Detailed information    

insolico Bioinformatically predicted

Overview

Name   clpE   Type   Regulator
Locus tag   SCIM_RS06595 Genome accession   NC_018073
Coordinates   1366574..1368841 (+) Length   755 a.a.
NCBI ID   WP_003076611.1    Uniprot ID   -
Organism   Streptococcus intermedius JTH08     
Function   degradation of ComX (predicted from homology)   
Competence regulation

Genomic Context

Location: 1361574..1373841
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  SCIM_RS06565 (SCIM_1188) - 1361602..1362894 (+) 1293 WP_003076587.1 ABC transporter permease -
  SCIM_RS06570 (SCIM_1189) - 1362906..1363553 (+) 648 WP_003071962.1 ABC transporter ATP-binding protein -
  SCIM_RS06575 (SCIM_1190) - 1363577..1364965 (+) 1389 WP_003071961.1 ABC transporter permease -
  SCIM_RS06585 (SCIM_1191) - 1365409..1365951 (-) 543 WP_003077029.1 ClbS/DfsB family four-helix bundle protein -
  SCIM_RS06590 - 1366104..1366334 (-) 231 WP_003023686.1 DUF1797 family protein -
  SCIM_RS06595 (SCIM_1192) clpE 1366574..1368841 (+) 2268 WP_003076611.1 ATP-dependent Clp protease ATP-binding subunit Regulator
  SCIM_RS06600 (SCIM_1193) - 1368888..1369493 (-) 606 WP_003071947.1 GyrI-like domain-containing protein -
  SCIM_RS06605 (SCIM_1194) - 1369553..1370446 (-) 894 WP_003077000.1 helix-turn-helix transcriptional regulator -
  SCIM_RS06610 (SCIM_1195) - 1370603..1371052 (+) 450 WP_003076391.1 NUDIX hydrolase -
  SCIM_RS06615 (SCIM_1196) - 1371116..1371415 (+) 300 WP_003076991.1 DUF1827 family protein -
  SCIM_RS06620 (SCIM_1197) - 1371490..1373544 (-) 2055 WP_003076739.1 cation:proton antiporter -
  SCIM_RS06625 - 1373556..1373810 (-) 255 WP_003077046.1 hypothetical protein -

Sequence

Protein


Download         Length: 755 a.a.        Molecular weight: 84334.58 Da        Isoelectric Point: 5.2792

>NTDB_id=51880 SCIM_RS06595 WP_003076611.1 1366574..1368841(+) (clpE) [Streptococcus intermedius JTH08]
MLCQNCKINESTIHLYTNVNGKQHQVDLCQNCYQIMKTDPNNALFRGMTNMNNQNNLDPFDDFFSNIGNFQNHQEPQTPP
TQSGGGYGNGGYGSNQGNSARQQASQQPKGLLEEFGINVTKFARRGEIDPVIGRDEEIVRVIEILNRRTKNNPVLIGEPG
VGKTAVVEGLAQKIVDGDVPHKLQGKEVIRLDVVSLVQGTGIRGQFEERMQKLMNEIRSRQDVILFIDEIHEIVGAGSAG
DGNMDAGNILKPALARGELQLVGATTLNEYRIIEKDAALERRMQPVKVDEPTVEETITILKGIQKKYEDYHHVKYTDDAI
EAAAVLSNRYIQDRFLPDKAIDLLDEAGSKMNLTLNFVDPKVIDQRLVEAENLKAQATRDEDFEKAAYFRDQIAKYKEMQ
QNKMADQDTPLISEKTIEHIIEQKTNIPVGDLKEKEQSQLISLADDLKTHVIGQDDAVDKIAKAIRRNRVGLGTPNRPIG
SFLFVGPTGVGKTELSKQLAIELFGSADSMIRFDMSEYMEKHSVAKLVGAPPGYVGYEEAGQLTERVRRNPYSLILLDEI
EKAHPDVMHMFLQVLDDGRLTDGQGRTVSFKDTIIIMTSNAGTGKVEANVGFGAAREGRTNSVIGELGNFFSPEFMNRFD
GIIEFKSLSKENLLQIVDLMLKDVNERLATNDIYLDVTDKVKEKLVNLGYDPKMGARPLRRTIQDHIEDAITDYYLEHPS
DKELKAIMTSNGKIVIKPAKKSENKSKTTIDNNAN

Nucleotide


Download         Length: 2268 bp        

>NTDB_id=51880 SCIM_RS06595 WP_003076611.1 1366574..1368841(+) (clpE) [Streptococcus intermedius JTH08]
ATGCTTTGTCAAAACTGTAAAATAAATGAATCTACCATTCATCTTTACACAAATGTTAATGGGAAACAACATCAAGTTGA
CCTCTGTCAAAATTGTTATCAAATCATGAAAACGGATCCAAACAATGCCTTGTTTCGTGGCATGACCAATATGAATAATC
AAAACAACCTAGATCCATTTGATGATTTCTTTAGCAATATAGGGAATTTTCAAAATCATCAAGAACCGCAGACTCCTCCT
ACTCAATCAGGTGGTGGATATGGCAATGGAGGCTATGGCTCCAATCAAGGCAATAGTGCACGCCAACAAGCATCACAGCA
ACCTAAAGGTCTCCTAGAGGAATTCGGTATCAATGTGACTAAATTTGCTCGGCGTGGTGAAATTGACCCCGTGATTGGTC
GTGATGAGGAAATTGTTCGTGTTATTGAAATCCTCAATCGTAGAACGAAGAACAACCCTGTCCTCATCGGAGAGCCCGGT
GTCGGTAAAACAGCAGTTGTCGAAGGCTTGGCTCAGAAAATTGTAGACGGTGATGTGCCACATAAACTCCAAGGCAAAGA
AGTTATCCGCTTAGATGTCGTTAGCTTGGTTCAAGGAACTGGCATCCGTGGTCAATTTGAAGAACGAATGCAAAAACTCA
TGAACGAAATTCGCTCTCGTCAGGATGTGATATTATTCATTGATGAAATTCACGAAATTGTTGGAGCTGGTTCTGCTGGT
GATGGAAATATGGATGCTGGAAACATTCTAAAACCAGCACTTGCTCGCGGTGAACTCCAATTAGTTGGTGCCACAACTCT
CAATGAATACCGGATTATCGAAAAAGATGCTGCACTGGAACGCCGTATGCAGCCTGTAAAAGTTGATGAACCAACAGTTG
AAGAAACGATCACTATCCTCAAAGGTATTCAAAAGAAATACGAAGACTATCACCACGTCAAATACACCGACGATGCCATT
GAAGCAGCAGCTGTCTTGTCCAATCGGTATATCCAAGATCGCTTCTTGCCTGATAAGGCCATTGACTTGCTAGATGAAGC
AGGCTCTAAGATGAATCTGACACTTAACTTTGTCGATCCAAAAGTCATTGATCAACGATTGGTAGAAGCTGAAAATCTCA
AGGCACAAGCTACTCGTGATGAAGATTTTGAAAAAGCTGCTTATTTCCGTGACCAAATTGCCAAATACAAAGAAATGCAG
CAAAATAAAATGGCTGATCAAGATACGCCTCTTATCAGTGAAAAAACCATTGAACATATCATTGAGCAAAAGACCAATAT
TCCAGTTGGCGACTTGAAAGAAAAGGAACAATCACAATTGATTAGTCTGGCTGATGATTTGAAAACTCATGTCATTGGTC
AAGATGATGCTGTTGATAAAATTGCCAAAGCTATTCGCCGTAATCGAGTTGGACTAGGTACACCAAACCGACCAATTGGT
TCTTTCCTTTTTGTTGGGCCAACCGGTGTCGGCAAAACAGAACTTTCTAAACAATTAGCGATTGAGCTCTTTGGTTCAGC
TGACAGCATGATTCGCTTTGATATGAGTGAGTATATGGAAAAACATAGCGTAGCAAAACTCGTCGGAGCTCCTCCAGGTT
ACGTTGGCTACGAAGAGGCTGGGCAATTAACAGAACGCGTACGTCGTAATCCTTATTCTCTCATTTTACTTGATGAAATA
GAAAAAGCTCACCCAGATGTCATGCACATGTTCTTGCAAGTACTGGATGACGGACGTCTGACAGATGGACAAGGTCGGAC
AGTCAGTTTCAAAGATACGATTATCATTATGACTTCCAACGCCGGTACTGGAAAAGTTGAAGCAAACGTCGGATTCGGTG
CAGCGCGTGAAGGACGAACCAATTCTGTTATCGGTGAATTAGGGAACTTCTTCAGTCCAGAATTTATGAACCGTTTTGAT
GGTATTATTGAGTTCAAATCTCTTAGCAAAGAAAATCTCCTACAAATCGTAGATTTGATGCTTAAAGATGTCAATGAACG
GCTTGCCACGAATGACATTTACCTAGATGTAACAGATAAAGTCAAGGAAAAATTAGTTAATCTTGGTTACGATCCGAAAA
TGGGAGCTCGTCCACTTCGTCGGACAATCCAAGATCACATTGAGGATGCTATCACTGACTACTATCTTGAACATCCAAGC
GACAAAGAGCTCAAAGCTATCATGACAAGTAATGGTAAGATTGTCATCAAACCAGCTAAAAAATCTGAGAATAAATCCAA
GACAACAATAGATAACAATGCTAATTAG

Domains

Predicted by InterproScan.

C-terminal, D2-small domain, of ClpB protein (ClpB_D2-small)

(648-722)

ATPase family associated with various cellular activities (AAA) (AAA)

(154-273)

AAA domain (Cdc48 subfamily) (AAA_2)

(477-640)

AAA lid domain (AAA_lid_9)

(292-389)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  clpE Streptococcus pneumoniae Rx1

86.765

99.073

0.86
  clpE Streptococcus pneumoniae D39

86.765

99.073

0.86
  clpE Streptococcus pneumoniae R6

86.765

99.073

0.86
  clpE Streptococcus pneumoniae TIGR4

86.765

99.073

0.86
  clpE Streptococcus mutans UA159

84.901

100

0.849
  clpC Lactococcus lactis subsp. cremoris KW2

76.658

99.868

0.766
  clpC Bacillus subtilis subsp. subtilis str. 168

51.642

88.742

0.458
  clpC Lactococcus lactis subsp. lactis strain DGCC12653

47.393

86.358

0.409
  clpC Streptococcus pneumoniae Rx1

48.226

82.119

0.396
  clpC Streptococcus pneumoniae D39

48.226

82.119

0.396
  clpC Streptococcus pneumoniae TIGR4

48.065

82.119

0.395
  clpC Streptococcus thermophilus LMG 18311

46.955

82.649

0.388
  clpC Streptococcus thermophilus LMD-9

47.03

82.517

0.388
  clpC Streptococcus mutans UA159

47.011

81.987

0.385

Multiple sequence alignment