Detailed information    

insolico Bioinformatically predicted

Overview

Name   clpE   Type   Regulator
Locus tag   KU539_RS01130 Genome accession   NZ_CP077889
Coordinates   227279..229384 (+) Length   701 a.a.
NCBI ID   WP_001058981.1    Uniprot ID   Q2FV74
Organism   Staphylococcus aureus strain 333     
Function   repress competence development (at the early growth phase) (predicted from homology)   
Competence regulation

Genomic Context

Location: 222279..234384
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  KU539_RS01105 (KU539_01105) - 222418..222552 (-) 135 WP_001789912.1 hypothetical protein -
  KU539_RS01110 (KU539_01110) - 222646..222903 (-) 258 WP_000402605.1 hypothetical protein -
  KU539_RS01115 (KU539_01115) - 223482..224759 (-) 1278 WP_001180323.1 hydroxymethylglutaryl-CoA reductase, degradative -
  KU539_RS01120 (KU539_01120) - 225013..226179 (+) 1167 WP_000151982.1 hydroxymethylglutaryl-CoA synthase -
  KU539_RS01125 (KU539_01125) - 226349..226870 (-) 522 WP_000455987.1 methylated-DNA--[protein]-cysteine S-methyltransferase -
  KU539_RS01130 (KU539_01130) clpE 227279..229384 (+) 2106 WP_001058981.1 ATP-dependent Clp protease ATP-binding subunit ClpL Regulator
  KU539_RS01135 (KU539_01135) - 229453..229623 (-) 171 WP_000111118.1 FeoB-associated Cys-rich membrane protein -
  KU539_RS01140 (KU539_01140) feoB 229636..231630 (-) 1995 WP_000432907.1 ferrous iron transport protein B -
  KU539_RS01145 (KU539_01145) - 231642..231869 (-) 228 WP_000932073.1 FeoA family protein -

Sequence

Protein


Download         Length: 701 a.a.        Molecular weight: 77836.26 Da        Isoelectric Point: 4.6294

>NTDB_id=509909 KU539_RS01130 WP_001058981.1 227279..229384(+) (clpE) [Staphylococcus aureus strain 333]
MNNGFFNSDFDSIFRRMMKDMQGSNQVGNKKYYINGKEVSPEELAQLTQQGGNHSAEQSAQAFQQAAQRQQGQQGGNGNY
LEQIGRNLTQEARDGLLDPVIGRDKEIQETAEVLSRRTKNNPILVGEAGVGKTAIVEGLAQAIVEGNVPAAIKDKEIISV
DISSLEAGTQYRGAFEENIQKLIEGVKSSQNAVLFFDEIHQIIGSGATGSDSGSKGLSDILKPALSRGEISIIGATTQDE
YRNNILKDAALTRRFNEVLVNEPSAKDTVEILKGIREKFEEHHQVKLPDDVLKACVDLSIQYIPQRLLPDKAIDVLDITA
AHLSAQSPAVDKVETEKRISELENDKRKAVSAEEYKKADDIQNEIKSLQDKLENSNGEHTAVATVHDISDTIQRLTGIPV
SQMDDNDIERLKNISNRLRSKIIGQDQAVEMVSRAIRRNRAGFDDGNRPIGSFLFVGPTGVGKTELAKQLAIDLFGNKDA
LIRLDMSEYSDTTAVSKMIGTTAGYVGYDDNSNTLTEKVRRNPYSVILFDEIEKANPQILTLLLQVMDDGNLTDGQGNVI
NFKNTIIICTSNAGFGNGNDAEEKDIMHEMKKFFRPEFLNRFNGIVEFLHLDKDALQDIVNLLLDDVQVTLDKKGITMDV
SQDAKDWLIEEGYDEELGARPLRRIVEQQVRDKITDYYLDHTDVKHVDIDVEDNELVVKGK

Nucleotide


Download         Length: 2106 bp        

>NTDB_id=509909 KU539_RS01130 WP_001058981.1 227279..229384(+) (clpE) [Staphylococcus aureus strain 333]
ATGAATAACGGTTTTTTCAATAGCGACTTTGATTCAATTTTTCGAAGAATGATGAAAGATATGCAAGGTTCAAATCAAGT
CGGAAACAAAAAGTACTATATTAATGGTAAAGAAGTTTCACCTGAAGAACTAGCGCAACTCACACAACAAGGTGGCAATC
ACTCTGCTGAACAAAGTGCGCAAGCTTTTCAACAAGCAGCACAAAGACAACAAGGGCAACAAGGTGGCAACGGCAATTAT
TTAGAACAAATTGGTCGTAACCTTACGCAAGAAGCACGTGACGGTTTATTAGATCCAGTCATTGGTCGTGATAAAGAAAT
TCAAGAAACTGCTGAAGTTTTAAGTAGACGAACTAAAAACAATCCTATATTAGTTGGAGAAGCTGGTGTTGGTAAAACTG
CGATTGTTGAAGGTTTAGCACAGGCAATCGTTGAAGGAAATGTACCAGCAGCAATCAAAGACAAAGAAATTATTTCTGTA
GACATTTCATCATTAGAAGCTGGAACGCAATATCGTGGTGCTTTTGAAGAAAATATTCAAAAATTAATCGAAGGTGTTAA
ATCTTCACAAAATGCCGTACTATTCTTTGATGAAATCCATCAAATTATCGGTTCAGGTGCCACAGGAAGTGATTCAGGTA
GCAAAGGGTTATCTGATATTTTGAAACCTGCATTAAGTCGTGGTGAGATTTCTATTATTGGTGCAACAACACAAGATGAA
TATCGAAACAATATTCTTAAAGATGCTGCATTAACGCGCAGATTTAATGAAGTGCTTGTTAATGAACCAAGCGCTAAAGA
TACTGTTGAAATTTTAAAAGGTATTCGCGAAAAATTCGAAGAACACCATCAAGTAAAATTACCAGATGACGTATTAAAAG
CATGTGTTGACTTATCAATTCAATATATTCCACAACGATTATTACCAGATAAAGCAATCGATGTGTTAGATATTACAGCA
GCACATTTATCTGCGCAAAGTCCAGCTGTCGATAAAGTTGAAACTGAAAAACGAATTTCTGAATTAGAAAATGATAAACG
TAAAGCAGTAAGTGCTGAAGAATATAAAAAAGCTGACGACATTCAAAATGAAATCAAATCATTACAAGATAAATTAGAAA
ATAGTAATGGTGAACATACTGCTGTTGCTACAGTTCATGATATTTCAGATACTATTCAACGATTAACTGGTATTCCAGTT
TCTCAAATGGATGATAACGATATTGAACGTTTAAAAAATATTTCTAATCGTTTAAGAAGTAAAATCATAGGTCAAGATCA
AGCTGTAGAAATGGTTTCACGTGCAATTCGCCGTAATCGTGCTGGGTTTGATGACGGCAACCGTCCAATTGGCAGTTTCC
TATTTGTTGGCCCTACTGGTGTTGGTAAAACAGAGCTTGCTAAACAATTAGCAATTGATTTATTTGGTAATAAAGATGCA
CTGATTCGACTTGATATGAGTGAATATAGTGACACAACAGCTGTTTCAAAAATGATTGGTACAACTGCTGGTTATGTTGG
TTATGATGACAATTCAAATACGTTAACTGAAAAAGTACGCCGTAATCCATACTCAGTCATTCTATTTGATGAAATCGAAA
AAGCAAATCCACAAATTTTAACATTGTTATTACAAGTAATGGATGATGGTAATTTGACTGATGGTCAAGGTAATGTCATC
AACTTTAAAAATACAATTATTATTTGTACATCAAATGCTGGCTTTGGCAATGGCAATGACGCTGAAGAAAAAGATATTAT
GCACGAAATGAAAAAATTCTTCCGCCCTGAATTCCTTAACCGCTTCAACGGCATCGTTGAATTCTTACATTTAGATAAAG
ATGCATTGCAAGATATCGTCAACTTATTATTAGACGATGTACAAGTTACATTAGACAAAAAAGGTATTACGATGGACGTT
TCTCAAGATGCGAAAGATTGGTTAATTGAAGAAGGCTATGATGAAGAATTAGGTGCACGTCCATTAAGACGTATTGTTGA
ACAGCAAGTACGTGACAAAATTACAGATTACTATTTAGATCATACAGACGTTAAACATGTGGATATAGATGTTGAGGATA
ACGAATTAGTCGTAAAAGGTAAATAA

Domains

Predicted by InterProScan.

AAA lid domain (AAA_lid_9)

(264-363)

AAA domain (Cdc48 subfamily) (AAA_2)

(448-603)

ATPase family associated with various cellular activities (AAA) (AAA)

(123-257)

C-terminal, D2-small domain, of ClpB protein (ClpB_D2-small)

(611-682)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB Q2FV74

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  clpE Streptococcus mutans UA159

48.834

91.726

0.448
  clpE Streptococcus pneumoniae Rx1

48.298

88.017

0.425
  clpE Streptococcus pneumoniae D39

48.298

88.017

0.425
  clpE Streptococcus pneumoniae R6

48.298

88.017

0.425
  clpE Streptococcus pneumoniae TIGR4

48.298

88.017

0.425
  clpC Lactococcus lactis subsp. cremoris KW2

46.815

89.586

0.419
  clpC Bacillus subtilis subsp. subtilis str. 168

44.564

93.153

0.415
  clpC Streptococcus thermophilus LMD-9

44.392

90.3

0.401
  clpC Streptococcus thermophilus LMG 18311

44.076

90.3

0.398
  clpC Streptococcus pneumoniae TIGR4

44.175

88.16

0.389
  clpC Streptococcus pneumoniae Rx1

44.175

88.16

0.389
  clpC Streptococcus pneumoniae D39

44.175

88.16

0.389
  clpC Streptococcus mutans UA159

43.577

87.732

0.382
  clpC Lactococcus lactis subsp. lactis strain DGCC12653

41.294

92.582

0.382