Detailed information NTG0508337

Bioinformatically predicted

Overview

• Name: hexB
• Type: Machinery gene
• Locus tag: KU520_RS05835
• Genome accession: NZ_CP077855
• Coordinates: 1133116..1135125 (-)
• Length: 669 a.a.
• NCBI ID: WP_000516269.1
• Uniprot ID: B1VK93
• Organism: Staphylococcus aureus strain L6
• Function: DNA mismatch repair (predicted from homology) Homologous recombination

Genomic Context

Location: 1128116..1140125

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
KU520_RS05820 (KU520_05795)	glpK	1129650..1131146 (-)	1497	WP_000417372.1	glycerol kinase GlpK	-
KU520_RS05825 (KU520_05800)	-	1131275..1132093 (-)	819	WP_001103743.1	MIP/aquaporin family protein	-
KU520_RS05830 (KU520_05805)	-	1132568..1133110 (-)	543	WP_001077635.1	glycerol-3-phosphate responsive antiterminator	-
KU520_RS05835 (KU520_05810)	hexB	1133116..1135125 (-)	2010	WP_000516269.1	DNA mismatch repair endonuclease MutL	Machinery gene
KU520_RS05840 (KU520_05815)	hexA	1135138..1137756 (-)	2619	WP_000073352.1	DNA mismatch repair protein MutS	Machinery gene
KU520_RS05845 (KU520_05820)	thiW	1138059..1138550 (-)	492	WP_000842277.1	energy coupling factor transporter S component ThiW	-
KU520_RS05850 (KU520_05825)	-	1138577..1138942 (-)	366	WP_000282386.1	RicAFT regulatory complex protein RicA family protein	-

Sequence

Protein

• Length: 669 a.a.
• Molecular weight: 76871.06 Da
• Isoelectric Point: 5.0107

>NTDB_id=508337 KU520_RS05835 WP_000516269.1 1133116..1135125(-) (hexB) [Staphylococcus aureus strain L6]
MGKIKELQTSLANKIAAGEVVERPSSVVKELLENAIDAGATEISIEVEESGVQSIRVVDNGSGIEAEDLGLVFHRHATSK
LDQDEDLFHIRTLGFRGEALASISSVAKVTLKTCTDNANGNEIYVENGEILNHKPAKAKKGTDILVESLFYNTPARLKYI
KSLYTELGKITDIVNRMAMSHPDIRIALISDGKTMLSTNGSGRTNEVMAEIYGMKVARDLVHISGDTSDYHIEGFVAKPE
HSRSNKHYISIFINGRYIKNFMLNKAILEGYHTLLTIGRFPICYINIEMDPILVDVNVHPTKLEVRLSKEEQLYQLIVSK
IQEAFKDRILIPKNNLDYVPKKNKVLYSFEQQKIEFEQRQNTENNQEKTFSSEESNSKSFMAENQNDEIVIKEDSYNPFV
TKTSESLITDDESSGYNNTREKDEDYFKKQQEILQEMDQTFDSNEDASVQNYENKASDDYYDVNDIKGTKSKDPKRRIPY
MEIVGQVHGTYIIAQNEFGMYMIDQHAAQERIKYEYFRDKIGEVTNEVQDLLIPLTFHFSKDEQLVIDQYKNELQQVGIM
LEHFGGHDYIVSSYPVWFPKDEVEEIIKDMIELILEEKKVDIKKLREDVAIMMSCKKSIKANHYLQKHEMSDLIDQLREA
EDPFTCPHGRPIIINFSKYELEKLFKRVM

Nucleotide

• Length: 2010 bp

>NTDB_id=508337 KU520_RS05835 WP_000516269.1 1133116..1135125(-) (hexB) [Staphylococcus aureus strain L6]
ATGGGGAAAATTAAAGAACTCCAAACCTCATTAGCAAATAAAATCGCAGCAGGTGAAGTAGTTGAAAGACCGAGTTCTGT
TGTGAAAGAACTGTTGGAAAATGCTATAGATGCAGGCGCTACAGAAATAAGCATTGAAGTAGAGGAATCTGGCGTCCAAT
CTATTCGCGTAGTCGATAATGGAAGCGGAATTGAAGCGGAAGACTTAGGATTAGTATTTCATAGACATGCGACTAGTAAA
TTAGATCAAGATGAAGATTTATTTCATATTAGGACATTAGGATTCCGTGGTGAAGCACTAGCCAGTATTTCATCAGTTGC
TAAAGTAACATTGAAGACTTGCACGGATAATGCTAATGGAAATGAAATATATGTAGAAAATGGTGAAATATTAAATCATA
AGCCTGCAAAAGCGAAAAAAGGAACAGATATACTTGTAGAATCATTATTTTATAATACACCAGCACGTTTAAAATATATT
AAAAGTTTATACACTGAACTAGGTAAAATAACAGATATTGTCAATAGAATGGCTATGAGCCATCCGGACATTCGAATAGC
ACTCATTTCAGATGGCAAAACAATGTTAAGTACAAATGGTTCAGGACGAACTAATGAAGTGATGGCAGAGATTTATGGGA
TGAAAGTTGCACGAGATTTAGTACATATATCTGGAGATACAAGTGATTATCACATTGAAGGTTTTGTTGCAAAGCCTGAA
CATTCTAGAAGTAATAAGCACTATATTTCTATTTTTATTAATGGACGATACATTAAAAACTTTATGCTAAATAAAGCGAT
TTTAGAAGGCTATCATACACTCTTAACAATAGGTAGGTTCCCGATTTGTTATATTAATATTGAAATGGATCCAATCTTAG
TAGACGTAAATGTTCATCCAACAAAACTAGAAGTGCGTTTATCAAAAGAAGAGCAACTATATCAATTGATAGTGAGCAAA
ATACAAGAAGCATTTAAAGACCGTATATTAATTCCTAAAAATAACTTGGATTATGTGCCAAAAAAAAATAAAGTATTATA
TTCATTCGAACAACAAAAAATCGAATTTGAACAAAGACAAAACACAGAGAATAACCAAGAGAAGACGTTTTCATCTGAAG
AAAGTAACAGTAAGTCATTTATGGCAGAAAATCAAAACGATGAGATAGTTATAAAAGAAGATTCATATAATCCATTCGTA
ACGAAAACATCTGAAAGTTTAATAACTGATGATGAATCTTCTGGTTATAATAATACACGTGAAAAAGATGAAGACTACTT
CAAAAAACAACAAGAAATTTTACAAGAAATGGATCAAACATTTGATTCAAATGAGGATGCATCTGTGCAAAATTATGAGA
ATAAAGCGTCTGATGATTATTATGATGTAAACGATATTAAAGGAACAAAAAGTAAAGACCCTAAACGAAGAATTCCATAT
ATGGAAATTGTTGGCCAAGTACATGGGACGTATATTATTGCTCAAAATGAATTTGGCATGTACATGATTGACCAGCATGC
AGCTCAAGAAAGAATAAAATATGAATATTTTCGAGATAAAATAGGTGAAGTTACCAATGAAGTACAAGATTTATTAATCC
CGTTAACATTTCATTTTTCAAAGGATGAACAATTAGTTATTGATCAATATAAAAATGAGCTTCAACAAGTAGGTATCATG
TTAGAACATTTTGGTGGTCATGATTATATTGTAAGTAGCTATCCAGTTTGGTTCCCTAAAGATGAAGTAGAAGAAATCAT
TAAAGATATGATTGAGCTAATTTTGGAAGAGAAAAAAGTAGATATTAAAAAATTACGTGAAGATGTAGCAATCATGATGT
CATGTAAAAAATCTATTAAAGCGAATCATTATTTACAAAAACATGAAATGTCTGATTTAATTGATCAATTAAGAGAAGCG
GAAGATCCATTTACATGTCCACATGGTCGTCCAATAATCATTAATTTTTCAAAATACGAATTAGAAAAATTATTTAAGCG
TGTGATGTAG

Domains

Predicted by InterProScan.

• MutL C terminal dimerisation domain (MutL_C) (483-625)

• DNA mismatch repair protein, C-terminal domain (DNA_mis_repair) (209-325)

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c_3) (25-118)

3D structure

• AlphaFold DB: B1VK93

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
hexB	Streptococcus pneumoniae R6	40.828	100	0.413