Detailed information NTG0527437

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: I6I40_RS06040
• Genome accession: NZ_CP068136
• Coordinates: 1291424..1292470 (+)
• Length: 348 a.a.
• NCBI ID: WP_001830374.1
• Uniprot ID: A0A0N1EGU4
• Organism: Staphylococcus epidermidis strain FDAARGOS_1083
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 1286424..1297470

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
I6I40_RS06015 (I6I40_06015)	isaB	1287565..1288101 (+)	537	WP_002470337.1	immunodominant staphylococcal antigen IsaB family protein	-
I6I40_RS06020 (I6I40_06020)	-	1288252..1289238 (-)	987	WP_001830388.1	FUSC family protein	-
I6I40_RS06025 (I6I40_06025)	map	1289412..1290167 (+)	756	WP_002457092.1	type I methionyl aminopeptidase	-
I6I40_RS06030 (I6I40_06030)	-	1290325..1290711 (+)	387	WP_001830382.1	hypothetical protein	-
I6I40_RS06035 (I6I40_06035)	liaF	1290726..1291427 (+)	702	WP_001830436.1	cell wall-active antibiotics response protein LiaF	-
I6I40_RS06040 (I6I40_06040)	vraS	1291424..1292470 (+)	1047	WP_001830374.1	sensor histidine kinase	Regulator
I6I40_RS06045 (I6I40_06045)	vraR	1292460..1293089 (+)	630	WP_001830439.1	two-component system response regulator VraR	Regulator
I6I40_RS06050 (I6I40_06050)	-	1293146..1294324 (-)	1179	WP_001830411.1	YihY/virulence factor BrkB family protein	-
I6I40_RS06055 (I6I40_06055)	-	1294731..1295015 (-)	285	WP_001830401.1	YtxH domain-containing protein	-
I6I40_RS06060 (I6I40_06060)	-	1295023..1295487 (-)	465	WP_001830437.1	low molecular weight protein-tyrosine-phosphatase	-
I6I40_RS06065 (I6I40_06065)	-	1295628..1295843 (+)	216	WP_001830421.1	DUF1128 domain-containing protein	-
I6I40_RS06070 (I6I40_06070)	-	1295845..1297086 (+)	1242	WP_001832467.1	aminopeptidase	-

Sequence

Protein

• Length: 348 a.a.
• Molecular weight: 40066.49 Da
• Isoelectric Point: 5.8512

>NTDB_id=527437 I6I40_RS06040 WP_001830374.1 1291424..1292470(+) (vraS) [Staphylococcus epidermidis strain FDAARGOS_1083]
MNHYIRAIGSMLILVYSMLIAFLFIDKVFVNIIFFQGMFYTQIFGIPVFLFLNLLIVLLCIIVGSVLAYKINQQNDWIIS
QIERSIEGQTVGINDQNIELYTETIDIYHTLVPLNQELHRLRMKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKESKLEPPLNQQIPILEKMVQDSQLEMRALLLHLRPIGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFEVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNQEDYLLLRIQDNGKGFNVDEKFEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEENSSGD

Nucleotide

• Length: 1047 bp

>NTDB_id=527437 I6I40_RS06040 WP_001830374.1 1291424..1292470(+) (vraS) [Staphylococcus epidermidis strain FDAARGOS_1083]
ATGAATCACTACATAAGAGCTATAGGCTCAATGCTTATATTAGTATATAGTATGCTTATTGCTTTTTTATTTATTGATAA
AGTGTTTGTAAATATTATCTTTTTTCAGGGGATGTTTTATACACAAATATTTGGAATACCTGTTTTTCTATTTTTAAATT
TATTAATTGTTCTTTTATGTATTATAGTTGGATCTGTTTTAGCTTATAAAATTAATCAACAAAATGATTGGATTATTTCA
CAAATAGAAAGATCAATAGAAGGACAAACAGTAGGTATCAATGATCAAAATATCGAATTATATACAGAAACGATAGATAT
TTATCATACACTAGTTCCATTAAATCAAGAATTACATCGACTTAGAATGAAGACTCAAAATTTAACTAATGAAAACTACA
ATATTAATGATGTAAAAGTCAAAAAGATTATCGAAGATGAGCGACAACGACTTGCCAGGGAATTACATGATTCTGTTAGT
CAACAATTATTTGCTGCGAGCATGATGCTATCGGCGATAAAAGAGTCGAAATTAGAACCACCTTTAAATCAACAGATACC
AATTCTTGAAAAAATGGTTCAAGACTCACAACTTGAAATGAGAGCTTTGTTATTACATTTAAGACCGATAGGTTTAAAAG
ATAAGTCTTTAGGTGAAGGAATTAAAGATTTAGTCATCGATTTACAAAAGAAAGTACCAATGAAAGTTGTGCATGAAATT
CAAGATTTTGAAGTGCCAAAAGGCATTGAAGATCACTTGTTCAGAATTACACAAGAAGCTATTTCAAATACATTGAGACA
TTCAAATGGTACAAAAGTAACTGTGGAATTATTTAATCAAGAGGATTATCTTTTACTAAGAATTCAAGATAATGGAAAAG
GGTTTAATGTAGATGAAAAATTTGAACAAAGTTATGGTTTGAAAAATATGCGAGAACGAGCGTTAGAAATTGGTGCGACG
TTTCATATTGTATCTTTACCTGATTCAGGTACACGAATTGAAGTTAAGGCACCATTGAATAAGGAGGAGAATTCAAGTGG
CGATTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0N1EGU4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	93.023	98.851	0.92