Detailed information    

insolico Bioinformatically predicted

Overview

Name   vicK   Type   Regulator
Locus tag   ST4134_RS05465 Genome accession   NZ_CP065478
Coordinates   1041644..1042984 (-) Length   446 a.a.
NCBI ID   WP_011681205.1    Uniprot ID   -
Organism   Streptococcus thermophilus strain 4134     
Function   repress comCDE expression; repress comX expression (predicted from homology)   
Competence regulation

Genomic Context

Location: 1036644..1047984
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  ST4134_RS05435 (ST4134_05430) - 1036750..1037136 (-) 387 WP_002953113.1 DUF1934 domain-containing protein -
  ST4134_RS05440 (ST4134_05435) - 1037228..1038120 (-) 893 Protein_1016 GNAT family N-acetyltransferase -
  ST4134_RS05445 (ST4134_05440) yidA 1038328..1039137 (+) 810 WP_011226081.1 sugar-phosphatase -
  ST4134_RS05450 (ST4134_05445) - 1039139..1040353 (+) 1215 WP_002953123.1 aminoacyltransferase -
  ST4134_RS05455 (ST4134_05450) - 1040405..1040766 (-) 362 Protein_1019 YbaN family protein -
  ST4134_RS05460 (ST4134_05455) vicX 1040826..1041635 (-) 810 WP_024704147.1 MBL fold metallo-hydrolase Regulator
  ST4134_RS05465 (ST4134_05460) vicK 1041644..1042984 (-) 1341 WP_011681205.1 cell wall metabolism sensor histidine kinase VicK Regulator
  ST4134_RS05470 (ST4134_05465) vicR 1042977..1043684 (-) 708 WP_011681206.1 response regulator YycF Regulator
  ST4134_RS05475 (ST4134_05470) - 1044211..1044978 (+) 768 WP_011681207.1 amino acid ABC transporter ATP-binding protein -
  ST4134_RS05480 (ST4134_05475) - 1044990..1045823 (+) 834 WP_011681208.1 transporter substrate-binding domain-containing protein -
  ST4134_RS05485 (ST4134_05480) - 1045841..1046539 (+) 699 WP_011681209.1 amino acid ABC transporter permease -
  ST4134_RS05490 (ST4134_05485) - 1046551..1047201 (+) 651 WP_024704148.1 amino acid ABC transporter permease -

Sequence

Protein


Download         Length: 446 a.a.        Molecular weight: 50791.08 Da        Isoelectric Point: 5.3933

>NTDB_id=510068 ST4134_RS05465 WP_011681205.1 1041644..1042984(-) (vicK) [Streptococcus thermophilus strain 4134]
MTSIGLNITSFELALLFTLLFVAFYFIFLAYRDYQQVKNIRKLTKRVKSLMAGNYNEKLRIKGDSELLELANSLNDLSDV
FRLTHENLIQEKNRLSSVLSYMSDGVIATNRLGQITMINSTAQRLLNLDRETATQMSILDILDGENPYTYSELLSKTPEI
HLSRRDANDEFVTLRVNFALIRKESGFISGLVAVLHDATEQEKEERERRLFVSNVSHELRTPLTSVKSYLEALDDGALNE
EIAPNFIKVSLDETNRMMRMISDLLALSRIDNKSTQLNVEMTNFTAFMTYILNRFGQIKSQETNPGKSYEIIRDYPVNSI
WVEIDTDKMTQVIDNILNNAIKYSPDGGKITVSMKTTDTQLIVSISDQGLGIPKKDLPLIFDRFYRVDKARSRAQGGTGL
GLSIAKEIVKQHNGFIWAKSEYGKGSTFTIVLPYDQDAMMVDEWEM

Nucleotide


Download         Length: 1341 bp        

>NTDB_id=510068 ST4134_RS05465 WP_011681205.1 1041644..1042984(-) (vicK) [Streptococcus thermophilus strain 4134]
ATGACTAGTATTGGCTTAAATATTACAAGCTTTGAACTAGCCTTACTCTTTACGCTCCTCTTTGTTGCTTTCTATTTCAT
TTTTCTAGCTTATCGTGATTATCAACAGGTCAAAAATATCCGAAAGTTGACTAAGAGAGTCAAATCCCTTATGGCAGGTA
ATTATAATGAAAAATTACGCATAAAGGGAGATTCAGAGCTTTTAGAGCTAGCTAATAGCTTGAATGATTTGTCGGACGTC
TTTCGTTTGACACATGAAAATCTAATCCAGGAAAAAAACCGCTTATCATCTGTTCTTTCGTACATGAGTGACGGGGTTAT
TGCGACCAATCGCCTTGGTCAGATTACTATGATTAATAGTACTGCCCAACGCTTGTTGAATTTAGATCGCGAAACTGCGA
CTCAGATGTCTATTTTGGATATATTAGATGGTGAGAATCCCTATACCTATAGTGAATTGTTGTCTAAGACACCCGAAATC
CATCTGTCGCGTCGAGATGCTAACGATGAATTTGTGACGCTACGTGTTAATTTTGCATTAATTCGTAAGGAATCTGGTTT
TATTTCAGGTCTGGTAGCCGTTCTTCATGATGCCACTGAGCAGGAAAAAGAAGAGCGCGAACGCCGTCTCTTCGTATCAA
ATGTTAGTCACGAATTGCGGACGCCTTTAACTTCTGTGAAATCCTATCTTGAAGCGCTTGATGATGGTGCTCTCAACGAA
GAGATTGCTCCAAACTTTATCAAAGTTTCTTTAGATGAAACCAACCGCATGATGCGTATGATTTCTGACCTCTTGGCATT
ATCTCGAATTGACAATAAAAGCACACAGCTTAATGTTGAAATGACAAACTTTACAGCCTTTATGACCTATATCTTGAATC
GGTTTGGTCAAATTAAGAGTCAAGAAACTAATCCAGGTAAGTCTTATGAAATCATTCGAGATTACCCAGTAAACTCTATT
TGGGTGGAAATTGATACTGATAAGATGACCCAGGTCATAGATAATATACTTAATAATGCCATCAAGTATTCTCCTGATGG
TGGGAAAATTACAGTATCTATGAAAACGACAGATACTCAGTTGATTGTTTCTATTTCTGACCAAGGTTTAGGAATTCCTA
AAAAAGATTTACCTCTGATTTTTGACCGTTTTTACCGTGTTGATAAGGCCAGAAGTCGTGCTCAGGGTGGAACAGGACTT
GGCTTATCCATTGCAAAAGAAATTGTTAAACAACATAATGGCTTCATTTGGGCTAAGAGTGAGTATGGTAAGGGGTCAAC
TTTTACAATTGTGCTTCCATATGACCAGGACGCAATGATGGTCGATGAATGGGAGATGTAG

Domains

Predicted by InterproScan.

His Kinase A (phospho-acceptor) domain (HisKA)

(208-272)

PAS fold (PAS)

(94-197)

HAMP domain (HAMP)

(37-79)

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c)

(325-435)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  vicK Streptococcus mutans UA159

74.396

92.825

0.691
  micB Streptococcus pneumoniae Cp1015

66.051

97.085

0.641