Detailed information NTG0503655

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: HWI18_RS08330
• Genome accession: NZ_CP064619
• Coordinates: 1674556..1675602 (-)
• Length: 348 a.a.
• NCBI ID: WP_001830374.1
• Uniprot ID: A0A0N1EGU4
• Organism: Staphylococcus epidermidis strain UMCG345
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 1669556..1680602

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
HWI18_RS08300 (HWI18_08215)	-	1669940..1671181 (-)	1242	WP_001832467.1	aminopeptidase	-
HWI18_RS08305 (HWI18_08220)	-	1671183..1671398 (-)	216	WP_001830421.1	DUF1128 domain-containing protein	-
HWI18_RS08310 (HWI18_08225)	-	1671539..1672003 (+)	465	WP_001830437.1	low molecular weight protein-tyrosine-phosphatase	-
HWI18_RS08315 (HWI18_08230)	-	1672011..1672295 (+)	285	WP_001830401.1	YtxH domain-containing protein	-
HWI18_RS08320 (HWI18_08235)	-	1672702..1673880 (+)	1179	WP_001830411.1	YihY/virulence factor BrkB family protein	-
HWI18_RS08325 (HWI18_08240)	vraR	1673937..1674566 (-)	630	WP_001830439.1	two-component system response regulator VraR	Regulator
HWI18_RS08330 (HWI18_08245)	vraS	1674556..1675602 (-)	1047	WP_001830374.1	sensor histidine kinase	Regulator
HWI18_RS08335 (HWI18_08250)	liaF	1675599..1676300 (-)	702	WP_063964223.1	cell wall-active antibiotics response protein LiaF	-
HWI18_RS08340 (HWI18_08255)	-	1676315..1676701 (-)	387	WP_001830382.1	hypothetical protein	-
HWI18_RS08345 (HWI18_08260)	map	1676859..1677614 (-)	756	WP_002457092.1	type I methionyl aminopeptidase	-
HWI18_RS08350 (HWI18_08265)	-	1677788..1678774 (+)	987	WP_001830388.1	aromatic acid exporter family protein	-
HWI18_RS08355 (HWI18_08270)	isaB	1678925..1679461 (-)	537	WP_002470337.1	immunodominant staphylococcal antigen IsaB family protein	-

Sequence

Protein

• Length: 348 a.a.
• Molecular weight: 40066.49 Da
• Isoelectric Point: 5.8512

>NTDB_id=503655 HWI18_RS08330 WP_001830374.1 1674556..1675602(-) (vraS) [Staphylococcus epidermidis strain UMCG345]
MNHYIRAIGSMLILVYSMLIAFLFIDKVFVNIIFFQGMFYTQIFGIPVFLFLNLLIVLLCIIVGSVLAYKINQQNDWIIS
QIERSIEGQTVGINDQNIELYTETIDIYHTLVPLNQELHRLRMKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKESKLEPPLNQQIPILEKMVQDSQLEMRALLLHLRPIGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFEVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNQEDYLLLRIQDNGKGFNVDEKFEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEENSSGD

Nucleotide

• Length: 1047 bp

>NTDB_id=503655 HWI18_RS08330 WP_001830374.1 1674556..1675602(-) (vraS) [Staphylococcus epidermidis strain UMCG345]
ATGAATCACTACATAAGAGCTATAGGCTCAATGCTTATATTAGTATATAGTATGCTTATTGCTTTTTTATTTATTGATAA
AGTGTTTGTAAATATTATCTTTTTTCAGGGGATGTTTTATACACAAATATTTGGAATACCTGTTTTTCTATTTTTAAATT
TATTAATTGTTCTTTTATGTATTATAGTTGGATCTGTTTTAGCTTATAAAATTAATCAACAAAATGATTGGATTATTTCA
CAAATAGAAAGATCAATAGAAGGACAAACAGTAGGTATCAATGATCAAAATATCGAATTATATACAGAAACGATAGATAT
TTATCATACACTAGTTCCATTAAATCAAGAATTACATCGACTTAGAATGAAGACTCAAAATTTAACTAATGAAAACTACA
ATATTAATGATGTAAAAGTCAAAAAGATTATCGAAGATGAGCGACAACGACTTGCCAGGGAATTACATGATTCTGTTAGT
CAACAATTATTTGCTGCGAGCATGATGCTATCGGCGATAAAAGAGTCGAAATTAGAACCACCTTTAAATCAACAGATACC
AATTCTTGAAAAAATGGTTCAAGACTCACAACTTGAAATGAGAGCTTTGTTATTACATTTAAGACCGATAGGTTTAAAAG
ATAAGTCTTTAGGTGAAGGAATTAAAGATTTAGTCATCGATTTACAAAAGAAAGTACCAATGAAAGTTGTGCATGAAATT
CAAGATTTTGAAGTGCCAAAAGGCATTGAAGATCACTTGTTCAGAATTACACAAGAAGCTATTTCAAATACATTGAGACA
TTCAAATGGTACAAAAGTAACTGTGGAATTATTTAATCAAGAGGATTATCTTTTACTAAGAATTCAAGATAATGGAAAAG
GGTTTAATGTAGATGAAAAATTTGAACAAAGTTATGGTTTGAAAAATATGCGAGAACGAGCGTTAGAAATTGGTGCGACG
TTTCATATTGTATCTTTACCTGATTCAGGTACACGAATTGAAGTTAAGGCACCATTGAATAAGGAGGAGAATTCAAGTGG
CGATTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0N1EGU4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	93.023	98.851	0.92