Detailed information    

insolico Bioinformatically predicted

Overview

Name   sepM   Type   Regulator
Locus tag   ST4067_RS07660 Genome accession   NZ_CP065496
Coordinates   1469844..1470920 (-) Length   358 a.a.
NCBI ID   WP_204360114.1    Uniprot ID   -
Organism   Streptococcus thermophilus strain 4067     
Function   processing of CSP (predicted from homology)   
Competence regulation

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type MGE coordinates Gene coordinates Relative position Distance (bp)
ICE 1464532..1534838 1469844..1470920 within 0


Gene organization within MGE regions


Location: 1464532..1534838
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  ST4067_RS07635 (ST4067_07650) - 1464556..1465338 (+) 783 WP_263604478.1 ABC transporter ATP-binding protein -
  ST4067_RS07640 (ST4067_07655) - 1465956..1468022 (-) 2067 WP_263604479.1 cation:proton antiporter -
  ST4067_RS07645 (ST4067_07660) - 1468031..1468273 (-) 243 WP_011226461.1 hypothetical protein -
  ST4067_RS07650 (ST4067_07665) - 1468270..1468818 (-) 549 WP_011226462.1 tRNA (mnm(5)s(2)U34)-methyltransferase -
  ST4067_RS07655 (ST4067_07670) - 1468815..1469759 (-) 945 WP_011226463.1 TIGR01212 family radical SAM protein -
  ST4067_RS07660 (ST4067_07675) sepM 1469844..1470920 (-) 1077 WP_204360114.1 SepM family pheromone-processing serine protease Regulator
  ST4067_RS07665 (ST4067_07680) coaD 1470898..1471395 (-) 498 WP_164178277.1 pantetheine-phosphate adenylyltransferase -
  ST4067_RS07670 (ST4067_07685) rsmD 1471429..1472028 (-) 600 Protein_1457 16S rRNA (guanine(966)-N(2))-methyltransferase RsmD -
  ST4067_RS07675 (ST4067_07690) trxB 1472119..1473072 (-) 954 WP_255136104.1 thioredoxin-disulfide reductase -
  ST4067_RS07680 (ST4067_07695) - 1473105..1473329 (-) 225 WP_002951743.1 DUF4059 family protein -
  ST4067_RS07685 (ST4067_07700) - 1473544..1474287 (-) 744 WP_164178279.1 amino acid ABC transporter ATP-binding protein -
  ST4067_RS07690 (ST4067_07705) - 1474287..1475033 (-) 747 WP_095559509.1 amino acid ABC transporter permease -
  ST4067_RS07695 (ST4067_07710) - 1475427..1476257 (-) 831 WP_263604480.1 transporter substrate-binding domain-containing protein -
  ST4067_RS07700 (ST4067_07715) - 1476838..1477071 (-) 234 WP_263604481.1 hypothetical protein -
  ST4067_RS07705 (ST4067_07720) dinB 1477357..1478460 (-) 1104 WP_263604482.1 DNA polymerase IV -
  ST4067_RS07710 (ST4067_07725) pflB 1478739..1481048 (+) 2310 WP_011226473.1 formate C-acetyltransferase -
  ST4067_RS07715 (ST4067_07730) - 1481315..1482097 (+) 783 WP_011681555.1 carbonic anhydrase -
  ST4067_RS07720 (ST4067_07735) - 1482148..1482600 (+) 453 WP_014608655.1 GNAT family N-acetyltransferase -
  ST4067_RS07725 (ST4067_07740) - 1482951..1483256 (-) 306 WP_014621914.1 restriction endonuclease subunit S -
  ST4067_RS09645 (ST4067_07745) mobV 1483281..1483789 (-) 509 Protein_1469 MobV family relaxase -
  ST4067_RS07735 (ST4067_07750) - 1484234..1484989 (-) 756 WP_011681558.1 ABC transporter permease -
  ST4067_RS07740 (ST4067_07755) - 1484986..1485636 (-) 651 WP_011681559.1 ATP-binding cassette domain-containing protein -
  ST4067_RS07745 (ST4067_07760) - 1485839..1486795 (-) 957 WP_002951776.1 serine hydrolase domain-containing protein -
  ST4067_RS07750 (ST4067_07765) - 1486795..1487550 (-) 756 WP_011681560.1 CppA family protein -
  ST4067_RS07755 (ST4067_07770) - 1487832..1488194 (+) 363 WP_014608659.1 CPBP family intramembrane glutamic endopeptidase -
  ST4067_RS07760 (ST4067_07775) - 1488392..1489641 (+) 1250 Protein_1475 ISL3 family transposase -
  ST4067_RS07765 (ST4067_07780) gla 1489700..1490563 (-) 864 WP_002951781.1 aquaglyceroporin Gla -
  ST4067_RS07770 (ST4067_07785) - 1490684..1492951 (+) 2268 WP_173940641.1 Xaa-Pro dipeptidyl-peptidase -
  ST4067_RS07775 (ST4067_07790) - 1493031..1493411 (-) 381 WP_002951783.1 hypothetical protein -
  ST4067_RS07780 (ST4067_07795) - 1493536..1493799 (-) 264 WP_002945924.1 hypothetical protein -
  ST4067_RS07785 (ST4067_07800) - 1494121..1494417 (-) 297 WP_004197070.1 bacteriocin immunity protein -
  ST4067_RS07790 (ST4067_07805) - 1494582..1494788 (-) 207 WP_011681562.1 hypothetical protein -
  ST4067_RS07795 (ST4067_07810) - 1494819..1495511 (-) 693 WP_224103184.1 thioredoxin family protein -
  ST4067_RS07800 (ST4067_07815) - 1495702..1497272 (+) 1571 WP_087009847.1 IS3-like element ISSth1b family transposase -
  ST4067_RS07805 (ST4067_07820) - 1497418..1497684 (-) 267 WP_263604483.1 ComC/BlpC family leader-containing pheromone/bacteriocin -
  ST4067_RS09650 - 1497935..1498336 (-) 402 WP_311316656.1 hypothetical protein -
  ST4067_RS07810 (ST4067_07825) - 1498666..1498827 (-) 162 WP_263604484.1 hypothetical protein -
  ST4067_RS07815 (ST4067_07830) - 1499317..1499547 (-) 231 WP_011226494.1 bacteriocin class II family protein -
  ST4067_RS07820 (ST4067_07835) - 1499797..1500528 (+) 732 WP_180477148.1 LytR/AlgR family response regulator transcription factor -
  ST4067_RS07825 - 1501065..1501868 (+) 804 WP_224103634.1 ATP-binding protein -
  ST4067_RS07830 (ST4067_07845) - 1501886..1502047 (-) 162 WP_011226496.1 ComC/BlpC family leader-containing pheromone/bacteriocin -
  ST4067_RS07835 (ST4067_07850) - 1502062..1503429 (-) 1368 WP_096811636.1 bacteriocin secretion accessory protein -
  ST4067_RS07840 (ST4067_07855) - 1503445..1505599 (-) 2155 Protein_1492 peptide cleavage/export ABC transporter -
  ST4067_RS07845 (ST4067_07860) - 1506613..1508358 (-) 1746 WP_263604486.1 ABC transporter ATP-binding protein -
  ST4067_RS07850 (ST4067_07865) - 1508351..1510108 (-) 1758 WP_014608668.1 ABC transporter ATP-binding protein -
  ST4067_RS07855 - 1510296..1510502 (-) 207 WP_002948879.1 hypothetical protein -
  ST4067_RS07860 (ST4067_07875) - 1510707..1511234 (-) 528 WP_011226503.1 VanZ family protein -
  ST4067_RS07865 (ST4067_07880) rlmN 1511236..1512405 (-) 1170 WP_011226504.1 23S rRNA (adenine(2503)-C(2))-methyltransferase RlmN -
  ST4067_RS07870 (ST4067_07885) - 1512409..1513131 (-) 723 WP_011226505.1 YutD family protein -
  ST4067_RS07875 (ST4067_07890) - 1513186..1514541 (-) 1356 WP_002948886.1 bifunctional metallophosphatase/5'-nucleotidase -
  ST4067_RS07880 (ST4067_07900) - 1515389..1516732 (-) 1344 WP_014608670.1 DEAD/DEAH box helicase -
  ST4067_RS07885 (ST4067_07905) mraY 1516807..1517829 (-) 1023 WP_263604487.1 phospho-N-acetylmuramoyl-pentapeptide- transferase -
  ST4067_RS07890 (ST4067_07910) pbp2X 1517831..1520098 (-) 2268 WP_011226508.1 penicillin-binding protein PBP2X -
  ST4067_RS07895 (ST4067_07915) ftsL 1520102..1520422 (-) 321 WP_014608671.1 cell division protein FtsL -
  ST4067_RS07900 (ST4067_07920) rsmH 1520425..1521375 (-) 951 WP_263604488.1 16S rRNA (cytosine(1402)-N(4))-methyltransferase RsmH -
  ST4067_RS07905 - 1521542..1522534 (-) 993 WP_263604489.1 hypothetical protein -
  ST4067_RS07910 (ST4067_07935) - 1522602..1522865 (+) 264 WP_232974239.1 hypothetical protein -
  ST4067_RS07915 (ST4067_07940) - 1523170..1523526 (-) 357 WP_082309125.1 DUF805 domain-containing protein -
  ST4067_RS07920 (ST4067_07945) - 1523746..1524042 (-) 297 WP_263604490.1 hypothetical protein -
  ST4067_RS07925 (ST4067_07950) - 1524378..1525628 (-) 1251 WP_263604491.1 glutamate-5-semialdehyde dehydrogenase -
  ST4067_RS07930 (ST4067_07955) proB 1525630..1526433 (-) 804 WP_011681591.1 glutamate 5-kinase -
  ST4067_RS07935 (ST4067_07960) - 1526554..1528143 (-) 1590 WP_263604492.1 ABC transporter permease -
  ST4067_RS07940 (ST4067_07965) - 1528146..1528877 (-) 732 WP_263604493.1 ABC transporter ATP-binding protein -
  ST4067_RS07945 (ST4067_07970) - 1529153..1529886 (+) 734 Protein_1513 DUF554 domain-containing protein -
  ST4067_RS07950 (ST4067_07975) addA 1530280..1533933 (-) 3654 WP_263604494.1 helicase-exonuclease AddAB subunit AddA -

Sequence

Protein


Download         Length: 358 a.a.        Molecular weight: 39230.10 Da        Isoelectric Point: 9.4989

>NTDB_id=511096 ST4067_RS07660 WP_204360114.1 1469844..1470920(-) (sepM) [Streptococcus thermophilus strain 4067]
MANKTKSKSLLEKMWRIKWWLLSIFTVLFLLFALFFPLNNYYVELPGGAFDTKEVLTVNKKADDSKGSYNFVAVAQTKAT
LALMLYAQFNDFAKLQTAEEATGNYSDEDFMRINQFYMETSQNQAVYQGLTLAGKEVSLEYMGVYVLQVADDSSFKGVLN
IADTVTAVNGKTFDNSTDMIKYVQGLKLGSKVRVTYMRDGKEKTATGKIIKIANGKNGIGIGLTDHTEIKSPENVKFKLD
GVGGPSAGLMFTLAIYDQVSGQDLKAGRKIAGTGTIEKDGAVGDIGGAYLKVKSAADSGADIFFVPNNLVTKEMKKADPD
AKTNYQEAKEAAEKLGTKMKIVPVKTAQEAIDYLKKTK

Nucleotide


Download         Length: 1077 bp        

>NTDB_id=511096 ST4067_RS07660 WP_204360114.1 1469844..1470920(-) (sepM) [Streptococcus thermophilus strain 4067]
GTGGCAAACAAGACAAAATCTAAATCGCTATTAGAGAAAATGTGGCGTATTAAGTGGTGGTTATTAAGTATTTTTACGGT
ACTTTTCCTCCTTTTTGCCCTCTTTTTCCCGCTCAATAATTACTATGTGGAGCTTCCGGGTGGTGCTTTTGATACCAAGG
AAGTCTTGACAGTGAATAAGAAAGCTGATGATTCTAAGGGCTCCTATAATTTTGTGGCGGTGGCTCAAACCAAGGCGACT
TTGGCCTTGATGCTCTATGCTCAGTTTAATGATTTTGCAAAGCTTCAAACGGCTGAAGAGGCAACTGGAAATTACTCTGA
TGAAGATTTCATGCGCATCAACCAATTTTACATGGAGACTTCTCAAAACCAAGCGGTTTATCAGGGCTTGACTCTGGCTG
GTAAGGAGGTTAGTTTGGAGTATATGGGTGTCTATGTGCTTCAGGTTGCTGATGATTCTAGCTTCAAGGGTGTCCTCAAT
ATTGCTGATACGGTGACGGCTGTTAATGGTAAGACCTTTGATAATTCTACTGACATGATTAAATACGTTCAAGGACTTAA
GCTGGGTTCAAAGGTCAGGGTCACTTATATGAGAGATGGCAAAGAAAAGACTGCTACTGGTAAGATTATTAAGATTGCCA
ATGGCAAAAATGGTATTGGTATCGGCCTAACGGACCATACTGAGATCAAGAGTCCTGAGAATGTTAAGTTTAAACTGGAT
GGTGTCGGTGGGCCAAGTGCTGGTCTTATGTTTACCTTGGCTATTTACGATCAGGTGTCTGGTCAAGACCTCAAGGCTGG
CCGCAAGATTGCTGGTACAGGAACTATTGAAAAAGATGGGGCTGTCGGTGATATCGGTGGGGCCTATCTCAAGGTGAAAT
CTGCGGCTGATAGTGGCGCAGACATTTTCTTCGTGCCAAATAATCTAGTAACTAAGGAAATGAAAAAGGCTGATCCGGAT
GCCAAGACTAATTATCAAGAGGCCAAGGAAGCTGCTGAGAAACTGGGGACCAAGATGAAAATCGTCCCTGTTAAAACAGC
TCAAGAAGCCATTGATTATTTGAAAAAGACTAAATGA

Domains

Predicted by InterproScan.

PDZ domain (PDZ_2)

(137-206)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  sepM Streptococcus mutans UA159

63.05

95.251

0.601