Detailed information    

insolico Bioinformatically predicted

Overview

Name   covS   Type   Regulator
Locus tag   ST4021_RS01695 Genome accession   NZ_CP065493
Coordinates   310758..312275 (+) Length   505 a.a.
NCBI ID   WP_002949640.1    Uniprot ID   A0A060BQ50
Organism   Streptococcus thermophilus strain 4021     
Function   repress comR expression (predicted from homology)   
Competence regulation

Genomic Context

Location: 305758..317275
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  ST4021_RS01665 - 306038..306208 (+) 171 Protein_275 ascorbate 6-phosphate lactonase -
  ST4021_RS01670 (ST4021_01670) - 306225..306896 (-) 672 WP_002946492.1 TrkA family potassium uptake protein -
  ST4021_RS01675 (ST4021_01675) - 306936..308300 (-) 1365 WP_011680735.1 potassium transporter TrkG -
  ST4021_RS01680 (ST4021_01680) rsmG 308370..309083 (-) 714 WP_002946490.1 16S rRNA (guanine(527)-N(7))-methyltransferase RsmG -
  ST4021_RS01685 (ST4021_01685) - 309380..309916 (+) 537 WP_002946488.1 YceD family protein -
  ST4021_RS01690 (ST4021_01690) covR 310072..310761 (+) 690 WP_011680737.1 response regulator transcription factor Regulator
  ST4021_RS01695 (ST4021_01695) covS 310758..312275 (+) 1518 WP_002949640.1 HAMP domain-containing histidine kinase Regulator
  ST4021_RS01700 (ST4021_01700) nrdR 312397..312876 (+) 480 WP_011680738.1 transcriptional regulator NrdR -
  ST4021_RS01705 (ST4021_01705) - 312873..314048 (+) 1176 WP_011680739.1 DnaD domain protein -
  ST4021_RS01710 (ST4021_01710) dnaI 314052..314954 (+) 903 WP_011680740.1 primosomal protein DnaI -
  ST4021_RS01715 (ST4021_01715) der 315060..316370 (+) 1311 WP_011680741.1 ribosome biogenesis GTPase Der -
  ST4021_RS01720 (ST4021_01720) - 316434..317093 (+) 660 Protein_286 HI_0552 family protein -

Sequence

Protein


Download         Length: 505 a.a.        Molecular weight: 57536.93 Da        Isoelectric Point: 5.2689

>NTDB_id=510944 ST4021_RS01695 WP_002949640.1 310758..312275(+) (covS) [Streptococcus thermophilus strain 4021]
MSKLFGKVTIRKKLTMTTAVVFFLVLSMFTLVVVFSANTLLLQRERQNVNNTISKVVTYIEKDWDSDEELSPEPLLAALY
SPKNIYPSIINGVLSEKRSLDGQVAVSNRLYSNQSVYVYDKKGTFIFTSEEDTDSPPGMSEVNKLKLVSYKGKRGFLLQV
PIYGKDKKTIVGYAQVFHDLEFYYALKERLIFLLIFLEVGMTVLVIAVTVVVLTSILRPMRQLHETMGIIIDSPSDLELR
SKIESHDEIGALALNFNCMMDKIQENNQMQMRFLSDVSHELRTPIAVIKGHMDLLQRWGKNDPEILEESLEAASHEANRM
TIMINDMLDSIRVKGSFDNHRNDTCDLNSSIRTVIGNFRVLHDDYQFYLNDSEGSDRPAQIYSQHFEQVITILIDNAVKY
SPVNKKIQITIKALEDEMLVQVQDNGEGISKEDIEHIFERFYRSDKARNRTTTQSGVGIGLSILYQIVEAYRCHIDVSSE
LGVGTRFDLYIPFAESETTTPQIEG

Nucleotide


Download         Length: 1518 bp        

>NTDB_id=510944 ST4021_RS01695 WP_002949640.1 310758..312275(+) (covS) [Streptococcus thermophilus strain 4021]
ATGAGTAAATTATTTGGTAAAGTAACCATTAGAAAAAAGTTGACCATGACAACTGCTGTGGTCTTCTTTCTTGTATTGTC
GATGTTCACTCTGGTTGTTGTATTTTCAGCCAATACGCTTCTTTTGCAACGTGAACGTCAAAATGTAAATAATACAATCT
CAAAAGTTGTTACTTATATCGAAAAGGACTGGGACTCTGATGAAGAGTTGAGTCCAGAGCCGCTTTTAGCGGCCCTTTAT
TCACCGAAAAATATCTATCCATCAATCATTAATGGAGTGCTTTCTGAAAAGCGTTCCTTAGATGGTCAAGTTGCGGTTTC
TAATAGATTATATTCCAACCAGTCTGTCTATGTTTATGACAAAAAGGGAACTTTTATCTTTACTTCTGAGGAGGATACAG
ACTCACCTCCAGGCATGTCTGAGGTCAATAAACTGAAGTTGGTTTCCTATAAAGGTAAACGTGGTTTCTTACTACAAGTT
CCAATCTATGGCAAGGATAAGAAGACCATTGTTGGGTATGCTCAAGTTTTCCATGATTTGGAATTCTACTATGCGTTAAA
AGAGCGTTTAATTTTCCTATTGATATTCCTTGAAGTAGGAATGACGGTCTTAGTTATTGCAGTAACTGTAGTTGTCTTGA
CATCTATTCTTCGTCCGATGAGGCAGTTACACGAAACGATGGGTATTATTATCGATTCGCCAAGTGATTTGGAGCTTCGA
TCTAAGATTGAGAGTCATGATGAGATTGGTGCTTTGGCACTTAACTTTAACTGTATGATGGATAAAATTCAAGAAAATAA
TCAGATGCAGATGCGTTTCTTGAGTGACGTCAGTCACGAATTACGTACTCCCATTGCAGTTATTAAAGGACATATGGACC
TCTTGCAACGTTGGGGTAAAAATGATCCTGAAATCCTTGAAGAAAGTCTTGAAGCTGCAAGTCACGAAGCCAACCGTATG
ACGATTATGATTAACGATATGTTGGATTCTATTCGTGTTAAAGGGTCATTTGACAATCATAGAAATGATACATGTGATTT
GAATTCTTCAATCCGTACGGTTATTGGGAATTTTCGTGTCCTACATGACGACTACCAATTCTACCTCAATGATTCTGAGG
GTTCAGATCGTCCAGCACAGATTTACAGCCAGCACTTTGAACAGGTTATTACTATTTTGATTGATAATGCGGTCAAGTAT
TCGCCTGTTAATAAGAAAATCCAGATTACTATCAAGGCTCTGGAAGATGAGATGCTGGTACAGGTACAGGATAATGGTGA
GGGTATCTCTAAAGAAGATATTGAACATATATTTGAACGCTTCTATCGTTCAGATAAGGCGCGTAATCGTACGACAACCC
AATCTGGTGTGGGTATTGGTTTATCAATCCTCTATCAAATTGTGGAAGCTTATCGATGCCATATCGATGTCAGTTCAGAA
CTTGGTGTGGGTACACGTTTTGACCTCTACATTCCTTTTGCAGAGTCAGAAACTACGACACCTCAAATTGAAGGTTAA

Domains

Predicted by InterproScan.

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c)

(384-494)

ArlS sensor domain (ArlS_N)

(39-187)

His Kinase A (phospho-acceptor) domain (HisKA)

(270-329)

HAMP domain (HAMP)

(213-265)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A060BQ50

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  covS Streptococcus salivarius strain HSISS4

94.622

99.406

0.941