Detailed information NTG0515007

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: I1A60_RS09955
• Genome accession: NZ_CP065857
• Coordinates: 2032122..2033165 (-)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus strain CC1153-MRSA
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 2027122..2038165

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
I1A60_RS09925 (I1A60_09925)	-	2027544..2028800 (-)	1257	WP_001793428.1	aminopeptidase	-
I1A60_RS09930 (I1A60_09930)	-	2028803..2029003 (-)	201	WP_000180460.1	DUF1128 family protein	-
I1A60_RS09935 (I1A60_09935)	-	2029150..2029614 (+)	465	WP_000228666.1	low molecular weight protein-tyrosine-phosphatase	-
I1A60_RS09940 (I1A60_09940)	-	2029621..2029896 (+)	276	WP_000428172.1	YtxH domain-containing protein	-
I1A60_RS09945 (I1A60_09945)	-	2030174..2031391 (+)	1218	WP_000037078.1	YihY/virulence factor BrkB family protein	-
I1A60_RS09950 (I1A60_09950)	vraR	2031503..2032132 (-)	630	WP_000153530.1	two-component system response regulator VraR	Regulator
I1A60_RS09955 (I1A60_09955)	vraS	2032122..2033165 (-)	1044	WP_001017131.1	sensor histidine kinase	Regulator
I1A60_RS09960 (I1A60_09960)	liaF	2033162..2033863 (-)	702	WP_000149064.1	cell wall-active antibiotics response protein LiaF	-
I1A60_RS09965 (I1A60_09965)	-	2033878..2034264 (-)	387	WP_001110179.1	hypothetical protein	-
I1A60_RS09970 (I1A60_09970)	map	2034481..2035239 (-)	759	WP_000636142.1	type I methionyl aminopeptidase	-
I1A60_RS09975 (I1A60_09975)	-	2035770..2036756 (+)	987	WP_000999713.1	FUSC family protein	-
I1A60_RS09980 (I1A60_09980)	-	2037187..2037600 (-)	414	WP_001566709.1	hypothetical protein	-
I1A60_RS09985 (I1A60_09985)	-	2037629..2037739 (-)	111	WP_001790257.1	hypothetical protein	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=515007 I1A60_RS09955 WP_001017131.1 2032122..2033165(-) (vraS) [Staphylococcus aureus strain CC1153-MRSA]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=515007 I1A60_RS09955 WP_001017131.1 2032122..2033165(-) (vraS) [Staphylococcus aureus strain CC1153-MRSA]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTGTTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTCTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTACTCGCTTACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACACTCGTACCTTTAAATCAAGAATTGCATAAGTTGCGACTTAAAACTCAAAACTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTAGCACGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTATCTGCTATCAAAGAAACGAAGTTAGAACCACCATTAGACCAACAAATTCC
TATTTTAGAGAAAATGGTTCAAGATTCGCAGTTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCAATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGATAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1