Detailed information NTG0508761

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: I5044_RS09430
• Genome accession: NZ_CP065354
• Coordinates: 1939949..1940992 (-)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus strain JW_comp_novo
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 1934949..1945992

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
I5044_RS09400 (I5044_09400)	-	1935370..1936626 (-)	1257	WP_078064589.1	aminopeptidase	-
I5044_RS09405 (I5044_09405)	-	1936629..1936829 (-)	201	WP_000180460.1	DUF1128 family protein	-
I5044_RS09410 (I5044_09410)	-	1936976..1937440 (+)	465	WP_000228666.1	low molecular weight protein-tyrosine-phosphatase	-
I5044_RS09415 (I5044_09415)	-	1937447..1937722 (+)	276	WP_000428172.1	YtxH domain-containing protein	-
I5044_RS09420 (I5044_09420)	-	1938000..1939217 (+)	1218	WP_000037087.1	YihY/virulence factor BrkB family protein	-
I5044_RS09425 (I5044_09425)	vraR	1939330..1939959 (-)	630	WP_000153526.1	two-component system response regulator VraR	Regulator
I5044_RS09430 (I5044_09430)	vraS	1939949..1940992 (-)	1044	WP_001017131.1	sensor histidine kinase	Regulator
I5044_RS09435 (I5044_09435)	liaF	1940989..1941690 (-)	702	WP_000149064.1	cell wall-active antibiotics response protein LiaF	-
I5044_RS09440 (I5044_09440)	-	1941705..1942091 (-)	387	WP_001110179.1	hypothetical protein	-
I5044_RS09445 (I5044_09445)	map	1942308..1943066 (-)	759	WP_000636142.1	type I methionyl aminopeptidase	-
I5044_RS09450 (I5044_09450)	-	1943478..1944464 (+)	987	WP_000999715.1	FUSC family protein	-
I5044_RS09455 (I5044_09455)	-	1944653..1945066 (-)	414	WP_025174552.1	hypothetical protein	-
I5044_RS09460 (I5044_09460)	-	1945095..1945205 (-)	111	WP_001790257.1	hypothetical protein	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=508761 I5044_RS09430 WP_001017131.1 1939949..1940992(-) (vraS) [Staphylococcus aureus strain JW_comp_novo]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=508761 I5044_RS09430 WP_001017131.1 1939949..1940992(-) (vraS) [Staphylococcus aureus strain JW_comp_novo]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTGTTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTCTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTACTCGCTTACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAACGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACACTTGTACCTTTAAATCAAGAATTGCATAAGTTGCGACTTAAAACTCAAAACTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTAGCACGAGAACTTCACGATTCTGTCAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTATCTGCTATCAAAGAAACGAAGTTAGAACCACCATTAGACCAACAAATTCC
GATTTTAGAGAAAATGGTTCAAGATTCGCAGTTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCAATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGACAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1