Detailed information
Bioinformatically predicted
Overview
| Name | ccrA | Type | Machinery gene |
| Locus tag | HWI20_RS13485 | Genome accession | NZ_CP064613 |
| Coordinates | 2728525..2729871 (+) | Length | 448 a.a. |
| NCBI ID | WP_000816499.1 | Uniprot ID | Q9R3W9 |
| Organism | Staphylococcus epidermidis strain UMCG347 | ||
| Function | promote SCCmec transfer (predicted from homology) Homologous recombination |
||
Related MGE
Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.
Gene-MGE association summary
| MGE type | MGE coordinates | Gene coordinates | Relative position | Distance (bp) |
|---|---|---|---|---|
| SCCmec | 2694719..2749683 | 2728525..2729871 | within | 0 |
Gene organization within MGE regions
Location: 2694719..2749683
| Locus tag | Gene name | Coordinates (strand) | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| HWI20_RS13305 (HWI20_13190) | - | 2694719..2695531 (-) | 813 | WP_002504699.1 | abortive infection system antitoxin AbiGi family protein | - |
| HWI20_RS13310 (HWI20_13195) | - | 2695722..2697236 (+) | 1515 | WP_002504700.1 | class I SAM-dependent DNA methyltransferase | - |
| HWI20_RS13315 (HWI20_13200) | - | 2697226..2698500 (+) | 1275 | WP_002504701.1 | restriction endonuclease subunit S | - |
| HWI20_RS13320 (HWI20_13205) | - | 2698484..2701603 (+) | 3120 | WP_002504702.1 | type I restriction endonuclease subunit R | - |
| HWI20_RS13325 (HWI20_13210) | - | 2701681..2702004 (-) | 324 | WP_001176049.1 | PepSY domain-containing protein | - |
| HWI20_RS13330 (HWI20_13215) | - | 2702398..2702619 (-) | 222 | WP_002504703.1 | hypothetical protein | - |
| HWI20_RS13335 (HWI20_13220) | - | 2702568..2703011 (-) | 444 | WP_000941333.1 | hypothetical protein | - |
| HWI20_RS13340 (HWI20_13225) | - | 2703073..2703600 (-) | 528 | WP_002504704.1 | hypothetical protein | - |
| HWI20_RS13345 (HWI20_13230) | - | 2703735..2704223 (-) | 489 | WP_000393586.1 | hypothetical protein | - |
| HWI20_RS13350 (HWI20_13235) | - | 2704239..2704529 (-) | 291 | WP_000065261.1 | hypothetical protein | - |
| HWI20_RS13355 (HWI20_13240) | - | 2704586..2705458 (-) | 873 | WP_000373149.1 | HTH domain-containing protein | - |
| HWI20_RS13360 (HWI20_13245) | - | 2705628..2706074 (-) | 447 | WP_002504705.1 | RadC family protein | - |
| HWI20_RS13365 (HWI20_13250) | - | 2706095..2706601 (-) | 507 | WP_000849085.1 | DUF1643 domain-containing protein | - |
| HWI20_RS13370 (HWI20_13255) | - | 2706617..2706928 (-) | 312 | WP_001083108.1 | DUF960 family protein | - |
| HWI20_RS13375 (HWI20_13260) | - | 2707024..2707362 (-) | 339 | WP_063964250.1 | SAUGI family uracil-DNA glycosylase inhibitor | - |
| HWI20_RS13380 (HWI20_13265) | ccrC | 2707468..2709144 (-) | 1677 | WP_002504707.1 | cassette chromosome recombinase CcrC | - |
| HWI20_RS13385 (HWI20_13270) | - | 2709369..2711012 (-) | 1644 | WP_002504708.1 | DUF5906 domain-containing protein | - |
| HWI20_RS13390 (HWI20_13275) | - | 2711009..2711380 (-) | 372 | WP_002437511.1 | hypothetical protein | - |
| HWI20_RS13395 (HWI20_13280) | - | 2711373..2712482 (-) | 1110 | WP_002437509.1 | DNA polymerase | - |
| HWI20_RS13400 (HWI20_13285) | - | 2712652..2714664 (-) | 2013 | WP_012088687.1 | hypothetical protein | - |
| HWI20_RS13405 (HWI20_13290) | - | 2714826..2715755 (-) | 930 | WP_002504713.1 | YafY family protein | - |
| HWI20_RS13410 (HWI20_13295) | - | 2715836..2716264 (+) | 429 | WP_000671997.1 | VOC family protein | - |
| HWI20_RS13415 (HWI20_13300) | - | 2716324..2716998 (-) | 675 | Protein_2601 | IS6 family transposase | - |
| HWI20_RS13420 (HWI20_13305) | - | 2717209..2718399 (+) | 1191 | WP_000716034.1 | YbfB/YjiJ family MFS transporter | - |
| HWI20_RS13425 (HWI20_13310) | - | 2718386..2719252 (+) | 867 | WP_002504710.1 | LysR family transcriptional regulator | - |
| HWI20_RS13430 (HWI20_13315) | - | 2719265..2720335 (+) | 1071 | WP_001054882.1 | nitronate monooxygenase family protein | - |
| HWI20_RS13435 (HWI20_13320) | - | 2720500..2720859 (+) | 360 | WP_000432280.1 | DUF4870 domain-containing protein | - |
| HWI20_RS13440 (HWI20_13325) | - | 2721097..2721870 (-) | 774 | WP_000998885.1 | hypothetical protein | - |
| HWI20_RS13445 (HWI20_13330) | - | 2722187..2722351 (-) | 165 | WP_001028954.1 | hypothetical protein | - |
| HWI20_RS13450 (HWI20_13335) | - | 2722556..2723389 (-) | 834 | WP_000694291.1 | CPBP family intramembrane glutamic endopeptidase | - |
| HWI20_RS13455 (HWI20_13340) | - | 2723426..2723752 (-) | 327 | WP_000624048.1 | helix-turn-helix domain-containing protein | - |
| HWI20_RS13460 (HWI20_13345) | - | 2724084..2724656 (-) | 573 | WP_000489177.1 | ADP-ribosyltransferase | - |
| HWI20_RS13465 (HWI20_13350) | - | 2724709..2725758 (-) | 1050 | WP_000613217.1 | hypothetical protein | - |
| HWI20_RS13470 (HWI20_13355) | ssb | 2725896..2726180 (+) | 285 | WP_000659554.1 | cassette chromosome ssDNA-binding protein | - |
| HWI20_RS13475 (HWI20_13360) | cch1 | 2726180..2727967 (+) | 1788 | WP_000181743.1 | cassette chromosome replicative helicase | - |
| HWI20_RS13480 (HWI20_13365) | - | 2728057..2728332 (+) | 276 | WP_001791132.1 | hypothetical protein | - |
| HWI20_RS13485 (HWI20_13370) | ccrA | 2728525..2729871 (+) | 1347 | WP_000816499.1 | cassette chromosome recombinase CcrA | Machinery gene |
| HWI20_RS13490 (HWI20_13375) | ccrB | 2729892..2731520 (+) | 1629 | WP_001186596.1 | cassette chromosome recombinase CcrB | Machinery gene |
| HWI20_RS13495 (HWI20_13380) | - | 2731991..2732341 (+) | 351 | WP_000171449.1 | SAUGI family uracil-DNA glycosylase inhibitor | - |
| HWI20_RS13500 (HWI20_13385) | - | 2732426..2732737 (+) | 312 | WP_000833212.1 | DUF960 family protein | - |
| HWI20_RS13505 (HWI20_13390) | - | 2732756..2733277 (+) | 522 | WP_000836008.1 | DUF1643 domain-containing protein | - |
| HWI20_RS13510 (HWI20_13395) | - | 2733279..2733485 (+) | 207 | WP_001077283.1 | hypothetical protein | - |
| HWI20_RS13515 (HWI20_13400) | - | 2733478..2733801 (+) | 324 | WP_000088091.1 | JAB domain-containing protein | - |
| HWI20_RS13520 (HWI20_13405) | - | 2733996..2735888 (+) | 1893 | WP_063964251.1 | site-specific integrase | - |
| HWI20_RS13525 (HWI20_13410) | - | 2735895..2736272 (+) | 378 | WP_001041908.1 | DUF6262 family protein | - |
| HWI20_RS13530 (HWI20_13415) | - | 2736510..2736875 (+) | 366 | WP_000159127.1 | metalloregulator ArsR/SmtB family transcription factor | - |
| HWI20_RS13535 (HWI20_13420) | - | 2736868..2739282 (+) | 2415 | WP_408020818.1 | heavy metal translocating P-type ATPase | - |
| HWI20_RS13540 (HWI20_13425) | - | 2739363..2739979 (+) | 617 | Protein_2626 | CadD family cadmium resistance transporter | - |
| HWI20_RS13545 (HWI20_13435) | - | 2740253..2740891 (-) | 639 | Protein_2627 | sulfite exporter TauE/SafE family protein | - |
| HWI20_RS13550 (HWI20_13440) | cstR | 2740891..2741151 (-) | 261 | WP_000220507.1 | persulfide-sensing transcriptional repressor CstR | - |
| HWI20_RS13555 (HWI20_13445) | - | 2741287..2742351 (+) | 1065 | WP_000438836.1 | DsrE/DsrF/DrsH-like family protein | - |
| HWI20_RS13560 (HWI20_13450) | cstB | 2742384..2743718 (+) | 1335 | Protein_2630 | persulfide dioxygenase-sulfurtransferase CstB | - |
| HWI20_RS13565 (HWI20_13455) | - | 2743832..2744962 (-) | 1131 | WP_010922808.1 | ROK family transcriptional regulator | - |
| HWI20_RS13570 (HWI20_13460) | psm-mec | 2745296..2745364 (+) | 69 | WP_014532405.1 | phenol-soluble modulin PSM-mec | - |
| HWI20_RS13575 (HWI20_13465) | mecI | 2745449..2745820 (-) | 372 | WP_000369214.1 | mecA-type methicillin resistance repressor MecI | - |
| HWI20_RS13580 (HWI20_13470) | mecR1 | 2745820..2747577 (-) | 1758 | WP_002504642.1 | beta-lactam sensor/signal transducer MecR1 | - |
| HWI20_RS13585 (HWI20_13475) | mecA | 2747674..2749683 (+) | 2010 | WP_001801873.1 | PBP2a family beta-lactam-resistant peptidoglycan transpeptidase MecA | - |
Sequence
Protein
Download Length: 448 a.a. Molecular weight: 52138.19 Da Isoelectric Point: 10.1760
>NTDB_id=503587 HWI20_RS13485 WP_000816499.1 2728525..2729871(+) (ccrA) [Staphylococcus epidermidis strain UMCG347]
MKRAIGYLRQSTTKQQSLPAQKQAIELLAPKHNIQNIQYISDKQSGRTDNRTGYQQVTERIQQRQCDVLCCYRLNRLHRN
LKNALKLMKLCQKYHVHILSVHDGYFDMDKAFDRLKLNIFMSLAELESDNIGEQVKNGLREKAKQGKLITTHAPFGYHYQ
NGTFIINNDESPTVKAVFNYYLQGYGYKKIAQYLEDDNKLITRKPYQVRNIIMNPNYCGRVINQYGQYNNMVPPIVSATK
YEHAQAIRNKKQLHCIPSENQLKQKIKCPCCDSTLTNMTIRKKHTLRYYICPKNMNESRFVCSFKGINAQKLEVQVLATC
QNFFQNQQLYSKINNAIHQRLKKQRVIEAKSTLTQEQLIDKLAKGMIDAESFRKQTHLMNQKHKTISSISDNQLQTSLQK
VIQKSFTLNMLHPYIDEIRITKNKALVGIYFKNEPLNIVNQTSQSSIA
MKRAIGYLRQSTTKQQSLPAQKQAIELLAPKHNIQNIQYISDKQSGRTDNRTGYQQVTERIQQRQCDVLCCYRLNRLHRN
LKNALKLMKLCQKYHVHILSVHDGYFDMDKAFDRLKLNIFMSLAELESDNIGEQVKNGLREKAKQGKLITTHAPFGYHYQ
NGTFIINNDESPTVKAVFNYYLQGYGYKKIAQYLEDDNKLITRKPYQVRNIIMNPNYCGRVINQYGQYNNMVPPIVSATK
YEHAQAIRNKKQLHCIPSENQLKQKIKCPCCDSTLTNMTIRKKHTLRYYICPKNMNESRFVCSFKGINAQKLEVQVLATC
QNFFQNQQLYSKINNAIHQRLKKQRVIEAKSTLTQEQLIDKLAKGMIDAESFRKQTHLMNQKHKTISSISDNQLQTSLQK
VIQKSFTLNMLHPYIDEIRITKNKALVGIYFKNEPLNIVNQTSQSSIA
Nucleotide
Download Length: 1347 bp
>NTDB_id=503587 HWI20_RS13485 WP_000816499.1 2728525..2729871(+) (ccrA) [Staphylococcus epidermidis strain UMCG347]
ATGAAACGAGCCATTGGTTATTTGCGCCAAAGTACAACGAAACAACAATCACTCCCAGCTCAAAAGCAAGCAATAGAATT
ATTAGCTCCAAAGCACAATATTCAAAATATCCAATACATTAGTGATAAGCAATCAGGCAGAACAGATAATCGAACAGGCT
ATCAACAAGTCACCGAACGCATCCAACAAAGACAATGTGACGTATTATGTTGTTATCGCTTGAATCGACTTCATCGCAAC
TTGAAAAATGCATTAAAACTCATGAAACTCTGTCAAAAATATCATGTTCATATTCTAAGTGTTCATGATGGCTATTTTGA
TATGGATAAAGCGTTTGATCGCCTAAAACTCAATATATTCATGAGTCTGGCTGAACTTGAATCCGATAATATTGGAGAAC
AAGTCAAAAATGGACTTAGAGAAAAGGCAAAACAAGGTAAACTCATAACGACCCATGCGCCTTTCGGTTATCACTATCAA
AATGGTACTTTCATCATTAATAATGATGAATCACCTACCGTCAAAGCTGTATTCAATTATTATCTTCAAGGATATGGCTA
CAAGAAGATTGCACAATATTTAGAAGACGATAATAAACTTATTACCCGCAAGCCTTATCAGGTACGAAATATAATTATGA
ACCCAAATTATTGTGGTCGTGTCATCAATCAATATGGTCAATATAACAATATGGTACCACCTATTGTTTCGGCAACGAAA
TATGAACATGCTCAAGCAATCCGTAATAAGAAGCAACTTCACTGTATACCTTCAGAGAATCAGCTGAAACAAAAGATCAA
ATGTCCTTGTTGTGACTCAACACTGACAAATATGACAATAAGAAAAAAACATACATTGCGATATTATATTTGTCCTAAAA
ATATGAATGAATCTCGCTTTGTCTGTTCATTCAAAGGAATAAATGCACAAAAATTAGAAGTTCAAGTCTTAGCTACATGT
CAGAACTTCTTTCAAAACCAACAGCTCTATTCAAAAATTAATAATGCAATTCATCAACGCCTCAAAAAACAAAGAGTGAT
AGAAGCTAAAAGTACGCTAACTCAAGAACAACTGATAGATAAACTTGCCAAAGGTATGATTGATGCTGAATCATTCAGAA
AACAGACTCATTTGATGAATCAAAAGCACAAAACCATATCCTCCATAAGTGATAATCAGTTACAAACATCACTACAAAAG
GTTATACAGAAAAGTTTCACGTTAAACATGCTGCATCCCTATATTGATGAAATTCGCATTACAAAAAATAAAGCCCTTGT
TGGGATCTATTTCAAAAATGAACCATTGAACATTGTGAACCAAACCTCGCAATCATCGATTGCTTAA
ATGAAACGAGCCATTGGTTATTTGCGCCAAAGTACAACGAAACAACAATCACTCCCAGCTCAAAAGCAAGCAATAGAATT
ATTAGCTCCAAAGCACAATATTCAAAATATCCAATACATTAGTGATAAGCAATCAGGCAGAACAGATAATCGAACAGGCT
ATCAACAAGTCACCGAACGCATCCAACAAAGACAATGTGACGTATTATGTTGTTATCGCTTGAATCGACTTCATCGCAAC
TTGAAAAATGCATTAAAACTCATGAAACTCTGTCAAAAATATCATGTTCATATTCTAAGTGTTCATGATGGCTATTTTGA
TATGGATAAAGCGTTTGATCGCCTAAAACTCAATATATTCATGAGTCTGGCTGAACTTGAATCCGATAATATTGGAGAAC
AAGTCAAAAATGGACTTAGAGAAAAGGCAAAACAAGGTAAACTCATAACGACCCATGCGCCTTTCGGTTATCACTATCAA
AATGGTACTTTCATCATTAATAATGATGAATCACCTACCGTCAAAGCTGTATTCAATTATTATCTTCAAGGATATGGCTA
CAAGAAGATTGCACAATATTTAGAAGACGATAATAAACTTATTACCCGCAAGCCTTATCAGGTACGAAATATAATTATGA
ACCCAAATTATTGTGGTCGTGTCATCAATCAATATGGTCAATATAACAATATGGTACCACCTATTGTTTCGGCAACGAAA
TATGAACATGCTCAAGCAATCCGTAATAAGAAGCAACTTCACTGTATACCTTCAGAGAATCAGCTGAAACAAAAGATCAA
ATGTCCTTGTTGTGACTCAACACTGACAAATATGACAATAAGAAAAAAACATACATTGCGATATTATATTTGTCCTAAAA
ATATGAATGAATCTCGCTTTGTCTGTTCATTCAAAGGAATAAATGCACAAAAATTAGAAGTTCAAGTCTTAGCTACATGT
CAGAACTTCTTTCAAAACCAACAGCTCTATTCAAAAATTAATAATGCAATTCATCAACGCCTCAAAAAACAAAGAGTGAT
AGAAGCTAAAAGTACGCTAACTCAAGAACAACTGATAGATAAACTTGCCAAAGGTATGATTGATGCTGAATCATTCAGAA
AACAGACTCATTTGATGAATCAAAAGCACAAAACCATATCCTCCATAAGTGATAATCAGTTACAAACATCACTACAAAAG
GTTATACAGAAAAGTTTCACGTTAAACATGCTGCATCCCTATATTGATGAAATTCGCATTACAAAAAATAAAGCCCTTGT
TGGGATCTATTTCAAAAATGAACCATTGAACATTGTGAACCAAACCTCGCAATCATCGATTGCTTAA
Similar proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|---|---|---|---|
| ccrA | Staphylococcus aureus COL |
78.174 |
100 |
0.783 |
| ccrA | Staphylococcus aureus N315 |
72.383 |
100 |
0.725 |