Detailed information
Bioinformatically predicted
Overview
| Name | sepM | Type | Regulator |
| Locus tag | STAVA1121_RS07900 | Genome accession | NZ_CP065488 |
| Coordinates | 1492678..1493754 (-) | Length | 358 a.a. |
| NCBI ID | WP_022096499.1 | Uniprot ID | - |
| Organism | Streptococcus thermophilus strain AVA1121 | ||
| Function | processing of CSP (predicted from homology) Competence regulation |
||
Related MGE
Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.
Gene-MGE association summary
| MGE type | MGE coordinates | Gene coordinates | Relative position | Distance (bp) |
|---|---|---|---|---|
| ICE | 1471800..1557808 | 1492678..1493754 | within | 0 |
Gene organization within MGE regions
Location: 1471800..1557808
| Locus tag | Gene name | Coordinates (strand) | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| STAVA1121_RS07785 (STAVA1121_07675) | gatA | 1473066..1474532 (-) | 1467 | WP_011681542.1 | Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase subunit GatA | - |
| STAVA1121_RS07790 (STAVA1121_07680) | gatC | 1474532..1474834 (-) | 303 | WP_002884769.1 | Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase subunit GatC | - |
| STAVA1121_RS07795 | - | 1474974..1475135 (-) | 162 | WP_224103235.1 | hypothetical protein | - |
| STAVA1121_RS07800 | - | 1475167..1475439 (-) | 273 | WP_224103183.1 | glycosyltransferase | - |
| STAVA1121_RS07805 (STAVA1121_07695) | - | 1475766..1477207 (-) | 1442 | Protein_1483 | 6-phospho-beta-glucosidase | - |
| STAVA1121_RS07810 (STAVA1121_07700) | msrA | 1477360..1477869 (-) | 510 | WP_041829085.1 | peptide-methionine (S)-S-oxide reductase MsrA | - |
| STAVA1121_RS07815 (STAVA1121_07705) | - | 1477881..1478729 (-) | 849 | WP_179967094.1 | MetQ/NlpA family ABC transporter substrate-binding protein | - |
| STAVA1121_RS07820 (STAVA1121_07710) | - | 1478853..1479404 (-) | 552 | WP_173940634.1 | isochorismatase family cysteine hydrolase | - |
| STAVA1121_RS07825 (STAVA1121_07715) | codY | 1479466..1480251 (-) | 786 | WP_002951720.1 | GTP-sensing pleiotropic transcriptional regulator CodY | - |
| STAVA1121_RS07830 (STAVA1121_07720) | - | 1480511..1481725 (-) | 1215 | WP_011226456.1 | pyridoxal phosphate-dependent aminotransferase | - |
| STAVA1121_RS07835 (STAVA1121_07725) | - | 1482080..1482532 (+) | 453 | WP_180477136.1 | universal stress protein | - |
| STAVA1121_RS07840 | - | 1482745..1482894 (+) | 150 | WP_232557033.1 | hypothetical protein | - |
| STAVA1121_RS07845 | - | 1483101..1483283 (+) | 183 | Protein_1491 | IS30 family transposase | - |
| STAVA1121_RS07850 (STAVA1121_07735) | - | 1483355..1483528 (-) | 174 | WP_011681546.1 | hypothetical protein | - |
| STAVA1121_RS07855 (STAVA1121_07740) | - | 1483589..1483963 (-) | 375 | WP_141326717.1 | hypothetical protein | - |
| STAVA1121_RS07860 (STAVA1121_07745) | pflA | 1484173..1484973 (-) | 801 | WP_002946980.1 | pyruvate formate-lyase-activating protein | - |
| STAVA1121_RS07865 (STAVA1121_07750) | - | 1485161..1485271 (-) | 111 | WP_014621906.1 | LPXTG cell wall anchor domain-containing protein | - |
| STAVA1121_RS07870 (STAVA1121_07755) | - | 1485965..1487287 (-) | 1323 | Protein_1496 | hemolysin family protein | - |
| STAVA1121_RS07875 (STAVA1121_07760) | - | 1487399..1488197 (+) | 799 | Protein_1497 | ABC transporter ATP-binding protein | - |
| STAVA1121_RS07880 (STAVA1121_07765) | - | 1488790..1490856 (-) | 2067 | WP_173940635.1 | sodium:proton antiporter | - |
| STAVA1121_RS07885 (STAVA1121_07770) | - | 1490865..1491107 (-) | 243 | WP_022096501.1 | hypothetical protein | - |
| STAVA1121_RS07890 (STAVA1121_07775) | - | 1491104..1491652 (-) | 549 | WP_011226462.1 | class I SAM-dependent methyltransferase | - |
| STAVA1121_RS07895 (STAVA1121_07780) | - | 1491649..1492593 (-) | 945 | WP_022096500.1 | TIGR01212 family radical SAM protein | - |
| STAVA1121_RS07900 (STAVA1121_07785) | sepM | 1492678..1493754 (-) | 1077 | WP_022096499.1 | SepM family pheromone-processing serine protease | Regulator |
| STAVA1121_RS07905 (STAVA1121_07790) | coaD | 1493732..1494229 (-) | 498 | WP_022096498.1 | pantetheine-phosphate adenylyltransferase | - |
| STAVA1121_RS07910 (STAVA1121_07795) | rsmD | 1494263..1494838 (-) | 576 | WP_347131594.1 | 16S rRNA (guanine(966)-N(2))-methyltransferase RsmD | - |
| STAVA1121_RS07915 (STAVA1121_07800) | trxB | 1494953..1495906 (-) | 954 | WP_255136104.1 | thioredoxin-disulfide reductase | - |
| STAVA1121_RS07920 (STAVA1121_07805) | - | 1495939..1496163 (-) | 225 | WP_087010135.1 | DUF4059 family protein | - |
| STAVA1121_RS07925 (STAVA1121_07810) | - | 1496378..1497121 (-) | 744 | WP_164178279.1 | amino acid ABC transporter ATP-binding protein | - |
| STAVA1121_RS07930 (STAVA1121_07815) | - | 1497121..1498044 (-) | 924 | WP_347131191.1 | amino acid ABC transporter permease | - |
| STAVA1121_RS07935 (STAVA1121_07820) | - | 1498255..1499085 (-) | 831 | WP_347131192.1 | transporter substrate-binding domain-containing protein | - |
| STAVA1121_RS07940 (STAVA1121_07825) | - | 1499546..1499779 (-) | 234 | WP_002947030.1 | hypothetical protein | - |
| STAVA1121_RS07945 (STAVA1121_07830) | dinB | 1500077..1501180 (-) | 1104 | WP_347131193.1 | DNA polymerase IV | - |
| STAVA1121_RS07950 (STAVA1121_07835) | pflB | 1501459..1503768 (+) | 2310 | WP_002947035.1 | formate C-acetyltransferase | - |
| STAVA1121_RS07955 (STAVA1121_07840) | - | 1504035..1504819 (+) | 785 | Protein_1513 | carbonic anhydrase family protein | - |
| STAVA1121_RS07960 (STAVA1121_07845) | - | 1504870..1505322 (+) | 453 | WP_180481095.1 | GNAT family N-acetyltransferase | - |
| STAVA1121_RS07965 (STAVA1121_07850) | - | 1505674..1505979 (-) | 306 | WP_347131195.1 | restriction endonuclease subunit S | - |
| STAVA1121_RS07970 (STAVA1121_07855) | mobV | 1506004..1506512 (-) | 509 | Protein_1516 | MobV family relaxase | - |
| STAVA1121_RS07975 (STAVA1121_07860) | - | 1506993..1507542 (-) | 550 | Protein_1517 | tyrosine-type recombinase/integrase | - |
| STAVA1121_RS07980 (STAVA1121_07865) | - | 1507674..1508360 (-) | 687 | WP_347131196.1 | hypothetical protein | - |
| STAVA1121_RS07985 (STAVA1121_07870) | fetB | 1508436..1509191 (-) | 756 | WP_347131197.1 | iron export ABC transporter permease subunit FetB | - |
| STAVA1121_RS07990 (STAVA1121_07875) | - | 1509188..1509838 (-) | 651 | WP_022096490.1 | ATP-binding cassette domain-containing protein | - |
| STAVA1121_RS07995 (STAVA1121_07880) | - | 1510040..1510996 (-) | 957 | WP_180477144.1 | serine hydrolase domain-containing protein | - |
| STAVA1121_RS08000 (STAVA1121_07885) | - | 1510996..1511751 (-) | 756 | WP_347131198.1 | CppA family protein | - |
| STAVA1121_RS08005 | - | 1512034..1512171 (+) | 138 | WP_347131199.1 | hypothetical protein | - |
| STAVA1121_RS08010 | - | 1512172..1512396 (+) | 225 | WP_347131201.1 | CPBP family intramembrane glutamic endopeptidase | - |
| STAVA1121_RS08015 (STAVA1121_07895) | gla | 1512483..1513346 (-) | 864 | WP_002951781.1 | aquaglyceroporin Gla | - |
| STAVA1121_RS08020 (STAVA1121_07900) | - | 1513467..1515734 (+) | 2268 | WP_141326711.1 | Xaa-Pro dipeptidyl-peptidase | - |
| STAVA1121_RS08025 (STAVA1121_07905) | - | 1515814..1516194 (-) | 381 | WP_002951783.1 | hypothetical protein | - |
| STAVA1121_RS08030 (STAVA1121_07910) | - | 1516319..1516582 (-) | 264 | WP_002945924.1 | hypothetical protein | - |
| STAVA1121_RS08035 (STAVA1121_07915) | - | 1516904..1517200 (-) | 297 | WP_347131204.1 | bacteriocin immunity protein | - |
| STAVA1121_RS08040 (STAVA1121_07920) | - | 1517365..1518261 (-) | 897 | WP_347131205.1 | thioredoxin family protein | - |
| STAVA1121_RS08045 (STAVA1121_07925) | - | 1518483..1520053 (+) | 1571 | Protein_1531 | IS3-like element ISSth1b family transposase | - |
| STAVA1121_RS08050 (STAVA1121_07930) | - | 1520199..1520441 (-) | 243 | WP_002948868.1 | Blp family class II bacteriocin | - |
| STAVA1121_RS08055 | - | 1520692..1521093 (-) | 402 | WP_011226490.1 | hypothetical protein | - |
| STAVA1121_RS08060 (STAVA1121_07935) | - | 1522061..1522267 (-) | 207 | WP_347131206.1 | bacteriocin class II family protein | - |
| STAVA1121_RS08065 (STAVA1121_07940) | - | 1522518..1523249 (+) | 732 | WP_002948869.1 | LytTR family DNA-binding domain-containing protein | - |
| STAVA1121_RS08070 | - | 1523786..1524589 (+) | 804 | WP_224103634.1 | ATP-binding protein | - |
| STAVA1121_RS08075 (STAVA1121_07950) | - | 1524607..1524768 (-) | 162 | WP_011226496.1 | ComC/BlpC family leader-containing pheromone/bacteriocin | - |
| STAVA1121_RS08080 (STAVA1121_07955) | - | 1524783..1526150 (-) | 1368 | WP_084829837.1 | bacteriocin secretion accessory protein | - |
| STAVA1121_RS08085 (STAVA1121_07960) | comA/nlmT | 1526166..1528256 (-) | 2091 | WP_347131208.1 | peptide cleavage/export ABC transporter | Regulator |
| STAVA1121_RS08090 (STAVA1121_07965) | - | 1529332..1531077 (-) | 1746 | WP_347131210.1 | ABC transporter ATP-binding protein | - |
| STAVA1121_RS08095 (STAVA1121_07970) | - | 1531070..1532827 (-) | 1758 | WP_347131211.1 | ABC transporter transmembrane domain-containing protein | - |
| STAVA1121_RS08100 | - | 1533015..1533221 (-) | 207 | WP_002948879.1 | hypothetical protein | - |
| STAVA1121_RS08105 (STAVA1121_07980) | - | 1533426..1533953 (-) | 528 | WP_347131213.1 | VanZ family protein | - |
| STAVA1121_RS08110 (STAVA1121_07985) | rlmN | 1533955..1535064 (-) | 1110 | WP_232972486.1 | 23S rRNA (adenine(2503)-C(2))-methyltransferase RlmN | - |
| STAVA1121_RS08115 (STAVA1121_07990) | - | 1535128..1535850 (-) | 723 | WP_347131214.1 | YutD family protein | - |
| STAVA1121_RS08120 (STAVA1121_07995) | - | 1535905..1537260 (-) | 1356 | WP_002948886.1 | metallophosphatase | - |
| STAVA1121_RS08125 (STAVA1121_08000) | - | 1537539..1537778 (-) | 240 | WP_041828333.1 | hypothetical protein | - |
| STAVA1121_RS08130 (STAVA1121_08005) | - | 1538109..1539452 (-) | 1344 | WP_347131216.1 | DEAD/DEAH box helicase | - |
| STAVA1121_RS08135 (STAVA1121_08010) | mraY | 1539527..1540549 (-) | 1023 | WP_011227524.1 | phospho-N-acetylmuramoyl-pentapeptide- transferase | - |
| STAVA1121_RS08140 (STAVA1121_08015) | pbp2X | 1540551..1542817 (-) | 2267 | Protein_1550 | penicillin-binding protein PBP2X | - |
| STAVA1121_RS08145 (STAVA1121_08020) | ftsL | 1542821..1543141 (-) | 321 | WP_014608671.1 | cell division protein FtsL | - |
| STAVA1121_RS08150 (STAVA1121_08025) | rsmH | 1543144..1544094 (-) | 951 | WP_002888254.1 | 16S rRNA (cytosine(1402)-N(4))-methyltransferase RsmH | - |
| STAVA1121_RS08155 | - | 1544260..1545246 (-) | 987 | WP_347131217.1 | hypothetical protein | - |
| STAVA1121_RS08160 (STAVA1121_08045) | - | 1545885..1546241 (-) | 357 | WP_014621938.1 | DUF805 domain-containing protein | - |
| STAVA1121_RS08165 (STAVA1121_08050) | - | 1546460..1546756 (-) | 297 | WP_347131218.1 | hypothetical protein | - |
| STAVA1121_RS08170 (STAVA1121_08055) | - | 1547089..1548339 (-) | 1251 | WP_347131219.1 | glutamate-5-semialdehyde dehydrogenase | - |
| STAVA1121_RS08175 (STAVA1121_08060) | proB | 1548341..1549144 (-) | 804 | WP_002948808.1 | glutamate 5-kinase | - |
| STAVA1121_RS08180 (STAVA1121_08065) | - | 1549265..1550854 (-) | 1590 | WP_180477154.1 | DUF4231 domain-containing protein | - |
| STAVA1121_RS08185 (STAVA1121_08070) | - | 1550857..1551588 (-) | 732 | WP_180477155.1 | ABC transporter ATP-binding protein | - |
| STAVA1121_RS08190 (STAVA1121_08075) | - | 1551862..1552595 (+) | 734 | Protein_1560 | DUF554 domain-containing protein | - |
| STAVA1121_RS08195 (STAVA1121_08080) | addA | 1552988..1556641 (-) | 3654 | WP_347131220.1 | helicase-exonuclease AddAB subunit AddA | - |
Sequence
Protein
Download Length: 358 a.a. Molecular weight: 39202.09 Da Isoelectric Point: 9.4944
>NTDB_id=510681 STAVA1121_RS07900 WP_022096499.1 1492678..1493754(-) (sepM) [Streptococcus thermophilus strain AVA1121]
MANKTKSKSLLEKMWRIKWWLLSIFTVLFLLFALFFPLNNYYVELPGGAFDTKEVLTVNKKADDSKGSYNFVAVAQTKAT
LALMLYAQFNDFAKLQTAEEATGNYSDEDFMRINQFYMETSQNQAVYQGLTLAGKEVSLEYMGVYVLQVADDSSFKGVLN
IADTVTAVNGKTFDNSTDMIKYVQGLKLGSKVKVTYMRDGKEKTATGKIIKIANGKNGIGIGLTDHTEIKSPENVKFKLD
GVGGPSAGLMFTLAIYDQVSGQDLKAGRKIAGTGTIEKDGAVGDIGGAYLKVKSAADSGADIFFVPNNLVTKEMKKADPD
AKTNYQEAKEAAEKLGTKMKIVPVKTAQEAIDYLKKTK
MANKTKSKSLLEKMWRIKWWLLSIFTVLFLLFALFFPLNNYYVELPGGAFDTKEVLTVNKKADDSKGSYNFVAVAQTKAT
LALMLYAQFNDFAKLQTAEEATGNYSDEDFMRINQFYMETSQNQAVYQGLTLAGKEVSLEYMGVYVLQVADDSSFKGVLN
IADTVTAVNGKTFDNSTDMIKYVQGLKLGSKVKVTYMRDGKEKTATGKIIKIANGKNGIGIGLTDHTEIKSPENVKFKLD
GVGGPSAGLMFTLAIYDQVSGQDLKAGRKIAGTGTIEKDGAVGDIGGAYLKVKSAADSGADIFFVPNNLVTKEMKKADPD
AKTNYQEAKEAAEKLGTKMKIVPVKTAQEAIDYLKKTK
Nucleotide
Download Length: 1077 bp
>NTDB_id=510681 STAVA1121_RS07900 WP_022096499.1 1492678..1493754(-) (sepM) [Streptococcus thermophilus strain AVA1121]
GTGGCAAACAAGACAAAATCTAAATCGCTATTAGAGAAAATGTGGCGTATTAAGTGGTGGTTATTAAGTATTTTTACGGT
ACTTTTCCTCCTTTTTGCCCTCTTTTTCCCGCTCAATAATTACTATGTGGAGCTTCCGGGTGGTGCTTTTGATACCAAGG
AAGTCTTGACAGTGAATAAGAAAGCTGATGATTCTAAGGGCTCCTATAATTTTGTGGCGGTGGCTCAAACCAAGGCGACT
TTGGCCTTGATGCTCTATGCTCAGTTTAATGATTTTGCAAAGCTTCAAACGGCTGAAGAGGCAACTGGAAATTACTCTGA
TGAAGATTTCATGCGCATCAACCAATTTTACATGGAGACTTCTCAAAACCAAGCGGTTTATCAGGGCTTGACTCTGGCTG
GTAAGGAGGTTAGTTTGGAGTATATGGGTGTCTATGTGCTTCAGGTTGCTGATGATTCTAGCTTCAAGGGTGTCCTCAAT
ATTGCTGATACGGTGACGGCTGTTAATGGTAAGACCTTTGATAATTCTACTGACATGATTAAATACGTTCAAGGACTTAA
GCTGGGTTCAAAGGTCAAGGTCACTTATATGAGAGATGGCAAAGAAAAGACTGCTACTGGTAAGATTATTAAGATTGCCA
ATGGCAAAAATGGTATTGGTATCGGCCTAACGGACCATACTGAGATCAAGAGTCCTGAGAATGTTAAGTTTAAACTGGAT
GGTGTCGGTGGGCCAAGTGCTGGTCTTATGTTTACCTTGGCTATTTACGATCAGGTGTCTGGTCAAGACCTCAAGGCTGG
CCGCAAGATTGCTGGTACAGGAACTATTGAAAAAGATGGGGCTGTCGGTGATATCGGTGGGGCCTATCTCAAGGTGAAAT
CTGCGGCTGATAGTGGCGCAGACATTTTCTTCGTGCCAAATAATCTAGTAACTAAGGAAATGAAAAAGGCTGATCCGGAT
GCCAAGACTAATTATCAAGAGGCCAAGGAAGCTGCCGAGAAACTGGGGACCAAGATGAAAATCGTCCCTGTTAAAACAGC
TCAAGAAGCCATTGATTATTTGAAAAAGACTAAATGA
GTGGCAAACAAGACAAAATCTAAATCGCTATTAGAGAAAATGTGGCGTATTAAGTGGTGGTTATTAAGTATTTTTACGGT
ACTTTTCCTCCTTTTTGCCCTCTTTTTCCCGCTCAATAATTACTATGTGGAGCTTCCGGGTGGTGCTTTTGATACCAAGG
AAGTCTTGACAGTGAATAAGAAAGCTGATGATTCTAAGGGCTCCTATAATTTTGTGGCGGTGGCTCAAACCAAGGCGACT
TTGGCCTTGATGCTCTATGCTCAGTTTAATGATTTTGCAAAGCTTCAAACGGCTGAAGAGGCAACTGGAAATTACTCTGA
TGAAGATTTCATGCGCATCAACCAATTTTACATGGAGACTTCTCAAAACCAAGCGGTTTATCAGGGCTTGACTCTGGCTG
GTAAGGAGGTTAGTTTGGAGTATATGGGTGTCTATGTGCTTCAGGTTGCTGATGATTCTAGCTTCAAGGGTGTCCTCAAT
ATTGCTGATACGGTGACGGCTGTTAATGGTAAGACCTTTGATAATTCTACTGACATGATTAAATACGTTCAAGGACTTAA
GCTGGGTTCAAAGGTCAAGGTCACTTATATGAGAGATGGCAAAGAAAAGACTGCTACTGGTAAGATTATTAAGATTGCCA
ATGGCAAAAATGGTATTGGTATCGGCCTAACGGACCATACTGAGATCAAGAGTCCTGAGAATGTTAAGTTTAAACTGGAT
GGTGTCGGTGGGCCAAGTGCTGGTCTTATGTTTACCTTGGCTATTTACGATCAGGTGTCTGGTCAAGACCTCAAGGCTGG
CCGCAAGATTGCTGGTACAGGAACTATTGAAAAAGATGGGGCTGTCGGTGATATCGGTGGGGCCTATCTCAAGGTGAAAT
CTGCGGCTGATAGTGGCGCAGACATTTTCTTCGTGCCAAATAATCTAGTAACTAAGGAAATGAAAAAGGCTGATCCGGAT
GCCAAGACTAATTATCAAGAGGCCAAGGAAGCTGCCGAGAAACTGGGGACCAAGATGAAAATCGTCCCTGTTAAAACAGC
TCAAGAAGCCATTGATTATTTGAAAAAGACTAAATGA
3D structure
| Source | ID | Structure |
|---|
Similar proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|---|---|---|---|
| sepM | Streptococcus mutans UA159 |
63.05 |
95.251 |
0.601 |