Detailed information    

insolico Bioinformatically predicted

Overview

Name   ciaR   Type   Regulator
Locus tag   HMPREF1038_RS03980 Genome accession   NC_018630
Coordinates   741521..742195 (+) Length   224 a.a.
NCBI ID   WP_000590640.1    Uniprot ID   D4I4V1
Organism   Streptococcus pneumoniae gamPNI0373     
Function   repress competence development; post-transcriptional repression of CSP production (predicted from homology)   
Competence regulation

Genomic Context

Location: 736521..747195
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  HMPREF1038_RS03960 (HMPREF1038_00804) - 736981..737481 (+) 501 WP_000403345.1 NUDIX hydrolase -
  HMPREF1038_RS03965 (HMPREF1038_00805) - 737459..738328 (+) 870 WP_001245818.1 putative PEP-binding protein -
  HMPREF1038_RS03970 (HMPREF1038_00806) - 738303..738743 (+) 441 WP_001820631.1 ASCH domain-containing protein -
  HMPREF1038_RS03975 (HMPREF1038_00807) - 738866..741412 (+) 2547 WP_001149118.1 M1 family metallopeptidase -
  HMPREF1038_RS03980 (HMPREF1038_00808) ciaR 741521..742195 (+) 675 WP_000590640.1 two-component system response regulator CiaR Regulator
  HMPREF1038_RS03985 (HMPREF1038_00809) ciaH 742185..743519 (+) 1335 WP_000491790.1 two-component system sensor histidine kinase CiaH Regulator
  HMPREF1038_RS03990 (HMPREF1038_00811) - 743553..743840 (-) 288 WP_001145225.1 DUF3270 domain-containing protein -
  HMPREF1038_RS03995 (HMPREF1038_00810) - 743980..744909 (+) 930 WP_000411857.1 peptidase U32 family protein -

Sequence

Protein


Download         Length: 224 a.a.        Molecular weight: 25466.29 Da        Isoelectric Point: 4.3283

>NTDB_id=53337 HMPREF1038_RS03980 WP_000590640.1 741521..742195(+) (ciaR) [Streptococcus pneumoniae gamPNI0373]
MIKILLVEDDLGLSNSVFDFLDDFADVMQVFDGEEGLYEAESGVYDLILLDLMLPEKNGFQVLKELREKGITTPVLIMTA
KESLDDKGHGFELGADDYLTKPFYLEELKMRIQALLKRSGKFNENTLTYGNIVVNLSTNTVKVEDTPVELLGKEFDLLVY
FLQNQNVILPKTQIFDRLWGFDSDTTISVVEVYVSKVRKKLKGTTFAENLQTLRSVGYLLKDVQ

Nucleotide


Download         Length: 675 bp        

>NTDB_id=53337 HMPREF1038_RS03980 WP_000590640.1 741521..742195(+) (ciaR) [Streptococcus pneumoniae gamPNI0373]
ATGATAAAAATCTTATTGGTTGAGGATGACCTAGGTCTGTCAAATTCAGTATTTGACTTTTTAGACGATTTTGCGGATGT
TATGCAGGTATTTGATGGAGAAGAAGGTCTCTACGAAGCTGAGAGTGGTGTCTATGATTTGATTTTGCTGGATTTGATGT
TGCCAGAAAAAAATGGTTTCCAAGTCTTAAAAGAATTGCGTGAAAAGGGAATTACGACACCAGTTCTGATTATGACTGCC
AAGGAAAGTTTGGATGACAAGGGACATGGATTTGAACTGGGAGCGGATGATTATCTGACCAAACCTTTCTACCTAGAAGA
ACTTAAAATGCGGATTCAGGCCCTTCTCAAACGTTCAGGGAAGTTTAATGAAAACACCTTGACTTATGGGAATATCGTGG
TTAATTTATCAACCAATACCGTTAAAGTTGAAGATACTCCTGTCGAATTGCTGGGGAAAGAGTTCGATTTACTAGTTTAT
TTCCTTCAAAATCAAAATGTGATTTTGCCTAAGACGCAGATTTTTGACCGTCTATGGGGATTTGATAGTGATACAACGAT
TTCGGTTGTCGAAGTCTATGTTTCAAAAGTCCGTAAGAAATTAAAGGGAACCACTTTTGCAGAGAATTTGCAAACCTTGC
GTAGTGTTGGGTATCTTTTAAAAGATGTTCAGTAA

Domains

Predicted by InterproScan.

Transcriptional regulatory protein, C terminal (Trans_reg_C)

(146-220)

Response regulator receiver domain (Response_reg)

(4-112)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB D4I4V1

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  ciaR Streptococcus pneumoniae Rx1

100

100

1
  ciaR Streptococcus pneumoniae D39

100

100

1
  ciaR Streptococcus pneumoniae R6

100

100

1
  ciaR Streptococcus pneumoniae TIGR4

100

100

1
  ciaR Streptococcus mutans UA159

88.393

100

0.884
  covR Lactococcus lactis subsp. lactis strain DGCC12653

36.726

100

0.371
  vicR Streptococcus mutans UA159

35.622

100

0.371

Multiple sequence alignment