Detailed information NTG0530460

Bioinformatically predicted

Overview

• Name: clpC
• Type: Regulator
• Locus tag: LLUC073_RS02765
• Genome accession: NZ_CP068698
• Coordinates: 518349..520799 (+)
• Length: 816 a.a.
• NCBI ID: WP_011675609.1
• Uniprot ID: -
• Organism: Lactococcus cremoris strain UC073
• Function: degradation of ComX (predicted from homology) Competence regulation

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type	MGE coordinates	Gene coordinates	Relative position	Distance (bp)
Prophage	503026..536397	518349..520799	within	0
IScluster/Tn	515078..517673	518349..520799	flank	676

Gene organization within MGE regions

Location: 503026..536397

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
LLUC073_RS02680 (LLUC073_02625)	-	503026..503694 (+)	669	WP_011675767.1	hypothetical protein	-
LLUC073_RS02685 (LLUC073_02630)	-	503859..504761 (+)	903	WP_011675768.1	SPFH domain-containing protein	-
LLUC073_RS02695 (LLUC073_13710)	-	505010..505453 (-)	444	WP_282670832.1	hypothetical protein	-
LLUC073_RS02700 (LLUC073_13715)	-	505540..505707 (-)	168	WP_282670833.1	hypothetical protein	-
LLUC073_RS02705 (LLUC073_02645)	-	506134..506481 (-)	348	WP_011675770.1	XRE family transcriptional regulator	-
LLUC073_RS02715 (LLUC073_02655)	rnz	507246..508169 (+)	924	WP_015082147.1	ribonuclease Z	-
LLUC073_RS02720 (LLUC073_02660)	-	508162..508863 (+)	702	WP_282670834.1	SDR family oxidoreductase	-
LLUC073_RS02725 (LLUC073_02665)	recJ	509036..511264 (+)	2229	WP_282670835.1	single-stranded-DNA-specific exonuclease RecJ	-
LLUC073_RS02730 (LLUC073_02670)	-	511388..511900 (+)	513	WP_011834623.1	adenine phosphoribosyltransferase	-
LLUC073_RS02735 (LLUC073_02675)	rpoE	512116..512679 (+)	564	WP_021211601.1	DNA-directed RNA polymerase subunit delta	-
LLUC073_RS02740 (LLUC073_02680)	mltG	512815..514455 (+)	1641	WP_021216101.1	endolytic transglycosylase MltG	-
LLUC073_RS02745 (LLUC073_02685)	greA	514516..514986 (+)	471	WP_014573028.1	transcription elongation factor GreA	-
LLUC073_RS02750 (LLUC073_02690)	-	515078..516452 (+)	1375	Protein_513	IS3-like element ISLla3 family transposase	-
LLUC073_RS02755 (LLUC073_02695)	-	516526..517673 (+)	1148	WP_205536541.1	IS3 family transposase	-
LLUC073_RS02760 (LLUC073_02700)	-	517904..518359 (+)	456	WP_011834627.1	CtsR family transcriptional regulator	-
LLUC073_RS02765 (LLUC073_02705)	clpC	518349..520799 (+)	2451	WP_011675609.1	ATP-dependent Clp protease ATP-binding subunit	Regulator
LLUC073_RS02770 (LLUC073_02710)	hpf	520934..521491 (+)	558	WP_011834629.1	ribosome hibernation-promoting factor, HPF/YfiA family	-
LLUC073_RS02775 (LLUC073_02715)	eno	521679..522980 (+)	1302	WP_282671398.1	surface-displayed alpha-enolase	-
LLUC073_RS02780 (LLUC073_02720)	-	523068..524003 (+)	936	WP_011675611.1	tyrosine-type recombinase/integrase	-
LLUC073_RS02785 (LLUC073_02725)	-	524130..524924 (+)	795	WP_197430804.1	hypothetical protein	-
LLUC073_RS02790 (LLUC073_02730)	-	525902..526081 (+)	180	WP_282671397.1	hypothetical protein	-
LLUC073_RS02805 (LLUC073_02745)	-	528623..529912 (+)	1290	WP_282671603.1	hypothetical protein	-
LLUC073_RS02815 (LLUC073_02755)	-	531637..532812 (-)	1176	WP_332373902.1	IS256-like element IS905 family transposase	-
LLUC073_RS02820 (LLUC073_02760)	-	532874..533581 (+)	708	WP_318299108.1	hypothetical protein	-
LLUC073_RS02825 (LLUC073_02765)	-	534070..534741 (-)	672	WP_014573010.1	ABC transporter ATP-binding protein	-
LLUC073_RS02830 (LLUC073_02770)	-	534743..535816 (-)	1074	WP_282671075.1	ABC transporter permease	-
LLUC073_RS02835 (LLUC073_02775)	-	535828..536397 (-)	570	WP_014573008.1	TetR/AcrR family transcriptional regulator	-

Sequence

Protein

• Length: 816 a.a.
• Molecular weight: 90298.65 Da
• Isoelectric Point: 6.5301

>NTDB_id=530460 LLUC073_RS02765 WP_011675609.1 518349..520799(+) (clpC) [Lactococcus cremoris strain UC073]
MKFENVKYTPTLDRIFEKAAEDAHQYQYGTIESAHLLAAMATTSGSIAYSILAGMNVDSSDLLIDLEDLSSHVKVKRSEL
RFSPRAEEVVTVASFLAVHNNAEAVGTEHLLYALLQVEDGFGIQLLKLQKINIVSLRKEIEKRTGLKVPENKKAVTPMSK
RKMAKGVAENSSTPTLDSVSSDLTEAARSGKLDPMIGREAEVDRLIHILSRRTKNNPVLVGEPGVGKSAIIEGLAQRIVN
GQVPIGLMNSRIMALNMATVVAGTKFRGEFEDRLTAIVEEVSADPDVIIFIDELHTIIGAGGGMDSVNDAANILKPALAR
GDFQMVGATTYHEYQKYIEKDEALERRLARINVDEPSPDEAIAILQGLREKFEDYHQVKFTDQAIKSAVTLSVRYMTSRK
LPDKAIDLLDEAAAAVKISVKNQETKRLELEKDLVKAQEELAEAVIKLDVKASRIKEKAVEKISDKIYKFSIKEEKRQEV
TDQAVIAVASTLTGVPITQMTKSESDRLINLEKELHKRVVGQEEAISAVSRAIRRARSGVADSRRPMGSFMFLGPTGVGK
TELAKALADSVFGSEDNMIRVDMSEFMEKHSTSRLIGAPPGYVGYDEGGQLTERVRNKPYSVVLLDEVEKAHPDVFNIML
QILDDGFVTDTKGRKVDFRNTIIIMTSNLGATALRDDKTVGFGAKNITADYSAMQSRILEELKRHYRPEFLNRIDENIVF
HSLESQEIEQIVKIMSKSLIKRLAEQDIHVKLTPSAIKLIAEVGFDPEYGARPLRKALQKEVEDLLSEQLLSGEIKAGNH
ISIGASNKKIKIAQIV

Nucleotide

• Length: 2451 bp

>NTDB_id=530460 LLUC073_RS02765 WP_011675609.1 518349..520799(+) (clpC) [Lactococcus cremoris strain UC073]
ATGAAATTTGAAAATGTAAAATATACACCAACACTGGACCGAATTTTCGAGAAAGCAGCAGAAGATGCCCACCAATATCA
ATACGGTACGATTGAAAGTGCTCATTTATTGGCAGCAATGGCTACTACTTCAGGCTCAATTGCTTACAGTATTCTTGCTG
GAATGAATGTTGATTCTTCAGACTTACTGATTGATTTGGAAGATTTATCTAGCCATGTCAAAGTGAAACGTTCTGAATTA
CGTTTCTCTCCTCGCGCAGAAGAAGTGGTCACTGTAGCTAGCTTTTTAGCTGTTCATAATAATGCAGAAGCAGTAGGAAC
GGAGCATTTGCTTTATGCATTACTTCAAGTCGAAGATGGTTTTGGTATTCAACTTTTGAAGTTACAAAAAATCAATATTG
TTTCTTTGCGAAAAGAAATTGAAAAAAGAACAGGACTTAAAGTTCCAGAAAACAAAAAAGCTGTAACACCAATGTCCAAA
CGTAAGATGGCAAAAGGGGTAGCAGAGAATTCAAGTACACCAACTTTGGATTCAGTTTCTTCAGATTTAACTGAAGCTGC
TCGTTCAGGAAAGCTTGACCCAATGATTGGTCGGGAAGCAGAAGTTGACCGTTTGATTCATATTCTTAGTCGTAGAACAA
AAAATAACCCTGTTTTAGTTGGCGAACCTGGTGTTGGTAAATCAGCAATAATCGAGGGATTGGCTCAAAGAATTGTCAAC
GGCCAAGTACCTATCGGTTTGATGAATAGCCGGATTATGGCCCTAAATATGGCAACTGTTGTTGCTGGTACAAAATTTAG
AGGTGAATTTGAAGACCGCTTGACAGCAATTGTTGAAGAAGTAAGTGCTGACCCAGATGTCATCATTTTCATTGATGAAT
TGCATACAATTATTGGTGCTGGCGGGGGCATGGACTCGGTCAATGATGCAGCAAATATTTTAAAACCAGCCCTTGCACGT
GGTGATTTTCAAATGGTTGGGGCAACGACTTATCACGAATACCAAAAATACATTGAAAAAGATGAAGCATTAGAACGTCG
TTTGGCAAGAATCAATGTTGATGAGCCAAGTCCAGATGAAGCCATTGCTATCCTACAAGGGTTACGTGAGAAATTTGAAG
ATTATCATCAAGTAAAATTTACTGACCAAGCGATTAAAAGCGCTGTGACACTTAGTGTTCGGTACATGACCAGTCGCAAA
TTGCCTGATAAAGCCATCGACTTGCTTGATGAAGCAGCGGCAGCAGTTAAAATTTCTGTTAAAAACCAAGAAACAAAACG
TCTTGAATTAGAGAAAGACTTAGTTAAAGCTCAAGAAGAACTAGCGGAAGCTGTCATTAAACTTGATGTTAAAGCCTCTC
GCATCAAAGAAAAAGCTGTTGAAAAAATTTCTGACAAGATTTATAAATTCTCAATAAAAGAGGAAAAACGTCAAGAAGTT
ACTGACCAAGCTGTTATTGCTGTTGCCTCAACGCTGACAGGTGTTCCAATTACTCAAATGACTAAATCTGAAAGCGACCG
TTTGATTAATCTTGAAAAAGAATTGCACAAACGGGTCGTTGGTCAAGAAGAAGCAATTTCTGCGGTTTCAAGAGCCATTC
GTCGGGCACGTTCTGGTGTGGCTGATAGTCGCCGTCCAATGGGTTCATTTATGTTTCTTGGACCAACTGGTGTTGGGAAA
ACTGAGTTAGCTAAGGCCTTGGCCGATAGTGTTTTTGGTAGCGAAGACAACATGATTCGAGTGGATATGAGTGAATTTAT
GGAAAAACATTCAACTTCACGATTGATTGGAGCACCTCCAGGATATGTTGGTTATGATGAAGGTGGTCAATTGACTGAAC
GTGTTCGTAATAAACCCTATTCTGTGGTTCTTTTAGATGAAGTTGAGAAAGCTCATCCTGACGTTTTCAATATCATGTTG
CAAATTCTAGATGATGGATTTGTGACAGATACAAAGGGTCGCAAAGTTGATTTTAGAAACACAATTATTATCATGACTTC
AAACTTGGGTGCAACGGCTCTTCGTGATGATAAAACAGTTGGTTTTGGTGCAAAAAATATCACGGCTGACTACTCAGCTA
TGCAATCAAGAATTTTGGAAGAACTTAAACGTCATTATCGTCCAGAGTTTCTCAATCGTATTGATGAAAACATTGTTTTC
CATTCATTGGAAAGTCAAGAAATTGAACAAATTGTTAAGATTATGAGCAAATCTTTGATTAAACGTTTGGCGGAACAAGA
TATTCATGTGAAACTTACGCCATCAGCAATAAAACTAATCGCTGAAGTAGGATTTGACCCAGAATATGGGGCACGTCCAT
TGCGTAAAGCACTCCAAAAAGAAGTTGAAGATCTTTTAAGTGAGCAATTGCTCTCGGGTGAGATTAAAGCAGGAAATCAT
ATTTCCATTGGTGCTTCTAATAAAAAAATTAAAATCGCTCAAATTGTTTGA

Domains

Predicted by InterproScan.

• C-terminal, D2-small domain, of ClpB protein (ClpB_D2-small) (723-802)

• Clp amino terminal domain, pathogenicity island component (Clp_N) (96-144)

• Clp amino terminal domain, pathogenicity island component (Clp_N) (23-69)

• ATPase family associated with various cellular activities (AAA) (AAA) (218-334)

• AAA domain (Cdc48 subfamily) (AAA_2) (545-716)

• AAA lid domain (AAA_lid_9) (357-449)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
clpC	Lactococcus lactis subsp. lactis strain DGCC12653	95.833	100	0.958
clpC	Streptococcus thermophilus LMD-9	51.023	100	0.52
clpC	Streptococcus thermophilus LMG 18311	50.903	100	0.518
clpC	Streptococcus pneumoniae Rx1	49.517	100	0.502
clpC	Streptococcus pneumoniae D39	49.517	100	0.502
clpC	Streptococcus pneumoniae TIGR4	49.396	100	0.501
clpC	Streptococcus mutans UA159	48.918	100	0.499
clpC	Bacillus subtilis subsp. subtilis str. 168	50.249	98.284	0.494
clpE	Streptococcus mutans UA159	46.923	79.657	0.374
clpC	Lactococcus lactis subsp. cremoris KW2	46.626	79.902	0.373
clpE	Streptococcus pneumoniae TIGR4	47.049	76.838	0.362
clpE	Streptococcus pneumoniae Rx1	47.049	76.838	0.362
clpE	Streptococcus pneumoniae D39	47.049	76.838	0.362
clpE	Streptococcus pneumoniae R6	47.049	76.838	0.362