NTDB

Overview

Name	mecA	Type	Regulator
Locus tag	ST90728_RS01020	Genome accession	NZ_CP065479
Coordinates	174127..174876 (+)	Length	249 a.a.
NCBI ID	WP_011225365.1	Uniprot ID	Q5M699
Organism	Streptococcus thermophilus strain 90728
Function	degradation of ComX (predicted from homology) Competence regulation

Genomic Context

Location: 169127..179876

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
ST90728_RS00990 (ST90728_00990)	-	169702..169872 (+)	171	WP_347114228.1	hypothetical protein	-
ST90728_RS00995 (ST90728_00995)	-	169959..170066 (+)	108	WP_011226802.1	LPXTG cell wall anchor domain-containing protein	-
ST90728_RS01000 (ST90728_01000)	-	170153..170893 (-)	741	WP_002949253.1	amino acid ABC transporter ATP-binding protein	-
ST90728_RS01005 (ST90728_01005)	-	170893..172443 (-)	1551	WP_014727298.1	ABC transporter substrate-binding protein/permease	-
ST90728_RS01010 (ST90728_01010)	-	172646..173500 (+)	855	WP_179966888.1	undecaprenyl-diphosphate phosphatase	-
ST90728_RS01015 (ST90728_01015)	-	173646..173861 (-)	216	WP_011226805.1	DUF3021 family protein	-
ST90728_RS01020 (ST90728_01020)	mecA	174127..174876 (+)	750	WP_011225365.1	adaptor protein MecA	Regulator
ST90728_RS01025 (ST90728_01025)	-	174880..176037 (+)	1158	WP_002947632.1	MraY family glycosyltransferase	-
ST90728_RS01030 (ST90728_01030)	sufC	176199..176969 (+)	771	WP_002947634.1	Fe-S cluster assembly ATPase SufC	-
ST90728_RS01035 (ST90728_01035)	sufD	177006..178268 (+)	1263	WP_002947640.1	Fe-S cluster assembly protein SufD	-
ST90728_RS01040 (ST90728_01040)	-	178322..179554 (+)	1233	WP_022096530.1	cysteine desulfurase	-

Sequence

Protein

Download Length: 249 a.a. Molecular weight: 29157.70 Da Isoelectric Point: 4.0659

                                >NTDB_id=510103 ST90728_RS01020 WP_011225365.1 174127..174876(+) (mecA) [Streptococcus thermophilus strain 90728]

MEMKQINETTLKIMITMEDLEEHGMELKDFLIPQEKTEEFFYTVMDELDLPDNFKNSGMLSFRVTPRKDRVDVFVTKSDL

KEALDFNDLSDMEDYSGLSPEEFLKALEDNFMDKGDIEAHHKLEEHDKTLKEVDETMTEPAKEVAEETIREDYTHYVLAF

SDFDQVVTFAQGLKNVSVEGSEFYKLGDVYYMTILLYLADEPDYYANNMYARFLEYANVADRTRPYLQEHATILMEEDAL

PVLQATKWS

Nucleotide

Download Length: 750 bp

                                >NTDB_id=510103 ST90728_RS01020 WP_011225365.1 174127..174876(+) (mecA) [Streptococcus thermophilus strain 90728]

ATGGAAATGAAACAAATAAACGAGACAACTCTAAAAATCATGATTACCATGGAAGATCTTGAAGAACATGGTATGGAGCT

GAAAGATTTCTTGATTCCCCAGGAAAAAACAGAGGAATTTTTCTATACTGTCATGGATGAGTTGGACTTGCCTGATAACT

TTAAAAATAGTGGGATGTTGAGCTTCCGTGTCACGCCACGAAAGGATCGTGTGGATGTTTTTGTGACTAAATCAGATCTT

AAGGAAGCCCTTGATTTTAATGATTTGTCAGATATGGAAGACTATTCAGGACTTTCTCCAGAAGAATTCCTCAAAGCTCT

TGAAGATAACTTTATGGATAAGGGAGATATTGAAGCCCACCATAAGCTCGAAGAGCATGATAAGACCTTGAAAGAGGTTG

ATGAGACTATGACAGAGCCGGCTAAGGAAGTGGCTGAGGAAACTATTCGTGAAGATTATACTCACTATGTCTTGGCTTTC

TCTGACTTTGATCAAGTAGTGACCTTTGCGCAAGGTTTGAAGAATGTGTCAGTGGAGGGTTCTGAATTTTATAAACTTGG

TGATGTCTACTATATGACTATCCTTCTTTACTTGGCTGATGAGCCTGATTATTACGCGAACAATATGTATGCGCGTTTTC

TTGAATATGCGAATGTGGCAGACCGAACACGTCCCTATCTACAAGAGCATGCAACAATCTTGATGGAAGAGGACGCCTTA

CCGGTATTACAAGCAACGAAATGGAGCTAG

Domains

Predicted by InterproScan.

Negative regulator of genetic competence (MecA) (MecA)

(1-242)

Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.

3D structure

Source	ID	Structure
AlphaFold DB	Q5M699

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.

Visualization of predicted probability:

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	H_a-value
mecA	Streptococcus thermophilus LMG 18311	100	100	1
mecA	Streptococcus thermophilus LMD-9	99.197	100	0.992
mecA	Streptococcus mutans UA159	57.377	97.992	0.562
mecA	Streptococcus pneumoniae Rx1	46.185	100	0.462
mecA	Streptococcus pneumoniae D39	46.185	100	0.462
mecA	Streptococcus pneumoniae R6	46.185	100	0.462
mecA	Streptococcus pneumoniae TIGR4	46.185	100	0.462

Detailed information NTG0510103