Detailed information NTG0512713

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: I6G70_RS02915
• Genome accession: NZ_CP065656
• Coordinates: 572667..573713 (+)
• Length: 348 a.a.
• NCBI ID: WP_001830374.1
• Uniprot ID: A0A0N1EGU4
• Organism: Staphylococcus epidermidis strain FDAARGOS_913
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 567667..578713

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
I6G70_RS02890 (I6G70_02890)	isaB	568808..569344 (+)	537	WP_001830372.1	immunodominant staphylococcal antigen IsaB family protein	-
I6G70_RS02895 (I6G70_02895)	-	569495..570481 (-)	987	WP_011082745.1	FUSC family protein	-
I6G70_RS02900 (I6G70_02900)	map	570655..571410 (+)	756	WP_002457092.1	type I methionyl aminopeptidase	-
I6G70_RS02905 (I6G70_02905)	-	571568..571954 (+)	387	WP_001830382.1	hypothetical protein	-
I6G70_RS02910 (I6G70_02910)	liaF	571969..572670 (+)	702	WP_002457093.1	cell wall-active antibiotics response protein LiaF	-
I6G70_RS02915 (I6G70_02915)	vraS	572667..573713 (+)	1047	WP_001830374.1	sensor histidine kinase	Regulator
I6G70_RS02920 (I6G70_02920)	vraR	573703..574332 (+)	630	WP_001830439.1	two-component system response regulator VraR	Regulator
I6G70_RS02925 (I6G70_02925)	-	574389..575567 (-)	1179	WP_002485151.1	YihY/virulence factor BrkB family protein	-
I6G70_RS02930 (I6G70_02930)	-	575974..576258 (-)	285	WP_001830401.1	YtxH domain-containing protein	-
I6G70_RS02935 (I6G70_02935)	-	576266..576730 (-)	465	WP_001830437.1	low molecular weight protein-tyrosine-phosphatase	-
I6G70_RS02940 (I6G70_02940)	-	576871..577086 (+)	216	WP_001830421.1	DUF1128 domain-containing protein	-
I6G70_RS02945 (I6G70_02945)	-	577088..578329 (+)	1242	WP_001832467.1	aminopeptidase	-

Sequence

Protein

• Length: 348 a.a.
• Molecular weight: 40066.49 Da
• Isoelectric Point: 5.8512

>NTDB_id=512713 I6G70_RS02915 WP_001830374.1 572667..573713(+) (vraS) [Staphylococcus epidermidis strain FDAARGOS_913]
MNHYIRAIGSMLILVYSMLIAFLFIDKVFVNIIFFQGMFYTQIFGIPVFLFLNLLIVLLCIIVGSVLAYKINQQNDWIIS
QIERSIEGQTVGINDQNIELYTETIDIYHTLVPLNQELHRLRMKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKESKLEPPLNQQIPILEKMVQDSQLEMRALLLHLRPIGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFEVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNQEDYLLLRIQDNGKGFNVDEKFEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEENSSGD

Nucleotide

• Length: 1047 bp

>NTDB_id=512713 I6G70_RS02915 WP_001830374.1 572667..573713(+) (vraS) [Staphylococcus epidermidis strain FDAARGOS_913]
ATGAATCACTACATAAGAGCTATAGGCTCAATGCTTATATTAGTATATAGTATGCTTATTGCTTTTTTATTTATTGATAA
AGTGTTTGTAAATATTATCTTTTTTCAGGGGATGTTTTATACACAAATATTTGGAATACCTGTTTTTCTATTTTTAAATT
TATTAATTGTTCTTTTATGTATTATAGTTGGATCTGTTTTAGCTTATAAAATTAATCAACAAAATGATTGGATTATTTCA
CAAATAGAAAGATCAATAGAAGGACAAACAGTAGGTATCAATGATCAAAATATCGAATTATATACAGAAACGATAGATAT
TTATCATACACTAGTTCCATTAAATCAAGAATTACATCGACTTAGAATGAAGACTCAAAATTTAACTAATGAAAACTACA
ATATTAATGATGTAAAAGTCAAAAAGATTATCGAAGATGAGCGACAACGACTTGCCAGGGAATTACATGATTCTGTTAGT
CAACAATTATTTGCTGCGAGCATGATGCTATCGGCGATAAAAGAGTCGAAATTAGAACCACCTTTAAATCAACAGATACC
AATTCTTGAAAAAATGGTTCAAGACTCACAACTTGAAATGAGAGCTTTGTTATTACATTTAAGACCGATAGGTTTAAAAG
ATAAGTCTTTAGGTGAAGGAATTAAAGATTTAGTCATCGATTTACAAAAGAAAGTACCAATGAAAGTTGTGCATGAAATT
CAAGATTTTGAAGTGCCAAAAGGCATTGAAGATCACTTGTTCAGAATTACACAAGAAGCTATTTCAAATACATTGAGACA
TTCAAATGGTACAAAAGTAACTGTGGAATTATTTAATCAAGAGGATTATCTTTTACTAAGAATTCAAGATAATGGAAAAG
GGTTTAATGTAGATGAAAAATTTGAACAAAGTTATGGTTTGAAAAATATGCGAGAACGAGCGTTAGAAATTGGTGCGACG
TTTCATATTGTATCTTTACCTGATTCAGGTACACGAATTGAAGTTAAGGCACCATTGAATAAGGAGGAGAATTCAAGTGG
CGATTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0N1EGU4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	93.023	98.851	0.92