Detailed information    

insolico Bioinformatically predicted

Overview

Name   clpE   Type   Regulator
Locus tag   JCR30_RS03680 Genome accession   NZ_CP067008
Coordinates   687336..689618 (-) Length   760 a.a.
NCBI ID   WP_011888739.1    Uniprot ID   -
Organism   Streptococcus pyogenes strain iGAS426     
Function   repress competence development (at the early growth phase) (predicted from homology)   
Competence regulation

Genomic Context

Location: 682336..694618
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  JCR30_RS03665 (JCR30_03665) ileS 683335..686136 (+) 2802 WP_011888738.1 isoleucine--tRNA ligase -
  JCR30_RS03670 (JCR30_03670) - 686400..686702 (-) 303 WP_002983878.1 DUF1827 family protein -
  JCR30_RS03675 (JCR30_03675) - 686753..687208 (-) 456 WP_002989103.1 NUDIX domain-containing protein -
  JCR30_RS03680 (JCR30_03680) clpE 687336..689618 (-) 2283 WP_011888739.1 ATP-dependent Clp protease ATP-binding subunit Regulator
  JCR30_RS03685 (JCR30_03685) - 689916..690146 (+) 231 WP_002983885.1 YkuJ family protein -
  JCR30_RS03690 (JCR30_03690) - 690273..690959 (+) 687 WP_002983887.1 amino acid ABC transporter permease -
  JCR30_RS03695 (JCR30_03695) - 690959..691693 (+) 735 WP_011888740.1 amino acid ABC transporter ATP-binding protein -
  JCR30_RS03700 (JCR30_03700) - 691842..693251 (+) 1410 WP_011888741.1 deoxyribodipyrimidine photo-lyase -
  JCR30_RS03705 (JCR30_03705) - 693261..694259 (-) 999 WP_200221173.1 IS30 family transposase -

Sequence

Protein


Download         Length: 760 a.a.        Molecular weight: 84731.92 Da        Isoelectric Point: 5.0552

>NTDB_id=524228 JCR30_RS03680 WP_011888739.1 687336..689618(-) (clpE) [Streptococcus pyogenes strain iGAS426]
MLCQNCNLNESTIHLYTSVNGKQRQVDLCQNCYQIMKSNPANSILNGLTPGYRAQDRSTSPFFDDFFGDLNNFRAFGNLP
NTPPTQAGQNGNGGGRYGGNYNGQRPAQPQTPNQQAKGLLEEFGINVTDIARNGNIDPVIGRDEEITRVIEILNRRTKNN
PVLIGEPGVGKTAVVEGLAQKIIDGTVPQKLQGKQVIRLDVVSLVQGTGIRGQFEERMQKLMEEIRNRKDVILFIDEIHE
IVGAGSAGDGNMDAGNILKPALARGELQLVGATTLNEYRIIEKDAALERRMQPVKVDEPSVEETITILKGIQPKYEDYHH
VKYSPAAIEAAAHLSNRYIQDRFLPDKAIDLLDEAGSKMNLTLNFVDPKEIDKRLIEAENLKAQATRDEDYERAAYFRDQ
ITKYKEMQAQKVDEQDIPIITEKTIEAIIEQKTNIPVGDLKEKEQSQLVNLANDLKAHVIGQDDAVDKIAKAIRRNRVGL
GTPNRPIGSFLFVGPTGVGKTELSKQLAIELFGSTNNMIRFDMSEYMEKHAVAKLVGAPPGYVGYEEAGQLTEQVRRNPY
SLILLDEVEKAHPDVMHMFLQVLDDGRLTDGQGRTVSFKDTIIIMTSNAGTGKSEASVGFGAAREGRTSSVLGELSNFFS
PEFMNRFDGIIEFKALSKEHLLHIVDLMLEDVNERLGYNGIHLDVTQKVKEKLVDLGYDPKMGARPLRRTIQDYIEDAIT
DYYLEHPTEKQLRALMTNSENITIKAVKEGDSFLNEESLD

Nucleotide


Download         Length: 2283 bp        

>NTDB_id=524228 JCR30_RS03680 WP_011888739.1 687336..689618(-) (clpE) [Streptococcus pyogenes strain iGAS426]
ATGCTGTGTCAAAATTGTAATTTAAACGAATCTACTATTCATCTTTATACAAGTGTTAATGGAAAACAAAGACAGGTTGA
TCTCTGTCAAAATTGTTATCAAATCATGAAATCCAATCCTGCCAATTCTATTTTAAATGGCCTAACCCCAGGATATAGAG
CACAAGATAGATCCACAAGTCCTTTCTTTGATGACTTTTTTGGTGATTTGAATAATTTTAGAGCTTTTGGTAATCTTCCA
AATACCCCACCTACTCAGGCAGGGCAAAATGGAAATGGCGGAGGACGCTATGGTGGTAACTACAACGGACAACGACCTGC
TCAGCCACAAACACCAAATCAGCAAGCAAAGGGCTTGTTAGAAGAGTTTGGGATTAATGTCACAGATATTGCAAGAAATG
GTAATATTGATCCTGTTATTGGTCGTGACGAAGAGATTACACGCGTTATCGAGATCCTCAACCGCCGTACTAAAAATAAT
CCTGTGCTAATTGGTGAGCCTGGAGTTGGTAAAACTGCTGTTGTAGAAGGTTTGGCTCAAAAAATTATTGATGGTACTGT
TCCTCAAAAACTCCAAGGCAAGCAAGTGATTCGTCTTGATGTGGTTAGCCTCGTTCAGGGAACAGGTATCCGTGGTCAGT
TTGAAGAGCGCATGCAAAAATTAATGGAAGAAATTCGCAATCGCAAGGATGTGATTCTCTTTATTGATGAAATTCATGAG
ATTGTCGGTGCTGGTTCTGCAGGAGACGGCAATATGGATGCTGGTAATATTTTAAAACCAGCCTTGGCCCGTGGTGAGTT
GCAACTCGTTGGTGCTACTACCTTAAATGAATACCGTATTATTGAAAAAGATGCTGCCTTGGAGCGACGTATGCAACCCG
TTAAAGTTGATGAACCTTCTGTTGAGGAAACCATCACGATTTTAAAAGGTATCCAACCGAAATACGAAGACTATCATCAT
GTCAAATATAGCCCAGCCGCTATTGAAGCTGCCGCTCATTTATCTAACCGCTATATTCAAGACCGTTTTCTTCCTGATAA
GGCTATTGACCTTCTGGACGAAGCTGGTTCCAAAATGAATCTAACCCTCAACTTTGTTGATCCTAAAGAAATTGACAAAC
GTCTTATTGAAGCTGAGAATCTCAAGGCGCAAGCTACTCGAGACGAAGACTATGAACGCGCAGCTTATTTCCGCGATCAA
ATTACAAAATACAAAGAAATGCAGGCTCAAAAAGTCGATGAGCAAGATATTCCTATCATTACTGAAAAAACCATTGAAGC
CATCATTGAACAAAAAACCAATATTCCAGTTGGCGACTTGAAAGAAAAAGAACAATCTCAACTCGTTAATTTGGCTAATG
ATTTGAAAGCTCACGTGATCGGGCAAGACGATGCTGTTGATAAAATCGCTAAGGCTATTCGTCGTAACCGTGTGGGATTA
GGAACTCCAAATCGCCCTATTGGTTCTTTCTTATTCGTTGGACCGACTGGGGTTGGTAAAACAGAATTGTCTAAACAACT
AGCCATTGAACTCTTTGGTTCGACAAACAATATGATTCGCTTTGACATGTCCGAATACATGGAAAAACACGCTGTCGCCA
AATTAGTCGGGGCTCCTCCAGGTTATGTCGGCTATGAAGAAGCTGGACAACTAACCGAACAAGTTCGTCGCAATCCTTAT
TCCCTTATTCTCTTAGATGAGGTGGAAAAAGCCCATCCTGACGTCATGCACATGTTCTTACAAGTTCTTGATGACGGTCG
CTTAACAGACGGCCAAGGGCGAACAGTCAGCTTCAAGGACACCATTATTATCATGACCTCTAATGCCGGAACAGGTAAAA
GCGAAGCTTCTGTCGGATTTGGTGCTGCTAGAGAAGGACGGACAAGTTCTGTCCTTGGTGAATTAAGCAACTTCTTCAGC
CCAGAGTTTATGAATCGTTTCGATGGTATTATTGAATTCAAAGCTTTATCTAAAGAACATTTGCTGCATATCGTTGATTT
AATGCTGGAAGATGTTAATGAGCGCTTAGGCTATAATGGGATTCATCTTGATGTGACACAAAAGGTCAAAGAAAAATTAG
TAGATTTAGGCTATGATCCTAAAATGGGCGCTCGGCCGCTCCGTCGTACTATCCAAGATTATATCGAAGATGCCATTACA
GACTATTATTTAGAACACCCAACTGAAAAACAGTTACGTGCACTGATGACAAACAGTGAAAACATTACGATTAAAGCTGT
TAAAGAGGGAGATTCTTTTCTTAACGAAGAGTCTCTAGATTAA

Domains

Predicted by InterproScan.

AAA lid domain (AAA_lid_9)

(300-397)

AAA domain (Cdc48 subfamily) (AAA_2)

(485-648)

ATPase family associated with various cellular activities (AAA) (AAA)

(162-281)

C-terminal, D2-small domain, of ClpB protein (ClpB_D2-small)

(656-729)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  clpE Streptococcus mutans UA159

84.492

98.421

0.832
  clpE Streptococcus pneumoniae Rx1

82.69

98.816

0.817
  clpE Streptococcus pneumoniae D39

82.69

98.816

0.817
  clpE Streptococcus pneumoniae R6

82.69

98.816

0.817
  clpE Streptococcus pneumoniae TIGR4

82.557

98.816

0.816
  clpC Lactococcus lactis subsp. cremoris KW2

75.033

100

0.751
  clpC Bacillus subtilis subsp. subtilis str. 168

51.442

86.711

0.446
  clpC Lactococcus lactis subsp. lactis strain DGCC12653

46

85.526

0.393
  clpC Streptococcus pneumoniae Rx1

47.84

82.237

0.393
  clpC Streptococcus pneumoniae D39

47.84

82.237

0.393
  clpC Streptococcus pneumoniae TIGR4

47.84

82.237

0.393
  clpC Streptococcus mutans UA159

47.573

81.316

0.387
  clpC Streptococcus thermophilus LMD-9

47.115

82.105

0.387
  clpC Streptococcus thermophilus LMG 18311

46.795

82.105

0.384