Detailed information NTG0511565

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: IQE12_RS10240
• Genome accession: NZ_CP065515
• Coordinates: 2069657..2070700 (-)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus strain GDY8P96A
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 2064657..2075700

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
IQE12_RS10210 (IQE12_10210)	-	2065085..2066341 (-)	1257	WP_001793428.1	aminopeptidase	-
IQE12_RS10215 (IQE12_10215)	-	2066344..2066544 (-)	201	WP_000180460.1	DUF1128 family protein	-
IQE12_RS10220 (IQE12_10220)	-	2066691..2067155 (+)	465	WP_000228666.1	low molecular weight protein-tyrosine-phosphatase	-
IQE12_RS10225 (IQE12_10225)	-	2067162..2067437 (+)	276	WP_000428172.1	YtxH domain-containing protein	-
IQE12_RS10230 (IQE12_10230)	-	2067715..2068926 (+)	1212	WP_000037091.1	YihY/virulence factor BrkB family protein	-
IQE12_RS10235 (IQE12_10235)	vraR	2069038..2069667 (-)	630	WP_000153535.1	two-component system response regulator VraR	Regulator
IQE12_RS10240 (IQE12_10240)	vraS	2069657..2070700 (-)	1044	WP_001017131.1	sensor histidine kinase	Regulator
IQE12_RS10245 (IQE12_10245)	liaF	2070697..2071398 (-)	702	WP_000149064.1	cell wall-active antibiotics response protein LiaF	-
IQE12_RS10250 (IQE12_10250)	-	2071413..2071799 (-)	387	WP_001110179.1	hypothetical protein	-
IQE12_RS10255 (IQE12_10255)	map	2072016..2072774 (-)	759	WP_000636142.1	type I methionyl aminopeptidase	-
IQE12_RS10260 (IQE12_10260)	-	2073190..2074176 (+)	987	WP_181188121.1	FUSC family protein	-
IQE12_RS10265 (IQE12_10265)	-	2074666..2075079 (-)	414	WP_001837236.1	hypothetical protein	-
IQE12_RS10270 (IQE12_10270)	-	2075108..2075219 (-)	112	Protein_2002	hypothetical protein	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=511565 IQE12_RS10240 WP_001017131.1 2069657..2070700(-) (vraS) [Staphylococcus aureus strain GDY8P96A]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=511565 IQE12_RS10240 WP_001017131.1 2069657..2070700(-) (vraS) [Staphylococcus aureus strain GDY8P96A]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTATTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTCTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTACTCGCATACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACACTCGTACCTTTAAATCAAGAATTGCATAAGTTGCGACTTAAAACTCAAAATTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTAGCTCGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTTTCTGCTATCAAAGAAACGAAGTTAGAACCACCATTAGACCAACAAATTCC
GATTTTAGAGAAAATGGTTCAAGATTCGCAGTTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCGATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGACAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1