Detailed information NTG0524311

Bioinformatically predicted

Overview

• Name: comR
• Type: Regulator
• Locus tag: JHX98_RS00570
• Genome accession: NZ_CP067010
• Coordinates: 92812..93723 (+)
• Length: 303 a.a.
• NCBI ID: WP_011888526.1
• Uniprot ID: -
• Organism: Streptococcus pyogenes strain iGAS376
• Function: activate transcription of comX (predicted from homology) Competence regulation

Genomic Context

Location: 87812..98723

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
JHX98_RS00550 (JHX98_00550)	purE	88401..88889 (+)	489	WP_011888522.1	5-(carboxyamino)imidazole ribonucleotide mutase	-
JHX98_RS00555 (JHX98_00555)	purK	88876..89949 (+)	1074	WP_011888523.1	5-(carboxyamino)imidazole ribonucleotide synthase	-
JHX98_RS00560 (JHX98_00560)	-	89951..91369 (+)	1419	WP_011888524.1	hypothetical protein	-
JHX98_RS00565 (JHX98_00565)	purB	91389..92681 (+)	1293	WP_011888525.1	adenylosuccinate lyase	-
JHX98_RS00570 (JHX98_00570)	comR	92812..93723 (+)	912	WP_011888526.1	XRE family transcriptional regulator	Regulator
JHX98_RS00575 (JHX98_00575)	comS	93814..93912 (+)	99	WP_020833188.1	quorum-sensing system DWW-type pheromone	Regulator
JHX98_RS00580 (JHX98_00580)	ruvB	93943..94941 (+)	999	WP_002986679.1	Holliday junction branch migration DNA helicase RuvB	-
JHX98_RS00585 (JHX98_00585)	-	95079..95516 (+)	438	WP_002994668.1	low molecular weight phosphotyrosine protein phosphatase	-
JHX98_RS00590 (JHX98_00590)	-	95539..95940 (+)	402	WP_011017240.1	MORN repeat-containing protein	-
JHX98_RS00595 (JHX98_00595)	-	95937..97712 (+)	1776	WP_011888527.1	acyltransferase family protein	-

Sequence

Protein

• Length: 303 a.a.
• Molecular weight: 35915.59 Da
• Isoelectric Point: 4.9349

>NTDB_id=524311 JHX98_RS00570 WP_011888526.1 92812..93723(+) (comR) [Streptococcus pyogenes strain iGAS376]
MLEHFGGKVKVLRLEKRISREDLCGDESELSVRQLARIELGQSIPSLSKVIFIAKALNVSVGYLTDGADLELPKRYKELK
YLILRTPTYMDDGKLQVREEQFDEIFEDYYDKLPEEEKVAVDIIQAKFEVYQTGDINFGYSILKEFLPQLKRKSIYNLNE
LLLIDLYLIILVVSHFSDDIFDVQFYEEITESMLKQHNNLSLEDLFLLNNILLSCADTYIRLKMFGRLKETLQLSHFIMS
TIQDFQKMPMYCMYEWKLSIFYLKDINRARNYFEQSILFTQMTGDTYLVQKLRGEWNKDIHYI

Nucleotide

• Length: 912 bp

>NTDB_id=524311 JHX98_RS00570 WP_011888526.1 92812..93723(+) (comR) [Streptococcus pyogenes strain iGAS376]
ATGTTAGAACATTTTGGTGGAAAAGTAAAAGTGTTAAGACTTGAAAAGAGGATTAGTCGCGAGGACTTGTGTGGGGATGA
GTCTGAACTTTCTGTTCGTCAATTAGCACGGATAGAACTAGGTCAATCCATACCAAGTTTAAGTAAGGTTATTTTTATTG
CAAAAGCCTTAAACGTTAGTGTCGGTTACTTAACTGATGGTGCTGATTTAGAACTACCTAAGCGTTACAAAGAATTAAAA
TACCTTATCTTAAGGACACCAACTTACATGGATGATGGAAAATTACAAGTACGAGAAGAGCAGTTTGATGAAATTTTTGA
GGATTATTATGATAAATTACCAGAGGAAGAGAAAGTTGCTGTTGATATTATCCAAGCAAAATTTGAAGTTTATCAAACCG
GAGATATTAATTTCGGATATAGTATTTTAAAAGAATTTCTACCACAGCTAAAAAGAAAATCTATCTATAATTTAAATGAA
TTATTACTTATAGATTTGTATTTGATTATTCTGGTAGTTTCTCATTTTTCAGATGATATATTTGATGTACAGTTTTATGA
AGAAATAACAGAGAGCATGTTAAAACAACACAATAATTTATCATTGGAAGATTTATTTTTACTGAATAATATCTTATTAT
CTTGTGCGGACACTTATATTCGTTTGAAGATGTTCGGTCGTCTAAAAGAAACATTACAACTTAGCCACTTTATAATGTCA
ACTATTCAAGATTTTCAAAAAATGCCTATGTATTGTATGTATGAATGGAAGCTATCTATTTTTTATTTGAAAGATATTAA
CCGAGCACGGAATTACTTTGAACAGTCTATTTTATTTACTCAAATGACAGGAGATACATATTTAGTTCAAAAATTACGGG
GAGAATGGAATAAAGATATTCATTATATTTAA

Domains

Predicted by InterproScan.

• Helix-turn-helix (HTH_3) (12-64)

• ComR tetratricopeptide (ComR_TPR) (73-296)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comR	Streptococcus pyogenes MGAS315	99.67	100	0.997
comR	Streptococcus pyogenes MGAS8232	58.472	99.34	0.581
comR	Streptococcus mutans UA159	47.157	98.68	0.465
comR	Streptococcus infantarius subsp. infantarius ATCC BAA-102	46.441	97.36	0.452
comR	Streptococcus suis P1/7	37.374	98.02	0.366
comR	Streptococcus suis 05ZYH33	37.374	98.02	0.366