Detailed information    

insolico Bioinformatically predicted

Overview

Name   ccrA   Type   Machinery gene
Locus tag   I1A60_RS00205 Genome accession   NZ_CP065857
Coordinates   48087..49436 (-) Length   449 a.a.
NCBI ID   WP_002486190.1    Uniprot ID   -
Organism   Staphylococcus aureus strain CC1153-MRSA     
Function   promote SCCmec transfer (predicted from homology)   
Homologous recombination

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type MGE coordinates Gene coordinates Relative position Distance (bp)
SCCmec 39730..49436 48087..49436 within 0


Gene organization within MGE regions


Location: 39730..49436
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  I1A60_RS00165 (I1A60_00165) mecA 39730..41739 (-) 2010 WP_001801873.1 PBP2a family beta-lactam-resistant peptidoglycan transpeptidase MecA -
  I1A60_RS00170 (I1A60_00170) - 41836..42822 (+) 987 WP_001549960.1 beta-lactam sensor/signal transducer MecR1 -
  I1A60_RS00175 (I1A60_00175) - 42812..43054 (+) 243 Protein_32 type I restriction enzyme endonuclease domain-containing protein -
  I1A60_RS00180 (I1A60_00180) - 43045..44655 (-) 1611 Protein_33 IS1182 family transposase -
  I1A60_RS00185 (I1A60_00185) - 44704..45210 (-) 507 WP_001092189.1 DUF1643 domain-containing protein -
  I1A60_RS00190 (I1A60_00190) - 45226..45537 (-) 312 WP_023604760.1 DUF960 family protein -
  I1A60_RS00195 (I1A60_00195) - 45624..45974 (-) 351 WP_002486173.1 SAUGI family uracil-DNA glycosylase inhibitor -
  I1A60_RS00200 (I1A60_00200) ccrB 46440..48065 (-) 1626 WP_002486185.1 cassette chromosome recombinase CcrB Machinery gene
  I1A60_RS00205 (I1A60_00205) ccrA 48087..49436 (-) 1350 WP_002486190.1 cassette chromosome recombinase CcrA Machinery gene

Sequence

Protein


Download         Length: 449 a.a.        Molecular weight: 52522.37 Da        Isoelectric Point: 9.9738

>NTDB_id=514974 I1A60_RS00205 WP_002486190.1 48087..49436(-) (ccrA) [Staphylococcus aureus strain CC1153-MRSA]
MKQAIGYLRQSTTKQQSLAAQKQTIEALAKKHNIQYITFYSDKQSGRTDKRNGYQQITELIQQGQCDVLCCYRLNRLHRN
LKNALKLMKLCQKYHVHILSVHDGYFDMDKAFDRLKLNIFISLAELESDNIGEQVKNGIKEKAKQGKMITTHAPFGYHYH
NGTFTIDTVKAPTVKAVFNYYLQGYGYKKIAQYLEADDKFINRKPYQVRNIILNPNYCGRVINQYGQYENMFPAIVSTTI
YEEAQVTRTQKPVKRKPSENQLKQKIKCPYCDSTLTNMTIRKKHHTLRYYVCPQNMNASRFVCEFKGINAQELETSVLAT
CQDFFQNQQLYSKINHTIQQRLKRQRDIETKTTLNHEQLIEKLAQGKIDAETFREQTQSLRQQSKPISSISTYQIRKAFQ
NIIQQRFTLNMLYPYIDEINISKNKSLAGIYFKNEPLNIVKQTMELSIV

Nucleotide


Download         Length: 1350 bp        

>NTDB_id=514974 I1A60_RS00205 WP_002486190.1 48087..49436(-) (ccrA) [Staphylococcus aureus strain CC1153-MRSA]
ATGAAACAAGCAATAGGTTACTTACGACAGAGCACTACAAAGCAACAATCCTTAGCAGCACAAAAACAAACCATCGAGGC
ATTAGCCAAAAAACATAATATTCAATACATTACCTTTTATAGCGATAAGCAATCAGGACGCACTGATAAGCGGAACGGTT
ACCAACAAATTACTGAACTGATTCAACAAGGACAATGTGATGTATTATGTTGTTACAGATTAAACCGACTTCATCGCAAT
CTTAAAAATGCATTAAAACTCATGAAATTGTGTCAAAAATACCATGTCCATATCTTAAGCGTTCATGATGGCTATTTTGA
TATGGATAAAGCATTCGATCGGCTCAAACTCAATATTTTCATCAGCTTGGCCGAACTAGAATCTGATAATATAGGCGAAC
AAGTCAAAAATGGAATCAAAGAAAAAGCGAAACAAGGTAAAATGATTACAACACATGCACCCTTTGGGTATCACTATCAT
AATGGTACTTTCACGATAGACACAGTAAAAGCACCAACAGTAAAAGCTGTGTTCAATTATTACCTTCAAGGTTATGGTTA
TAAAAAAATTGCGCAATACTTAGAAGCTGATGATAAATTCATTAATCGTAAGCCCTATCAAGTGCGTAATATTATCCTTA
ACCCTAATTACTGTGGCCGTGTTATCAATCAATACGGACAATATGAAAACATGTTCCCAGCTATTGTCAGTACAACGATA
TACGAAGAAGCTCAAGTTACCCGAACTCAGAAACCAGTAAAACGTAAGCCGTCAGAAAACCAACTCAAACAAAAAATCAA
ATGTCCTTATTGTGATTCAACACTAACTAATATGACCATTAGAAAAAAGCACCATACATTACGTTATTATGTTTGTCCTC
AAAATATGAATGCATCTCGTTTTGTCTGTGAATTCAAAGGGATCAACGCACAAGAATTAGAAACAAGTGTTTTAGCGACT
TGTCAGGACTTCTTTCAAAATCAACAGCTCTATTCAAAAATAAACCATACTATTCAACAACGACTCAAAAGACAAAGAGA
TATAGAAACTAAAACTACACTCAATCACGAGCAGCTGATAGAAAAATTAGCCCAAGGCAAAATTGATGCAGAAACGTTCA
GAGAACAAACGCAATCATTACGTCAGCAATCAAAACCTATATCATCAATCAGTACGTATCAAATTCGAAAAGCTTTCCAA
AACATCATTCAACAACGTTTCACGCTAAACATGTTGTACCCCTATATTGATGAAATTAATATTTCTAAAAATAAAAGCCT
CGCTGGCATCTATTTCAAAAATGAACCACTGAATATTGTAAAGCAGACTATGGAATTATCAATTGTATAA

Domains

Predicted by InterproScan.

Resolvase, N terminal domain (Resolvase)

(4-147)

Recombinase (Recombinase)

(170-249)

Recombinase zinc beta ribbon domain (Zn_ribbon_recom)

(262-322)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  ccrA Staphylococcus aureus COL

99.777

100

0.998
  ccrA Staphylococcus aureus N315

75.056

100

0.751