Detailed information
Bioinformatically predicted
Overview
| Name | ccrA | Type | Machinery gene |
| Locus tag | HWI14_RS13480 | Genome accession | NZ_CP064631 |
| Coordinates | 2729448..2730794 (+) | Length | 448 a.a. |
| NCBI ID | WP_000816499.1 | Uniprot ID | Q9R3W9 |
| Organism | Staphylococcus epidermidis strain UMCG341 | ||
| Function | promote SCCmec transfer (predicted from homology) Homologous recombination |
||
Related MGE
Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.
Gene-MGE association summary
| MGE type | MGE coordinates | Gene coordinates | Relative position | Distance (bp) |
|---|---|---|---|---|
| SCCmec | 2695642..2750606 | 2729448..2730794 | within | 0 |
Gene organization within MGE regions
Location: 2695642..2750606
| Locus tag | Gene name | Coordinates (strand) | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| HWI14_RS13300 (HWI14_13175) | - | 2695642..2696454 (-) | 813 | WP_002504699.1 | abortive infection system antitoxin AbiGi family protein | - |
| HWI14_RS13305 (HWI14_13180) | - | 2696645..2698159 (+) | 1515 | WP_002504700.1 | class I SAM-dependent DNA methyltransferase | - |
| HWI14_RS13310 (HWI14_13185) | - | 2698149..2699423 (+) | 1275 | WP_002504701.1 | restriction endonuclease subunit S | - |
| HWI14_RS13315 (HWI14_13190) | - | 2699407..2702526 (+) | 3120 | WP_002504702.1 | type I restriction endonuclease subunit R | - |
| HWI14_RS13320 (HWI14_13195) | - | 2702604..2702927 (-) | 324 | WP_001176049.1 | PepSY domain-containing protein | - |
| HWI14_RS13325 (HWI14_13200) | - | 2703321..2703542 (-) | 222 | WP_002504703.1 | hypothetical protein | - |
| HWI14_RS13330 (HWI14_13205) | - | 2703491..2703934 (-) | 444 | WP_000941333.1 | hypothetical protein | - |
| HWI14_RS13335 (HWI14_13210) | - | 2703996..2704523 (-) | 528 | WP_002504704.1 | hypothetical protein | - |
| HWI14_RS13340 (HWI14_13215) | - | 2704658..2705146 (-) | 489 | WP_000393586.1 | hypothetical protein | - |
| HWI14_RS13345 (HWI14_13220) | - | 2705162..2705452 (-) | 291 | WP_000065261.1 | hypothetical protein | - |
| HWI14_RS13350 (HWI14_13225) | - | 2705509..2706381 (-) | 873 | WP_000373149.1 | HTH domain-containing protein | - |
| HWI14_RS13355 (HWI14_13230) | - | 2706551..2706997 (-) | 447 | WP_002504705.1 | RadC family protein | - |
| HWI14_RS13360 (HWI14_13235) | - | 2707018..2707524 (-) | 507 | WP_000849085.1 | DUF1643 domain-containing protein | - |
| HWI14_RS13365 (HWI14_13240) | - | 2707540..2707851 (-) | 312 | WP_001083108.1 | DUF960 family protein | - |
| HWI14_RS13370 (HWI14_13245) | - | 2707947..2708285 (-) | 339 | WP_063964250.1 | SAUGI family uracil-DNA glycosylase inhibitor | - |
| HWI14_RS13375 (HWI14_13250) | ccrC | 2708391..2710067 (-) | 1677 | WP_002504707.1 | cassette chromosome recombinase CcrC | - |
| HWI14_RS13380 (HWI14_13255) | - | 2710292..2711935 (-) | 1644 | WP_002504708.1 | DUF5906 domain-containing protein | - |
| HWI14_RS13385 (HWI14_13260) | - | 2711932..2712303 (-) | 372 | WP_002437511.1 | hypothetical protein | - |
| HWI14_RS13390 (HWI14_13265) | - | 2712296..2713405 (-) | 1110 | WP_002437509.1 | DNA polymerase | - |
| HWI14_RS13395 (HWI14_13270) | - | 2713575..2715587 (-) | 2013 | WP_012088687.1 | hypothetical protein | - |
| HWI14_RS13400 (HWI14_13275) | - | 2715749..2716678 (-) | 930 | WP_002504713.1 | YafY family protein | - |
| HWI14_RS13405 (HWI14_13280) | - | 2716759..2717187 (+) | 429 | WP_000671997.1 | VOC family protein | - |
| HWI14_RS13410 (HWI14_13285) | - | 2717247..2717921 (-) | 675 | Protein_2600 | IS6 family transposase | - |
| HWI14_RS13415 (HWI14_13290) | - | 2718132..2719322 (+) | 1191 | WP_000716034.1 | YbfB/YjiJ family MFS transporter | - |
| HWI14_RS13420 (HWI14_13295) | - | 2719309..2720175 (+) | 867 | WP_002504710.1 | LysR family transcriptional regulator | - |
| HWI14_RS13425 (HWI14_13300) | - | 2720188..2721258 (+) | 1071 | WP_001054882.1 | nitronate monooxygenase family protein | - |
| HWI14_RS13430 (HWI14_13305) | - | 2721423..2721782 (+) | 360 | WP_000432280.1 | DUF4870 domain-containing protein | - |
| HWI14_RS13435 (HWI14_13310) | - | 2722020..2722793 (-) | 774 | WP_000998885.1 | hypothetical protein | - |
| HWI14_RS13440 (HWI14_13315) | - | 2723110..2723274 (-) | 165 | WP_001028954.1 | hypothetical protein | - |
| HWI14_RS13445 (HWI14_13320) | - | 2723479..2724312 (-) | 834 | WP_000694291.1 | CPBP family intramembrane glutamic endopeptidase | - |
| HWI14_RS13450 (HWI14_13325) | - | 2724349..2724675 (-) | 327 | WP_000624048.1 | helix-turn-helix domain-containing protein | - |
| HWI14_RS13455 (HWI14_13330) | - | 2725007..2725579 (-) | 573 | WP_000489177.1 | ADP-ribosyltransferase | - |
| HWI14_RS13460 (HWI14_13335) | - | 2725632..2726681 (-) | 1050 | WP_000613217.1 | hypothetical protein | - |
| HWI14_RS13465 (HWI14_13340) | ssb | 2726819..2727103 (+) | 285 | WP_000659554.1 | cassette chromosome ssDNA-binding protein | - |
| HWI14_RS13470 (HWI14_13345) | cch1 | 2727103..2728890 (+) | 1788 | WP_000181743.1 | cassette chromosome replicative helicase | - |
| HWI14_RS13475 (HWI14_13350) | - | 2728980..2729255 (+) | 276 | WP_001791132.1 | hypothetical protein | - |
| HWI14_RS13480 (HWI14_13355) | ccrA | 2729448..2730794 (+) | 1347 | WP_000816499.1 | cassette chromosome recombinase CcrA | Machinery gene |
| HWI14_RS13485 (HWI14_13360) | ccrB | 2730815..2732443 (+) | 1629 | WP_001186596.1 | cassette chromosome recombinase CcrB | Machinery gene |
| HWI14_RS13490 (HWI14_13365) | - | 2732914..2733264 (+) | 351 | WP_000171449.1 | SAUGI family uracil-DNA glycosylase inhibitor | - |
| HWI14_RS13495 (HWI14_13370) | - | 2733349..2733660 (+) | 312 | WP_000833212.1 | DUF960 family protein | - |
| HWI14_RS13500 (HWI14_13375) | - | 2733679..2734200 (+) | 522 | WP_000836008.1 | DUF1643 domain-containing protein | - |
| HWI14_RS13505 (HWI14_13380) | - | 2734202..2734408 (+) | 207 | WP_001077283.1 | hypothetical protein | - |
| HWI14_RS13510 (HWI14_13385) | - | 2734401..2734724 (+) | 324 | WP_000088091.1 | JAB domain-containing protein | - |
| HWI14_RS13515 (HWI14_13390) | - | 2734919..2736811 (+) | 1893 | WP_063964251.1 | site-specific integrase | - |
| HWI14_RS13520 (HWI14_13395) | - | 2736818..2737195 (+) | 378 | WP_001041908.1 | DUF6262 family protein | - |
| HWI14_RS13525 (HWI14_13400) | - | 2737433..2737798 (+) | 366 | WP_000159127.1 | metalloregulator ArsR/SmtB family transcription factor | - |
| HWI14_RS13530 (HWI14_13405) | - | 2737791..2740205 (+) | 2415 | WP_408020818.1 | heavy metal translocating P-type ATPase | - |
| HWI14_RS13535 (HWI14_13410) | - | 2740286..2740902 (+) | 617 | Protein_2625 | CadD family cadmium resistance transporter | - |
| HWI14_RS13540 (HWI14_13420) | - | 2741176..2741814 (-) | 639 | Protein_2626 | sulfite exporter TauE/SafE family protein | - |
| HWI14_RS13545 (HWI14_13425) | cstR | 2741814..2742074 (-) | 261 | WP_000220507.1 | persulfide-sensing transcriptional repressor CstR | - |
| HWI14_RS13550 (HWI14_13430) | - | 2742210..2743274 (+) | 1065 | WP_000438836.1 | DsrE/DsrF/DrsH-like family protein | - |
| HWI14_RS13555 (HWI14_13435) | cstB | 2743307..2744641 (+) | 1335 | Protein_2629 | persulfide dioxygenase-sulfurtransferase CstB | - |
| HWI14_RS13560 (HWI14_13440) | - | 2744755..2745885 (-) | 1131 | WP_010922808.1 | ROK family transcriptional regulator | - |
| HWI14_RS13565 (HWI14_13445) | psm-mec | 2746219..2746287 (+) | 69 | WP_014532405.1 | phenol-soluble modulin PSM-mec | - |
| HWI14_RS13570 (HWI14_13450) | mecI | 2746372..2746743 (-) | 372 | WP_000369214.1 | mecA-type methicillin resistance repressor MecI | - |
| HWI14_RS13575 (HWI14_13455) | mecR1 | 2746743..2748500 (-) | 1758 | WP_002504642.1 | beta-lactam sensor/signal transducer MecR1 | - |
| HWI14_RS13580 (HWI14_13460) | mecA | 2748597..2750606 (+) | 2010 | WP_001801873.1 | PBP2a family beta-lactam-resistant peptidoglycan transpeptidase MecA | - |
Sequence
Protein
Download Length: 448 a.a. Molecular weight: 52138.19 Da Isoelectric Point: 10.1760
>NTDB_id=503814 HWI14_RS13480 WP_000816499.1 2729448..2730794(+) (ccrA) [Staphylococcus epidermidis strain UMCG341]
MKRAIGYLRQSTTKQQSLPAQKQAIELLAPKHNIQNIQYISDKQSGRTDNRTGYQQVTERIQQRQCDVLCCYRLNRLHRN
LKNALKLMKLCQKYHVHILSVHDGYFDMDKAFDRLKLNIFMSLAELESDNIGEQVKNGLREKAKQGKLITTHAPFGYHYQ
NGTFIINNDESPTVKAVFNYYLQGYGYKKIAQYLEDDNKLITRKPYQVRNIIMNPNYCGRVINQYGQYNNMVPPIVSATK
YEHAQAIRNKKQLHCIPSENQLKQKIKCPCCDSTLTNMTIRKKHTLRYYICPKNMNESRFVCSFKGINAQKLEVQVLATC
QNFFQNQQLYSKINNAIHQRLKKQRVIEAKSTLTQEQLIDKLAKGMIDAESFRKQTHLMNQKHKTISSISDNQLQTSLQK
VIQKSFTLNMLHPYIDEIRITKNKALVGIYFKNEPLNIVNQTSQSSIA
MKRAIGYLRQSTTKQQSLPAQKQAIELLAPKHNIQNIQYISDKQSGRTDNRTGYQQVTERIQQRQCDVLCCYRLNRLHRN
LKNALKLMKLCQKYHVHILSVHDGYFDMDKAFDRLKLNIFMSLAELESDNIGEQVKNGLREKAKQGKLITTHAPFGYHYQ
NGTFIINNDESPTVKAVFNYYLQGYGYKKIAQYLEDDNKLITRKPYQVRNIIMNPNYCGRVINQYGQYNNMVPPIVSATK
YEHAQAIRNKKQLHCIPSENQLKQKIKCPCCDSTLTNMTIRKKHTLRYYICPKNMNESRFVCSFKGINAQKLEVQVLATC
QNFFQNQQLYSKINNAIHQRLKKQRVIEAKSTLTQEQLIDKLAKGMIDAESFRKQTHLMNQKHKTISSISDNQLQTSLQK
VIQKSFTLNMLHPYIDEIRITKNKALVGIYFKNEPLNIVNQTSQSSIA
Nucleotide
Download Length: 1347 bp
>NTDB_id=503814 HWI14_RS13480 WP_000816499.1 2729448..2730794(+) (ccrA) [Staphylococcus epidermidis strain UMCG341]
ATGAAACGAGCCATTGGTTATTTGCGCCAAAGTACAACGAAACAACAATCACTCCCAGCTCAAAAGCAAGCAATAGAATT
ATTAGCTCCAAAGCACAATATTCAAAATATCCAATACATTAGTGATAAGCAATCAGGCAGAACAGATAATCGAACAGGCT
ATCAACAAGTCACCGAACGCATCCAACAAAGACAATGTGACGTATTATGTTGTTATCGCTTGAATCGACTTCATCGCAAC
TTGAAAAATGCATTAAAACTCATGAAACTCTGTCAAAAATATCATGTTCATATTCTAAGTGTTCATGATGGCTATTTTGA
TATGGATAAAGCGTTTGATCGCCTAAAACTCAATATATTCATGAGTCTGGCTGAACTTGAATCCGATAATATTGGAGAAC
AAGTCAAAAATGGACTTAGAGAAAAGGCAAAACAAGGTAAACTCATAACGACCCATGCGCCTTTCGGTTATCACTATCAA
AATGGTACTTTCATCATTAATAATGATGAATCACCTACCGTCAAAGCTGTATTCAATTATTATCTTCAAGGATATGGCTA
CAAGAAGATTGCACAATATTTAGAAGACGATAATAAACTTATTACCCGCAAGCCTTATCAGGTACGAAATATAATTATGA
ACCCAAATTATTGTGGTCGTGTCATCAATCAATATGGTCAATATAACAATATGGTACCACCTATTGTTTCGGCAACGAAA
TATGAACATGCTCAAGCAATCCGTAATAAGAAGCAACTTCACTGTATACCTTCAGAGAATCAGCTGAAACAAAAGATCAA
ATGTCCTTGTTGTGACTCAACACTGACAAATATGACAATAAGAAAAAAACATACATTGCGATATTATATTTGTCCTAAAA
ATATGAATGAATCTCGCTTTGTCTGTTCATTCAAAGGAATAAATGCACAAAAATTAGAAGTTCAAGTCTTAGCTACATGT
CAGAACTTCTTTCAAAACCAACAGCTCTATTCAAAAATTAATAATGCAATTCATCAACGCCTCAAAAAACAAAGAGTGAT
AGAAGCTAAAAGTACGCTAACTCAAGAACAACTGATAGATAAACTTGCCAAAGGTATGATTGATGCTGAATCATTCAGAA
AACAGACTCATTTGATGAATCAAAAGCACAAAACCATATCCTCCATAAGTGATAATCAGTTACAAACATCACTACAAAAG
GTTATACAGAAAAGTTTCACGTTAAACATGCTGCATCCCTATATTGATGAAATTCGCATTACAAAAAATAAAGCCCTTGT
TGGGATCTATTTCAAAAATGAACCATTGAACATTGTGAACCAAACCTCGCAATCATCGATTGCTTAA
ATGAAACGAGCCATTGGTTATTTGCGCCAAAGTACAACGAAACAACAATCACTCCCAGCTCAAAAGCAAGCAATAGAATT
ATTAGCTCCAAAGCACAATATTCAAAATATCCAATACATTAGTGATAAGCAATCAGGCAGAACAGATAATCGAACAGGCT
ATCAACAAGTCACCGAACGCATCCAACAAAGACAATGTGACGTATTATGTTGTTATCGCTTGAATCGACTTCATCGCAAC
TTGAAAAATGCATTAAAACTCATGAAACTCTGTCAAAAATATCATGTTCATATTCTAAGTGTTCATGATGGCTATTTTGA
TATGGATAAAGCGTTTGATCGCCTAAAACTCAATATATTCATGAGTCTGGCTGAACTTGAATCCGATAATATTGGAGAAC
AAGTCAAAAATGGACTTAGAGAAAAGGCAAAACAAGGTAAACTCATAACGACCCATGCGCCTTTCGGTTATCACTATCAA
AATGGTACTTTCATCATTAATAATGATGAATCACCTACCGTCAAAGCTGTATTCAATTATTATCTTCAAGGATATGGCTA
CAAGAAGATTGCACAATATTTAGAAGACGATAATAAACTTATTACCCGCAAGCCTTATCAGGTACGAAATATAATTATGA
ACCCAAATTATTGTGGTCGTGTCATCAATCAATATGGTCAATATAACAATATGGTACCACCTATTGTTTCGGCAACGAAA
TATGAACATGCTCAAGCAATCCGTAATAAGAAGCAACTTCACTGTATACCTTCAGAGAATCAGCTGAAACAAAAGATCAA
ATGTCCTTGTTGTGACTCAACACTGACAAATATGACAATAAGAAAAAAACATACATTGCGATATTATATTTGTCCTAAAA
ATATGAATGAATCTCGCTTTGTCTGTTCATTCAAAGGAATAAATGCACAAAAATTAGAAGTTCAAGTCTTAGCTACATGT
CAGAACTTCTTTCAAAACCAACAGCTCTATTCAAAAATTAATAATGCAATTCATCAACGCCTCAAAAAACAAAGAGTGAT
AGAAGCTAAAAGTACGCTAACTCAAGAACAACTGATAGATAAACTTGCCAAAGGTATGATTGATGCTGAATCATTCAGAA
AACAGACTCATTTGATGAATCAAAAGCACAAAACCATATCCTCCATAAGTGATAATCAGTTACAAACATCACTACAAAAG
GTTATACAGAAAAGTTTCACGTTAAACATGCTGCATCCCTATATTGATGAAATTCGCATTACAAAAAATAAAGCCCTTGT
TGGGATCTATTTCAAAAATGAACCATTGAACATTGTGAACCAAACCTCGCAATCATCGATTGCTTAA
Similar proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|---|---|---|---|
| ccrA | Staphylococcus aureus COL |
78.174 |
100 |
0.783 |
| ccrA | Staphylococcus aureus N315 |
72.383 |
100 |
0.725 |