Detailed information    

insolico Bioinformatically predicted

Overview

Name   uvrC   Type   Machinery gene
Locus tag   HPB14_RS02570 Genome accession   NC_017733
Coordinates   521813..523597 (-) Length   594 a.a.
NCBI ID   WP_000774373.1    Uniprot ID   -
Organism   Helicobacter pylori HUP-B14     
Function   integration of short DNA fragment (predicted from homology)   
DNA binding and uptake

Genomic Context

Location: 516813..528597
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  HPB14_RS02540 (HPB14_02525) - 517190..517438 (+) 249 WP_000790561.1 RNA-binding protein -
  HPB14_RS02545 (HPB14_02530) - 517663..518484 (-) 822 WP_001263405.1 glycosyltransferase family 25 protein -
  HPB14_RS02550 (HPB14_02535) trxB 518842..519777 (-) 936 WP_000564408.1 thioredoxin-disulfide reductase -
  HPB14_RS02555 (HPB14_02540) trxA 519783..520103 (-) 321 WP_000020199.1 thioredoxin -
  HPB14_RS02560 (HPB14_02545) - 520192..520536 (-) 345 WP_001211720.1 YraN family protein -
  HPB14_RS02565 (HPB14_02550) - 520537..521802 (-) 1266 WP_000746840.1 homoserine dehydrogenase -
  HPB14_RS02570 (HPB14_02555) uvrC 521813..523597 (-) 1785 WP_000774373.1 excinuclease ABC subunit UvrC Machinery gene
  HPB14_RS02575 (HPB14_02560) - 523598..524059 (-) 462 WP_000437184.1 hypothetical protein -
  HPB14_RS02580 (HPB14_02565) - 524051..524230 (+) 180 WP_000468797.1 hypothetical protein -
  HPB14_RS02585 (HPB14_02570) - 524233..524883 (-) 651 WP_000659424.1 ATP-binding cassette domain-containing protein -
  HPB14_RS02590 (HPB14_02575) - 524885..526546 (-) 1662 WP_001133294.1 ABC transporter permease/substrate-binding protein -
  HPB14_RS02595 (HPB14_02580) - 526616..527053 (-) 438 WP_001879940.1 hypothetical protein -
  HPB14_RS02600 (HPB14_02585) motB 527059..527832 (-) 774 WP_001085335.1 flagellar motor protein MotB -

Sequence

Protein


Download         Length: 594 a.a.        Molecular weight: 68802.08 Da        Isoelectric Point: 9.7159

>NTDB_id=50433 HPB14_RS02570 WP_000774373.1 521813..523597(-) (uvrC) [Helicobacter pylori HUP-B14]
MADLLSSLKNLSNSSGVYQYFDKNRQLLYIGKAKNLKKRIKSYFSIHNNEITPNHRASLRIQMMVKQIAFLETILVENEQ
DALILENSLIKQLKPKYNILLRDDKTYPYIYMDFSTDFPIPLITRKILKQPGVKYFGPFTSGAKDILDSLYELLPLVQKK
NCIKDKKACMFYQIERCKAPCEDKITKEEYLKIAKECLEMIENKDRLIKELELKMERLSSNLRFEEALIYRDRIAKIQKI
APFTCMDLAKLYDLDIFAFYGRNNKAVLVKMFMRGGKIISSAFEKIHSLNGFDTDEAMKQAIINHYQLHLPLMPEQILLS
ACSNEVLKELQEFISHQYSKKIALSIPKKGDKLALIEIAMKNAQEIFSQEKTSNEDWILEEVRSLFNLECVPYRVEIFDT
SHHSNSQCVGGMVVYENNAFQKNSYRRYHLKGSNEYAQMSELLTRRALDFAKEPPPNLWVIDGGRAQLNIALEILKSSGS
FVEVIAISKEKRDSKAYRSKGGAKDIIHTPSNTFKLLPSDKRLQWVQKLRDESHRYAINFHRSTKLKNMKQIALLKEKGI
GEASVKKLLDYFGSFEAIEKASEQEKNAVLKKRI

Nucleotide


Download         Length: 1785 bp        

>NTDB_id=50433 HPB14_RS02570 WP_000774373.1 521813..523597(-) (uvrC) [Helicobacter pylori HUP-B14]
ATGGCTGATTTATTGTCCAGTTTGAAAAACCTTTCTAATAGCAGTGGCGTGTATCAATATTTTGATAAAAACCGCCAATT
ACTCTATATCGGTAAAGCAAAAAACTTAAAAAAGCGCATCAAAAGCTATTTTTCTATCCATAATAATGAAATCACGCCCA
ATCATCGCGCAAGCTTACGCATCCAAATGATGGTCAAACAAATCGCTTTTTTAGAAACCATTTTAGTGGAAAACGAGCAA
GACGCTTTGATTTTAGAAAATTCTTTAATCAAGCAGCTCAAGCCCAAATACAACATTCTTTTAAGAGACGATAAAACTTA
CCCTTATATTTACATGGATTTTTCCACTGATTTCCCTATCCCTTTAATCACACGAAAAATTTTAAAACAGCCTGGCGTTA
AATATTTTGGCCCTTTTACGAGCGGGGCTAAGGATATTTTGGACAGCTTGTATGAGTTGCTCCCGTTGGTTCAAAAGAAA
AATTGCATCAAGGATAAAAAGGCATGCATGTTTTATCAAATAGAGCGTTGTAAAGCCCCATGCGAGGATAAAATCACTAA
AGAAGAGTATTTAAAAATCGCTAAAGAATGTTTAGAAATGATTGAAAATAAAGACAGACTCATCAAAGAGCTTGAATTGA
AAATGGAGCGCCTTTCTAGCAATTTGCGTTTTGAAGAAGCCCTAATTTACAGGGATAGGATTGCAAAAATCCAAAAAATC
GCCCCTTTCACTTGCATGGATTTGGCCAAACTCTACGATTTGGATATTTTTGCTTTTTATGGTAGGAACAATAAGGCGGT
GTTAGTGAAAATGTTTATGCGTGGGGGTAAAATCATTTCTTCAGCGTTTGAAAAAATCCACTCCCTCAATGGGTTTGACA
CCGATGAAGCGATGAAACAAGCCATTATCAACCATTACCAATTGCATTTGCCTTTGATGCCTGAACAGATCTTATTGAGC
GCTTGCTCTAATGAGGTGCTTAAAGAATTGCAAGAGTTTATCTCTCACCAATACTCTAAAAAAATCGCTCTTAGCATTCC
TAAAAAAGGCGATAAGCTCGCTTTAATAGAAATCGCTATGAAAAACGCTCAAGAGATTTTTAGCCAAGAAAAAACCTCTA
ATGAAGATTGGATTTTAGAAGAAGTGCGATCGCTTTTCAATTTAGAGTGCGTGCCTTATAGGGTGGAAATTTTTGACACA
AGCCACCATTCAAACAGCCAATGCGTGGGGGGAATGGTCGTGTATGAAAATAACGCCTTCCAAAAAAACTCTTACCGGCG
CTACCATCTAAAAGGCTCTAACGAATACGCTCAAATGAGCGAATTGCTCACCAGAAGGGCTTTAGATTTTGCTAAAGAGC
CACCGCCTAATTTGTGGGTGATTGATGGAGGGAGGGCGCAATTAAACATCGCTTTAGAAATTTTAAAAAGCAGCGGGAGT
TTTGTAGAAGTGATCGCTATTTCTAAAGAAAAAAGGGATTCTAAAGCTTATCGTTCTAAAGGGGGCGCTAAAGACATTAT
CCATACGCCTAGCAATACTTTTAAATTGCTCCCTAGCGACAAACGCTTGCAATGGGTGCAAAAATTGCGCGATGAAAGCC
ACCGGTATGCGATAAACTTCCACAGATCCACTAAACTTAAAAACATGAAACAAATCGCTCTTTTAAAAGAAAAGGGCATA
GGAGAAGCCAGCGTGAAAAAATTATTGGATTATTTTGGGAGTTTTGAAGCGATAGAAAAAGCGAGCGAGCAGGAAAAAAA
CGCCGTTTTGAAAAAACGAATCTAA

Domains

Predicted by InterproScan.

UvrC RNAse H endonuclease domain (UvrC_RNaseH_dom)

(385-538)

GIY-YIG catalytic domain (GIY-YIG)

(15-98)

UvrB/uvrC motif (UVR)

(205-239)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  uvrC Helicobacter pylori 26695

96.97

100

0.97

Multiple sequence alignment