAAAGAGAAGAGAGAGCCAGTTCTTCT
AAAAATCGTTCAGAGCGCTTGGGGACAGAACTTCCTTTCTTTATTAAAAGTGGAGTCACTATTCCTAAAAAAATCCTACT
TATAGATGATATCTATACTACAGGAGCAACTATAAATCGTGTTAAGAAACTGTTGGAAGAAGCCGGTGCTAAGGATGTAA
AAACATTTTCCCTTGTAAGATGA

Domains

Predicted by InterproScan.

• Phosphoribosyl transferase domain (Pribosyltran) (153-219)

3D structure

• AlphaFold DB: A0A0F7YBW3

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comFC/cflB	Streptococcus pneumoniae Rx1	100	100	1
comFC/cflB	Streptococcus pneumoniae D39	100	100	1
comFC/cflB	Streptococcus pneumoniae R6	100	100	1
comFC/cflB	Streptococcus pneumoniae TIGR4	99.545	100	0.995
comFC/cflB	Streptococcus mitis NCTC 12261	91.364	100	0.914
comFC/cflB	Streptococcus mitis SK321	90.909	100	0.909