Detailed information    

insolico Bioinformatically predicted

Overview

Name   endA   Type   Machinery gene
Locus tag   I6H78_RS03975 Genome accession   NZ_CP066059
Coordinates   844188..845012 (-) Length   274 a.a.
NCBI ID   WP_198460149.1    Uniprot ID   A0A7T4IU54
Organism   Streptococcus oralis strain FDAARGOS_1021     
Function   cleavage of dsDNA into ssDNA (predicted from homology)   
DNA processing

Genomic Context

Location: 839188..850012
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  I6H78_RS03960 (I6H78_03960) amiA 840225..842204 (-) 1980 WP_198460147.1 peptide ABC transporter substrate-binding protein Regulator
  I6H78_RS03970 (I6H78_03970) - 842721..844052 (-) 1332 WP_198460148.1 hemolysin family protein -
  I6H78_RS03975 (I6H78_03975) endA 844188..845012 (-) 825 WP_198460149.1 DNA/RNA non-specific endonuclease Machinery gene
  I6H78_RS03980 (I6H78_03980) - 845053..845247 (-) 195 WP_198460150.1 DNA-directed RNA polymerase subunit beta -
  I6H78_RS03985 (I6H78_03985) murA 845234..846517 (-) 1284 WP_198460151.1 UDP-N-acetylglucosamine 1-carboxyvinyltransferase -
  I6H78_RS03990 (I6H78_03990) - 846541..846771 (-) 231 WP_002892633.1 DUF1146 family protein -
  I6H78_RS03995 (I6H78_03995) sepM 846827..847864 (-) 1038 WP_084939620.1 SepM family pheromone-processing serine protease Regulator
  I6H78_RS04000 (I6H78_04000) coaD 847848..848336 (-) 489 WP_084872220.1 pantetheine-phosphate adenylyltransferase -
  I6H78_RS04005 (I6H78_04005) rsmD 848326..848865 (-) 540 WP_198460152.1 16S rRNA (guanine(966)-N(2))-methyltransferase RsmD -
  I6H78_RS04010 (I6H78_04010) asnA 848930..849922 (-) 993 WP_000747987.1 aspartate--ammonia ligase -

Sequence

Protein


Download         Length: 274 a.a.        Molecular weight: 30016.60 Da        Isoelectric Point: 9.5989

>NTDB_id=516951 I6H78_RS03975 WP_198460149.1 844188..845012(-) (endA) [Streptococcus oralis strain FDAARGOS_1021]
MDKKTRQALIGLLIFLLLAAGSYYIKQMQTAPNTPRTKVSQKKQDSEAPSQELAESVLTESIKNQIKGNLEWNGAGAFIV
NGNKTNLDAKVSSKPYADNKTKTVGKETVPTVANAILSKATRQYKNREETGNGSTSWTPPGWHQVKNLKGAYTHAVDRGH
LLGYALIGGLDGFDASTSNPKNIAVQTAWANQAQAEDSTGQNYYESLVRKALDQNKRVRYRVTLHYATNEDLVPSASQIE
AKSSDGELEFNVLIPNVQKGIQLDYQTGQVTVTD

Nucleotide


Download         Length: 825 bp        

>NTDB_id=516951 I6H78_RS03975 WP_198460149.1 844188..845012(-) (endA) [Streptococcus oralis strain FDAARGOS_1021]
ATGGACAAAAAAACAAGACAGGCTCTGATAGGGCTACTCATATTCTTACTCTTGGCTGCTGGAAGCTATTACATCAAGCA
GATGCAGACAGCGCCAAACACCCCTAGAACCAAGGTTAGTCAGAAAAAACAAGATTCAGAAGCTCCCAGTCAGGAGCTGG
CAGAAAGTGTCTTAACTGAGTCAATCAAAAACCAAATCAAGGGAAATCTCGAGTGGAATGGAGCAGGGGCCTTCATTGTC
AATGGCAATAAAACCAATCTAGATGCCAAGGTTTCTAGCAAACCCTATGCGGATAATAAAACAAAGACAGTTGGAAAAGA
AACAGTCCCGACTGTTGCCAATGCCATCTTATCCAAAGCGACTCGGCAGTATAAGAATCGTGAAGAGACTGGAAATGGCT
CAACCTCTTGGACGCCACCAGGATGGCATCAGGTCAAGAATCTAAAGGGAGCCTATACACATGCAGTTGATAGAGGACAT
CTGCTGGGCTATGCCTTGATAGGTGGTTTGGATGGTTTTGATGCTTCTACTAGCAATCCCAAGAACATTGCAGTTCAGAC
AGCTTGGGCAAACCAAGCACAGGCTGAGGATTCGACAGGTCAGAACTACTATGAGAGTCTAGTCAGAAAAGCCTTGGACC
AAAATAAGAGGGTCCGTTATCGGGTGACACTCCACTATGCGACAAATGAGGATTTAGTTCCATCCGCTTCACAAATCGAA
GCCAAGTCTTCAGATGGCGAATTGGAATTCAATGTCCTAATCCCCAATGTTCAAAAGGGAATCCAGCTTGATTACCAAAC
AGGTCAAGTAACGGTGACAGATTAG

Domains

Predicted by InterproScan.

DNA/RNA non-specific endonuclease (Endonuclease_NS)

(76-273)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A7T4IU54

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  endA Streptococcus pneumoniae Rx1

88.645

99.635

0.883
  endA Streptococcus pneumoniae D39

88.645

99.635

0.883
  endA Streptococcus pneumoniae R6

88.645

99.635

0.883
  endA Streptococcus pneumoniae TIGR4

88.645

99.635

0.883