Detailed information NTG0519529

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: ICN77_RS05020
• Genome accession: NZ_CP066376
• Coordinates: 929546..930592 (+)
• Length: 348 a.a.
• NCBI ID: WP_001830374.1
• Uniprot ID: A0A0N1EGU4
• Organism: Staphylococcus epidermidis strain PH1-28
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 924546..935592

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
ICN77_RS04995 (ICN77_000854)	-	925687..926223 (+)	537	WP_001830372.1	hypothetical protein	-
ICN77_RS05000 (ICN77_000855)	-	926374..927360 (-)	987	WP_002503580.1	aromatic acid exporter family protein	-
ICN77_RS05005 (ICN77_000856)	map	927534..928289 (+)	756	WP_198895867.1	type I methionyl aminopeptidase	-
ICN77_RS05010 (ICN77_000857)	-	928447..928833 (+)	387	WP_001830382.1	hypothetical protein	-
ICN77_RS05015 (ICN77_000858)	liaF	928848..929549 (+)	702	WP_002473931.1	cell wall-active antibiotics response protein LiaF	-
ICN77_RS05020 (ICN77_000859)	vraS	929546..930592 (+)	1047	WP_001830374.1	sensor histidine kinase	Regulator
ICN77_RS05025 (ICN77_000860)	vraR	930582..931211 (+)	630	WP_001830439.1	two-component system response regulator VraR	Regulator
ICN77_RS05030 (ICN77_000861)	-	931268..932446 (-)	1179	WP_002503581.1	YihY/virulence factor BrkB family protein	-
ICN77_RS05035 (ICN77_000862)	-	932853..933137 (-)	285	WP_001830401.1	YtxH domain-containing protein	-
ICN77_RS05040 (ICN77_000863)	-	933145..933609 (-)	465	WP_198895868.1	low molecular weight protein-tyrosine-phosphatase	-
ICN77_RS05045 (ICN77_000864)	-	933750..933965 (+)	216	WP_001830421.1	DUF1128 domain-containing protein	-
ICN77_RS05050 (ICN77_000865)	-	933967..935208 (+)	1242	WP_002503582.1	aminopeptidase	-

Sequence

Protein

• Length: 348 a.a.
• Molecular weight: 40066.49 Da
• Isoelectric Point: 5.8512

>NTDB_id=519529 ICN77_RS05020 WP_001830374.1 929546..930592(+) (vraS) [Staphylococcus epidermidis strain PH1-28]
MNHYIRAIGSMLILVYSMLIAFLFIDKVFVNIIFFQGMFYTQIFGIPVFLFLNLLIVLLCIIVGSVLAYKINQQNDWIIS
QIERSIEGQTVGINDQNIELYTETIDIYHTLVPLNQELHRLRMKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKESKLEPPLNQQIPILEKMVQDSQLEMRALLLHLRPIGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFEVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNQEDYLLLRIQDNGKGFNVDEKFEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEENSSGD

Nucleotide

• Length: 1047 bp

>NTDB_id=519529 ICN77_RS05020 WP_001830374.1 929546..930592(+) (vraS) [Staphylococcus epidermidis strain PH1-28]
ATGAATCACTACATAAGAGCTATAGGCTCAATGCTTATATTAGTATATAGTATGCTTATTGCTTTTTTATTTATTGATAA
AGTGTTTGTAAATATTATCTTTTTTCAGGGGATGTTTTATACACAAATATTTGGAATACCTGTTTTTCTATTTTTAAATT
TATTAATTGTTCTTTTATGTATTATAGTTGGATCTGTTTTAGCTTATAAAATTAATCAACAAAATGATTGGATTATTTCA
CAAATAGAAAGATCAATAGAAGGACAAACAGTAGGTATCAATGATCAAAATATCGAATTATATACAGAAACGATAGATAT
TTATCATACACTAGTTCCATTAAATCAAGAATTACATCGACTTAGAATGAAGACTCAAAATTTAACTAATGAAAACTACA
ATATTAATGATGTAAAAGTCAAAAAGATTATCGAAGATGAGCGACAACGACTTGCCAGGGAATTACATGATTCTGTTAGT
CAACAATTATTTGCTGCGAGCATGATGCTATCGGCGATAAAAGAGTCGAAATTAGAACCACCTTTAAATCAACAGATACC
AATTCTTGAAAAAATGGTTCAAGACTCACAACTTGAAATGAGAGCTTTGTTATTACATTTAAGGCCGATAGGTTTAAAAG
ATAAGTCTTTAGGTGAAGGAATTAAAGATTTAGTCATCGATTTACAAAAGAAAGTACCAATGAAAGTTGTGCATGAAATT
CAAGATTTTGAAGTGCCAAAAGGCATTGAAGATCACTTGTTCAGAATTACACAAGAAGCTATTTCAAATACATTGAGACA
TTCAAATGGTACAAAAGTAACTGTGGAATTATTTAATCAAGAGGATTATCTTTTACTAAGAATTCAAGATAATGGAAAAG
GGTTTAATGTAGATGAAAAATTTGAACAAAGTTATGGTTTGAAAAATATGCGAGAACGAGCGTTAGAAATTGGTGCGACG
TTTCATATTGTATCTTTACCTGATTCAGGTACACGAATTGAAGTTAAGGCACCATTGAATAAGGAGGAGAATTCAAGTGG
CGATTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0N1EGU4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	93.023	98.851	0.92