Detailed information NTG0052136

Bioinformatically predicted

Overview

• Name: letS
• Type: Regulator
• Locus tag: LPO_RS09355
• Genome accession: NC_018139
• Coordinates: 2051903..2054635 (+)
• Length: 910 a.a.
• NCBI ID: WP_014841967.1
• Uniprot ID: A0AAV2V0G3
• Organism: Legionella pneumophila subsp. pneumophila
• Function: regulate competence development (predicted from homology) Competence regulation

Genomic Context

Location: 2046903..2059635

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
LPO_RS09330 (LPO_1982)	-	2048307..2049251 (+)	945	WP_014841754.1	IS110 family transposase	-
LPO_RS09335 (LPO_1983)	-	2049301..2049594 (-)	294	WP_010946556.1	GIY-YIG nuclease family protein	-
LPO_RS16865	-	2049620..2050079 (-)	460	Protein_1820	hypothetical protein	-
LPO_RS17240	-	2050114..2050332 (+)	219	WP_154080655.1	hypothetical protein	-
LPO_RS09350 (LPO_1987)	gltX	2050392..2051804 (-)	1413	WP_014841966.1	glutamate--tRNA ligase	-
LPO_RS09355 (LPO_1988)	letS	2051903..2054635 (+)	2733	WP_014841967.1	two-component system sensor histidine kinase LetS	Regulator
LPO_RS09360 (LPO_1989)	-	2054733..2055977 (+)	1245	WP_011214166.1	6-phosphofructokinase	-
LPO_RS09365 (LPO_1990)	pilA2	2055974..2056387 (-)	414	WP_013101573.1	pilin	Machinery gene
LPO_RS09370 (LPO_1991)	pilA2	2056585..2056995 (-)	411	WP_011214168.1	pilin	Machinery gene
LPO_RS09375 (LPO_1992)	-	2057298..2057615 (+)	318	WP_014841968.1	BolA family protein	-
LPO_RS09380 (LPO_1993)	-	2057690..2059111 (+)	1422	WP_014841969.1	APC family permease	-

Sequence

Protein

• Length: 910 a.a.
• Molecular weight: 102974.40 Da
• Isoelectric Point: 7.5329

>NTDB_id=52136 LPO_RS09355 WP_014841967.1 2051903..2054635(+) (letS) [Legionella pneumophila subsp. pneumophila]
MLKSIGIKYQLRITTLIPAFLVALLFAFFYNGLFGKDLKQHMSRLGEAYIRQLLPAAQYAMLRNDYRTLQGLINASTINP
EVKALAFYNADGRLIAYRGGKHSIHKPFNPPDYTGDYIESKQINPFTINFIAPITIPKFNLYSSTEFKEPSTPKIFQADD
ILGWLSIDIDTQSLLIKRYQMLIVTIFITLFGLLMGLTIHYFLSKRIYMPIARLRRSMKQILSNEFETEIRVSSPGELGI
IEKGCAHLQRQYLNTVRDLNHHIEIATADLQQSLELLEEKNIELSLEKKKTEEKSRQKSEFIANMSHEIRTPMNGVIGFT
NVLLESKLDPLQLDYVKTIKSSAQDLLSIINDILDFSKIDAGKLNLDCIPLDVRGCIDEVLSLASPNAHKKGIDLIPITD
INVPKMVLGDPLRIKQIISNLVTNAVKFTDHGYVLIRTKIEQETDKDYTLLFAITDTGIGISPEDQTKLFTAFNQADTSI
TRRYGGSGLGLVICKKLCEEMHGRISLTSEINKGSTFSARIKVEKLVAYEIEKNQTHRFAHLKIICFDDNPLHLEAIGNG
LGFWGIEAIRVDSFNKLSRTLTKHKDCKIAFINVNQGCERQAAELIAKHKQIPFVLISKWPINDFAALGARGFLYKPISI
QKLQDLIESIANENQTEKNTNQELDTLREQLRFLHPEILIAEDNPVNKMLLTSLLNNNANITTVDDGEMAVTACEDKKFD
MILLDLHMPKLNGLEAAKMIRQKSLMNKHSPIVLITASSSDLSSIDMKKSGVDFCFQKPIDEKQLLIQILRIVDKTKHAA
IDWQLCVQKVSGNQALAEEFLAKFIEELYKNRDEFIELMHQKNVKGLADLAHKLHGACCFCGVPILQKRVAQLEKLARRT
ANADNLTEAFTDLIQSIDAVISEYENQYSQ

Nucleotide

• Length: 2733 bp

>NTDB_id=52136 LPO_RS09355 WP_014841967.1 2051903..2054635(+) (letS) [Legionella pneumophila subsp. pneumophila]
ATGTTGAAAAGTATTGGTATTAAATATCAGCTAAGAATCACTACTCTTATTCCTGCCTTTTTAGTCGCCTTGCTTTTTGC
TTTTTTTTATAACGGCCTATTTGGTAAAGATCTAAAGCAGCATATGTCCAGACTGGGTGAAGCCTATATTAGGCAATTAC
TTCCAGCAGCCCAGTATGCCATGCTTCGTAATGATTACCGTACATTGCAGGGTTTAATCAATGCCTCAACCATTAACCCG
GAGGTAAAAGCTTTGGCATTTTATAATGCTGATGGTCGATTAATTGCTTATCGTGGTGGCAAGCACTCTATTCATAAACC
ATTCAATCCACCTGACTATACAGGTGACTACATTGAAAGTAAGCAAATTAACCCATTCACCATTAATTTTATAGCGCCGA
TTACTATCCCAAAGTTCAATTTGTACTCCAGCACAGAATTCAAAGAGCCTTCTACGCCTAAAATATTCCAGGCTGACGAT
ATATTAGGCTGGTTATCCATTGACATTGATACACAATCACTACTTATAAAACGCTATCAAATGCTCATCGTTACCATTTT
TATTACTCTATTCGGTTTACTGATGGGTTTAACAATTCATTACTTCTTGTCTAAACGAATTTACATGCCTATTGCTCGAT
TGCGTCGAAGTATGAAGCAAATTTTAAGCAATGAATTTGAAACTGAAATTCGTGTTTCAAGTCCAGGAGAATTAGGAATA
ATTGAAAAAGGTTGCGCTCATTTACAACGACAATATTTAAATACAGTTCGTGATTTGAATCACCACATTGAAATCGCCAC
CGCAGATCTGCAACAAAGTCTCGAACTTCTGGAAGAAAAAAACATTGAGCTATCACTGGAAAAGAAAAAAACTGAAGAAA
AAAGTCGACAAAAATCAGAATTTATTGCCAACATGAGTCATGAAATTCGCACCCCAATGAATGGCGTGATTGGTTTTACA
AATGTTTTATTGGAAAGCAAGCTGGACCCTTTACAACTGGACTACGTTAAAACGATCAAATCATCAGCGCAGGATTTGTT
AAGTATCATCAATGATATTCTGGATTTTTCTAAAATTGATGCGGGCAAATTAAATCTTGATTGCATCCCGCTAGACGTAA
GAGGTTGCATTGATGAGGTTTTATCCCTGGCAAGCCCCAATGCGCACAAAAAAGGAATCGATTTAATTCCGATTACAGAC
ATCAATGTGCCCAAAATGGTATTGGGTGACCCTTTAAGAATCAAACAAATCATCAGTAATCTGGTGACCAATGCAGTAAA
ATTTACAGATCATGGATACGTTCTTATACGTACTAAAATCGAGCAAGAAACAGATAAGGATTATACCTTGCTATTTGCCA
TTACGGATACGGGAATAGGTATTTCACCAGAGGATCAAACGAAACTGTTTACTGCCTTTAATCAGGCAGACACCAGCATC
ACACGCCGTTACGGTGGCTCAGGATTAGGCTTGGTTATATGTAAAAAGCTATGTGAAGAAATGCATGGACGTATTAGTCT
AACCAGTGAAATCAACAAAGGCTCTACTTTTAGTGCACGCATTAAAGTTGAAAAACTTGTTGCTTATGAGATTGAAAAAA
ATCAAACTCATCGTTTCGCGCATTTAAAAATCATTTGCTTTGATGACAATCCCCTCCATTTGGAAGCAATAGGTAATGGC
TTGGGATTTTGGGGTATAGAGGCTATACGCGTTGACTCATTTAATAAACTTTCCCGAACATTGACAAAACATAAAGATTG
CAAAATTGCCTTTATTAACGTCAATCAAGGATGTGAGCGACAAGCCGCTGAACTCATTGCCAAACATAAGCAAATCCCTT
TTGTGTTAATTTCCAAATGGCCTATTAATGACTTTGCAGCGCTTGGTGCCAGGGGTTTTCTTTACAAACCTATTAGTATC
CAAAAGCTTCAGGATCTGATTGAATCGATAGCCAATGAAAACCAAACCGAGAAAAATACGAACCAGGAACTGGATACTTT
ACGCGAACAGCTTCGTTTTCTTCATCCAGAGATACTGATTGCAGAAGACAACCCTGTCAATAAAATGCTATTAACATCCC
TATTAAACAATAATGCCAATATAACAACGGTTGACGATGGCGAAATGGCCGTTACTGCTTGTGAGGATAAAAAATTTGAT
ATGATTTTACTGGATCTGCATATGCCAAAACTTAATGGTTTGGAAGCAGCCAAAATGATACGTCAAAAATCCCTAATGAA
TAAACACTCCCCTATCGTTCTCATTACCGCCAGTAGCAGTGATCTGAGCTCCATCGATATGAAAAAATCCGGAGTTGATT
TTTGTTTTCAAAAACCTATAGATGAAAAGCAATTGTTAATCCAAATTCTTCGCATCGTTGATAAAACCAAACATGCTGCC
ATCGATTGGCAATTATGCGTTCAGAAAGTTTCAGGTAATCAAGCGCTTGCTGAAGAGTTCCTCGCCAAATTCATAGAAGA
ATTATATAAGAATCGTGACGAGTTTATTGAGTTAATGCATCAAAAAAACGTAAAGGGCCTGGCTGATTTGGCTCATAAAT
TACATGGCGCCTGTTGTTTTTGTGGCGTACCTATTTTACAAAAGAGAGTAGCTCAACTAGAGAAGCTTGCAAGACGAACA
GCTAATGCTGATAATTTAACCGAAGCCTTTACCGATTTAATACAAAGTATTGATGCAGTGATTAGTGAATATGAAAATCA
GTATTCACAATAA

Domains

Predicted by InterproScan.

• His Kinase A (phospho-acceptor) domain (HisKA) (298-362)

• Response regulator receiver domain (Response_reg) (678-787)

• Single cache domain 4 (sCache_4) (36-180)

• Hpt domain (Hpt) (819-899)

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (409-524)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
letS	Legionella pneumophila strain ERS1305867	99.341	100	0.993