Detailed information NTG0053223

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: C248_RS09800
• Genome accession: NC_018608
• Coordinates: 1975865..1976908 (-)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus 08BA02176
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 1970865..1981908

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
C248_RS09770 (C248_1951)	-	1971286..1972542 (-)	1257	WP_074347694.1	aminopeptidase	-
C248_RS09775 (C248_1952)	-	1972545..1972745 (-)	201	WP_000180460.1	DUF1128 family protein	-
C248_RS09780 (C248_1953)	-	1972892..1973356 (+)	465	WP_000228666.1	low molecular weight protein-tyrosine-phosphatase	-
C248_RS09785 (C248_1954)	-	1973363..1973638 (+)	276	WP_000428172.1	YtxH domain-containing protein	-
C248_RS09790 (C248_1955)	-	1973916..1975133 (+)	1218	WP_000037081.1	YihY/virulence factor BrkB family protein	-
C248_RS09795 (C248_1956)	vraR	1975246..1975875 (-)	630	WP_000153535.1	two-component system response regulator VraR	Regulator
C248_RS09800 (C248_1957)	vraS	1975865..1976908 (-)	1044	WP_001017131.1	sensor histidine kinase	Regulator
C248_RS09805 (C248_1958)	liaF	1976905..1977606 (-)	702	WP_000149064.1	cell wall-active antibiotics response protein LiaF	-
C248_RS09810 (C248_1959)	-	1977621..1978007 (-)	387	WP_001110182.1	hypothetical protein	-
C248_RS09815 (C248_1960)	map	1978224..1978983 (-)	760	Protein_1872	type I methionyl aminopeptidase	-
C248_RS09830 (C248_1961)	-	1979567..1980553 (+)	987	WP_000999712.1	aromatic acid exporter family protein	-
C248_RS09835 (C248_1962)	-	1980742..1981155 (-)	414	WP_078064776.1	hypothetical protein	-
C248_RS09840 (C248_1963)	-	1981184..1981294 (-)	111	WP_014937049.1	hypothetical protein	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=53223 C248_RS09800 WP_001017131.1 1975865..1976908(-) (vraS) [Staphylococcus aureus 08BA02176]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=53223 C248_RS09800 WP_001017131.1 1975865..1976908(-) (vraS) [Staphylococcus aureus 08BA02176]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTGTTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTCTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTTCTCGCTTACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACACTCGTACCTTTAAATCAAGAATTGCATAAATTGCGACTTAAAACTCAAAACTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTAGCACGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTATCTGCTATCAAAGAAACGAAATTAGAACCACCATTAGACCAACAAATTCC
GATTTTAGAGAAAATGGTTCAAGATTCGCAGCTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCAATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGACAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1