Detailed information    

insolico Bioinformatically predicted

Overview

Name   clpE   Type   Regulator
Locus tag   LA346_RS08670 Genome accession   NZ_CP083627
Coordinates   1666154..1668412 (-) Length   752 a.a.
NCBI ID   WP_000882520.1    Uniprot ID   -
Organism   Streptococcus pneumoniae strain FDAARGOS_1508     
Function   degradation of ComX (predicted from homology)   
Competence regulation

Genomic Context

Location: 1661154..1673412
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  LA346_RS08640 (LA346_08640) - 1662056..1662280 (+) 225 Protein_1682 hypothetical protein -
  LA346_RS08645 (LA346_08645) - 1662416..1663294 (+) 879 Protein_1683 IS630 family transposase -
  LA346_RS08650 (LA346_08650) tnpB 1663518..1663754 (-) 237 WP_000973006.1 IS66 family insertion sequence element accessory protein TnpB -
  LA346_RS08655 (LA346_08655) - 1664015..1664314 (-) 300 WP_000767195.1 DUF1827 family protein -
  LA346_RS08660 (LA346_08660) - 1664479..1664915 (-) 437 Protein_1686 NUDIX hydrolase -
  LA346_RS08665 (LA346_08665) - 1664997..1665947 (+) 951 Protein_1687 IS630 transposase-related protein -
  LA346_RS08670 (LA346_08670) clpE 1666154..1668412 (-) 2259 WP_000882520.1 ATP-dependent Clp protease ATP-binding subunit Regulator
  LA346_RS08675 (LA346_08675) - 1668641..1668871 (-) 231 WP_000443573.1 YkuJ family protein -
  LA346_RS08680 (LA346_08680) - 1669061..1669744 (+) 684 WP_001011635.1 amino acid ABC transporter permease -
  LA346_RS08685 (LA346_08685) - 1669744..1670478 (+) 735 WP_000140941.1 amino acid ABC transporter ATP-binding protein -
  LA346_RS08690 (LA346_08690) - 1670632..1671489 (+) 858 WP_000192110.1 bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase -
  LA346_RS08695 (LA346_08695) - 1671631..1672503 (+) 873 WP_000864690.1 NAD(P)H-hydrate dehydratase -

Sequence

Protein


Download         Length: 752 a.a.        Molecular weight: 83854.34 Da        Isoelectric Point: 5.4541

>NTDB_id=532966 LA346_RS08670 WP_000882520.1 1666154..1668412(-) (clpE) [Streptococcus pneumoniae strain FDAARGOS_1508]
MLCQNCKINDSTIHLYTNLNGKQKQIDLCQNCYKIIKTDPNNSLFKGMTDLNNRDFDPFGDFFNDLNNFRPSSNTPPIPP
TQSGGGYGGNGGYGSQNRGSAQTPPPSQEKGLLEEFGINVTEIARRGDIDPVIGRDDEIIRVIEILNRRTKNNPVLIGEP
GVGKTAVVEGLAQKIVDGDVPHKLQGKQVIRLDVVSLVQGTGIRGQFEERMQKLMEEIRKREDIILFIDEIHEIVGAGSA
SDGNMDAGNILKPALARGELQLVGATTLNEYRIIEKDAALERRMQPVKVDEPTVDETITILKGIQKKYEDYHHVQYTDAA
IEAAATLSNRYIQDRFLPDKAIDLLDEAGSKMNLTLNFVDPKVIDQRLIEAENLKSQATREEDFEKAAYFRDQIAKYKEM
QKKKITDQDTPIISEKTIEHIIEQKTNIPVGDLKEKEQSQLIHLAEDLKSHVIGQDDAVDKIAKAIRRNRVGLGTPNRPI
GSFLFVGPTGVGKTELSKQLAIELFGSADSMIRFDMSEYMEKHSVAKLVGAPPGYVGYDEAGQLTEKVRHNPYSLILLDE
VEKAHPDVMHMFLQVLDDGRLTDGQGRTVSFKDAIIIMTSNAGTGKTEASVGFGAAREGRTNSVLGELGNFFSPEFMNRF
DGIIEFKALSKDNLLQIVELMLADVNKRLSSNNIRLDVTDKVKEKLVDLGYDPKMGARPLRRTIQDYIEDTITDYYLENP
SEKVLKAVMTSKGNIQIKSAKKTEVKSSEKEK

Nucleotide


Download         Length: 2259 bp        

>NTDB_id=532966 LA346_RS08670 WP_000882520.1 1666154..1668412(-) (clpE) [Streptococcus pneumoniae strain FDAARGOS_1508]
ATGCTTTGTCAAAACTGTAAAATTAACGACTCAACAATTCATCTTTACACCAATCTCAATGGAAAACAAAAACAAATTGA
CCTCTGTCAAAACTGCTATAAGATTATCAAAACAGATCCTAACAATAGCCTCTTCAAAGGTATGACGGATCTGAACAATC
GTGACTTCGATCCCTTTGGTGATTTCTTCAATGATCTAAACAATTTCAGACCTTCTAGCAATACTCCTCCTATTCCCCCA
ACCCAATCAGGTGGAGGTTACGGTGGAAACGGCGGTTATGGTTCCCAAAATCGTGGATCTGCTCAAACTCCGCCACCTAG
CCAAGAAAAAGGCCTGCTGGAAGAATTTGGTATTAATGTAACTGAAATTGCCCGTCGTGGAGACATTGACCCCGTTATTG
GGCGCGACGATGAGATTATCCGTGTCATCGAGATTCTCAATCGTAGAACCAAGAATAATCCTGTCCTTATCGGTGAACCT
GGTGTCGGAAAAACGGCCGTTGTCGAAGGTCTAGCTCAGAAAATTGTCGATGGCGATGTGCCACATAAACTCCAAGGTAA
ACAAGTCATCCGTCTGGATGTGGTTAGCTTAGTTCAAGGAACGGGGATTCGAGGACAATTTGAAGAACGCATGCAAAAAC
TCATGGAAGAAATTCGCAAACGTGAAGACATCATCCTCTTTATCGATGAAATCCATGAAATTGTTGGTGCTGGTTCTGCG
AGTGATGGTAATATGGACGCAGGAAATATCCTCAAGCCAGCCCTTGCTCGTGGAGAACTGCAACTAGTCGGTGCTACTAC
CCTCAATGAATACCGTATCATTGAAAAGGATGCTGCCCTCGAGCGTCGTATGCAGCCTGTTAAAGTCGATGAACCAACGG
TGGACGAAACAATCACTATTCTCAAAGGGATTCAAAAGAAATACGAAGATTACCACCACGTTCAATATACAGATGCTGCG
ATTGAAGCAGCTGCAACTCTTTCCAATCGCTACATCCAAGATCGCTTCTTGCCTGACAAGGCCATTGACCTCCTAGATGA
AGCTGGTTCTAAGATGAACTTGACCTTGAATTTTGTGGATCCTAAAGTAATTGATCAGCGCTTGATTGAGGCTGAAAATC
TCAAGTCTCAAGCTACACGAGAAGAAGATTTTGAGAAGGCGGCCTACTTCCGCGACCAGATTGCCAAGTATAAGGAAATG
CAAAAGAAAAAGATCACAGACCAGGATACTCCTATCATCAGCGAGAAAACTATTGAGCACATTATCGAGCAGAAAACCAA
TATCCCTGTTGGTGATTTGAAAGAGAAAGAACAATCTCAACTCATCCATCTAGCCGAAGATCTCAAGTCTCATGTTATTG
GTCAAGATGATGCAGTCGATAAGATTGCCAAGGCTATTCGCCGTAATCGTGTCGGACTTGGTACCCCTAACCGCCCAATC
GGAAGCTTCCTCTTCGTTGGGCCAACTGGTGTCGGTAAGACAGAACTTTCCAAACAACTGGCTATCGAACTTTTTGGTTC
TGCTGATAGTATGATTCGCTTTGATATGAGTGAATACATGGAAAAACATAGTGTGGCTAAGTTGGTCGGCGCTCCTCCAG
GTTATGTTGGCTATGATGAGGCTGGTCAATTAACTGAAAAAGTTCGCCACAATCCATATTCTCTCATCCTTCTCGATGAA
GTGGAAAAAGCTCACCCAGATGTTATGCACATGTTTCTTCAAGTCTTGGACGATGGTCGTTTGACAGACGGGCAAGGACG
CACCGTTAGCTTCAAGGATGCCATCATTATCATGACCTCAAATGCAGGTACAGGAAAGACCGAAGCTAGCGTTGGATTTG
GTGCTGCTAGAGAAGGACGTACCAATTCTGTCCTCGGTGAACTCGGTAACTTCTTTAGCCCAGAGTTTATGAACCGTTTT
GATGGCATTATCGAATTTAAGGCTCTCAGCAAGGATAACCTCCTTCAGATTGTCGAGCTCATGCTAGCAGATGTTAACAA
GCGCCTCTCTAGCAACAACATTCGTTTGGATGTAACTGACAAGGTCAAGGAAAAGTTGGTTGACCTAGGTTATGATCCAA
AAATGGGAGCACGCCCACTTCGTCGAACTATTCAAGACTATATTGAGGACACAATCACTGACTACTACCTTGAAAATCCA
AGCGAAAAAGTTCTCAAAGCAGTTATGACTAGCAAGGGAAACATTCAGATTAAATCTGCCAAAAAAACTGAAGTTAAAAG
TTCTGAAAAAGAAAAATAA

Domains

Predicted by InterProScan.

C-terminal, D2-small domain, of ClpB protein (ClpB_D2-small)

(649-723)

AAA lid domain (AAA_lid_9)

(293-390)

ATPase family associated with various cellular activities (AAA) (AAA)

(155-276)

AAA domain (Cdc48 subfamily) (AAA_2)

(478-641)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  clpE Streptococcus pneumoniae Rx1

99.734

100

0.997
  clpE Streptococcus pneumoniae D39

99.734

100

0.997
  clpE Streptococcus pneumoniae R6

99.734

100

0.997
  clpE Streptococcus pneumoniae TIGR4

99.601

100

0.996
  clpE Streptococcus mutans UA159

82.731

99.335

0.822
  clpC Lactococcus lactis subsp. cremoris KW2

76.839

97.606

0.75
  clpC Bacillus subtilis subsp. subtilis str. 168

51.108

90.027

0.46
  clpC Lactococcus lactis subsp. lactis strain DGCC12653

47.687

83.378

0.398
  clpC Streptococcus pneumoniae Rx1

46.91

83.91

0.394
  clpC Streptococcus pneumoniae D39

46.91

83.91

0.394
  clpC Streptococcus pneumoniae TIGR4

46.91

83.91

0.394
  clpC Streptococcus thermophilus LMD-9

46.795

82.979

0.388
  clpC Streptococcus mutans UA159

46.571

83.378

0.388
  clpC Streptococcus thermophilus LMG 18311

46.4

83.112

0.386