Detailed information NTG0524360

Bioinformatically predicted

Overview

• Name: clpC
• Type: Regulator
• Locus tag: JHX98_RS08955
• Genome accession: NZ_CP067010
• Coordinates: 1769571..1772015 (-)
• Length: 814 a.a.
• NCBI ID: WP_076640698.1
• Uniprot ID: -
• Organism: Streptococcus pyogenes strain iGAS376
• Function: degradation of ComX (predicted from homology) Competence regulation

Genomic Context

Location: 1764571..1777015

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
JHX98_RS08935 (JHX98_08935)	-	1764735..1766234 (+)	1500	WP_011889202.1	C69 family dipeptidase	-
JHX98_RS09680	-	1766528..1766897 (+)	370	Protein_1714	8-oxo-dGTP diphosphatase	-
JHX98_RS08940 (JHX98_08940)	-	1766940..1767234 (-)	295	Protein_1715	helix-turn-helix transcriptional regulator	-
JHX98_RS08945 (JHX98_08945)	groL	1767436..1769067 (-)	1632	WP_002982320.1	chaperonin GroEL	-
JHX98_RS08950 (JHX98_08950)	groES	1769103..1769393 (-)	291	WP_002991292.1	co-chaperone GroES	-
JHX98_RS08955 (JHX98_08955)	clpC	1769571..1772015 (-)	2445	WP_076640698.1	ATP-dependent Clp protease ATP-binding subunit	Regulator
JHX98_RS08960 (JHX98_08960)	-	1772015..1772476 (-)	462	WP_002982312.1	CtsR family transcriptional regulator	-
JHX98_RS08965 (JHX98_08965)	-	1772672..1772875 (-)	204	WP_011889204.1	cold-shock protein	-
JHX98_RS08975 (JHX98_08975)	ahpC	1773860..1774420 (+)	561	WP_002982304.1	alkyl hydroperoxide reductase subunit C	-
JHX98_RS08980 (JHX98_08980)	ahpF	1774441..1775973 (+)	1533	WP_011889205.1	alkyl hydroperoxide reductase subunit F	-

Sequence

Protein

• Length: 814 a.a.
• Molecular weight: 90607.33 Da
• Isoelectric Point: 6.9601

>NTDB_id=524360 JHX98_RS08955 WP_076640698.1 1769571..1772015(-) (clpC) [Streptococcus pyogenes strain iGAS376]
MIMYSTKMQDIFRQAQFQAARFDSHCLETWHVLLAMVAVDNSLANMILSEYDAQVAIEEYEAAAILAMGKPPKEQLSRVD
FRPQSKTLTNLLAFAQAISQITRDQEVGSEHVLFAILLNPDIMASRLLEIAGYQIKDSGNGQPRLADLRKAIERHAGYSK
EMIKAIHELRKPKKTKTQGTFSDMMKPPSTAGELSDFTRDLTEMARQGLLESVIGRDQEVSRMIQVLSRKTKNNPVLVGD
AGVGKTALAYGLAQRIANGAIPYELKEMRVLELDMMSVVAGTRFRGDFEERMNQIIDDIEADGQIILFVDELHTIMGSGS
GIDSTLDAANILKPALSRGTLHMVGATTQEEYQKHIEKDAALSRRFAKILIEEPNTEDAYQILIGLKLSYETYHNVSISN
EAVKTAVKMAHRYLTSKNLPDSAIDLLDEASAAVQNMVKKSAPETLTPIDQALINGDMKKVSRLLAKEAKGQMRKPTPVT
EDDILATLSKLSGIPLEKLTQADSKKYLNLEKELHKRVIGQDAAVTAISRAIRRNQSGIRTGKRPIGSFMFLGPTGVGKT
ELAKALAEVLFDDEAALIRFDMSEYMEKFAASRLNGAPPGYVGYDEGGELTQKVRNKPYSVLLFDEVEKAHPDIFNVLLQ
VLDDGILTDSRGRKVDFSNTIIIMTSNLGATALRDDKTVGFGVKGIHQDHQAMEKRILEELRKTYRPEFINRIDEKVVFH
SLTQDNMRDVVKIMVQPLITTLAEKGITLKIQPLALKHLSEVGYDEHMGARPLRRTLQTEIEDKLSELILSRELTSGHTL
KIGLSHGKLTFHIA

Nucleotide

• Length: 2445 bp

>NTDB_id=524360 JHX98_RS08955 WP_076640698.1 1769571..1772015(-) (clpC) [Streptococcus pyogenes strain iGAS376]
ATGATTATGTATTCAACGAAGATGCAAGACATTTTTAGACAGGCGCAGTTCCAAGCTGCTCGCTTTGATAGCCATTGCCT
GGAAACTTGGCATGTTTTGTTAGCTATGGTAGCTGTAGATAATTCTTTAGCAAATATGATTTTAAGTGAATATGATGCCC
AAGTCGCCATAGAAGAATATGAAGCTGCAGCTATTTTAGCCATGGGCAAACCCCCTAAGGAACAGTTGTCTCGTGTAGAC
TTCAGACCTCAATCTAAAACTTTGACTAACTTGTTAGCTTTTGCGCAGGCTATTAGCCAAATCACTAGGGATCAAGAAGT
CGGCTCTGAGCATGTCTTATTTGCTATTTTATTGAATCCAGATATCATGGCGAGTCGTTTGTTAGAAATAGCAGGCTATC
AGATAAAAGATAGCGGCAATGGGCAGCCGCGATTAGCTGACTTACGAAAAGCAATAGAACGTCATGCAGGTTACAGTAAG
GAAATGATTAAGGCTATTCACGAACTACGTAAGCCTAAAAAAACGAAAACACAAGGGACCTTTTCAGATATGATGAAGCC
ACCAAGTACAGCTGGTGAGTTGAGTGATTTCACAAGAGATTTGACTGAAATGGCAAGACAAGGTTTGTTAGAATCGGTGA
TTGGACGTGACCAAGAAGTATCTCGTATGATTCAGGTACTAAGTCGTAAAACGAAAAACAATCCTGTCTTGGTAGGTGAT
GCAGGTGTTGGTAAAACTGCGCTTGCTTATGGCCTTGCTCAACGGATCGCAAATGGCGCTATTCCTTATGAACTTAAGGA
GATGCGTGTCCTAGAATTAGACATGATGAGTGTGGTAGCAGGAACCCGTTTTCGTGGGGATTTTGAAGAGCGCATGAATC
AAATCATTGATGATATTGAAGCTGATGGTCAGATTATTCTTTTTGTTGATGAACTACATACTATTATGGGTTCTGGCAGT
GGTATTGACAGTACACTTGATGCGGCTAACATTTTAAAACCAGCATTATCGCGCGGTACTCTTCATATGGTTGGAGCAAC
AACTCAAGAAGAATATCAAAAACATATTGAAAAAGATGCAGCTCTTTCGCGTCGTTTTGCTAAAATATTAATTGAAGAAC
CTAATACAGAAGATGCTTATCAGATTTTGATAGGGCTAAAATTATCTTATGAGACCTACCATAATGTCTCGATATCAAAT
GAGGCAGTTAAAACAGCTGTAAAAATGGCACACCGTTATTTAACCAGTAAAAATCTCCCTGATTCAGCTATCGATTTATT
AGATGAAGCTAGTGCTGCTGTGCAAAACATGGTGAAAAAATCAGCACCTGAGACTTTAACACCAATAGACCAAGCTCTTA
TCAATGGTGATATGAAAAAAGTATCTCGCCTCTTAGCTAAAGAAGCAAAAGGTCAGATGAGAAAACCAACACCAGTCACA
GAAGATGATATTTTGGCAACCTTGAGTAAGTTATCGGGAATTCCACTTGAAAAACTGACGCAAGCTGATAGCAAAAAATA
CCTCAATTTAGAAAAAGAACTGCATAAGCGTGTGATTGGTCAGGATGCTGCTGTTACGGCTATTTCAAGAGCCATTCGTC
GTAATCAGTCAGGTATTCGAACAGGAAAACGTCCTATTGGATCATTTATGTTTCTTGGCCCAACAGGAGTAGGTAAGACA
GAACTAGCAAAGGCCCTTGCAGAAGTTCTCTTTGATGATGAAGCAGCGCTTATTCGTTTTGATATGTCTGAGTACATGGA
AAAATTCGCAGCATCTAGGCTTAATGGAGCACCTCCTGGTTATGTCGGCTATGATGAAGGAGGTGAACTGACACAGAAAG
TTAGAAATAAACCTTATTCAGTCTTGCTTTTTGATGAAGTGGAAAAAGCACATCCTGATATTTTTAACGTTCTCCTTCAA
GTATTAGATGATGGTATATTGACTGATAGTCGTGGGCGTAAGGTCGATTTTTCAAATACTATTATTATCATGACCAGCAA
TCTTGGCGCAACAGCCCTGCGCGATGATAAAACGGTCGGTTTTGGGGTCAAAGGCATTCACCAAGACCATCAAGCTATGG
AGAAACGTATTTTAGAAGAATTAAGAAAAACTTACCGCCCAGAATTTATCAATCGTATTGATGAAAAAGTGGTCTTTCAT
AGTCTGACCCAAGATAACATGCGCGATGTGGTTAAAATCATGGTACAGCCCCTGATTACTACATTGGCAGAAAAAGGTAT
TACCCTTAAAATTCAGCCTTTGGCCTTGAAACATTTGTCCGAGGTCGGCTATGATGAGCATATGGGGGCAAGACCATTAC
GTCGAACGCTGCAAACTGAGATAGAAGATAAGCTATCAGAGCTTATTCTTTCTCGAGAATTGACAAGTGGGCATACGCTA
AAAATTGGATTATCACATGGCAAATTAACGTTTCACATAGCTTAA

Domains

Predicted by InterproScan.

• Clp amino terminal domain, pathogenicity island component (Clp_N) (95-130)

• ATPase family associated with various cellular activities (AAA) (AAA) (236-368)

• C-terminal, D2-small domain, of ClpB protein (ClpB_D2-small) (722-801)

• AAA lid domain (AAA_lid_9) (376-459)

• AAA domain (Cdc48 subfamily) (AAA_2) (544-715)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
clpC	Streptococcus mutans UA159	75.154	99.877	0.751
clpC	Streptococcus thermophilus LMG 18311	71.324	100	0.715
clpC	Streptococcus thermophilus LMD-9	71.201	100	0.714
clpC	Streptococcus pneumoniae TIGR4	65.725	100	0.657
clpC	Streptococcus pneumoniae Rx1	65.725	100	0.657
clpC	Streptococcus pneumoniae D39	65.725	100	0.657
clpC	Lactococcus lactis subsp. lactis strain DGCC12653	47.852	100	0.493
clpC	Bacillus subtilis subsp. subtilis str. 168	42.206	100	0.432