Detailed information    

insolico Bioinformatically predicted

Overview

Name   pepF   Type   Regulator
Locus tag   I8F59_RS11840 Genome accession   NZ_CP065784
Coordinates   2377518..2379329 (-) Length   603 a.a.
NCBI ID   WP_002356480.1    Uniprot ID   -
Organism   Enterococcus faecalis strain 18-243     
Function   degradation of XIP; competence shut-off (predicted from homology)   
Competence regulation

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type MGE coordinates Gene coordinates Relative position Distance (bp)
ICE 2365196..2415554 2377518..2379329 within 0


Gene organization within MGE regions


Location: 2365196..2415554
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  I8F59_RS11785 (I8F59_11785) - 2367648..2368292 (-) 645 WP_002411327.1 histidine phosphatase family protein -
  I8F59_RS11790 (I8F59_11790) trmL 2368509..2369015 (-) 507 WP_002356493.1 tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL -
  I8F59_RS11795 (I8F59_11795) - 2369328..2370173 (-) 846 WP_002362549.1 methyltransferase domain-containing protein -
  I8F59_RS11800 (I8F59_11800) cutC 2370303..2370932 (+) 630 WP_002359565.1 copper homeostasis protein CutC -
  I8F59_RS11805 (I8F59_11805) mgtE 2371050..2372411 (-) 1362 WP_002362548.1 magnesium transporter -
  I8F59_RS11810 (I8F59_11810) - 2372442..2373335 (-) 894 WP_002362547.1 RluA family pseudouridine synthase -
  I8F59_RS11815 (I8F59_11815) - 2373343..2374140 (-) 798 WP_002356486.1 NAD kinase -
  I8F59_RS11820 (I8F59_11820) - 2374153..2374827 (-) 675 WP_002356484.1 GTP pyrophosphokinase family protein -
  I8F59_RS11825 (I8F59_11825) - 2375024..2375602 (+) 579 WP_002356483.1 CYTH domain-containing protein -
  I8F59_RS11830 (I8F59_11830) - 2375666..2376325 (+) 660 WP_002362545.1 ClpXP adapter SpxH family protein -
  I8F59_RS11835 (I8F59_11835) - 2376608..2377327 (-) 720 WP_002356481.1 helix-turn-helix transcriptional regulator -
  I8F59_RS11840 (I8F59_11840) pepF 2377518..2379329 (-) 1812 WP_002356480.1 oligoendopeptidase F Regulator
  I8F59_RS11845 (I8F59_11845) - 2379377..2380555 (-) 1179 WP_142954345.1 competence protein CoiA -
  I8F59_RS11850 (I8F59_11850) - 2380644..2381306 (-) 663 WP_002356478.1 adaptor protein MecA -
  I8F59_RS11855 (I8F59_11855) spxA 2381649..2382047 (-) 399 WP_002356477.1 transcriptional regulator SpxA -
  I8F59_RS11860 (I8F59_11860) trpS 2382407..2383417 (+) 1011 WP_002359559.1 tryptophan--tRNA ligase -
  I8F59_RS11865 (I8F59_11865) - 2383461..2385176 (-) 1716 WP_002394119.1 ABC transporter ATP-binding protein -
  I8F59_RS11870 (I8F59_11870) - 2385504..2386217 (+) 714 WP_002356474.1 HAD family hydrolase -
  I8F59_RS11875 (I8F59_11875) - 2386254..2387201 (-) 948 WP_002400957.1 DUF916 and DUF3324 domain-containing protein -
  I8F59_RS11880 (I8F59_11880) elrD 2387276..2388052 (-) 777 WP_002362542.1 WxL domain-containing protein ElrD -
  I8F59_RS11885 (I8F59_11885) elrC 2388092..2388874 (-) 783 WP_002362540.1 WxL domain-containing protein ElrC -
  I8F59_RS11890 (I8F59_11890) - 2389242..2389556 (+) 315 WP_000420682.1 YdcP family protein -
  I8F59_RS11895 (I8F59_11895) - 2389572..2389958 (+) 387 WP_000985015.1 YdcP family protein -
  I8F59_RS11900 (I8F59_11900) - 2389987..2391372 (+) 1386 WP_000813488.1 FtsK/SpoIIIE domain-containing protein -
  I8F59_RS11905 (I8F59_11905) - 2391375..2391527 (+) 153 WP_000879507.1 hypothetical protein -
  I8F59_RS11910 (I8F59_11910) mobT 2391550..2392755 (+) 1206 WP_000398284.1 MobT family relaxase -
  I8F59_RS11915 (I8F59_11915) - 2392798..2393019 (+) 222 WP_001009056.1 hypothetical protein -
  I8F59_RS11920 (I8F59_11920) - 2393136..2393633 (+) 498 WP_000342539.1 antirestriction protein ArdA -
  I8F59_RS11925 (I8F59_11925) - 2393722..2394114 (+) 393 WP_000723888.1 conjugal transfer protein -
  I8F59_RS11930 (I8F59_11930) - 2394098..2396545 (+) 2448 WP_000331160.1 ATP-binding protein -
  I8F59_RS11935 (I8F59_11935) - 2396548..2398725 (+) 2178 WP_000804748.1 CD3337/EF1877 family mobilome membrane protein -
  I8F59_RS11940 (I8F59_11940) - 2398722..2399723 (+) 1002 WP_000769868.1 lysozyme family protein -
  I8F59_RS11945 (I8F59_11945) - 2399720..2400652 (+) 933 WP_001224318.1 conjugal transfer protein -
  I8F59_RS15580 - 2400966..2401013 (+) 48 Protein_2339 hypothetical protein -
  I8F59_RS11955 (I8F59_11955) tet(M) 2401029..2402948 (+) 1920 WP_000691749.1 tetracycline resistance ribosomal protection protein Tet(M) -
  I8F59_RS11960 (I8F59_11960) - 2403067..2403234 (+) 168 WP_000336323.1 cysteine-rich KTR domain-containing protein -
  I8F59_RS11965 (I8F59_11965) - 2403294..2403647 (-) 354 WP_001227347.1 helix-turn-helix transcriptional regulator -
  I8F59_RS11970 (I8F59_11970) - 2404152..2404574 (+) 423 WP_000804885.1 sigma-70 family RNA polymerase sigma factor -
  I8F59_RS11975 (I8F59_11975) - 2404571..2404801 (+) 231 WP_000857133.1 helix-turn-helix domain-containing protein -
  I8F59_RS15435 - 2405027..2405278 (-) 252 WP_001845478.1 hypothetical protein -
  I8F59_RS11980 (I8F59_11980) - 2405262..2405465 (+) 204 WP_000814511.1 excisionase -
  I8F59_RS11985 (I8F59_11985) - 2405547..2406764 (+) 1218 WP_001291561.1 tyrosine-type recombinase/integrase -
  I8F59_RS11990 (I8F59_11990) elrB 2406926..2407282 (-) 357 WP_202496619.1 LPXTG anchor domain-containing protein ElrB -
  I8F59_RS11995 (I8F59_11995) elrA 2407286..2409457 (-) 2172 WP_002392868.1 enterococcal leucine-rich protein ElrA -
  I8F59_RS12000 (I8F59_12000) elrR 2409647..2410552 (-) 906 WP_002400960.1 Rgg family transcriptional regulator ElrR -
  I8F59_RS12005 (I8F59_12005) - 2410620..2413817 (-) 3198 WP_002404069.1 DEAD/DEAH box helicase -

Sequence

Protein


Download         Length: 603 a.a.        Molecular weight: 68835.12 Da        Isoelectric Point: 4.7145

>NTDB_id=514225 I8F59_RS11840 WP_002356480.1 2377518..2379329(-) (pepF) [Enterococcus faecalis strain 18-243]
MSEIKQLPTRDEVPTPLTWDLTKIFKDDAAFDVAYNQLTEELNQAESFKGTLGNGAEAFLAALEYVLDVYRKVETLYVYS
HLKNDQDTTNTAYQALYARASSLYAQVSEAVSWFDPEVLTLSDEQIWGYFEEQPKLAVYRHYIQNILDERPHVLSMEQEA
LLAGASEIFGASSNTFSILNNADLEFPTVQNAEGETIQLSHGVYGQLMESVDPSVREAAFKGLYKVYKQFRNTLASTLGA
HVKTHNYKAKIRNYDSARAASLASNHIPESVHETLVAVVNKHLPLLHRYVKLRKKLLNVEELHMYDLYAPLLGEAPIRYS
YEEAKEKAIEALKPLGEDYLSIVKEAFSSRWIDVIENQGKRSGAYSSGAYDTAPYILMNWHDSLDQLFTLVHEMGHSVHS
YYTRNNQPYVYGDYSIFLAEIASTTNENILTEYLLQTETDPKVRAYVLNHYLDGFKGTIFRQTQFAEFEHFIHTEDAKGT
PLTSEYLSEYYGELNAKYYGPEVVRDEEISYEWARIPHFYYNYYVYQYATGFSAASALSKHILAGEEGALENYLNYLKAG
SSDFPIEVMKKAGVDMTQAAYIEDAMKVFEERLTELEALVEKL

Nucleotide


Download         Length: 1812 bp        

>NTDB_id=514225 I8F59_RS11840 WP_002356480.1 2377518..2379329(-) (pepF) [Enterococcus faecalis strain 18-243]
ATGAGCGAAATTAAACAATTACCAACACGTGATGAAGTTCCAACTCCATTGACTTGGGATTTAACCAAAATTTTTAAAGA
TGATGCTGCTTTTGATGTTGCGTATAATCAGTTGACAGAGGAGCTAAATCAAGCAGAGTCATTTAAAGGTACCTTAGGGA
ATGGCGCAGAAGCTTTTCTAGCTGCGTTAGAATACGTTTTAGATGTCTATCGAAAAGTGGAAACATTATATGTCTATTCT
CATTTAAAAAATGATCAAGACACTACAAATACAGCTTACCAAGCTTTATATGCCAGAGCTAGTTCTCTATATGCACAAGT
TAGTGAAGCTGTTTCTTGGTTTGACCCAGAGGTTTTAACATTAAGTGATGAACAAATCTGGGGATATTTTGAAGAGCAGC
CCAAATTAGCTGTTTATCGTCACTATATTCAAAATATTTTAGATGAACGTCCCCATGTTTTATCGATGGAACAAGAAGCT
TTACTGGCGGGGGCTAGTGAAATTTTTGGTGCCTCAAGTAATACATTTTCAATTTTAAATAATGCAGATTTAGAATTTCC
AACTGTGCAAAATGCTGAAGGCGAAACAATTCAACTTTCTCATGGCGTTTATGGTCAATTAATGGAGAGTGTCGATCCAT
CTGTTCGTGAAGCAGCATTTAAAGGGTTGTACAAAGTGTACAAACAATTTAGAAATACATTAGCCTCAACTTTAGGTGCA
CATGTTAAAACGCATAATTATAAAGCAAAAATTAGAAATTATGATTCTGCTCGGGCAGCCTCTTTAGCAAGTAATCATAT
CCCTGAAAGTGTTCACGAAACATTAGTAGCTGTAGTAAATAAACATTTACCTTTGCTACATCGTTATGTAAAATTAAGAA
AAAAATTATTAAACGTAGAAGAATTACACATGTACGACTTGTATGCGCCTTTGCTAGGTGAAGCACCAATTCGTTACAGC
TATGAAGAAGCAAAAGAAAAAGCAATTGAGGCTTTAAAACCACTAGGTGAAGACTATTTATCTATTGTTAAAGAAGCTTT
TTCAAGTCGCTGGATTGATGTGATTGAAAATCAAGGAAAACGAAGCGGCGCATATTCTTCCGGAGCTTATGATACAGCCC
CATACATTTTAATGAATTGGCATGATAGTTTGGATCAACTATTTACATTAGTCCATGAGATGGGTCATAGTGTTCATAGT
TACTATACAAGAAATAATCAGCCGTATGTTTATGGCGACTATTCAATTTTCTTAGCTGAGATTGCTTCAACCACAAATGA
AAATATTTTAACAGAATATTTATTACAAACAGAAACAGATCCTAAAGTACGTGCGTATGTCTTAAATCACTATTTAGACG
GCTTTAAGGGAACCATTTTCCGTCAAACACAATTTGCGGAATTTGAACATTTTATTCACACGGAAGATGCTAAAGGCACG
CCATTAACGAGTGAATATTTGAGTGAGTATTATGGCGAGCTCAATGCTAAATATTATGGACCAGAAGTAGTTAGAGACGA
AGAAATCAGTTACGAATGGGCGAGAATTCCCCATTTTTATTACAATTACTATGTTTATCAATATGCAACTGGCTTCTCAG
CCGCTTCGGCATTGTCTAAACATATTTTAGCTGGAGAAGAGGGAGCTTTAGAGAACTACCTTAACTACTTGAAAGCAGGA
AGTAGTGACTTCCCAATTGAAGTGATGAAAAAAGCGGGCGTGGATATGACACAAGCCGCGTATATCGAAGATGCAATGAA
AGTTTTTGAAGAACGTTTAACGGAATTAGAAGCTTTGGTTGAAAAATTATAA

Domains

Predicted by InterproScan.

Peptidase family M3 (Peptidase_M3)

(207-587)

Oligopeptidase F (Peptidase_M3_N)

(117-186)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  pepF Streptococcus salivarius strain HSISS4

54.637

98.342

0.537