Detailed information    

insolico Bioinformatically predicted

Overview

Name   hexB   Type   Machinery gene
Locus tag   I6L86_RS02790 Genome accession   NZ_CP077259
Coordinates   611971..613920 (-) Length   649 a.a.
NCBI ID   WP_217003397.1    Uniprot ID   -
Organism   Streptococcus mitis strain FDAARGOS 1456     
Function   DNA mismatch repair (predicted from homology)   
Homologous recombination

Genomic Context

Location: 606971..618920
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  I6L86_RS02760 (I6L86_02760) - 607528..608472 (+) 945 WP_000815623.1 magnesium transporter CorA family protein -
  I6L86_RS02765 (I6L86_02765) - 608484..609161 (+) 678 WP_000078009.1 DUF1129 domain-containing protein -
  I6L86_RS02770 (I6L86_02770) - 609302..610336 (+) 1035 WP_000626031.1 S66 family peptidase -
  I6L86_RS02775 (I6L86_02775) - 610442..610705 (+) 264 WP_000166114.1 SemiSWEET family transporter -
  I6L86_RS02780 (I6L86_02780) - 610789..611352 (-) 564 WP_000166574.1 DNA-3-methyladenine glycosylase I -
  I6L86_RS02785 (I6L86_02785) ruvA 611362..611955 (-) 594 WP_000273422.1 Holliday junction branch migration protein RuvA Machinery gene
  I6L86_RS02790 (I6L86_02790) hexB 611971..613920 (-) 1950 WP_217003397.1 DNA mismatch repair endonuclease MutL Machinery gene
  I6L86_RS02795 (I6L86_02795) - 614126..614566 (+) 441 WP_000861976.1 LytTR family DNA-binding domain-containing protein -
  I6L86_RS02800 (I6L86_02800) - 614563..615021 (+) 459 WP_000743962.1 DUF3021 domain-containing protein -
  I6L86_RS02805 (I6L86_02805) nrdI 615069..615533 (-) 465 WP_000849612.1 class Ib ribonucleoside-diphosphate reductase assembly flavoprotein NrdI -
  I6L86_RS02810 (I6L86_02810) - 615611..616144 (-) 534 WP_000729020.1 hypothetical protein -
  I6L86_RS02815 (I6L86_02815) - 616205..617491 (-) 1287 WP_000278883.1 response regulator transcription factor -

Sequence

Protein


Download         Length: 649 a.a.        Molecular weight: 73354.71 Da        Isoelectric Point: 5.2932

>NTDB_id=505992 I6L86_RS02790 WP_217003397.1 611971..613920(-) (hexB) [Streptococcus mitis strain FDAARGOS 1456]
MSHIIELPEVLANQIAAGEVIERPASVVKELVENAIDAGSSQIIIEIEEAGLKKIQITDNGHGIAHDEVELALRRHATSK
IKNQADLFRIRTLGFCGEALPSIASVSVLTLLTAVDGASHGTKLVARGGEVEEVIPATSPVGTKVCVEDLFFNTPARLKY
MKSQQAELSHIIDIVNRLGLAHPEISFSLISDGKEMTRTAGTGQLRQAIAGIYGLVSAKKMIEIENSDLDFEISGFVSLP
ELTRANRNYISLFINGRYIKNFLLNRAILDGYGSKLMVGRFPLAVIHIHIDPYLADVNVHPTKQEVRISKEKELMALVSE
AIANSLKEQTLIPDALENLAKSTVRNRQKVEQTILPLKENTLYYEKTESIRSSQAEVADYQVELTEEGQDLTLFAKETLD
QLTKPAKLHFAERKPANYDQLDHPELDLASLDKAYDKLEREESSSFPELEFFGQMHGTYLFAQGRDGLYIIDQHAAQERV
KYEEYRESIGNVDQSQQQLLVPYIFEFPADDALRLKERMTHLEEVGVFLAEYGENQFILREHPIWMAEEEIESGIYEMCD
MLLLTKEVSIKKYRAELAIMMSCKRSIKANHRIDDHSARQLLYQLSQCDNPYNCPHGRPVLVHFTKSDMEKMFRRIQENH
TSLRELGKY

Nucleotide


Download         Length: 1950 bp        

>NTDB_id=505992 I6L86_RS02790 WP_217003397.1 611971..613920(-) (hexB) [Streptococcus mitis strain FDAARGOS 1456]
ATGTCTCATATTATTGAATTGCCAGAGGTGCTGGCAAACCAGATCGCGGCTGGAGAGGTTATCGAGCGTCCAGCTAGCGT
TGTTAAGGAGCTAGTAGAAAACGCCATTGACGCGGGCTCTAGTCAGATTATCATTGAGATTGAGGAAGCTGGTCTCAAGA
AAATCCAAATCACAGATAATGGTCATGGAATTGCCCACGATGAGGTGGAATTGGCCTTGCGTCGTCATGCGACCAGTAAG
ATAAAAAATCAGGCAGATCTCTTTCGGATTCGGACGCTTGGTTTTTGTGGTGAAGCCTTGCCTTCTATCGCTTCTGTTAG
TGTTTTGACCCTTTTGACGGCGGTGGATGGTGCAAGTCATGGAACCAAGCTCGTCGCGCGTGGGGGAGAAGTTGAAGAAG
TCATCCCAGCGACTAGTCCTGTGGGAACCAAGGTTTGTGTGGAGGACCTCTTTTTCAACACGCCTGCCCGCCTCAAGTAT
ATGAAGAGCCAGCAAGCGGAGTTGTCTCATATCATTGATATTGTCAATCGTCTGGGCTTGGCCCATCCTGAAATTTCGTT
TAGTTTAATCAGTGATGGCAAGGAGATGACGCGGACAGCTGGGACTGGTCAATTGCGCCAAGCTATCGCAGGAATTTACG
GTTTGGTGAGTGCCAAGAAGATGATTGAAATTGAGAATTCTGACCTAGATTTCGAAATTTCAGGTTTTGTGTCCTTGCCT
GAGTTAACTCGAGCCAACCGCAACTATATCAGTCTCTTCATCAATGGCCGTTATATAAAGAACTTCCTGCTCAATCGTGC
AATTCTAGATGGCTATGGCAGTAAGCTTATGGTAGGCCGTTTTCCACTGGCTGTCATTCACATTCATATCGACCCTTATC
TAGCGGATGTCAATGTACACCCAACCAAGCAAGAGGTGCGGATTTCCAAGGAAAAAGAACTGATGGCGCTGGTCTCAGAA
GCTATTGCAAACAGTCTCAAGGAACAAACCTTGATACCTGATGCCTTGGAAAATCTTGCTAAATCGACCGTGCGCAATCG
TCAAAAGGTGGAGCAGACCATTCTCCCACTCAAAGAAAATACGCTCTACTATGAGAAAACAGAGTCGATAAGATCCAGTC
AAGCTGAGGTGGCTGATTATCAGGTAGAATTAACTGAGGAAGGGCAAGACTTGACTTTGTTTGCCAAGGAAACCTTGGAT
CAGCTAACCAAGCCAGCAAAACTGCATTTTGCAGAGAGAAAGCCTGCTAACTACGACCAGCTAGATCACCCAGAGTTAGA
CCTTGCGAGTCTTGATAAGGCTTATGACAAGCTGGAGCGAGAAGAATCATCCAGCTTCCCAGAATTGGAATTTTTCGGGC
AAATGCACGGGACTTATCTCTTTGCCCAAGGGCGAGATGGGCTCTATATCATAGACCAGCACGCGGCTCAGGAACGGGTC
AAGTACGAGGAATACCGTGAAAGTATTGGCAATGTTGACCAGAGCCAGCAGCAACTCCTAGTGCCCTATATCTTTGAATT
TCCAGCGGATGATGCTCTTCGTCTCAAGGAAAGAATGACACATTTGGAGGAAGTGGGCGTCTTTCTAGCAGAGTACGGAG
AAAATCAATTTATCCTGCGTGAACATCCTATTTGGATGGCAGAGGAGGAAATCGAGTCAGGCATCTATGAGATGTGCGAC
ATGCTCCTTTTGACCAAGGAAGTTTCTATCAAGAAATATCGAGCAGAGTTGGCTATTATGATGTCCTGCAAGCGGTCTAT
CAAGGCCAACCATCGTATTGACGACCATTCGGCTAGACAGCTCCTCTATCAGCTCTCTCAATGTGACAATCCCTATAACT
GTCCCCACGGACGCCCTGTTTTGGTGCATTTTACCAAGTCGGATATGGAAAAGATGTTCCGACGTATTCAGGAAAATCAC
ACCAGTCTCCGTGAGTTGGGGAAATATTAA

Domains

Predicted by InterProScan.

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c_3)

(25-83)

MutL C terminal dimerisation domain (MutL_C)

(450-592)

DNA mismatch repair protein, C-terminal domain (DNA_mis_repair)

(209-326)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  hexB Streptococcus pneumoniae R6

97.535

100

0.975