Detailed information NTG0513177

Bioinformatically predicted

Overview

• Name: clpC
• Type: Regulator
• Locus tag: I6G43_RS00590
• Genome accession: NZ_CP065706
• Coordinates: 130190..132622 (-)
• Length: 810 a.a.
• NCBI ID: WP_001109728.1
• Uniprot ID: A0A7T3DU19
• Organism: Streptococcus oralis strain FDAARGOS_886
• Function: degradation of ComW (predicted from homology) Competence regulation

Genomic Context

Location: 125190..137622

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
I6G43_RS00565 (I6G43_00565)	dusB	125389..126369 (+)	981	WP_038805910.1	tRNA dihydrouridine synthase DusB	-
I6G43_RS00570 (I6G43_00570)	-	126436..127119 (-)	684	WP_038805911.1	hypothetical protein	-
I6G43_RS00575 (I6G43_00575)	-	127423..128196 (-)	774	WP_000763401.1	NUDIX domain-containing protein	-
I6G43_RS00580 (I6G43_00580)	pnuC	128198..128977 (-)	780	WP_000736878.1	nicotinamide riboside transporter PnuC	-
I6G43_RS00585 (I6G43_00585)	-	128987..130045 (-)	1059	WP_000730559.1	AAA family ATPase	-
I6G43_RS00590 (I6G43_00590)	clpC	130190..132622 (-)	2433	WP_001109728.1	ATP-dependent Clp protease ATP-binding subunit	Regulator
I6G43_RS00595 (I6G43_00595)	-	132624..133082 (-)	459	WP_001211263.1	CtsR family transcriptional regulator	-
I6G43_RS00600 (I6G43_00600)	-	133304..133474 (-)	171	WP_000841982.1	helix-turn-helix domain-containing protein	-
I6G43_RS00605 (I6G43_00605)	-	133471..133719 (-)	249	WP_000039417.1	hypothetical protein	-
I6G43_RS00610 (I6G43_00610)	-	133896..134198 (-)	303	WP_227698227.1	hypothetical protein	-
I6G43_RS00615 (I6G43_00615)	-	134214..134942 (-)	729	WP_000136237.1	ABC transporter ATP-binding protein	-
I6G43_RS00620 (I6G43_00620)	-	134942..135949 (-)	1008	WP_038805912.1	ABC transporter substrate-binding protein	-
I6G43_RS00625 (I6G43_00625)	-	135988..136746 (-)	759	WP_025168363.1	ABC transporter permease	-
I6G43_RS00630 (I6G43_00630)	-	136709..136999 (-)	291	WP_000647670.1	MTH1187 family thiamine-binding protein	-

Sequence

Protein

• Length: 810 a.a.
• Molecular weight: 90398.21 Da
• Isoelectric Point: 6.0781

>NTDB_id=513177 I6G43_RS00590 WP_001109728.1 130190..132622(-) (clpC) [Streptococcus oralis strain FDAARGOS_886]
MNYSKALNECIESAYMVASHFGARYLESWHLLIAMSNHSYSVAGATLNDYPYEMDRLEEVALELTETDYSQDETFTELPF
SHRLEVLFAEAEYVASVVHAKVLGTEHVLYAILHDGNALATRILERAGFSYEDQKDQVRIAALRRNLEERAGWTREDLKA
LRQRHRTVTDKQNSMANMMGMPQAQSGGLEDYTHDLTEQARSGKLEPVIGRDKEISRMIQILSRKTKNNPVLVGDAGVGK
TALALGLAQRIASGDVPAEMAKMRVLELDLMNVVAGTRFRGDFEERMNNIIKDIEEDGKVILFIDELHTIMGSGSGIDST
LDAANILKPALARGTLRTVGATTQEEYQKHIEKDAALSRRFAKVTIEEPSLADSMTILQGLKATYEKHHRVQITDEAVET
AVKMAHRYLTSRHLPDSAIDLLDEAAATVQNKSKHVKADESDLSPADKALMDGRWKQAAQLIAKEQEVPVYKDLVTETEI
LTTLSRLSGIPVQKLTQTDAKKYLNLEAELHKRVIGQDQAVSSISRAIRRNQSGIRSHKRPIGSFMFLGPTGVGKTELAK
ALAEVLFDDESALIRFDMSEYMEKFAASRLNGAPPGYVGYEEGGELTEKVRNKPYSVLLFDEVEKAHPDIFNVLLQVLDD
GVLTDSKGRKVDFSNTIIIMTSNLGATALRDDKTVGFGAKDIRFDQENMEKRIFEELKKTYRPEFINRIDEKVVFHSLDS
EHMQEIVKIMVKPLIASLAEKGIDLKLQASALKLLASHGYNPEMGARPLRRTLQTEVEDKLAELLLKGELVAGKTLKIGV
KAGQLKFDIA

Nucleotide

• Length: 2433 bp

>NTDB_id=513177 I6G43_RS00590 WP_001109728.1 130190..132622(-) (clpC) [Streptococcus oralis strain FDAARGOS_886]
ATGAACTATTCAAAAGCATTGAATGAATGTATCGAAAGTGCCTACATGGTTGCGAGCCATTTTGGAGCTCGTTACCTAGA
GTCATGGCACTTGTTGATTGCCATGTCCAATCACAGTTACAGCGTGGCAGGTGCGACTCTAAATGATTATCCTTATGAAA
TGGACCGTTTAGAAGAGGTTGCTTTAGAACTGACTGAAACCGACTATAGCCAAGATGAAACCTTTACGGAATTACCCTTT
TCCCATCGTTTAGAGGTCCTCTTTGCAGAAGCAGAGTACGTGGCCTCAGTGGTCCACGCAAAGGTGCTAGGGACAGAACA
TGTATTATATGCAATCTTGCATGATGGCAATGCCTTGGCAACTCGTATCTTGGAGAGAGCGGGCTTCTCTTATGAAGACC
AGAAAGATCAGGTCAGAATTGCCGCTCTTCGTCGCAATCTAGAAGAGCGTGCAGGATGGACTCGTGAAGACCTTAAGGCT
TTGCGTCAACGCCATCGCACAGTAACTGACAAGCAAAATTCCATGGCCAATATGATGGGCATGCCTCAAGCTCAAAGTGG
AGGCCTAGAGGATTACACGCATGACCTGACGGAGCAAGCGCGCTCTGGCAAGTTAGAGCCAGTTATCGGTCGTGACAAGG
AAATCTCACGTATGATTCAGATTTTGAGTCGTAAGACCAAGAACAATCCTGTCTTGGTTGGTGATGCTGGTGTTGGGAAA
ACAGCTCTGGCACTTGGACTTGCCCAGCGTATTGCTAGTGGGGACGTACCTGCAGAAATGGCAAAGATGCGTGTTCTAGA
GCTTGATTTGATGAATGTTGTTGCAGGGACACGTTTCCGTGGTGACTTTGAAGAACGTATGAACAACATCATCAAGGATA
TAGAGGAAGATGGCAAAGTGATTCTCTTTATCGATGAACTCCACACCATTATGGGTTCTGGAAGCGGTATTGACTCGACT
CTGGATGCGGCCAATATCTTGAAACCAGCCTTGGCGCGTGGAACTTTGAGAACGGTTGGTGCAACCACTCAGGAAGAATA
CCAAAAACACATCGAAAAAGATGCTGCCCTTTCTCGTCGTTTTGCCAAAGTTACGATTGAAGAGCCAAGTCTAGCTGACA
GCATGACTATTTTGCAAGGTTTGAAAGCGACCTATGAGAAACACCATCGTGTGCAAATCACAGATGAAGCCGTTGAAACA
GCTGTCAAGATGGCGCATCGTTACTTGACCAGTCGTCACTTACCAGACTCTGCTATCGACCTTTTGGATGAAGCGGCAGC
AACAGTGCAAAACAAATCCAAGCATGTGAAAGCAGACGAATCCGACTTGAGTCCAGCTGACAAGGCTCTGATGGATGGCA
GGTGGAAACAAGCTGCCCAGTTAATCGCAAAAGAGCAGGAAGTCCCTGTCTATAAAGACTTGGTGACAGAGACTGAAATT
TTGACTACCTTGAGTCGCTTGTCAGGGATTCCAGTCCAAAAATTGACGCAAACAGATGCTAAGAAATACCTGAATCTGGA
AGCCGAACTTCACAAACGGGTGATTGGTCAAGATCAGGCTGTTTCAAGTATTAGCCGTGCGATTCGCCGCAATCAGTCAG
GGATTCGCAGTCACAAGCGTCCGATTGGTTCCTTTATGTTCCTAGGACCGACGGGTGTCGGTAAGACCGAATTGGCCAAG
GCTCTGGCAGAAGTCCTCTTTGATGACGAATCAGCCCTTATCCGCTTTGATATGAGTGAATATATGGAGAAATTTGCAGC
TAGCCGTCTCAATGGAGCTCCTCCAGGCTATGTGGGCTACGAAGAAGGTGGGGAGTTGACGGAGAAGGTTCGCAACAAAC
CTTACTCTGTGCTCCTCTTTGACGAGGTAGAAAAGGCCCACCCAGACATCTTTAATGTCCTCTTGCAGGTTCTGGACGAC
GGTGTCTTGACAGATAGCAAGGGGCGCAAGGTTGATTTTTCAAATACCATTATTATCATGACGTCAAACCTTGGCGCGAC
GGCTCTTCGTGATGACAAGACTGTTGGCTTTGGCGCGAAAGACATTCGTTTCGACCAGGAAAATATGGAAAAACGAATCT
TTGAAGAGTTGAAAAAAACTTATCGACCAGAGTTTATCAACCGTATTGATGAAAAGGTGGTCTTCCACAGCTTGGATAGC
GAACACATGCAGGAAATCGTTAAGATTATGGTTAAACCATTGATTGCTAGTCTAGCAGAGAAGGGCATCGACTTGAAACT
ACAAGCTTCGGCACTGAAGTTGCTAGCTAGTCACGGTTACAATCCAGAAATGGGAGCTCGCCCACTTCGCAGAACACTGC
AAACAGAGGTGGAAGACAAGTTGGCAGAACTCCTCCTCAAGGGAGAACTGGTAGCAGGCAAGACCCTCAAGATAGGTGTC
AAAGCTGGACAATTGAAATTTGATATTGCTTAA

Domains

Predicted by InterproScan.

• AAA lid domain (AAA_lid_9) (371-444)

• AAA domain (Cdc48 subfamily) (AAA_2) (540-711)

• Clp amino terminal domain, pathogenicity island component (Clp_N) (103-133)

• Clp amino terminal domain, pathogenicity island component (Clp_N) (14-49)

• C-terminal, D2-small domain, of ClpB protein (ClpB_D2-small) (718-797)

• ATPase family associated with various cellular activities (AAA) (AAA) (231-362)

3D structure

• AlphaFold DB: A0A7T3DU19

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
clpC	Streptococcus pneumoniae Rx1	96.296	100	0.963
clpC	Streptococcus pneumoniae D39	96.296	100	0.963
clpC	Streptococcus pneumoniae TIGR4	96.296	100	0.963
clpC	Streptococcus mutans UA159	67.528	100	0.678
clpC	Streptococcus thermophilus LMD-9	67.076	100	0.674
clpC	Streptococcus thermophilus LMG 18311	66.953	100	0.673
clpC	Lactococcus lactis subsp. lactis strain DGCC12653	49.275	100	0.504
clpC	Bacillus subtilis subsp. subtilis str. 168	44.828	100	0.449
clpE	Streptococcus mutans UA159	48.71	76.543	0.373
clpC	Lactococcus lactis subsp. cremoris KW2	46.571	77.407	0.36