Detailed information    

insolico Bioinformatically predicted

Overview

Name   ciaH   Type   Regulator
Locus tag   I6G42_RS05965 Genome accession   NZ_CP065707
Coordinates   1219982..1221319 (+) Length   445 a.a.
NCBI ID   WP_000482352.1    Uniprot ID   A0A7T3DYE6
Organism   Streptococcus oralis strain FDAARGOS_885     
Function   repress competence development; post-transcriptional repression of CSP production (predicted from homology)   
Competence regulation

Genomic Context

Location: 1214982..1226319
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  I6G42_RS05940 (I6G42_05940) - 1215085..1215444 (+) 360 WP_000800853.1 hypothetical protein -
  I6G42_RS05945 (I6G42_05945) - 1215478..1216074 (+) 597 WP_001101063.1 DUF6707 family protein -
  I6G42_RS05950 (I6G42_05950) - 1216099..1216539 (+) 441 WP_000188803.1 ASCH domain-containing protein -
  I6G42_RS05955 (I6G42_05955) - 1216662..1219208 (+) 2547 WP_001149137.1 M1 family metallopeptidase -
  I6G42_RS05960 (I6G42_05960) ciaR 1219318..1219992 (+) 675 WP_000590630.1 two-component system response regulator CiaR Regulator
  I6G42_RS05965 (I6G42_05965) ciaH 1219982..1221319 (+) 1338 WP_000482352.1 sensor histidine kinase Regulator
  I6G42_RS05970 (I6G42_05970) - 1221384..1221668 (-) 285 WP_001111509.1 DUF3270 domain-containing protein -
  I6G42_RS05975 (I6G42_05975) - 1222054..1223109 (+) 1056 WP_000280274.1 ABC transporter permease -
  I6G42_RS05980 (I6G42_05980) - 1223123..1223803 (+) 681 WP_000125736.1 ABC transporter ATP-binding protein -
  I6G42_RS05985 (I6G42_05985) - 1223929..1224858 (+) 930 WP_038805085.1 peptidase U32 family protein -
  I6G42_RS05990 (I6G42_05990) rpiA 1224963..1225646 (+) 684 WP_038805086.1 ribose-5-phosphate isomerase RpiA -

Sequence

Protein


Download         Length: 445 a.a.        Molecular weight: 50799.53 Da        Isoelectric Point: 9.5602

>NTDB_id=513307 I6G42_RS05965 WP_000482352.1 1219982..1221319(+) (ciaH) [Streptococcus oralis strain FDAARGOS_885]
MFNKLKKTWYADDFSYFIRNFGVFTLIFSAMTLIILQVMHSSLYTSVDEKLQALSTSPQAVIQLALNRATEEVKDIQPAT
ADASKAEIKPNVSSNTEVLLFDKDFNQLLLGNRFLGLDKIKLDKKELNHIRQIQVVNSYGQEETYRMILMETNSSTVSSN
VKYAAVLINTSQLEQISQNHEHLIVVVMASFWLLSLIASVYLARVSVKPLLESMQKQKSFVENASHELRTPLAVLQNRLE
TLFRKPEATIMESSESIASSLEEVRNMRFLTTNLLNLARRDDGLKPEIAEVSPQFFKTTFTNYELIASENDRVFDYENRI
YRPFMTDQLLLKQLMTILFDNAIKYTEEDGKIEFVVYATDRHLYLTVADNGIGISAADKKKIFDRFYRVDKARTRQKGGF
GLGLSLAKQIVDALRGTISVKDNKPRGTIFEVKVAIQSPPKRKNK

Nucleotide


Download         Length: 1338 bp        

>NTDB_id=513307 I6G42_RS05965 WP_000482352.1 1219982..1221319(+) (ciaH) [Streptococcus oralis strain FDAARGOS_885]
ATGTTCAATAAACTAAAAAAAACATGGTATGCGGATGATTTCAGTTATTTCATTCGAAACTTTGGAGTGTTCACCCTGAT
CTTCTCTGCTATGACCTTGATTATCCTTCAGGTCATGCACTCGAGTCTCTACACTTCTGTAGATGAAAAACTACAAGCCC
TTAGCACTAGCCCTCAAGCTGTCATCCAATTAGCCCTTAATCGGGCAACTGAAGAAGTCAAAGATATTCAACCAGCAACA
GCGGATGCCAGCAAGGCTGAAATCAAGCCCAATGTCAGCTCCAATACGGAAGTCTTGCTCTTTGACAAGGATTTTAACCA
ACTCTTACTGGGTAACCGCTTTTTAGGCTTGGACAAGATCAAACTGGACAAGAAAGAGTTGAATCATATTCGGCAAATCC
AAGTTGTCAATAGCTACGGTCAGGAAGAAACCTACCGAATGATCTTGATGGAAACAAATTCGTCCACTGTTTCAAGCAAT
GTTAAATATGCGGCGGTTCTAATCAATACCAGCCAGCTTGAGCAAATCAGCCAAAATCACGAGCATTTAATTGTTGTAGT
CATGGCTAGTTTCTGGCTCCTGTCTTTAATTGCCAGTGTTTACTTGGCACGTGTCAGTGTCAAACCCTTGCTGGAAAGTA
TGCAAAAGCAGAAGTCCTTTGTTGAAAATGCAAGCCACGAACTGAGAACACCTTTGGCTGTTTTACAAAATCGTTTAGAG
ACTCTCTTTCGAAAACCAGAAGCGACGATCATGGAATCCAGCGAAAGTATTGCTTCTAGCCTCGAAGAAGTTCGGAATAT
GCGTTTCCTTACAACCAACCTTCTCAATTTAGCACGTCGAGATGATGGACTTAAGCCAGAAATAGCAGAAGTTTCTCCAC
AATTCTTTAAAACCACCTTTACCAACTATGAGTTAATTGCTTCTGAAAATGATCGAGTTTTTGACTATGAAAATCGGATT
TATCGTCCCTTCATGACCGATCAGTTGCTCTTAAAACAACTCATGACCATCTTGTTTGATAATGCCATCAAGTATACCGA
AGAAGATGGAAAAATTGAGTTTGTGGTTTATGCTACAGATCGCCACCTCTATCTAACAGTAGCGGATAATGGGATTGGAA
TCTCAGCTGCTGACAAGAAGAAAATCTTTGACCGTTTTTACCGTGTAGACAAGGCGAGAACCCGTCAGAAAGGTGGCTTT
GGCCTTGGATTATCTTTGGCCAAGCAGATTGTTGATGCCTTACGAGGAACGATTAGCGTAAAAGATAACAAACCTAGAGG
AACGATTTTTGAAGTTAAAGTCGCTATCCAATCTCCTCCAAAACGAAAGAATAAATAA

Domains

Predicted by InterproScan.

His Kinase A (phospho-acceptor) domain (HisKA)

(218-283)

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c)

(327-434)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A7T3DYE6

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  ciaH Streptococcus pneumoniae Rx1

83.973

99.551

0.836
  ciaH Streptococcus pneumoniae D39

83.973

99.551

0.836
  ciaH Streptococcus pneumoniae R6

83.973

99.551

0.836
  ciaH Streptococcus pneumoniae TIGR4

83.973

99.551

0.836
  ciaH Streptococcus mutans UA159

55.023

98.427

0.542