Detailed information    

insolico Bioinformatically predicted

Overview

Name   uvrC   Type   Machinery gene
Locus tag   HPSH112_RS02820 Genome accession   NC_017741
Coordinates   578980..580764 (-) Length   594 a.a.
NCBI ID   WP_000774345.1    Uniprot ID   A0AAE7TS96
Organism   Helicobacter pylori Shi112     
Function   integration of short DNA fragment (predicted from homology)   
DNA binding and uptake

Genomic Context

Location: 573980..585764
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  HPSH112_RS02790 (HPSH112_02850) - 574571..574819 (+) 249 WP_000790556.1 RNA-binding protein -
  HPSH112_RS02795 (HPSH112_02855) - 575021..575842 (-) 822 WP_001263421.1 glycosyltransferase family 25 protein -
  HPSH112_RS02800 (HPSH112_02860) trxB 576009..576944 (-) 936 WP_000564371.1 thioredoxin-disulfide reductase -
  HPSH112_RS02805 (HPSH112_02865) trxA 576950..577270 (-) 321 WP_000020197.1 thioredoxin -
  HPSH112_RS02810 (HPSH112_02870) - 577359..577703 (-) 345 WP_001211675.1 YraN family protein -
  HPSH112_RS02815 (HPSH112_02875) - 577704..578969 (-) 1266 WP_000746802.1 homoserine dehydrogenase -
  HPSH112_RS02820 (HPSH112_02880) uvrC 578980..580764 (-) 1785 WP_000774345.1 excinuclease ABC subunit UvrC Machinery gene
  HPSH112_RS02825 (HPSH112_02885) - 580765..581226 (-) 462 WP_000437151.1 hypothetical protein -
  HPSH112_RS02830 (HPSH112_02890) - 581218..581397 (+) 180 WP_000468794.1 hypothetical protein -
  HPSH112_RS02835 (HPSH112_02895) - 581409..582050 (-) 642 WP_000659419.1 ATP-binding cassette domain-containing protein -
  HPSH112_RS02840 (HPSH112_02900) - 582052..582849 (-) 798 Protein_554 glycine betaine ABC transporter substrate-binding protein -
  HPSH112_RS02845 (HPSH112_02905) - 582937..583590 (+) 654 WP_001042542.1 IS607-like element IS607 family transposase -
  HPSH112_RS02850 (HPSH112_02910) - 583565..584824 (+) 1260 WP_001274344.1 RNA-guided endonuclease InsQ/TnpB family protein -
  HPSH112_RS02855 (HPSH112_02915) - 584856..585740 (-) 885 Protein_557 ABC transporter permease -

Sequence

Protein


Download         Length: 594 a.a.        Molecular weight: 68865.22 Da        Isoelectric Point: 9.8089

>NTDB_id=50540 HPSH112_RS02820 WP_000774345.1 578980..580764(-) (uvrC) [Helicobacter pylori Shi112]
MADLLSSLKNLSHSSGVYQYFDKNHQLLYIGKAKNLKKRIKSYFSVRNNEITPNYRTSLRIQMMVKQIAFLETILVENEQ
DALILENSLIKQLKPKYNILLRDDKTYPYIYMDFSTDFPIPLITRKILKQPGVKYFGPFTSGAKDILDSLYELLPLVQKK
NCIKDKKACMFYQIERCKAPCENKITKEEYLKIAKECLEMIENKDKLIKELELKMERLSNNLRFEEALIYRDRIAKIQKI
APFTCMDLAKLYDLDIFAFYGKGNKAVLVKMFMRRGKIISSSFEKIHSLNGFDTDEAMKQAIINHYQSHLPLIPEQILLN
ACSNETLKELQEFISHRYSKKIALSIPKKGDKLALIEIAMKNAQEIFSQEKTSNEDLILEEARSLFKLECMPYRVEIFDT
SHHANSQCVGGMVVYENHAFQKNSYRRYHLKGSNEYTQMSELLTRRALDFAKEPPPNLWVIDGGRAQLNIALEILKSSGS
FVEVIAISKEKRDSKAYRSKGGAKDIIHTASDTFKLLPSDKRLQWVQKLRDESHRYAINFHRSTKLKNMKQIALLKEKGI
GEASVKKLLDYFGSFEAIEKASEQEKNAVLKKRI

Nucleotide


Download         Length: 1785 bp        

>NTDB_id=50540 HPSH112_RS02820 WP_000774345.1 578980..580764(-) (uvrC) [Helicobacter pylori Shi112]
ATGGCTGATTTATTGTCCAGTTTGAAAAACCTTTCTCATAGCAGTGGCGTGTATCAATATTTTGACAAAAACCACCAATT
ACTCTATATCGGTAAGGCGAAAAATTTAAAAAAGCGCATCAAAAGCTATTTTTCTGTCCGCAATAATGAAATCACGCCCA
ATTATCGCACCAGCTTACGCATCCAAATGATGGTCAAACAGATCGCTTTTTTAGAAACCATTTTAGTGGAAAACGAGCAA
GACGCTTTGATTTTAGAAAATTCTTTAATCAAGCAGCTCAAACCCAAATACAACATTCTTTTAAGAGACGATAAAACTTA
CCCTTATATTTACATGGATTTTTCCACTGATTTCCCTATCCCTTTAATCACACGAAAAATTTTAAAACAGCCTGGCGTTA
AATATTTTGGGCCTTTTACGAGCGGGGCTAAGGATATTTTAGACAGCTTGTATGAATTGCTCCCGTTAGTTCAAAAGAAA
AATTGCATCAAAGATAAAAAGGCATGCATGTTTTATCAAATAGAGCGTTGTAAAGCCCCATGCGAGAATAAAATCACCAA
AGAAGAGTATTTGAAAATCGCTAAAGAATGTTTAGAAATGATTGAAAATAAAGACAAACTCATCAAAGAGCTTGAATTAA
AAATGGAGCGCCTTTCTAATAACTTGCGTTTTGAAGAAGCCCTCATTTATAGGGACAGGATTGCAAAAATCCAAAAAATC
GCCCCTTTCACTTGCATGGATTTAGCCAAACTCTACGATTTGGATATTTTTGCTTTTTATGGCAAGGGTAATAAGGCGGT
GTTAGTGAAAATGTTTATGCGTAGGGGTAAAATCATTTCTTCATCGTTTGAAAAAATCCACTCTCTCAATGGGTTTGACA
CTGATGAAGCGATGAAACAAGCCATTATCAATCATTACCAATCGCATTTGCCTTTAATTCCAGAACAAATCTTATTGAAC
GCTTGTTCTAATGAAACGCTTAAAGAATTGCAAGAATTTATCTCTCACCGATACTCTAAAAAAATCGCTCTTAGTATTCC
TAAAAAAGGCGATAAGCTCGCTTTAATAGAAATCGCTATGAAAAACGCTCAAGAGATTTTTAGCCAGGAAAAAACCTCTA
ATGAAGATCTGATTTTAGAAGAAGCGCGATCGCTCTTTAAATTAGAGTGCATGCCTTATAGGGTGGAAATCTTTGACACA
AGCCACCATGCCAACAGCCAATGCGTGGGGGGAATGGTCGTGTATGAAAACCATGCATTTCAAAAAAACTCCTATCGGCG
CTACCATTTAAAAGGCTCTAATGAATACACTCAAATGAGCGAATTGCTCACCAGAAGGGCTTTAGACTTTGCCAAAGAGC
CGCCGCCTAATTTGTGGGTGATCGATGGAGGGAGGGCGCAATTAAACATCGCTTTAGAAATTTTAAAAAGCAGCGGGAGT
TTTGTAGAAGTGATCGCTATTTCTAAAGAAAAAAGGGATTCTAAAGCTTATCGCTCTAAAGGGGGCGCTAAAGACATTAT
CCACACCGCTAGCGATACTTTTAAATTGCTCCCTAGCGACAAGCGCTTGCAGTGGGTGCAAAAATTGCGCGATGAAAGCC
ACCGGTATGCGATAAACTTCCATAGATCCACTAAACTTAAAAACATGAAACAAATCGCTCTTTTAAAAGAAAAGGGTATA
GGAGAAGCCAGCGTGAAAAAATTGTTGGATTATTTTGGGAGTTTTGAAGCGATAGAAAAAGCGAGCGAGCAGGAAAAAAA
CGCTGTTTTAAAAAAACGAATCTAA

Domains

Predicted by InterproScan.

GIY-YIG catalytic domain (GIY-YIG)

(15-98)

UvrB/uvrC motif (UVR)

(205-239)

UvrC RNAse H endonuclease domain (UvrC_RNaseH_dom)

(385-538)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  uvrC Helicobacter pylori 26695

96.801

100

0.968

Multiple sequence alignment